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This gene is a member of the monocarboxylate transporter family. Members in this family transport metabolites, such as lactate, pyruvate, and ketone bodies. The protein encoded by this gene catalyzes the proton-linked transport of monocarboxylates and has the highest affinity for pyruvate. This protein has been reported to be more highly expressed in prostate and colorectal can... See more...
Aliases for SLC16A7 Gene
Aliases for SLC16A7 Gene
- Solute Carrier Family 16 Member 7 2 3 4 5
- MCT2 2 3 4
- Solute Carrier Family 16 (Monocarboxylate Transporter), Member 7 2 3
- Monocarboxylate Transporter 2 3 4
- Solute Carrier Family 16, Member 7 (Monocarboxylic Acid Transporter 2) 3
- Solute Carrier Family 16 (Monocarboxylic Acid Transporters), Member 7 2
- SLC16A7 5
- MCT 2 4
External Ids for SLC16A7 Gene
- HGNC: 10928
- Entrez Gene: 9194
- Ensembl: ENSG00000118596
- OMIM: 603654
- UniProtKB: O60669
Previous GeneCards Identifiers for SLC16A7 Gene
- GC12P059779
- GC12P060132
- GC12P058276
- GC12P058369
- GC12P057131
- GC12P059989
Summaries for SLC16A7 Gene
-
This gene is a member of the monocarboxylate transporter family. Members in this family transport metabolites, such as lactate, pyruvate, and ketone bodies. The protein encoded by this gene catalyzes the proton-linked transport of monocarboxylates and has the highest affinity for pyruvate. This protein has been reported to be more highly expressed in prostate and colorectal cancer specimens when compared to control specimens. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2012]
GeneCards Summary for SLC16A7 Gene
SLC16A7 (Solute Carrier Family 16 Member 7) is a Protein Coding gene. Diseases associated with SLC16A7 include Fanconi-Like Syndrome and Colorectal Cancer. Among its related pathways are Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds. Gene Ontology (GO) annotations related to this gene include symporter activity and secondary active monocarboxylate transmembrane transporter activity. An important paralog of this gene is SLC16A1.
UniProtKB/Swiss-Prot Summary for SLC16A7 Gene
-
Proton-coupled monocarboxylate transporter. Catalyzes the rapid transport across the plasma membrane of many monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and the ketone bodies acetoacetate, beta-hydroxybutyrate and acetate. Functions as high-affinity pyruvate transporter.
-
Monocarboxylate transporters (MCT) catalyze the bidirectional proton-linked transport of short-chain monocarboxylates such as L-lactate, ketone bodies and pyruvate across the plasma membrane of mammalian cells. MCT1-4 are key in the regulation of many cellular processes.
Additional gene information for SLC16A7 Gene
- HGNC(10928)
- Entrez Gene(9194)
- Ensembl(ENSG00000118596)
- OMIM(603654)
- UniProtKB(O60669)
- Open Targets Platform(ENSG00000118596)
- Monarch Initiative
- Search for SLC16A7 at DataMed
- Search for SLC16A7 at HumanCyc
No data available for CIViC Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for SLC16A7 Gene
Genomics for SLC16A7 Gene
GeneHancer (GH) Regulatory Elements Pubs
Promoters and enhancers for SLC16A7 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around SLC16A7 on the GeneHancer Hub at the UCSC Golden Path
Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for SLC16A7
- Top Transcription factor binding sites by QIAGEN in the SLC16A7 gene promoter:
-
- Cart-1
- FOXO1
- FOXO1a
- HNF-3beta
- HOXA9
- HOXA9B
- Meis-1
- Meis-1b
- POU2F1
- POU2F1a
Genomic Locations for SLC16A7 Gene
Genomic Locations for SLC16A7 Gene
- chr12:59,595,934-59,789,855
- (GRCh38/hg38)
- Size:
- 193,922 bases
- Orientation:
- Plus strand
- chr12:59,989,848-60,176,395
- (GRCh37/hg19)
- Size:
- 186,548 bases
- Orientation:
- Plus strand
Genomic View for SLC16A7 Gene
Genes around SLC16A7 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 12q14.1 by HGNC
- 12q14.1 by Entrez Gene
- 12q14.1 by Ensembl
SLC16A7 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for SLC16A7 Gene
Proteins for SLC16A7 Gene
-
Protein details for SLC16A7 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- O60669-MOT2_HUMAN
- Recommended name:
- Monocarboxylate transporter 2
- Protein Accession:
- O60669
- Q8NEM3
- Q9UPB3
Protein attributes for SLC16A7 Gene
- Size:
- 478 amino acids
- Molecular mass:
- 52200 Da
- Quaternary structure:
-
- Interacts with GRID2IP.
Protein Expression for SLC16A7 Gene
Post-translational modifications for SLC16A7 Gene
Other Protein References for SLC16A7 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- LifeSpan BioSciences SLC16A7 / MCT2 Antibody (LS-B6440) and SLC16A7 / MCT2 Antibody (LS-B15408)
- G Biosciences Immunotag™ MOT2 Antibody
-
Custom Antibody ServicesOriGene Antibodies for SLC16A7
- Novus Biologicals Antibodies for SLC16A7
-
Abcam antibodies for SLC16A7
- Invitrogen Antibodies for SLC16A7 (AFLGC-SLC16A7)
-
Boster Bio Antibodies for SLC16A7
Protein Products
-
OriGene Purified Proteins for SLC16A7
- Search Origene for MassSpec and Protein Over-expression Lysates for SLC16A7
- Origene Custom Protein Services for SLC16A7
-
Signalway Proteins for SLC16A7
Assay Products
- G Biosciences Immunotag™ Monocarboxylate transporter 2 ELISA Kit
- antibodies-online: Show 8 available SLC16A7 Elisa Kits ranked by validation data
- Compare Top SLC16A7 Elisa Kits
-
Quality Products:
No data available for DME Specific Peptides for SLC16A7 Gene
Domains & Families for SLC16A7 Gene
Gene Families for SLC16A7 Gene
- HGNC:
- IUPHAR :
- Human Protein Atlas (HPA):
-
- Predicted membrane proteins
- Transporters
Suggested Antigen Peptide Sequences for SLC16A7 Gene
- GenScript: Design optimal peptide antigens:
-
- Solute carrier family 16 member 7 (MOT2_HUMAN)
- cDNA, FLJ93868, Homo sapiens solute carrier family 16 (monocarboxylic acid transporters), member 7 (SLC16A7), mRNA (Q8NEM3_HUMAN)
Graphical View of Domain Structure for InterPro Entry
O60669UniProtKB/Swiss-Prot:
MOT2_HUMAN :- Belongs to the major facilitator superfamily. Monocarboxylate porter (TC 2.A.1.13) family.
- Family:
-
- Belongs to the major facilitator superfamily. Monocarboxylate porter (TC 2.A.1.13) family.
Function for SLC16A7 Gene
Molecular function for SLC16A7 Gene
- UniProtKB/Swiss-Prot Function:
- Proton-coupled monocarboxylate transporter. Catalyzes the rapid transport across the plasma membrane of many monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and the ketone bodies acetoacetate, beta-hydroxybutyrate and acetate. Functions as high-affinity pyruvate transporter.
- GENATLAS Biochemistry:
- solute carrier family 16,member A7,monocarboxylic acids transporter,high affinity pyruvate transporter,restricted in normal tissues,widely expressed in cancer cell lines
Phenotypes From GWAS Catalog for SLC16A7 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005477 | pyruvate secondary active transmembrane transporter activity | TAS | 9786900 |
| GO:0008028 | monocarboxylic acid transmembrane transporter activity | IEA,IBA | 21873635 |
| GO:0015129 | lactate transmembrane transporter activity | IDA | 9786900 |
| GO:0015293 | symporter activity | IEA | -- |
| GO:0050833 | pyruvate transmembrane transporter activity | IDA | 9786900 |
Phenotypes for SLC16A7 Gene
Animal Model Products
-
Taconic Biosciences Mouse Models for SLC16A7
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for SLC16A7 - Select products 50% OFF >
- * SLC16A7 CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for SLC16A7
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for SLC16A7
-
Santa Cruz Biotechnology (SCBT) CRISPR for SLC16A7
miRNA for SLC16A7 Gene
- miRTarBase miRNAs that target SLC16A7
-
- mmu-miR-26a-5p (MIRT011361)
- hsa-miR-215-5p (MIRT024296)
- hsa-miR-192-5p (MIRT026289)
- hsa-miR-4423-3p (MIRT467922)
- hsa-miR-496 (MIRT467923)
- hsa-miR-20a-3p (MIRT467924)
- hsa-miR-4729 (MIRT467925)
- hsa-miR-759 (MIRT467926)
- hsa-miR-506-5p (MIRT467927)
- hsa-miR-892c-5p (MIRT467928)
- hsa-miR-329-5p (MIRT467929)
- hsa-miR-4748 (MIRT467930)
- hsa-miR-4464 (MIRT467931)
- mmu-miR-433-3p (MIRT596398)
- mmu-miR-9-5p (MIRT605494)
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for SLC16A7
- Browse OriGene Inhibitory RNA Products For SLC16A7
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for SLC16A7
Clone Products
- Applied Biological Materials (abm): Clones for SLC16A7 - Select products 50% OFF >
- * SLC16A7 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
- Sino Biological Human cDNA Clone for SLC16A7
- Addgene plasmids for SLC16A7
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for SLC16A7
Cell Line Products
-
Horizon Cell Lines for SLC16A7
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for SLC16A7 Gene
Localization for SLC16A7 Gene
Subcellular locations from UniProtKB/Swiss-Prot for SLC16A7 Gene
- Cell membrane. Multi-pass membrane protein.
| Compartment | Confidence |
|---|---|
| plasma membrane | 5 |
| extracellular | 2 |
| mitochondrion | 2 |
| nucleus | 2 |
| cytosol | 2 |
| cytoskeleton | 1 |
| peroxisome | 1 |
| endoplasmic reticulum | 1 |
| endosome | 1 |
| lysosome | 1 |
| golgi apparatus | 1 |
- Plasma membrane (3)
- Nucleoplasm (2)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005886 | plasma membrane | TAS | -- |
| GO:0005887 | integral component of plasma membrane | IEA,IDA | 15505343 |
| GO:0016020 | membrane | IEA | -- |
| GO:0016021 | integral component of membrane | IEA,IBA | 21873635 |
Pathways & Interactions for SLC16A7 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds |
.37
|
|
Pathways by source for SLC16A7 Gene
Interacting Proteins for SLC16A7 Gene
Selected Interacting proteins:
O60669-MOT2_HUMAN
ENSP00000261187
for SLC16A7 Gene via
UniProtKB
STRING
IID
GPS-Prot Interaction Network for SLC16A7
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0015718 | monocarboxylic acid transport | IEA,IBA | 21873635 |
| GO:0035873 | lactate transmembrane transport | IMP | 9786900 |
| GO:0055085 | transmembrane transport | IEA | -- |
| GO:1901475 | pyruvate transmembrane transport | IEA,IDA | 9786900 |
No data available for SIGNOR curated interactions for SLC16A7 Gene
Drugs & Compounds for SLC16A7 Gene
| Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
|---|---|---|---|---|---|---|
| 4-Hydroxybutyric acid | Approved, Illicit, Investigational | Pharma | Transporter, inhibitor | 0 | ||
| Probenecid | Approved, Investigational | Pharma | Inhibitor, Inhibition, Activator, Transporter, inhibitor | 40 | ||
| Pyruvic acid | Approved, Investigational | Nutra | Target, Transporter, substrate, inhibitor | 0 | ||
| Lactic acid | Approved, Vet_approved | Pharma | Transporter, substrate, inhibitor | 0 | ||
| Methotrexate | Approved | Pharma | Folate antagonist,inhibits DFHR | 1825 |
| Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs | |
|---|---|---|---|---|---|---|
| SR 13800 |
|
227321-12-2 |
|
|
(4) Tocris Compounds for SLC16A7 Gene
| Compound | Action | Cas Number |
|---|---|---|
| AR-C155858 | MCT1 and MCT2 inhibitor; inhibits glycolysis in cancer cells | 496791-37-8 |
| CHC | MCT inhibitor; decreases glycoloysis | 28166-41-8 |
| SR 13800 | Potent MCT1 inhibitor | 227321-12-2 |
| UK 5099 | MCT inhibitor; also inhibits of pyruvate transport | 56396-35-1 |
(2) ApexBio Compounds for SLC16A7 Gene
| Compound | Action | Cas Number |
|---|---|---|
| AR-C155858 | MCT1 and MCT2 inhibitor | 496791-37-8 |
| UK-5099 | MCTs and MPC inhibitor | 56396-35-1 |
Transcripts for SLC16A7 Gene
mRNA/cDNA for SLC16A7 Gene
- 3 REFSEQ mRNAs :
- 9 NCBI additional mRNA sequence :
- 16 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000261187 11777 nts (view in UCSC)
- ENST00000546459 605 nts (view in UCSC)
- ENST00000547379 11936 nts (view in UCSC)
- ENST00000547801 547 nts (view in UCSC)
- ENST00000548444 797 nts (view in UCSC)
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for SLC16A7 - Select products 50% OFF >
- * SLC16A7 CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for SLC16A7
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for SLC16A7
-
Santa Cruz Biotechnology (SCBT) CRISPR for SLC16A7
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for SLC16A7
- Browse OriGene Inhibitory RNA Products For SLC16A7
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for SLC16A7
Clone Products
- Applied Biological Materials (abm): Clones for SLC16A7 - Select products 50% OFF >
- * SLC16A7 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
- Sino Biological Human cDNA Clone for SLC16A7
- Addgene plasmids for SLC16A7
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for SLC16A7
Relevant External Links for SLC16A7 Gene
- GeneLoc Exon Structure for
- SLC16A7
Expression for SLC16A7 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
-
Skeletal Muscle (Muscoskeletal System)
- Muscle Progenitor Cells Mandibular Arch Muscles
- Muscle Progenitor Cells Hyoid Arch Muscles
- Adipose (Muscoskeletal System)
-
Peripheral Nervous System (Nervous System)
- Schwann Precursor Cells Peripheral Nerve Domain
- Spleen (Hematopoietic System)
- Blood (Cardiovascular System)
- Neural Tube (Nervous System)
- Kidney (Urinary System)
mRNA differential expression in normal tissues according to GTEx for SLC16A7 Gene
This gene is overexpressed in Heart - Left Ventricle (x5.7).
This gene is overexpressed in Pancreas (13.2), Frontal cortex (11.3), Heart (8.7), Kidney (7.3), and Peripheral blood mononuclear cells (6.9).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for SLC16A7 Gene
Transcriptomic regulation report from SPP (The Signaling Pathways Project) for SLC16A7
SOURCE GeneReport for Unigene cluster for SLC16A7 Gene:
Hs.88156mRNA Expression by UniProt/SwissProt for SLC16A7 Gene:
O60669-MOT2_HUMAN
Tissue specificity:
Detected in heart and in blood lymphocytes and monocytes (at protein level). High expression in testis, moderate to low in spleen, heart, kidney, pancreas, skeletal muscle, brain and Leukocyte. Restricted expression in normal tissues, but widely expressed in cancer cells.
Evidence on tissue expression from TISSUES for SLC16A7 Gene
- Liver(4.4)
- Heart(2.8)
- Muscle(2.7)
- Nervous system(2.7)
- Kidney(2.5)
- Blood(2.3)
- Stomach(2.1)
- Intestine(2.1)
Primer Products
-
OriGene qPCR primer pairs for SLC16A7
-
OriGene qPCR primer pairs and template standards for SLC16A7
Gene Expression Assay Products
No data available for Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for SLC16A7 Gene
Orthologs for SLC16A7 Gene
This gene was present in the common ancestor of animals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| Chimpanzee (Pan troglodytes) |
Mammalia | SLC16A7 30 31 |
|
OneToOne | |
| Dog (Canis familiaris) |
Mammalia | SLC16A7 30 31 |
|
OneToOne | |
| Cow (Bos Taurus) |
Mammalia | SLC16A7 30 31 |
|
OneToOne | |
| Rat (Rattus norvegicus) |
Mammalia | Slc16a7 30 |
|
||
| Mouse (Mus musculus) |
Mammalia | Slc16a7 30 17 31 |
|
OneToOne | |
| Oppossum (Monodelphis domestica) |
Mammalia | SLC16A7 31 |
|
OneToOne | |
| Platypus (Ornithorhynchus anatinus) |
Mammalia | SLC16A7 31 |
|
OneToOne | |
| Chicken (Gallus gallus) |
Aves | SLC16A7 30 31 |
|
OneToOne | |
| Lizard (Anolis carolinensis) |
Reptilia | SLC16A7 31 |
|
OneToOne | |
| Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | slc16a7 30 |
|
||
| Zebrafish (Danio rerio) |
Actinopterygii | SLC16A7 31 |
|
OneToOne | |
| zgc:165507 30 |
|
||||
| Fruit Fly (Drosophila melanogaster) |
Insecta | CG13907 32 |
|
|
- Species where no ortholog for SLC16A7 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Eremothecium gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- Alpha proteobacteria (Wolbachia pipientis)
- Amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- Baker's yeast (Saccharomyces cerevisiae)
- Barley (Hordeum vulgare)
- Beta proteobacteria (Neisseria meningitidis)
- Bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- Common water flea (Daphnia pulex)
- Corn (Zea mays)
- E. coli (Escherichia coli)
- Filamentous fungi (Aspergillus nidulans)
- Firmicute Bacteria (Streptococcus pneumoniae)
- Fission Yeast (Schizosaccharomyces pombe)
- Green Algae (Chlamydomonas reinhardtii)
- Honey Bee (Apis mellifera)
- K. Lactis Yeast (Kluyveromyces lactis)
- Loblloly Pine (Pinus taeda)
- Malaria Parasite (Plasmodium falciparum)
- Medicago Trunc (Medicago Truncatula)
- Moss (Physcomitrella patens)
- Orangutan (Pongo pygmaeus)
- Pig (Sus scrofa)
- Rainbow Trout (Oncorhynchus mykiss)
- Rice (Oryza sativa)
- Rice Blast Fungus (Magnaporthe grisea)
- Schistosome Parasite (Schistosoma mansoni)
- Sea Anemone (Nematostella vectensis)
- Sea Vase (Ciona intestinalis)
- Sea Squirt (Ciona savignyi)
- Sea Urchin (Strongylocentrotus purpuratus)
- Sorghum (Sorghum bicolor)
- Soybean (Glycine max)
- Stem Rust Fungus (Puccinia graminis)
- Sugarcane (Saccharum officinarum)
- Thale Cress (Arabidopsis thaliana)
- Tomato (Lycopersicon esculentum)
- Toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- Wheat (Triticum aestivum)
- Worm (Caenorhabditis elegans)
Evolution for SLC16A7 Gene
- ENSEMBL:
- Gene Tree for SLC16A7 (if available)
- TreeFam:
- Gene Tree for SLC16A7 (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for SLC16A7: view image
Paralogs for SLC16A7 Gene
Paralogs for SLC16A7 Gene
(13) SIMAP similar genes for SLC16A7 Gene using alignment to 10 proteins:
- MOT2_HUMAN
- F5H843_HUMAN
- F8VQS4_HUMAN
- F8VS95_HUMAN
- F8VVU7_HUMAN
- F8VXG4_HUMAN
- F8VYZ2_HUMAN
- F8W0N3_HUMAN
- F8W0U4_HUMAN
- F8W1M4_HUMAN
Variants for SLC16A7 Gene
Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for SLC16A7 Gene
| SNP ID | Clinical significance and condition | Chr 12 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| 746430 | Likely Benign: not provided | 59,774,805(+) | T/C | NON_CODING_TRANSCRIPT_VARIANT,SYNONYMOUS_VARIANT | |
| 768560 | Benign: not provided | 59,704,906(+) | A/G | NON_CODING_TRANSCRIPT_VARIANT,SYNONYMOUS_VARIANT | |
| 768561 | Benign: not provided | 59,774,897(+) | A/G | MISSENSE_VARIANT,NON_CODING_TRANSCRIPT_VARIANT | |
| rs3763980 | - | p.Thr445Ser |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| dgv295e199 | CNV | deletion | 23128226 |
| esv23936 | CNV | loss | 19812545 |
| esv2670981 | CNV | deletion | 23128226 |
| esv275119 | CNV | loss | 21479260 |
| esv2762982 | CNV | gain | 21179565 |
| esv3306085 | CNV | mobile element insertion | 20981092 |
| esv3306780 | CNV | mobile element insertion | 20981092 |
| esv3309227 | CNV | mobile element insertion | 20981092 |
| esv3354729 | CNV | insertion | 20981092 |
| esv3380560 | CNV | insertion | 20981092 |
| esv3409549 | CNV | insertion | 20981092 |
| esv3446144 | CNV | insertion | 20981092 |
| esv3549273 | CNV | deletion | 23714750 |
| esv3580288 | CNV | loss | 25503493 |
| esv3629653 | CNV | gain | 21293372 |
| esv3629661 | CNV | gain | 21293372 |
| esv3629664 | CNV | loss | 21293372 |
| esv3629666 | CNV | loss | 21293372 |
| nsv1038100 | CNV | loss | 25217958 |
| nsv1048949 | CNV | gain | 25217958 |
| nsv1120263 | CNV | tandem duplication | 24896259 |
| nsv559050 | CNV | gain | 21841781 |
| nsv559101 | CNV | loss | 21841781 |
| nsv559102 | CNV | loss | 21841781 |
| nsv957254 | CNV | deletion | 24416366 |
Residual Variation Intolerance Score:
42.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
2.32;
41.39% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for SLC16A7 Gene
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SLC16A7 Gene
Disorders for SLC16A7 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| fanconi-like syndrome |
|
|
| colorectal cancer |
|
|
Search SLC16A7 in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for SLC16A7
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
- Open Targets Platform
No data available for UniProtKB/Swiss-Prot and Genatlas for SLC16A7 Gene
Publications for SLC16A7 Gene
- Human monocarboxylate transporter 2 (MCT2) is a high affinity pyruvate transporter. (PMID: 9786900) Lin RY … Golde DW (The Journal of biological chemistry 1998) 2 3 4 23 26
- Presence and localization of three lactic acid transporters (MCT1, -2, and -4) in separated human granulocytes, lymphocytes, and monocytes. (PMID: 15505343) Merezhinskaya N … Fishbein WN (The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society 2004) 3 4 23
- Expression of monocarboxylate transporters 1, 2, and 4 in human tumours and their association with CD147 and CD44. (PMID: 20454640) Pinheiro C … Baltazar F (Journal of biomedicine & biotechnology 2010) 3 23
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Products for SLC16A7 Gene
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