Aliases for SLC16A7 Gene
Aliases for SLC16A7 Gene
- Solute Carrier Family 16 Member 7 2 3 4 5
- Solute Carrier Family 16 (Monocarboxylate Transporter), Member 7 2 3
- MCT2 3 4
- Solute Carrier Family 16, Member 7 (Monocarboxylic Acid Transporter 2) 3
- Solute Carrier Family 16 (Monocarboxylic Acid Transporters), Member 7 2
- Monocarboxylate Transporter 2 3
- MCT 2 4
External Ids for SLC16A7 Gene
- HGNC: 10928
- Entrez Gene: 9194
- Ensembl: ENSG00000118596
- OMIM: 603654
- UniProtKB: O60669
Previous GeneCards Identifiers for SLC16A7 Gene
- GC12P059779
- GC12P060132
- GC12P058276
- GC12P058369
- GC12P057131
- GC12P059989
Summaries for SLC16A7 Gene
-
This gene is a member of the monocarboxylate transporter family. Members in this family transport metabolites, such as lactate, pyruvate, and ketone bodies. The protein encoded by this gene catalyzes the proton-linked transport of monocarboxylates and has the highest affinity for pyruvate. This protein has been reported to be more highly expressed in prostate and colorectal cancer specimens when compared to control specimens. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2012]
GeneCards Summary for SLC16A7 Gene
SLC16A7 (Solute Carrier Family 16 Member 7) is a Protein Coding gene. Among its related pathways are Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds. Gene Ontology (GO) annotations related to this gene include symporter activity and secondary active monocarboxylate transmembrane transporter activity. An important paralog of this gene is SLC16A1.
UniProtKB/Swiss-Prot for SLC16A7 Gene
-
Proton-coupled monocarboxylate transporter. Catalyzes the rapid transport across the plasma membrane of many monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and the ketone bodies acetoacetate, beta-hydroxybutyrate and acetate. Functions as high-affinity pyruvate transporter.
-
Monocarboxylate transporters (MCT) catalyze the bidirectional proton-linked transport of short-chain monocarboxylates such as L-lactate, ketone bodies and pyruvate across the plasma membrane of mammalian cells. MCT1-4 are key in the regulation of many cellular processes.
Additional gene information for SLC16A7 Gene
- Monarch Initiative
- Search for SLC16A7 at DataMed
- Search for SLC16A7 at HumanCyc
No data available for CIViC summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SLC16A7 Gene
Genomics for SLC16A7 Gene
GeneHancer (GH) Regulatory Elements for SLC16A7 Gene
Promoters and enhancers for SLC16A7 Gene
| GeneHancer (GH) Identifier | GH Type | GH Score |
GH Sources | Gene Association Score | Total Score | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites |
Gene Targets |
|---|---|---|---|---|---|---|---|---|---|---|
| GH12I059594 | Promoter/Enhancer | 1.9 | EPDnew Ensembl ENCODE | 550.8 | +0.9 | 929 | 3.7 | CLOCK SIN3A DMAP1 YY1 ETS1 GLIS2 ATF7 FOS RUNX3 ZNF202 | SLC16A7 LINC02448 GC12P059617 | |
| GH12I059698 | Promoter/Enhancer | 1.8 | EPDnew FANTOM5 Ensembl ENCODE dbSUPER | 556.1 | +103.5 | 103483 | 2.1 | RXRA HLF CEBPB CEBPG EP300 RAD21 MAFF ATF3 FOS MAFK | SLC16A7 LOC100996696 ENSG00000257146 GC12P059617 | |
| GH12I059689 | Promoter | 0.5 | EPDnew | 550.2 | +93.4 | 93419 | 0.1 | SLC16A7 RNU4-20P ENSG00000257146 GC12P059617 | ||
| GH12I059736 | Enhancer | 1.1 | Ensembl ENCODE dbSUPER | 10.6 | +141.5 | 141473 | 2.7 | PKNOX1 CTBP1 GATA3 POLR2A FOS FOSL2 TCF7L2 SMARCE1 CEBPB DPF2 | SLC16A7 LOC100996696 ENSG00000257146 | |
| GH12I059650 | Enhancer | 0.6 | Ensembl ENCODE | 11.8 | +55.7 | 55697 | 1.4 | CTCF SOX13 GATA3 | SLC16A7 RNU4-20P GC12P059617 ENSG00000257146 |
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data dump
GeneHancers around SLC16A7 on UCSC Golden Path with GeneCards custom track
Regulatory Element Products
Genomic Locations for SLC16A7 Gene
Genomic Locations for SLC16A7 Gene
- chr12:59,595,934-59,789,855
- (GRCh38/hg38)
- Size:
- 193,922 bases
- Orientation:
- Plus strand
- chr12:59,989,848-60,176,395
- (GRCh37/hg19)
Genomic View for SLC16A7 Gene
Genes around SLC16A7 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 12q14.1 by Ensembl
- 12q14.1 by Entrez Gene
- 12q14.1 by HGNC
SLC16A7 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for SLC16A7 Gene
Proteins for SLC16A7 Gene
-
Protein details for SLC16A7 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- O60669-MOT2_HUMAN
- Recommended name:
- Monocarboxylate transporter 2
- Protein Accession:
- O60669
- Q8NEM3
- Q9UPB3
Protein attributes for SLC16A7 Gene
- Size:
- 478 amino acids
- Molecular mass:
- 52200 Da
- Quaternary structure:
-
- Interacts with GRID2IP.
Protein Expression for SLC16A7 Gene
Post-translational modifications for SLC16A7 Gene
No Post-translational modifications
Other Protein References for SLC16A7 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
-
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- Novus Biologicals Antibodies for SLC16A7
-
Abcam antibodies for SLC16A7
- Invitrogen Antibodies for SLC16A7
- GeneTex SLC16A7 antibody for SLC16A7
Protein Products
-
OriGene Purified Proteins for SLC16A7
- Search Origene for MassSpec and Protein Over-expression Lysates for SLC16A7
- Origene Custom Protein Services for SLC16A7
- Search GeneTex for Proteins for SLC16A7
Assay Products
- antibodies-online: Search results for 7 available SLC16A7 Elisa Kits ranked by validation data
- Compare Top SLC16A7 Elisa Kits
-
Quality Products:
No data available for DME Specific Peptides for SLC16A7 Gene
Domains & Families for SLC16A7 Gene
Gene Families for SLC16A7 Gene
- HGNC:
- IUPHAR :
- Human Protein Atlas (HPA):
-
- Predicted membrane proteins
- Transporters
Suggested Antigen Peptide Sequences for SLC16A7 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
O60669UniProtKB/Swiss-Prot:
MOT2_HUMAN :- Belongs to the major facilitator superfamily. Monocarboxylate porter (TC 2.A.1.13) family.
- Family:
-
- Belongs to the major facilitator superfamily. Monocarboxylate porter (TC 2.A.1.13) family.
Function for SLC16A7 Gene
Molecular function for SLC16A7 Gene
- GENATLAS Biochemistry:
- solute carrier family 16,member A7,monocarboxylic acids transporter,high affinity pyruvate transporter,restricted in normal tissues,widely expressed in cancer cell lines
- UniProtKB/Swiss-Prot Function:
- Proton-coupled monocarboxylate transporter. Catalyzes the rapid transport across the plasma membrane of many monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and the ketone bodies acetoacetate, beta-hydroxybutyrate and acetate. Functions as high-affinity pyruvate transporter.
Phenotypes From GWAS Catalog for SLC16A7 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005477 | pyruvate secondary active transmembrane transporter activity | TAS | 9786900 |
| GO:0008028 | monocarboxylic acid transmembrane transporter activity | TAS,IEA | -- |
| GO:0015129 | lactate transmembrane transporter activity | IDA | 9786900 |
| GO:0015293 | symporter activity | IEA | -- |
| GO:0050833 | pyruvate transmembrane transporter activity | IDA | 9786900 |
Phenotypes for SLC16A7 Gene
Animal Model Products
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-
-
ViGene Biosciences lentiviral particle packaged cDNA for SLC16A7 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for SLC16A7 gene
- Search ViGene Biosciences for SLC16A7
CRISPR Products
-
OriGene CRISPR knockouts for SLC16A7
- genomics-online: gRNA clones - Search results for 100 available SLC16A7 gene related products
- Overview of 100 available SLC16A7 gene related products
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-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for SLC16A7
- GenScript: Design CRISPR guide RNA sequences for SLC16A7
miRNA for SLC16A7 Gene
- miRTarBase miRNAs that target SLC16A7
-
- hsa-mir-215-5p (MIRT024296)
- hsa-mir-192-5p (MIRT026289)
- hsa-mir-4423-3p (MIRT467922)
- hsa-mir-496 (MIRT467923)
- hsa-mir-20a-3p (MIRT467924)
- hsa-mir-4729 (MIRT467925)
- hsa-mir-759 (MIRT467926)
- hsa-mir-506-5p (MIRT467927)
- hsa-mir-892c-5p (MIRT467928)
- hsa-mir-329-5p (MIRT467929)
- hsa-mir-4748 (MIRT467930)
- hsa-mir-4464 (MIRT467931)
miRNA Products
- Search ViGene Biosciences for SLC16A7
Inhibitory RNA Products
- Origene shrna and RNAi products in human, mouse, rat for SLC16A7
- Browse OriGene Inhibitory RNA Products For SLC16A7
- genomics-online: shRNA clones - Search results for 100 available SLC16A7 gene related products
- Overview of 100 available SLC16A7 gene related products
-
ViGene Biosciences ready-to-package AAV shRNAs for SLC16A7 gene
Clone Products
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- VectorBuilder custom plasmid, inducible vectors for SLC16A7
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-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Applied Biological Materials Clones for SLC16A7
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Cell Line Products
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Horizon Cell Lines for SLC16A7
-
ViGene Biosciences adenoviral particle packaged cDNA for SLC16A7 gene
-
ViGene Biosciences lentiviral particle packaged cDNA for SLC16A7 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for SLC16A7 gene
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for SLC16A7 Gene
Localization for SLC16A7 Gene
Subcellular locations from UniProtKB/Swiss-Prot for SLC16A7 Gene
- Cell membrane; Multi-pass membrane protein.
| Compartment | Confidence |
|---|---|
| plasma membrane | 5 |
| mitochondrion | 2 |
| extracellular | 1 |
| peroxisome | 1 |
| nucleus | 1 |
- Plasma membrane (3)
- Nucleoplasm (2)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005886 | plasma membrane | TAS | -- |
| GO:0005887 | integral component of plasma membrane | IDA,IEA | 15505343 |
| GO:0016020 | membrane | IEA | -- |
| GO:0016021 | integral component of membrane | IEA | -- |
Pathways & Interactions for SLC16A7 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds |
.37
|
|
Pathways by source for SLC16A7 Gene
Interacting Proteins for SLC16A7 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0006810 | transport | IEA | -- |
| GO:0015718 | monocarboxylic acid transport | IEA | -- |
| GO:0035873 | lactate transmembrane transport | IMP | 9786900 |
| GO:0055085 | transmembrane transport | IEA | -- |
| GO:1901475 | pyruvate transmembrane transport | IDA,IEA | 9786900 |
No data available for SIGNOR curated interactions for SLC16A7 Gene
Drugs & Compounds for SLC16A7 Gene
| Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
|---|---|---|---|---|---|---|
| Gamma Hydroxybutyric Acid | Approved, Illicit, Investigational | Pharma | Transporter, inhibitor | 0 | ||
| Niflumic Acid | Approved | Pharma | Channel blocker, Transporter, inhibitor | Ca2+-activated Cl- channel blocker | 0 | |
| Probenecid | Approved, Investigational | Pharma | Inhibition, Inhibitor, Transporter, inhibitor | 35 | ||
| Pyruvic acid | Approved, Investigational | Nutra | Target, Transporter, substrate, inhibitor | 0 | ||
| Lactic Acid | Approved, Vet_approved | Pharma | Transporter, substrate, inhibitor | 0 |
| Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs | |
|---|---|---|---|---|---|---|
| SR 13800 |
|
227321-12-2 |
|
|
(4) Tocris Compounds for SLC16A7 Gene
| Compound | Action | Cas Number |
|---|---|---|
| AR-C155858 | MCT1 and MCT2 inhibitor; inhibits glycolysis in cancer cells | 496791-37-8 |
| CHC | MCT inhibitor; decreases glycoloysis | 28166-41-8 |
| SR 13800 | Potent MCT1 inhibitor | 227321-12-2 |
| UK 5099 | MCT inhibitor; also inhibits of pyruvate transport | 56396-35-1 |
(2) ApexBio Compounds for SLC16A7 Gene
| Compound | Action | Cas Number |
|---|---|---|
| AR-C155858 | MCT1 and MCT2 inhibitor | 496791-37-8 |
| UK-5099 | MCTs and MPC inhibitor | 56396-35-1 |
Transcripts for SLC16A7 Gene
mRNA/cDNA for SLC16A7 Gene
- (14) REFSEQ mRNAs :
- (9) Additional mRNA sequences :
- (28) Selected AceView cDNA sequences:
- (16) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for SLC16A7 Gene
CRISPR Products
-
OriGene CRISPR knockouts for SLC16A7
- genomics-online: gRNA clones - Search results for 100 available SLC16A7 gene related products
- Overview of 100 available SLC16A7 gene related products
- Applied Biological Materials CRISPR for SLC16A7
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for SLC16A7
- GenScript: Design CRISPR guide RNA sequences for SLC16A7
miRNA Products
- Search ViGene Biosciences for SLC16A7
Inhibitory RNA Products
- Origene shrna and RNAi products in human, mouse, rat for SLC16A7
- Browse OriGene Inhibitory RNA Products For SLC16A7
- genomics-online: shRNA clones - Search results for 100 available SLC16A7 gene related products
- Overview of 100 available SLC16A7 gene related products
-
ViGene Biosciences ready-to-package AAV shRNAs for SLC16A7 gene
Clone Products
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- VectorBuilder custom plasmid, inducible vectors for SLC16A7
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for SLC16A7
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Applied Biological Materials Clones for SLC16A7
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Expression for SLC16A7 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
-
Skeletal Muscle (Muscoskeletal System)
- Muscle Progenitor Cells Mandibular Arch Muscles
- Muscle Progenitor Cells Hyoid Arch Muscles
- Adipose (Muscoskeletal System)
-
Peripheral Nervous System (Nervous System)
- Schwann Precursor Cells Peripheral Nerve Domain
- Spleen (Hematopoietic System)
- Blood (Cardiovascular System)
- Neural Tube (Nervous System)
- Kidney (Urinary System)
mRNA differential expression in normal tissues according to GTEx for SLC16A7 Gene
This gene is overexpressed in Heart - Left Ventricle (x5.7).
This gene is overexpressed in Pancreas (13.2), Frontal cortex (11.3), Heart (8.7), Kidney (7.3), and Peripheral blood mononuclear cells (6.9).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for SLC16A7 Gene
NURSA nuclear receptor signaling pathways regulating expression of SLC16A7 Gene:
SLC16A7SOURCE GeneReport for Unigene cluster for SLC16A7 Gene:
Hs.88156mRNA Expression by UniProt/SwissProt for SLC16A7 Gene:
O60669-MOT2_HUMAN
Tissue specificity:
Detected in heart and in blood lymphocytes and monocytes (at protein level). High expression in testis, moderate to low in spleen, heart, kidney, pancreas, skeletal muscle, brain and Leukocyte. Restricted expression in normal tissues, but widely expressed in cancer cells.
Evidence on tissue expression from TISSUES for SLC16A7 Gene
- Liver(4.3)
- Heart(2.3)
- Muscle(2.2)
- Nervous system(2.2)
Primer Products
-
OriGene qPCR primer pairs for SLC16A7
-
OriGene qPCR primer pairs and template standards for SLC16A7
No data available for Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for SLC16A7 Gene
Orthologs for SLC16A7 Gene
This gene was present in the common ancestor of animals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | SLC16A7 33 34 |
|
||
| dog (Canis familiaris) |
Mammalia | SLC16A7 33 34 |
|
||
| cow (Bos Taurus) |
Mammalia | SLC16A7 33 34 |
|
||
| rat (Rattus norvegicus) |
Mammalia | Slc16a7 33 |
|
||
| mouse (Mus musculus) |
Mammalia | Slc16a7 33 16 34 |
|
||
| oppossum (Monodelphis domestica) |
Mammalia | SLC16A7 34 |
|
OneToOne | |
| platypus (Ornithorhynchus anatinus) |
Mammalia | SLC16A7 34 |
|
OneToOne | |
| chicken (Gallus gallus) |
Aves | SLC16A7 33 34 |
|
||
| lizard (Anolis carolinensis) |
Reptilia | SLC16A7 34 |
|
OneToOne | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | slc16a7 33 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | SLC16A7 34 |
|
OneToOne | |
| zgc:165507 33 |
|
||||
| fruit fly (Drosophila melanogaster) |
Insecta | CG13907 35 |
|
|
- Species where no ortholog for SLC16A7 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea squirt (Ciona intestinalis)
- sea squirt (Ciona savignyi)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
Paralogs for SLC16A7 Gene
Paralogs for SLC16A7 Gene
(13) SIMAP similar genes for SLC16A7 Gene using alignment to 10 proteins:
Variants for SLC16A7 Gene
| SNP ID | Clin | Chr 12 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs1000004014 | -- | 59,774,447(+) | A/G | intron_variant | |
| rs1000047756 | -- | 59,739,178(+) | A/T | intron_variant | |
| rs1000048362 | -- | 59,697,774(+) | T/C | genic_upstream_transcript_variant, intron_variant | |
| rs1000053169 | -- | 59,767,116(+) | C/T | intron_variant | |
| rs1000062088 | -- | 59,752,932(+) | G/T | intron_variant |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| nsv957254 | CNV | deletion | 24416366 |
| nsv559102 | CNV | loss | 21841781 |
| nsv559101 | CNV | loss | 21841781 |
| nsv559050 | CNV | gain | 21841781 |
| nsv1120263 | CNV | tandem duplication | 24896259 |
| nsv1048949 | CNV | gain | 25217958 |
| nsv1038100 | CNV | loss | 25217958 |
| esv3629666 | CNV | loss | 21293372 |
| esv3629664 | CNV | loss | 21293372 |
| esv3629661 | CNV | gain | 21293372 |
| esv3629653 | CNV | gain | 21293372 |
| esv3580288 | CNV | loss | 25503493 |
| esv3549273 | CNV | deletion | 23714750 |
| esv3446144 | CNV | insertion | 20981092 |
| esv3409549 | CNV | insertion | 20981092 |
| esv3380560 | CNV | insertion | 20981092 |
| esv3354729 | CNV | insertion | 20981092 |
| esv3309227 | CNV | mobile element insertion | 20981092 |
| esv3306780 | CNV | mobile element insertion | 20981092 |
| esv3306085 | CNV | mobile element insertion | 20981092 |
| esv2762982 | CNV | gain | 21179565 |
| esv275119 | CNV | loss | 21479260 |
| esv2670981 | CNV | deletion | 23128226 |
| esv23936 | CNV | loss | 19812545 |
| dgv295e199 | CNV | deletion | 23128226 |
Residual Variation Intolerance Score:
42.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
2.32;
41.39% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for SLC16A7 Gene
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SLC16A7 Gene
Disorders for SLC16A7 Gene
Additional Disease Information for SLC16A7
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
No disorders were found for SLC16A7 Gene.
No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SLC16A7 Gene
Publications for SLC16A7 Gene
- Human monocarboxylate transporter 2 (MCT2) is a high affinity pyruvate transporter. (PMID: 9786900) Lin RY … Golde DW (The Journal of biological chemistry 1998) 2 3 4 22 25 58
- Presence and localization of three lactic acid transporters (MCT1, -2, and -4) in separated human granulocytes, lymphocytes, and monocytes. (PMID: 15505343) Merezhinskaya N … Fishbein WN (The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society 2004) 3 4 22 58
- Hypoxia stimulates lactate release and modulates monocarboxylate transporter (MCT1, MCT2, and MCT4) expression in human adipocytes. (PMID: 19876643) Pérez de Heredia F … Trayhurn P (Pflugers Archiv : European journal of physiology 2010) 3 22 58
- Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 44 58
- Expression of monocarboxylate transporters 1, 2, and 4 in human tumours and their association with CD147 and CD44. (PMID: 20454640) Pinheiro C … Baltazar F (Journal of biomedicine & biotechnology 2010) 3 22 58
Products for SLC16A7 Gene
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- Custom Assay Services
- OriGene Purified Proteins for SLC16A7
- Search Origene for MassSpec and Protein Over-expression Lysates for SLC16A7
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- Origene shrna and RNAi products in human, mouse, rat for SLC16A7
- Browse OriGene Inhibitory RNA Products For SLC16A7
- OriGene qPCR primer pairs and template standards for SLC16A7
- OriGene qPCR primer pairs for SLC16A7
- OriGene CRISPR knockouts for SLC16A7
- OriGene ORF clones in human for SLC16A7
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Browse OriGene miRNA Products For SLC16A7
- GenScript: Next-day shipping of latest version cDNA ORF clones for SLC16A7 in any vector
- GenScript Custom Purified and Recombinant Proteins Services for SLC16A7
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- GenScript: Design CRISPR guide RNA sequences for SLC16A7
- Design optimal peptide antigens
- CloneReady with Over 120,000 Genes
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- Vector-based siRNA and miRNA, Ready for Transfection
- Gene Mutant Library, Variants up to 10^11
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- Sino Biological Transfection Reagent
- Sino Biological Anti-His Tag Antibody
- Novus Biologicals Antibodies for SLC16A7
- Novus Biologicals lysates and proteins for SLC16A7
- Novus Biologicals
- Novus Biologicals Tissue Microarrays
- Browse Antibodies
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- Abcam antibodies for SLC16A7
- Find your target
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- Browse Antibodies at Cloud-Clone Corp.
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- Cloud-Clone Corp. disease models service
- Browse cDNA clones at Cloud-Clone Corp.
- Browse primers at Cloud-Clone Corp.
- Cloud-Clone Corp. primary cells service
- Invitrogen Antibodies for SLC16A7
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- ApexBio compounds for SLC16A7
- Cyagen custom Knockout/knockin (KOKI) mouse models for SLC16A7
- VectorBuilder custom plasmid, inducible vectors for SLC16A7
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for SLC16A7
- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- antibodies-online: Search results for 62 available SLC16A7 Antibodies ranked by validation data
- Compare Top SLC16A7 Antibodies
- antibodies-online: Search results for 7 available SLC16A7 Elisa Kits ranked by validation data
- Compare Top SLC16A7 Elisa Kits
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- antibodies-online: Search results for available SLC16A7 related products ranked by validation data
- GeneTex SLC16A7 antibody for SLC16A7
- Search GeneTex for Proteins for SLC16A7
- ViGene Biosciences adenoviral particle packaged cDNA for SLC16A7 gene
- ViGene Biosciences lentiviral particle packaged cDNA for SLC16A7 gene
- ViGene Biosciences ready-to-package AAV shRNAs for SLC16A7 gene
- Search ViGene Biosciences for SLC16A7
- Browse Santa Cruz Biotechnology (SCBT) Antibodies
- Search Santa Cruz Biotechnology (SCBT) for SLC16A7 siRNA/shRNA
- Santa Cruz Biotechnology (SCBT) CRISPR for SLC16A7
- Horizon Cell Lines for SLC16A7
- genomics-online: cdna clones - Search results for 100 available SLC16A7 gene related products
- Overview of 100 available SLC16A7 gene related products
- orf clones - Search results for 100 available SLC16A7 gene related products
- Overview of 100 available SLC16A7 gene related products
- genomics-online: gRNA clones - Search results for 100 available SLC16A7 gene related products
- Overview of 100 available SLC16A7 gene related products
- genomics-online: primer clones - Search results for 100 available SLC16A7 gene related products
- Overview of 100 available SLC16A7 gene related products
- genomics-online: shRNA clones - Search results for 100 available SLC16A7 gene related products
- Overview of 100 available SLC16A7 gene related products
Sources for SLC16A7 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) ASD
- (29) ECgene
- (30) GeneAnnot
- (31) CGAP SAGE
- (32) SOURCE
- (33) HomoloGene
- (34) PanEnsembl
- (35) euGenes
- (36) SGD
- (37) FlyBase
- (38) WormBase
- (39) Pseudogene
- (40) DGV
- (41) dbSNP
- (42) GenAtlas
- (43) HGMD
- (44) GAD
- (45) BGMUT
- (46) HuGE
- (47) Atlas
- (48) Cell Signaling Technology
- (49) GenBank
- (50) H-invDB
- (51) HORDE
- (52) HUGE
- (53) IMGT
- (54) Leiden
- (55) miRBase
- (56) DME
- (57) OriGene
- (58) PubMed
- (59) R&D Systems
- (60) TGDB
- (61) Tocris
- (62) Abcam
- (63) Novus Biologicals
- (64) ProSpec
- (65) Sino Biological
- (66) GenScript
- (67) Qiagen
- (68) Cloud-Clone Corp.
- (69) OCA
- (70) Proteopedia
- (71) MOPED
- (72) neXtProt
- (73) Reactome
- (74) GeneGo (Thomson Reuters)
- (75) fRNAdb
- (76) DISEASES
- (77) SIMAP
- (78) GenomeRNAi
- (79) LifeMap
- (80) miRTarBase
- (81) MalaCards
- (82) Invitrogen
- (83) BitterDB
- (84) Vector BioLabs
- (85) ESI-BIO
- (86) RefSeq
- (87) BioSystems
- (88) MaxQB
- (89) IUPHAR
- (90) BioGPS
- (91) Illumina
- (92) COMPARTMENTS
- (93) HOMER
- (94) PaxDb
- (95) ApexBio
- (96) Addgene
- (97) antibodies-online
- (98) CYP
- (99) NONCODE
- (100) SwitchGear Genomics
- (101) TreeFam
- (102) PathCards
- (103) GeneReviews
- (104) GeneTex
- (105) Taconic Biosciences
- (106) GTEx
- (107) ProteomicsDB
- (108) SCBT
- (109) DGIdb
- (110) ClinicalTrials
- (111) FDA Approved Drugs
- (112) RVIS
- (113) SIGNOR
- (114) diseasecard
- (115) NIH Rare Diseases
- (116) Orphanet
- (117) UMLS
- (118) GTR
- (119) Disease Ontology
- (120) Genetics Home Reference
- (121) MeSH
- (122) MedlinePlus
- (123) CDC
- (124) NINDS
- (125) NCBI Bookshelf
- (126) ClinVar
- (127) Gene Damage Index
- (128) ViGene Biosciences
- (129) HPO
- (130) UDN
- (131) VISTA
- (132) FANTOM5
- (133) ENCODE
- (134) ProSci
- (135) Horizon
- (136) NURSA
- (137) IID
- (138) Cyagen
- (139) VectorBuilder
- (140) SNPedia
- (141) BRCA Exchange
- (142) St John's Lab
- (143) CIViC
- (144) ProteoGenix
- (145) dbSUPER
- (146) TISSUES
- (147) Gene ORGANizer
- (148) abm
- (149) CrownBio
- (150) Human Protein Atlas
- (151) GWAS Catalog
- (152) Monarch Initiative
- (153) DataMed
- (154) HumanCyc
- (155) genomics-online
- (156) UCNEbase
- (157) EPDnew