Aliases for SLC16A7 Gene
- Solute Carrier Family 16 Member 7 2 3 4 5
- MCT2 2 3 4
- Solute Carrier Family 16 (Monocarboxylate Transporter), Member 7 2 3
- Monocarboxylate Transporter 2 3 4
- Solute Carrier Family 16, Member 7 (Monocarboxylic Acid Transporter 2) 3
- Solute Carrier Family 16 (Monocarboxylic Acid Transporters), Member 7 2
- SLC16A7 5
- MCT 2 4
External Ids for SLC16A7 Gene
Previous GeneCards Identifiers for SLC16A7 Gene
This gene is a member of the monocarboxylate transporter family. Members in this family transport metabolites, such as lactate, pyruvate, and ketone bodies. The protein encoded by this gene catalyzes the proton-linked transport of monocarboxylates and has the highest affinity for pyruvate. This protein has been reported to be more highly expressed in prostate and colorectal cancer specimens when compared to control specimens. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2012]
GeneCards Summary for SLC16A7 Gene
SLC16A7 (Solute Carrier Family 16 Member 7) is a Protein Coding gene. Diseases associated with SLC16A7 include Colorectal Cancer. Among its related pathways are Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds. Gene Ontology (GO) annotations related to this gene include symporter activity and secondary active monocarboxylate transmembrane transporter activity. An important paralog of this gene is SLC16A1.
UniProtKB/Swiss-Prot Summary for SLC16A7 Gene
Proton-coupled monocarboxylate transporter. Catalyzes the rapid transport across the plasma membrane of many monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and the ketone bodies acetoacetate, beta-hydroxybutyrate and acetate. Functions as high-affinity pyruvate transporter.
Monocarboxylate transporters (MCT) catalyze the bidirectional proton-linked transport of short-chain monocarboxylates such as L-lactate, ketone bodies and pyruvate across the plasma membrane of mammalian cells. MCT1-4 are key in the regulation of many cellular processes.