Aliases for SLC16A8 Gene
- Solute Carrier Family 16 Member 8 2 3 4 5
- Monocarboxylate Transporter 3 2 3 4
- Solute Carrier Family 16 (Monocarboxylate Transporter), Member 8 2 3
- Solute Carrier 16 (Monocarboxylic Acid Transporters), Member 8 2 3
- MCT 3 3 4
- MCT3 3 4
- Solute Carrier Family 16, Member 8 (Monocarboxylic Acid Transporter 3) 3
- REMP 3
External Ids for SLC16A8 Gene
Previous GeneCards Identifiers for SLC16A8 Gene
SLC16A8 is a member of a family of proton-coupled monocarboxylate transporters that mediate lactate transport across cell membranes (Yoon et al., 1999 [PubMed 10493836]).[supplied by OMIM, Apr 2010]
GeneCards Summary for SLC16A8 Gene
SLC16A8 (Solute Carrier Family 16 Member 8) is a Protein Coding gene. Diseases associated with SLC16A8 include Macular Degeneration, Age-Related, 1. Among its related pathways are Cell surface interactions at the vascular wall and Basigin interactions. Gene Ontology (GO) annotations related to this gene include symporter activity and secondary active monocarboxylate transmembrane transporter activity. An important paralog of this gene is SLC16A3.
UniProtKB/Swiss-Prot Summary for SLC16A8 Gene
Proton-linked monocarboxylate transporter. Catalyzes the rapid transport across the plasma membrane of many monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and the ketone bodies acetoacetate, beta-hydroxybutyrate and acetate (By similarity).
Monocarboxylate transporters (MCT) catalyze the bidirectional proton-linked transport of short-chain monocarboxylates such as L-lactate, ketone bodies and pyruvate across the plasma membrane of mammalian cells. MCT1-4 are key in the regulation of many cellular processes.