SLC16A8 is a member of a family of proton-coupled monocarboxylate transporters that mediate lactate transport across cell membranes (Yoon et al., 1999 [PubMed 10493836]).[supplied by OMIM, Apr 2010] See more...

Aliases for SLC16A8 Gene

Aliases for SLC16A8 Gene

  • Solute Carrier Family 16 Member 8 2 3 4 5
  • Monocarboxylate Transporter 3 2 3 4
  • MCT3 2 3 4
  • Solute Carrier Family 16 (Monocarboxylate Transporter), Member 8 2 3
  • Solute Carrier 16 (Monocarboxylic Acid Transporters), Member 8 2 3
  • MCT 3 3 4
  • REMP 2 3
  • Solute Carrier Family 16, Member 8 (Monocarboxylic Acid Transporter 3) 3
  • SLC16A8 5

External Ids for SLC16A8 Gene

Previous GeneCards Identifiers for SLC16A8 Gene

  • GC22M035088
  • GC22M036717
  • GC22M036798
  • GC22M038474
  • GC22M021438
  • GC22M038393
  • GC22M038515
  • GC22M043819
  • GC22M044198
  • GC22M044524
  • GC22M045374
  • GC22M038827
  • GC22M039964
  • GC22M040655
  • GC22M041104
  • GC22M041507
  • GC22M041917
  • GC22M042357
  • GC22M043447
  • GC22M046225
  • GC22M047268

Summaries for SLC16A8 Gene

Entrez Gene Summary for SLC16A8 Gene

  • SLC16A8 is a member of a family of proton-coupled monocarboxylate transporters that mediate lactate transport across cell membranes (Yoon et al., 1999 [PubMed 10493836]).[supplied by OMIM, Apr 2010]

GeneCards Summary for SLC16A8 Gene

SLC16A8 (Solute Carrier Family 16 Member 8) is a Protein Coding gene. Diseases associated with SLC16A8 include Macular Degeneration, Age-Related, 1. Among its related pathways are Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds and Cell surface interactions at the vascular wall. Gene Ontology (GO) annotations related to this gene include symporter activity and secondary active monocarboxylate transmembrane transporter activity. An important paralog of this gene is SLC16A3.

UniProtKB/Swiss-Prot Summary for SLC16A8 Gene

  • Proton-linked monocarboxylate transporter. Catalyzes the rapid transport across the plasma membrane of many monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and the ketone bodies acetoacetate, beta-hydroxybutyrate and acetate (By similarity).

Tocris Summary for SLC16A8 Gene

  • Monocarboxylate transporters (MCT) catalyze the bidirectional proton-linked transport of short-chain monocarboxylates such as L-lactate, ketone bodies and pyruvate across the plasma membrane of mammalian cells. MCT1-4 are key in the regulation of many cellular processes.

No data available for CIViC Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for SLC16A8 Gene

Genomics for SLC16A8 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for SLC16A8 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH22J038082 Promoter 0.6 Ensembl 250.7 +1.4 1383 0.4 SP2 NRF1 RUNX3 KDM1A MGA ENSG00000272720 SLC16A8 NONHSAG033903.2 PICK1 TMEM184B
GH22J038084 Promoter/Enhancer 0.5 EPDnew Ensembl 250.7 -0.8 -817 2.8 SLC16A8 BAIAP2L2 PICK1 PLA2G6 TMEM184B ENSG00000272720 HSALNG0135382 NONHSAG033903.2
GH22J037993 Enhancer 1.4 VISTA ENCODE dbSUPER 10 +87.1 87069 7.8 ZNF600 JUND ZNF223 NFIC ZIC2 FEZF1 ZNF341 MAX KLF9 CTBP1 SLC16A8 GALR3 TRIOBP BAIAP2L2 KDELR3 MIR4534 SOX10 piR-57460-458 POLR2F PICK1
GH22J038107 Promoter/Enhancer 1.9 EPDnew Ensembl ENCODE dbSUPER 5.6 -26.0 -25999 6.1 SSRP1 ZMYM3 KLF9 ZIC2 CHD4 MXD4 KLF11 HOMEZ THAP11 KDM6A BAIAP2L2 PLA2G6 ANKRD54 PICK1 SLC16A8 ENSG00000272669 HSALNG0135382 L13304-023
GH22J038186 Enhancer 1.2 Ensembl ENCODE dbSUPER 4.4 -103.8 -103817 4.4 CEBPA ATF3 YY1 CEBPB MAX THAP11 FOXA2 KDM6A ZNF623 SMAD4 TMEM184B EIF3L H1-0 BAIAP2L2 PLA2G6 SLC16A8 lnc-MAFF-3 lnc-BAIAP2L2-4 MAFF RF00017-3460
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around SLC16A8 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for SLC16A8

Top Transcription factor binding sites by QIAGEN in the SLC16A8 gene promoter:
  • AhR
  • Arnt
  • ATF6
  • c-Ets-1
  • CREB
  • FOXL1
  • NF-1
  • NF-1/L
  • Sp1
  • Zic3

Genomic Locations for SLC16A8 Gene

Latest Assembly
chr22:38,078,134-38,084,184
(GRCh38/hg38)
Size:
6,051 bases
Orientation:
Minus strand

Previous Assembly
chr22:38,474,144-38,480,191
(GRCh37/hg19 by Entrez Gene)
Size:
6,048 bases
Orientation:
Minus strand

chr22:38,474,141-38,480,100
(GRCh37/hg19 by Ensembl)
Size:
5,960 bases
Orientation:
Minus strand

Genomic View for SLC16A8 Gene

Genes around SLC16A8 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SLC16A8 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SLC16A8 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SLC16A8 Gene

Proteins for SLC16A8 Gene

  • Protein details for SLC16A8 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O95907-MOT3_HUMAN
    Recommended name:
    Monocarboxylate transporter 3
    Protein Accession:
    O95907
    Secondary Accessions:
    • Q9UBE2

    Protein attributes for SLC16A8 Gene

    Size:
    504 amino acids
    Molecular mass:
    52319 Da
    Quaternary structure:
    No Data Available

neXtProt entry for SLC16A8 Gene

Post-translational modifications for SLC16A8 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for SLC16A8 Gene

No data available for DME Specific Peptides for SLC16A8 Gene

Domains & Families for SLC16A8 Gene

Gene Families for SLC16A8 Gene

HGNC:
IUPHAR :
Human Protein Atlas (HPA):
  • Plasma proteins
  • Predicted membrane proteins
  • Transporters

Protein Domains for SLC16A8 Gene

Suggested Antigen Peptide Sequences for SLC16A8 Gene

GenScript: Design optimal peptide antigens:
  • Solute carrier family 16 member 8 (MOT3_HUMAN)

Graphical View of Domain Structure for InterPro Entry

O95907

UniProtKB/Swiss-Prot:

MOT3_HUMAN :
  • Belongs to the major facilitator superfamily. Monocarboxylate porter (TC 2.A.1.13) family.
Family:
  • Belongs to the major facilitator superfamily. Monocarboxylate porter (TC 2.A.1.13) family.
genes like me logo Genes that share domains with SLC16A8: view

Function for SLC16A8 Gene

Molecular function for SLC16A8 Gene

UniProtKB/Swiss-Prot Function:
Proton-linked monocarboxylate transporter. Catalyzes the rapid transport across the plasma membrane of many monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and the ketone bodies acetoacetate, beta-hydroxybutyrate and acetate (By similarity).

Phenotypes From GWAS Catalog for SLC16A8 Gene

Gene Ontology (GO) - Molecular Function for SLC16A8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008028 monocarboxylic acid transmembrane transporter activity IEA,IBA 21873635
GO:0015129 lactate transmembrane transporter activity IEA --
GO:0015293 symporter activity IEA --
GO:0022857 transmembrane transporter activity IEA --
genes like me logo Genes that share ontologies with SLC16A8: view
genes like me logo Genes that share phenotypes with SLC16A8: view

Animal Models for SLC16A8 Gene

MGI Knock Outs for SLC16A8:

Animal Models for research

  • Taconic Biosciences Mouse Models for SLC16A8

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for SLC16A8

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for SLC16A8 Gene

Localization for SLC16A8 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SLC16A8 Gene

Cell membrane. Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SLC16A8 gene
Compartment Confidence
plasma membrane 5
extracellular 2
mitochondrion 2
cytoskeleton 1
peroxisome 1
nucleus 1
endoplasmic reticulum 1
endosome 1
cytosol 1
lysosome 1
golgi apparatus 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Focal adhesion sites (2)
  • Intermediate filaments (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for SLC16A8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane IEA,IBA 21873635
GO:0016020 membrane TAS 10493836
GO:0016021 integral component of membrane IEA,IBA 21873635
GO:0016323 basolateral plasma membrane IDA 31791063
genes like me logo Genes that share ontologies with SLC16A8: view

Pathways & Interactions for SLC16A8 Gene

genes like me logo Genes that share pathways with SLC16A8: view

Interacting Proteins for SLC16A8 Gene

Gene Ontology (GO) - Biological Process for SLC16A8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006090 pyruvate metabolic process TAS --
GO:0015718 monocarboxylic acid transport IEA,IBA 21873635
GO:0015727 lactate transport TAS 10493836
GO:0035873 lactate transmembrane transport IEA --
GO:0050900 leukocyte migration TAS --
genes like me logo Genes that share ontologies with SLC16A8: view

No data available for SIGNOR curated interactions for SLC16A8 Gene

Drugs & Compounds for SLC16A8 Gene

(4) Drugs for SLC16A8 Gene - From: DrugBank, HMDB, and Tocris

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Pyruvic acid Approved, Investigational Nutra Target 0
AR-C155858 Pharma MCT1 and MCT2 inhibitor, MCT1 and MCT2 inhibitor; inhibits glycolysis in cancer cells 0
CHC Pharma MCT inhibitor; decreases glycoloysis 0
UK 5099 Pharma MCTs and MPC inhibitor, MCT inhibitor; also inhibits of pyruvate transport 0

(1) Additional Compounds for SLC16A8 Gene - From: Tocris

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
SR 13800
227321-12-2

(4) Tocris Compounds for SLC16A8 Gene

Compound Action Cas Number
AR-C155858 MCT1 and MCT2 inhibitor; inhibits glycolysis in cancer cells 496791-37-8
CHC MCT inhibitor; decreases glycoloysis 28166-41-8
SR 13800 Potent MCT1 inhibitor 227321-12-2
UK 5099 MCT inhibitor; also inhibits of pyruvate transport 56396-35-1
genes like me logo Genes that share compounds with SLC16A8: view

Transcripts for SLC16A8 Gene

mRNA/cDNA for SLC16A8 Gene

1 REFSEQ mRNAs :
4 NCBI additional mRNA sequence :
4 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for SLC16A8

Alternative Splicing Database (ASD) splice patterns (SP) for SLC16A8 Gene

No ASD Table

Relevant External Links for SLC16A8 Gene

GeneLoc Exon Structure for
SLC16A8

Expression for SLC16A8 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for SLC16A8 Gene

Protein differential expression in normal tissues from HIPED for SLC16A8 Gene

This gene is overexpressed in Monocytes (36.6) and Tlymphocyte (28.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for SLC16A8 Gene



Protein tissue co-expression partners for SLC16A8 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for SLC16A8

SOURCE GeneReport for Unigene cluster for SLC16A8 Gene:

Hs.745256

mRNA Expression by UniProt/SwissProt for SLC16A8 Gene:

O95907-MOT3_HUMAN
Tissue specificity: Retinal pigment epithelium.

Evidence on tissue expression from TISSUES for SLC16A8 Gene

  • Eye(2.3)
genes like me logo Genes that share expression patterns with SLC16A8: view

Primer products for research

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for SLC16A8 Gene

Orthologs for SLC16A8 Gene

This gene was present in the common ancestor of animals.

Orthologs for SLC16A8 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia SLC16A8 29 30
  • 99.34 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia SLC16A8 29 30
  • 88.03 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia SLC16A8 29 30
  • 87.09 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Slc16a8 29
  • 83.68 (n)
Mouse
(Mus musculus)
Mammalia Slc16a8 29 16 30
  • 83.61 (n)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia SLC16A8 30
  • 70 (a)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia SLC16A8 30
  • 66 (a)
OneToOne
Chicken
(Gallus gallus)
Aves SLC16A8 29
  • 65.42 (n)
SLC16A3 30
  • 58 (a)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia SLC16A8 30
  • 56 (a)
OneToOne
Zebrafish
(Danio rerio)
Actinopterygii slc16a8 30
  • 62 (a)
OneToOne
LOC557884 29
  • 59.18 (n)
Fruit Fly
(Drosophila melanogaster)
Insecta CG8271 31
  • 38 (a)
CG13907 31
  • 36 (a)
Species where no ortholog for SLC16A8 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for SLC16A8 Gene

ENSEMBL:
Gene Tree for SLC16A8 (if available)
TreeFam:
Gene Tree for SLC16A8 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for SLC16A8: view image
Alliance of Genome Resources:
Additional Orthologs for SLC16A8

Paralogs for SLC16A8 Gene

(10) SIMAP similar genes for SLC16A8 Gene using alignment to 2 proteins:

  • MOT3_HUMAN
  • B0QYL4_HUMAN
genes like me logo Genes that share paralogs with SLC16A8: view

Variants for SLC16A8 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for SLC16A8 Gene

SNP ID Clinical significance and condition Chr 22 pos Variation AA Info Type
rs140740838 Benign: not provided 38,078,443(-) TCGCCCCGGGCG/T
NM_013356.3(SLC16A8):c.1449_1459del (p.Ser483fs)
FRAMESHIFT
rs187455529 Benign: not provided 38,078,399(-) C/T
NM_013356.3(SLC16A8):c.1504G>A (p.Glu502Lys)
MISSENSE
rs188395735 Benign: not provided 38,082,672(-) G/A
NM_013356.3(SLC16A8):c.202C>T (p.Leu68Phe)
MISSENSE
rs8135665 Not Provided: not provided 38,080,269(-) C/T
NM_013356.2(SLC16A8):c.1198+571G>A
INTRON
rs2076371 -- p.Val405Ala

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for SLC16A8 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for SLC16A8 Gene

Variant ID Type Subtype PubMed ID
nsv471198 CNV loss 18288195
nsv476631 CNV novel sequence insertion 20440878
nsv527871 CNV loss 19592680
nsv834193 CNV loss 17160897
nsv834194 CNV loss 17160897

Variation tolerance for SLC16A8 Gene

Gene Damage Index Score: 8.83; 86.91% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for SLC16A8 Gene

Human Gene Mutation Database (HGMD)
SLC16A8
SNPedia medical, phenotypic, and genealogical associations of SNPs for
SLC16A8
Leiden Open Variation Database (LOVD)
SLC16A8

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SLC16A8 Gene

Disorders for SLC16A8 Gene

MalaCards: The human disease database

(1) MalaCards diseases for SLC16A8 Gene - From: COP

Disorder Aliases PubMed IDs
macular degeneration, age-related, 1
  • armd1
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for SLC16A8

Human Genome Epidemiology Navigator
(HuGE)
Atlas
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
Open Targets Platform
genes like me logo Genes that share disorders with SLC16A8: view

No data available for UniProtKB/Swiss-Prot and Genatlas for SLC16A8 Gene

Publications for SLC16A8 Gene

  1. Cloning of the human monocarboxylate transporter MCT3 gene: localization to chromosome 22q12.3-q13.2. (PMID: 10493836) Yoon H … Philp NJ (Genomics 1999) 2 3 4 22
  2. L-type voltage-dependent calcium channel alpha subunit 1C is a novel candidate gene associated with secondary hyperparathyroidism: an application of haplotype-based analysis for multiple linked single nucleotide polymorphisms. (PMID: 20424473) Yokoyama K … Hosoya T (Nephron. Clinical practice 2010) 3 40
  3. The DNA sequence of human chromosome 22. (PMID: 10591208) Dunham I … O'Brien KP (Nature 1999) 3 4
  4. Quantitative Protein Expression in the Human Retinal Pigment Epithelium: Comparison Between Apical and Basolateral Plasma Membranes With Emphasis on Transporters. (PMID: 31791063) Hellinen L … Urtti A (Investigative ophthalmology & visual science 2019) 3
  5. Synergistic drug combinations for cancer identified in a CRISPR screen for pairwise genetic interactions. (PMID: 28319085) Han K … Bassik MC (Nature biotechnology 2017) 3

Products for SLC16A8 Gene

  • Biorbyt antibodies for SLC16A8

Sources for SLC16A8 Gene