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Aliases for SLC16A9 Gene

Aliases for SLC16A9 Gene

  • Solute Carrier Family 16 Member 9 2 3 4 5
  • Solute Carrier Family 16 (Monocarboxylic Acid Transporters), Member 9 2 3
  • Monocarboxylic Acid Transporter 9 2 3
  • C10orf36 3 4
  • MCT 9 3 4
  • MCT9 3 4
  • Solute Carrier Family 16, Member 9 (Monocarboxylic Acid Transporter 9) 2
  • Chromosome 10 Open Reading Frame 36 2
  • Solute Carrier Family 16, Member 9 2
  • Monocarboxylate Transporter 9 3

External Ids for SLC16A9 Gene

Previous HGNC Symbols for SLC16A9 Gene

  • C10orf36

Previous GeneCards Identifiers for SLC16A9 Gene

  • GC10M060757
  • GC10M060755
  • GC10M061080
  • GC10M061410
  • GC10M055397

Summaries for SLC16A9 Gene

GeneCards Summary for SLC16A9 Gene

SLC16A9 (Solute Carrier Family 16 Member 9) is a Protein Coding gene. Diseases associated with SLC16A9 include Gout. Gene Ontology (GO) annotations related to this gene include symporter activity and monocarboxylic acid transmembrane transporter activity. An important paralog of this gene is SLC16A14.

UniProtKB/Swiss-Prot for SLC16A9 Gene

  • Proton-linked monocarboxylate transporter. May catalyze the transport of monocarboxylates across the plasma membrane.

Gene Wiki entry for SLC16A9 Gene

Additional gene information for SLC16A9 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SLC16A9 Gene

Genomics for SLC16A9 Gene

GeneHancer (GH) Regulatory Elements for SLC16A9 Gene

Promoters and enhancers for SLC16A9 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH10J059708 Promoter/Enhancer 1.4 Ensembl ENCODE 8.8 +26.3 26298 2 ZSCAN4 KLF17 SIN3A ZNF2 ZNF335 GLIS2 EGR1 ZFP91 KLF7 KLF13 SLC16A9 GC10P059652
GH10J059648 Enhancer 0.6 ENCODE 15.8 +87.1 87093 1.3 MAFG BACH1 MAFF ZNF316 NFE2 MAFK EMSY NFE2L2 SLC16A9 CCDC6 GC10P059652 LOC105378319 ENSG00000235140
GH10J059748 Enhancer 0.4 ENCODE 18.8 -13.1 -13076 0.9 JUNB REST BATF SLC16A9 MRLN
GH10J059778 Enhancer 0.4 ENCODE 17.5 -44.0 -44004 2.1 REST ZBTB8A SLC16A9 CCDC6 MRLN
GH10J059676 Enhancer 0.8 ENCODE 6.5 +57.0 56999 4.6 ELF3 FOXA2 BATF IRF4 ZSCAN9 RARA ETV6 CREM MIXL1 JUNB SLC16A9 GC10P059652
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around SLC16A9 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the SLC16A9 gene promoter:
  • c-Myb
  • HNF-1A
  • HNF-1
  • TBP
  • NF-AT4
  • NF-AT3
  • NF-AT2
  • NF-AT1
  • NF-AT
  • MEF-2A

Genomic Locations for SLC16A9 Gene

Genomic Locations for SLC16A9 Gene
85,242 bases
Minus strand
85,239 bases
Minus strand

Genomic View for SLC16A9 Gene

Genes around SLC16A9 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SLC16A9 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SLC16A9 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SLC16A9 Gene

Proteins for SLC16A9 Gene

  • Protein details for SLC16A9 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Monocarboxylate transporter 9
    Protein Accession:
    Secondary Accessions:
    • Q6ZMI2
    • Q9UFH8

    Protein attributes for SLC16A9 Gene

    509 amino acids
    Molecular mass:
    55794 Da
    Quaternary structure:
    No Data Available
    • Sequence=BAD18743.1; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for SLC16A9 Gene

Post-translational modifications for SLC16A9 Gene

  • Ubiquitination at posLast=504504
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for SLC16A9 Gene

Domains & Families for SLC16A9 Gene

Gene Families for SLC16A9 Gene

Human Protein Atlas (HPA):
  • Predicted membrane proteins
  • Transporters

Protein Domains for SLC16A9 Gene


Suggested Antigen Peptide Sequences for SLC16A9 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the major facilitator superfamily. Monocarboxylate porter (TC 2.A.1.13) family.
  • Belongs to the major facilitator superfamily. Monocarboxylate porter (TC 2.A.1.13) family.
genes like me logo Genes that share domains with SLC16A9: view

Function for SLC16A9 Gene

Molecular function for SLC16A9 Gene

UniProtKB/Swiss-Prot Function:
Proton-linked monocarboxylate transporter. May catalyze the transport of monocarboxylates across the plasma membrane.

Phenotypes From GWAS Catalog for SLC16A9 Gene

Gene Ontology (GO) - Molecular Function for SLC16A9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005215 transporter activity IBA --
GO:0005515 protein binding IPI 25416956
GO:0008028 monocarboxylic acid transmembrane transporter activity IBA --
GO:0015293 symporter activity IEA --
genes like me logo Genes that share ontologies with SLC16A9: view
genes like me logo Genes that share phenotypes with SLC16A9: view

Animal Model Products

miRNA for SLC16A9 Gene

miRTarBase miRNAs that target SLC16A9

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for SLC16A9 Gene

Localization for SLC16A9 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SLC16A9 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SLC16A9 gene
Compartment Confidence
plasma membrane 5

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cell Junctions (2)
  • Nucleus (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for SLC16A9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane IEA --
GO:0005887 integral component of plasma membrane IBA --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA,IBA --
genes like me logo Genes that share ontologies with SLC16A9: view

Pathways & Interactions for SLC16A9 Gene

SuperPathways for SLC16A9 Gene

No Data Available

Gene Ontology (GO) - Biological Process for SLC16A9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0015718 monocarboxylic acid transport IBA --
GO:0046415 urate metabolic process IMP 19503597
GO:0055085 transmembrane transport IEA --
genes like me logo Genes that share ontologies with SLC16A9: view

No data available for Pathways by source and SIGNOR curated interactions for SLC16A9 Gene

Drugs & Compounds for SLC16A9 Gene

No Compound Related Data Available

Transcripts for SLC16A9 Gene

Unigene Clusters for SLC16A9 Gene

Solute carrier family 16, member 9 (monocarboxylic acid transporter 9):
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for SLC16A9 Gene

ExUns: 1 ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7a · 7b ^ 8 ^ 9a · 9b · 9c ^ 10a · 10b
SP1: - - - - - -
SP2: - - -
SP3: - -
SP5: - -

Relevant External Links for SLC16A9 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for SLC16A9 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for SLC16A9 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SLC16A9 Gene

This gene is overexpressed in Adrenal Gland (x13.4) and Kidney - Cortex (x5.9).

Protein differential expression in normal tissues from HIPED for SLC16A9 Gene

This gene is overexpressed in Urine (68.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for SLC16A9 Gene

Protein tissue co-expression partners for SLC16A9 Gene

NURSA nuclear receptor signaling pathways regulating expression of SLC16A9 Gene:


SOURCE GeneReport for Unigene cluster for SLC16A9 Gene:


Evidence on tissue expression from TISSUES for SLC16A9 Gene

  • Intestine(4.2)
  • Kidney(2.6)
  • Adrenal gland(2)
genes like me logo Genes that share expression patterns with SLC16A9: view

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for SLC16A9 Gene

Orthologs for SLC16A9 Gene

This gene was present in the common ancestor of animals.

Orthologs for SLC16A9 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia SLC16A9 34 33
  • 99.67 (n)
(Canis familiaris)
Mammalia SLC16A9 34 33
  • 90.83 (n)
(Bos Taurus)
Mammalia SLC16A9 34 33
  • 90.75 (n)
(Ornithorhynchus anatinus)
Mammalia SLC16A9 34
  • 85 (a)
(Mus musculus)
Mammalia Slc16a9 16 34 33
  • 82.61 (n)
(Rattus norvegicus)
Mammalia LOC687808 33
  • 79.56 (n)
(Monodelphis domestica)
Mammalia SLC16A9 34
  • 65 (a)
(Gallus gallus)
Aves SLC16A9 34 33
  • 76.96 (n)
(Anolis carolinensis)
Reptilia SLC16A9 34
  • 74 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100485780 33
  • 63.41 (n)
(Danio rerio)
Actinopterygii slc16a9a 34 33
  • 58.58 (n)
slc16a9b 34
  • 51 (a)
-- 33
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP001782 33
  • 46.91 (n)
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 25 (a)
Species where no ortholog for SLC16A9 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for SLC16A9 Gene

Gene Tree for SLC16A9 (if available)
Gene Tree for SLC16A9 (if available)
Evolutionary constrained regions (ECRs) for SLC16A9: view image

Paralogs for SLC16A9 Gene

Paralogs for SLC16A9 Gene

(4) SIMAP similar genes for SLC16A9 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with SLC16A9: view

Variants for SLC16A9 Gene

Sequence variations from dbSNP and Humsavar for SLC16A9 Gene

SNP ID Clin Chr 10 pos Variation AA Info Type
rs1000126693 -- 59,660,772(-) A/G intron_variant
rs1000136761 -- 59,682,920(-) A/G intron_variant
rs1000144812 -- 59,703,609(-) G/T intron_variant
rs1000189746 -- 59,689,853(-) G/A intron_variant
rs1000199639 -- 59,689,653(-) C/T intron_variant

Structural Variations from Database of Genomic Variants (DGV) for SLC16A9 Gene

Variant ID Type Subtype PubMed ID
dgv462n106 CNV deletion 24896259
esv1583704 CNV deletion 17803354
esv2613224 CNV deletion 19546169
esv2674517 CNV deletion 23128226
esv2737462 CNV deletion 23290073
esv3623459 CNV loss 21293372
esv3891831 CNV loss 25118596
nsv473192 CNV novel sequence insertion 20440878
nsv819969 CNV loss 19587683
nsv825405 CNV loss 20364138
nsv955979 CNV deletion 24416366

Variation tolerance for SLC16A9 Gene

Residual Variation Intolerance Score: 24% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.84; 58.67% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for SLC16A9 Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SLC16A9 Gene

Disorders for SLC16A9 Gene

MalaCards: The human disease database

(1) MalaCards diseases for SLC16A9 Gene - From: HGMD, DISEASES, and GeneCards

Disorder Aliases PubMed IDs
  • articular gout
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for SLC16A9

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with SLC16A9: view

No data available for UniProtKB/Swiss-Prot and Genatlas for SLC16A9 Gene

Publications for SLC16A9 Gene

  1. Human metabolic individuality in biomedical and pharmaceutical research. (PMID: 21886157) Suhre K … Gieger C (Nature 2011) 3 44 58
  2. Replication of the five novel loci for uric acid concentrations and potential mediating mechanisms. (PMID: 19861489) van der Harst P … Navis G (Human molecular genetics 2010) 3 44 58
  3. A genome-wide perspective of genetic variation in human metabolism. (PMID: 20037589) Illig T … Suhre K (Nature genetics 2010) 3 44 58
  4. Meta-analysis of 28,141 individuals identifies common variants within five new loci that influence uric acid concentrations. (PMID: 19503597) Kolz M … Gieger C (PLoS genetics 2009) 3 44 58
  5. Common polymorphisms influencing serum uric acid levels contribute to susceptibility to gout, but not to coronary artery disease. (PMID: 19890391) Stark K … Hengstenberg C (PloS one 2009) 3 44 58

Products for SLC16A9 Gene

Sources for SLC16A9 Gene

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