Aliases for SLC16A5 Gene
- Solute Carrier Family 16 Member 5 2 3 4 5
- Solute Carrier Family 16, Member 5 (Monocarboxylic Acid Transporter 6) 2 3
- Solute Carrier Family 16 (Monocarboxylic Acid Transporters), Member 5 2 3
- Solute Carrier Family 16 (Monocarboxylate Transporter), Member 5 2 3
- Monocarboxylate Transporter 5 3 4
- MCT5 3 4
External Ids for SLC16A5 Gene
Previous GeneCards Identifiers for SLC16A5 Gene
This gene encodes a member of the monocarboxylate transporter family and the major facilitator superfamily. The encoded protein is localized to the cell membrane and acts as a proton-linked transporter of bumetanide. Transport by the encoded protein is inhibited by four loop diuretics, nateglinide, thiazides, probenecid, and glibenclamide. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2012]
GeneCards Summary for SLC16A5 Gene
SLC16A5 (Solute Carrier Family 16 Member 5) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include symporter activity and lactate transmembrane transporter activity. An important paralog of this gene is SLC16A8.
UniProtKB/Swiss-Prot for SLC16A5 Gene
Proton-linked monocarboxylate transporter. Catalyzes the rapid transport across the plasma membrane of many monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and the ketone bodies acetoacetate, beta-hydroxybutyrate and acetate (By similarity).
Monocarboxylate transporters (MCT) catalyze the bidirectional proton-linked transport of short-chain monocarboxylates such as L-lactate, ketone bodies and pyruvate across the plasma membrane of mammalian cells. MCT1-4 are key in the regulation of many cellular processes.