This gene encodes a member of the monocarboxylate transporter family and the major facilitator superfamily. The encoded protein is localized to the cell membrane and acts as a proton-linked transporter of bumetanide. Transport by the encoded protein is inhibited by four loop diuretics, nateglinide, thiazides, probenecid, and glibenclamide. Alternative splicing results in multip... See more...

Aliases for SLC16A5 Gene

Aliases for SLC16A5 Gene

  • Solute Carrier Family 16 Member 5 2 3 4 5
  • MCT5 2 3 4
  • MCT6 2 3 4
  • Solute Carrier Family 16, Member 5 (Monocarboxylic Acid Transporter 6) 2 3
  • Solute Carrier Family 16 (Monocarboxylic Acid Transporters), Member 5 2 3
  • Solute Carrier Family 16 (Monocarboxylate Transporter), Member 5 2 3
  • Monocarboxylate Transporter 6 3 4
  • Monocarboxylate Transporter 5 3 4
  • SLC16A5 5
  • MCT 6 4
  • MCT 5 4

External Ids for SLC16A5 Gene

Previous GeneCards Identifiers for SLC16A5 Gene

  • GC17P073054
  • GC17P076143
  • GC17P073547
  • GC17P073680
  • GC17P073681
  • GC17P070595
  • GC17P073084
  • GC17P068493
  • GC17P075094
  • GC17P075126
  • GC17P075133
  • GC17P075144
  • GC17P075153
  • GC17P075095
  • GC17P075104
  • GC17P075108
  • GC17P075114
  • GC17P075117
  • GC17P075124
  • GC17P075160

Summaries for SLC16A5 Gene

Entrez Gene Summary for SLC16A5 Gene

  • This gene encodes a member of the monocarboxylate transporter family and the major facilitator superfamily. The encoded protein is localized to the cell membrane and acts as a proton-linked transporter of bumetanide. Transport by the encoded protein is inhibited by four loop diuretics, nateglinide, thiazides, probenecid, and glibenclamide. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2012]

GeneCards Summary for SLC16A5 Gene

SLC16A5 (Solute Carrier Family 16 Member 5) is a Protein Coding gene. Diseases associated with SLC16A5 include Allan-Herndon-Dudley Syndrome. Gene Ontology (GO) annotations related to this gene include symporter activity and lactate transmembrane transporter activity. An important paralog of this gene is SLC16A8.

UniProtKB/Swiss-Prot Summary for SLC16A5 Gene

  • Proton-linked monocarboxylate transporter. Catalyzes the rapid transport across the plasma membrane of many monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and the ketone bodies acetoacetate, beta-hydroxybutyrate and acetate (By similarity).

Tocris Summary for SLC16A5 Gene

  • Monocarboxylate transporters (MCT) catalyze the bidirectional proton-linked transport of short-chain monocarboxylates such as L-lactate, ketone bodies and pyruvate across the plasma membrane of mammalian cells. MCT1-4 are key in the regulation of many cellular processes.

No data available for CIViC Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for SLC16A5 Gene

Genomics for SLC16A5 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for SLC16A5 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around SLC16A5 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for SLC16A5

Top Transcription factor binding sites by QIAGEN in the SLC16A5 gene promoter:
  • AP-1
  • c-Fos
  • c-Jun
  • E47
  • Egr-1
  • Hand1
  • Lmo2
  • NRSF form 1
  • NRSF form 2

Genomic Locations for SLC16A5 Gene

Latest Assembly
chr17:75,087,727-75,106,162
(GRCh38/hg38)
Size:
18,436 bases
Orientation:
Plus strand

Previous Assembly
chr17:73,083,860-73,102,257
(GRCh37/hg19 by Entrez Gene)
Size:
18,398 bases
Orientation:
Plus strand

chr17:73,083,822-73,102,257
(GRCh37/hg19 by Ensembl)
Size:
18,436 bases
Orientation:
Plus strand

Genomic View for SLC16A5 Gene

Genes around SLC16A5 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SLC16A5 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SLC16A5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SLC16A5 Gene

Proteins for SLC16A5 Gene

  • Protein details for SLC16A5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O15375-MOT6_HUMAN
    Recommended name:
    Monocarboxylate transporter 6
    Protein Accession:
    O15375
    Secondary Accessions:
    • B4E288

    Protein attributes for SLC16A5 Gene

    Size:
    505 amino acids
    Molecular mass:
    54994 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for SLC16A5 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SLC16A5 Gene

Post-translational modifications for SLC16A5 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for SLC16A5 Gene

Domains & Families for SLC16A5 Gene

Gene Families for SLC16A5 Gene

Protein Domains for SLC16A5 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for SLC16A5 Gene

GenScript: Design optimal peptide antigens:
  • cDNA FLJ59816, highly similar to Monocarboxylate transporter 6 (B4E288_HUMAN)
  • Solute carrier family 16 member 5 (MOT6_HUMAN)

Graphical View of Domain Structure for InterPro Entry

O15375

UniProtKB/Swiss-Prot:

MOT6_HUMAN :
  • Belongs to the major facilitator superfamily. Monocarboxylate porter (TC 2.A.1.13) family.
Family:
  • Belongs to the major facilitator superfamily. Monocarboxylate porter (TC 2.A.1.13) family.
genes like me logo Genes that share domains with SLC16A5: view

Function for SLC16A5 Gene

Molecular function for SLC16A5 Gene

UniProtKB/Swiss-Prot Function:
Proton-linked monocarboxylate transporter. Catalyzes the rapid transport across the plasma membrane of many monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and the ketone bodies acetoacetate, beta-hydroxybutyrate and acetate (By similarity).

Phenotypes From GWAS Catalog for SLC16A5 Gene

Gene Ontology (GO) - Molecular Function for SLC16A5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 32296183
GO:0008028 monocarboxylic acid transmembrane transporter activity TAS,IBA 21873635
GO:0015293 symporter activity IEA --
GO:0022857 transmembrane transporter activity IEA --
genes like me logo Genes that share ontologies with SLC16A5: view
genes like me logo Genes that share phenotypes with SLC16A5: view

Animal Models for research

  • Taconic Biosciences Mouse Models for SLC16A5

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for SLC16A5

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for SLC16A5 Gene

Localization for SLC16A5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SLC16A5 Gene

Cell membrane. Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SLC16A5 gene
Compartment Confidence
plasma membrane 5
extracellular 1
cytoskeleton 1
mitochondrion 1
peroxisome 1
nucleus 1
endoplasmic reticulum 1
cytosol 1

Gene Ontology (GO) - Cellular Components for SLC16A5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane IEA --
GO:0005887 integral component of plasma membrane TAS,IBA 21873635
GO:0016020 membrane IEA,TAS 9425115
GO:0016021 integral component of membrane IEA,IBA 21873635
genes like me logo Genes that share ontologies with SLC16A5: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for SLC16A5 Gene

Pathways & Interactions for SLC16A5 Gene

PathCards logo

SuperPathways for SLC16A5 Gene

No Data Available

Interacting Proteins for SLC16A5 Gene

Gene Ontology (GO) - Biological Process for SLC16A5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0015718 monocarboxylic acid transport TAS,IBA 21873635
GO:0055085 transmembrane transport IEA --
genes like me logo Genes that share ontologies with SLC16A5: view

No data available for Pathways by source and SIGNOR curated interactions for SLC16A5 Gene

Drugs & Compounds for SLC16A5 Gene

(7) Drugs for SLC16A5 Gene - From: DrugBank, PharmGKB, ApexBio, HMDB, and Tocris

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Pyruvic acid Approved, Investigational Nutra Target 0
Cisplatin Approved Pharma Inhibits DNA synthesis,chemotherapy drug, Potent pro-apoptotic anticancer agent; activates caspase-3, Platinum 3579
7ACC1 Pharma 0
7ACC2 Pharma 0
AR-C155858 Pharma MCT1 and MCT2 inhibitor, MCT1 and MCT2 inhibitor; inhibits glycolysis in cancer cells 0

(1) Additional Compounds for SLC16A5 Gene - From: Tocris

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
SR 13800
227321-12-2

(4) Tocris Compounds for SLC16A5 Gene

Compound Action Cas Number
AR-C155858 MCT1 and MCT2 inhibitor; inhibits glycolysis in cancer cells 496791-37-8
CHC MCT inhibitor; decreases glycoloysis 28166-41-8
SR 13800 Potent MCT1 inhibitor 227321-12-2
UK 5099 MCT inhibitor; also inhibits of pyruvate transport 56396-35-1

(2) ApexBio Compounds for SLC16A5 Gene

Compound Action Cas Number
7ACC1 50995-74-9
7ACC2 1472624-85-3
genes like me logo Genes that share compounds with SLC16A5: view

Drug products for research

Transcripts for SLC16A5 Gene

mRNA/cDNA for SLC16A5 Gene

3 REFSEQ mRNAs :
8 NCBI additional mRNA sequence :
10 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for SLC16A5

Alternative Splicing Database (ASD) splice patterns (SP) for SLC16A5 Gene

ExUns: 1a · 1b ^ 2a · 2b · 2c ^ 3 ^ 4a · 4b · 4c ^ 5 ^ 6 ^ 7a · 7b · 7c · 7d ^ 8 ^ 9a · 9b · 9c · 9d · 9e ^ 10a · 10b · 10c · 10d ^ 11a ·
SP1: - - - - - - - - - -
SP2: - - - - - - -
SP3: - - - -
SP4: - - - - - -
SP5: - - - - - -
SP6: - - - - - -
SP7: - - - - - - -
SP8: - - -
SP9: - -
SP10: - - - - - - - -
SP11: - - - -
SP12: -
SP13: -

ExUns: 11b · 11c ^ 12
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:

Relevant External Links for SLC16A5 Gene

GeneLoc Exon Structure for
SLC16A5

Expression for SLC16A5 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for SLC16A5 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SLC16A5 Gene

This gene is overexpressed in Kidney - Cortex (x8.1) and Whole Blood (x6.0).

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for SLC16A5

SOURCE GeneReport for Unigene cluster for SLC16A5 Gene:

Hs.592095

mRNA Expression by UniProt/SwissProt for SLC16A5 Gene:

O15375-MOT6_HUMAN
Tissue specificity: Highly expressed in kidney.

Evidence on tissue expression from TISSUES for SLC16A5 Gene

  • Blood(4.2)
  • Pancreas(4.2)
  • Kidney(2)
genes like me logo Genes that share expression patterns with SLC16A5: view

Primer products for research

No data available for Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for SLC16A5 Gene

Orthologs for SLC16A5 Gene

This gene was present in the common ancestor of chordates.

Orthologs for SLC16A5 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia SLC16A5 30 31
  • 99.12 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia SLC16A5 30 31
  • 84.17 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia SLC16A5 30 31
  • 81.63 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Slc16a5 30
  • 76.82 (n)
Mouse
(Mus musculus)
Mammalia Slc16a5 30 17 31
  • 76.53 (n)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia SLC16A5 31
  • 70 (a)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia SLC16A5 31
  • 65 (a)
OneToOne
Chicken
(Gallus gallus)
Aves SLC16A5 30 31
  • 63.19 (n)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia SLC16A5 31
  • 55 (a)
OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia slc16a5 30
  • 58.05 (n)
Zebrafish
(Danio rerio)
Actinopterygii LOC794371 30
  • 56.55 (n)
slc16a5 31
  • 42 (a)
OneToMany
SLC16A5 (1 of 2) 31
  • 37 (a)
OneToMany
Species where no ortholog for SLC16A5 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for SLC16A5 Gene

ENSEMBL:
Gene Tree for SLC16A5 (if available)
TreeFam:
Gene Tree for SLC16A5 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for SLC16A5: view image

Paralogs for SLC16A5 Gene

(8) SIMAP similar genes for SLC16A5 Gene using alignment to 6 proteins:

  • MOT6_HUMAN
  • B4E288_HUMAN
  • J3KS19_HUMAN
  • J3KT93_HUMAN
  • J3QL40_HUMAN
  • J3QQW5_HUMAN
genes like me logo Genes that share paralogs with SLC16A5: view

Variants for SLC16A5 Gene

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for SLC16A5 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for SLC16A5 Gene

Variant ID Type Subtype PubMed ID
dgv567e199 CNV deletion 23128226
esv3641257 CNV loss 21293372
nsv470602 CNV loss 18288195

Variation tolerance for SLC16A5 Gene

Residual Variation Intolerance Score: 66.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.94; 35.98% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for SLC16A5 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
SLC16A5

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for SLC16A5 Gene

Disorders for SLC16A5 Gene

MalaCards: The human disease database

(1) MalaCards diseases for SLC16A5 Gene - From: COP

Disorder Aliases PubMed IDs
allan-herndon-dudley syndrome
  • ahds
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for SLC16A5

genes like me logo Genes that share disorders with SLC16A5: view

No data available for UniProtKB/Swiss-Prot and Genatlas for SLC16A5 Gene

Publications for SLC16A5 Gene

  1. Cloning and sequencing of four new mammalian monocarboxylate transporter (MCT) homologues confirms the existence of a transporter family with an ancient past. (PMID: 9425115) Price NT … Halestrap AP (The Biochemical journal 1998) 2 3 4
  2. Functional characterization of human monocarboxylate transporter 6 (SLC16A5). (PMID: 16174808) Murakami Y … Yamamoto T (Drug metabolism and disposition: the biological fate of chemicals 2005) 3 23
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4
  5. A reference map of the human binary protein interactome. (PMID: 32296183) Luck K … Calderwood MA (Nature 2020) 3

Products for SLC16A5 Gene

Sources for SLC16A5 Gene