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This gene is a member of the monocarboxylate transporter family. Members in this family transport metabolites, such as lactate, pyruvate, and ketone bodies. The protein encoded by this gene catalyzes the proton-linked transport of monocarboxylates and has the highest affinity for pyruvate. This protein has been reported to be more highly expressed in prostate and colorectal cancer specimens when compared to control specimens. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2012]
SLC16A7 (Solute Carrier Family 16 Member 7) is a Protein Coding gene. Diseases associated with SLC16A7 include Fanconi-Like Syndrome and Colorectal Cancer. Among its related pathways are Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds. Gene Ontology (GO) annotations related to this gene include symporter activity and secondary active monocarboxylate transmembrane transporter activity. An important paralog of this gene is SLC16A1.
Monocarboxylate transporters (MCT) catalyze the bidirectional proton-linked transport of short-chain monocarboxylates such as L-lactate, ketone bodies and pyruvate across the plasma membrane of mammalian cells. MCT1-4 are key in the regulation of many cellular processes.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005477 | pyruvate secondary active transmembrane transporter activity | TAS | 9786900 |
GO:0008028 | monocarboxylic acid transmembrane transporter activity | IEA,IBA | 21873635 |
GO:0015129 | lactate transmembrane transporter activity | IDA | 9786900 |
GO:0015293 | symporter activity | IEA | -- |
GO:0050833 | pyruvate transmembrane transporter activity | IDA | 9786900 |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005886 | plasma membrane | TAS | -- |
GO:0005887 | integral component of plasma membrane | IEA,IDA | 15505343 |
GO:0016020 | membrane | IEA | -- |
GO:0016021 | integral component of membrane | IEA,IBA | 21873635 |
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds |
.37
|
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0015718 | monocarboxylic acid transport | IEA,IBA | 21873635 |
GO:0035873 | lactate transmembrane transport | IMP | 9786900 |
GO:0055085 | transmembrane transport | IEA | -- |
GO:1901475 | pyruvate transmembrane transport | IEA,IDA | 9786900 |
Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
---|---|---|---|---|---|---|
4-Hydroxybutyric acid | Approved, Illicit, Investigational | Pharma | Transporter, inhibitor | 0 | ||
Probenecid | Approved, Investigational | Pharma | Inhibitor, Inhibition, Activator, Transporter, inhibitor | 40 | ||
Pyruvic acid | Approved, Investigational | Nutra | Target, Transporter, substrate, inhibitor | 0 | ||
Lactic acid | Approved, Vet_approved | Pharma | Transporter, substrate, inhibitor | 0 | ||
Methotrexate | Approved | Pharma | Folate antagonist,inhibits DFHR | 1825 |
Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs | |
---|---|---|---|---|---|---|
SR 13800 |
|
227321-12-2 |
|
|
Compound | Action | Cas Number |
---|---|---|
AR-C155858 | MCT1 and MCT2 inhibitor; inhibits glycolysis in cancer cells | 496791-37-8 |
CHC | MCT inhibitor; decreases glycoloysis | 28166-41-8 |
SR 13800 | Potent MCT1 inhibitor | 227321-12-2 |
UK 5099 | MCT inhibitor; also inhibits of pyruvate transport | 56396-35-1 |
Compound | Action | Cas Number |
---|---|---|
AR-C155858 | MCT1 and MCT2 inhibitor | 496791-37-8 |
UK-5099 | MCTs and MPC inhibitor | 56396-35-1 |
This gene was present in the common ancestor of animals.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Chimpanzee (Pan troglodytes) |
Mammalia | SLC16A7 30 31 |
|
OneToOne | |
Dog (Canis familiaris) |
Mammalia | SLC16A7 30 31 |
|
OneToOne | |
Cow (Bos Taurus) |
Mammalia | SLC16A7 30 31 |
|
OneToOne | |
Rat (Rattus norvegicus) |
Mammalia | Slc16a7 30 |
|
||
Mouse (Mus musculus) |
Mammalia | Slc16a7 30 17 31 |
|
OneToOne | |
Oppossum (Monodelphis domestica) |
Mammalia | SLC16A7 31 |
|
OneToOne | |
Platypus (Ornithorhynchus anatinus) |
Mammalia | SLC16A7 31 |
|
OneToOne | |
Chicken (Gallus gallus) |
Aves | SLC16A7 30 31 |
|
OneToOne | |
Lizard (Anolis carolinensis) |
Reptilia | SLC16A7 31 |
|
OneToOne | |
Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | slc16a7 30 |
|
||
Zebrafish (Danio rerio) |
Actinopterygii | SLC16A7 31 |
|
OneToOne | |
zgc:165507 30 |
|
||||
Fruit Fly (Drosophila melanogaster) |
Insecta | CG13907 32 |
|
|
SNP ID | Clinical significance and condition | Chr 12 pos | Variation | AA Info | Type |
---|---|---|---|---|---|
746430 | Likely Benign: not provided | 59,774,805(+) | T/C | NON_CODING_TRANSCRIPT_VARIANT,SYNONYMOUS_VARIANT | |
768560 | Benign: not provided | 59,704,906(+) | A/G | NON_CODING_TRANSCRIPT_VARIANT,SYNONYMOUS_VARIANT | |
768561 | Benign: not provided | 59,774,897(+) | A/G | MISSENSE_VARIANT,NON_CODING_TRANSCRIPT_VARIANT | |
rs3763980 | - | p.Thr445Ser |
Variant ID | Type | Subtype | PubMed ID |
---|---|---|---|
dgv295e199 | CNV | deletion | 23128226 |
esv23936 | CNV | loss | 19812545 |
esv2670981 | CNV | deletion | 23128226 |
esv275119 | CNV | loss | 21479260 |
esv2762982 | CNV | gain | 21179565 |
esv3306085 | CNV | mobile element insertion | 20981092 |
esv3306780 | CNV | mobile element insertion | 20981092 |
esv3309227 | CNV | mobile element insertion | 20981092 |
esv3354729 | CNV | insertion | 20981092 |
esv3380560 | CNV | insertion | 20981092 |
esv3409549 | CNV | insertion | 20981092 |
esv3446144 | CNV | insertion | 20981092 |
esv3549273 | CNV | deletion | 23714750 |
esv3580288 | CNV | loss | 25503493 |
esv3629653 | CNV | gain | 21293372 |
esv3629661 | CNV | gain | 21293372 |
esv3629664 | CNV | loss | 21293372 |
esv3629666 | CNV | loss | 21293372 |
nsv1038100 | CNV | loss | 25217958 |
nsv1048949 | CNV | gain | 25217958 |
nsv1120263 | CNV | tandem duplication | 24896259 |
nsv559050 | CNV | gain | 21841781 |
nsv559101 | CNV | loss | 21841781 |
nsv559102 | CNV | loss | 21841781 |
nsv957254 | CNV | deletion | 24416366 |
Disorder | Aliases | PubMed IDs |
---|---|---|
fanconi-like syndrome |
|
|
colorectal cancer |
|
|