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SLC17A1 (Solute Carrier Family 17 Member 1) is a Protein Coding gene. Diseases associated with SLC17A1 include Gout and Hyperuricemia. Among its related pathways are Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds and Uricosurics Pathway, Pharmacodynamics. Gene Ontology (GO) annotations related to this gene include symporter activity and phosphate ion transmembrane transporter activity. An important paralog of this gene is SLC17A2.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005436 | sodium:phosphate symporter activity | TAS | 8867793 |
GO:0015114 | phosphate ion transmembrane transporter activity | IEA | -- |
GO:0015136 | sialic acid transmembrane transporter activity | IBA | 21873635 |
GO:0015293 | symporter activity | IEA | -- |
GO:0022857 | transmembrane transporter activity | IBA | 21873635 |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005764 | lysosome | IBA | 21873635 |
GO:0005886 | plasma membrane | TAS | -- |
GO:0005887 | integral component of plasma membrane | TAS,IBA | 21873635 |
GO:0016020 | membrane | TAS | 8288239 |
GO:0016021 | integral component of membrane | IBA | 21873635 |
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds | ||
2 | Uricosurics Pathway, Pharmacodynamics |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0006811 | ion transport | TAS | -- |
GO:0006814 | sodium ion transport | IEA | -- |
GO:0006817 | phosphate ion transport | TAS | 8867793 |
GO:0006820 | anion transport | IBA | 21873635 |
GO:0015739 | sialic acid transport | IBA | 21873635 |
Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
---|---|---|---|---|---|---|
Phosphate | Experimental | Pharma | 0 |
Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs | |
---|---|---|---|---|---|---|
sodium |
|
7440-23-5 |
|
ExUns: | 1 | ^ | 2a | · | 2b | ^ | 3 | ^ | 4 | ^ | 5a | · | 5b | ^ | 6 | ^ | 7 | ^ | 8 | ^ | 9 | ^ | 10 | ^ | 11 | ^ | 12 | ^ | 13 |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
SP1: | |||||||||||||||||||||||||||||
SP2: | - | ||||||||||||||||||||||||||||
SP3: |
This gene was present in the common ancestor of animals.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Chimpanzee (Pan troglodytes) |
Mammalia | SLC17A1 30 31 |
|
OneToOne | |
Dog (Canis familiaris) |
Mammalia | SLC17A1 30 31 |
|
OneToOne | |
Cow (Bos Taurus) |
Mammalia | SLC17A1 30 31 |
|
OneToOne | |
Rat (Rattus norvegicus) |
Mammalia | Slc17a1 30 |
|
||
Mouse (Mus musculus) |
Mammalia | Slc17a1 30 17 31 |
|
OneToOne | |
Oppossum (Monodelphis domestica) |
Mammalia | -- 31 |
|
ManyToMany | |
-- 31 |
|
ManyToMany | |||
-- 31 |
|
ManyToMany | |||
Platypus (Ornithorhynchus anatinus) |
Mammalia | -- 31 |
|
ManyToMany | |
-- 31 |
|
ManyToMany | |||
Zebrafish (Danio rerio) |
Actinopterygii | CU929219.1 31 |
|
OneToMany | |
Worm (Caenorhabditis elegans) |
Secernentea | T09B9.2 32 |
|
|
|
F21F8.11 32 |
|
|
SNP ID | Clinical significance and condition | Chr 06 pos | Variation | AA Info | Type |
---|---|---|---|---|---|
rs74521692 | Benign: not provided | 25,798,815(-) |
C/T NM_005074.5(SLC17A1):c.1374G>A (p.Trp458Ter) |
NONSENSE | |
rs1165196 | - |
p.Thr269Ile |
|||
rs6933573 | - |
p.Ser76Asn |
Disorder | Aliases | PubMed IDs |
---|---|---|
gout |
|
|
hyperuricemia |
|
|
fanconi renotubular syndrome 2 |
|
|
purine-pyrimidine metabolic disorder |
|
|
lesch-nyhan syndrome |
|
|