Aliases for SLC16A4 Gene

Aliases for SLC16A4 Gene

  • Solute Carrier Family 16 Member 4 2 3 4 5
  • Solute Carrier Family 16, Member 4 (Monocarboxylic Acid Transporter 5) 2 3
  • Solute Carrier Family 16 (Monocarboxylic Acid Transporters), Member 4 2 3
  • Monocarboxylate Transporter 4 3 4
  • Monocarboxylate Transporter 5 3 4
  • MCT 4 3 4
  • MCT 5 3 4
  • MCT4 3 4
  • MCT5 3 4
  • Solute Carrier Family 16, Member 4 2

External Ids for SLC16A4 Gene

Previous GeneCards Identifiers for SLC16A4 Gene

  • GC01M111321
  • GC01M109772
  • GC01M110007
  • GC01M110204
  • GC01M110617
  • GC01M110905
  • GC01M108777

Summaries for SLC16A4 Gene

GeneCards Summary for SLC16A4 Gene

SLC16A4 (Solute Carrier Family 16 Member 4) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include symporter activity and monocarboxylic acid transmembrane transporter activity. An important paralog of this gene is SLC16A12.

UniProtKB/Swiss-Prot Summary for SLC16A4 Gene

  • Proton-linked monocarboxylate transporter. Catalyzes the rapid transport across the plasma membrane of many monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and the ketone bodies acetoacetate, beta-hydroxybutyrate and acetate (By similarity).

Gene Wiki entry for SLC16A4 Gene

Additional gene information for SLC16A4 Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for SLC16A4 Gene

Genomics for SLC16A4 Gene

GeneHancer (GH) Regulatory Elements for SLC16A4 Gene

Promoters and enhancers for SLC16A4 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around SLC16A4 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the SLC16A4 gene promoter:
  • AML1a
  • CUTL1
  • FOXD3
  • Pax-2
  • Pax-2a
  • Pax-2b
  • Pax-4a
  • Roaz

Genomic Locations for SLC16A4 Gene

Genomic Locations for SLC16A4 Gene
chr1:110,362,851-110,391,409
(GRCh38/hg38)
Size:
28,559 bases
Orientation:
Minus strand
chr1:110,905,470-110,933,704
(GRCh37/hg19)
Size:
28,235 bases
Orientation:
Minus strand

Genomic View for SLC16A4 Gene

Genes around SLC16A4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SLC16A4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SLC16A4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SLC16A4 Gene

Proteins for SLC16A4 Gene

  • Protein details for SLC16A4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O15374-MOT5_HUMAN
    Recommended name:
    Monocarboxylate transporter 5
    Protein Accession:
    O15374
    Secondary Accessions:
    • A8K3V5
    • B2R9C9
    • B4DJ67
    • B4DPX7
    • E7EPY8
    • G3V175
    • Q5T612
    • Q8WU09

    Protein attributes for SLC16A4 Gene

    Size:
    487 amino acids
    Molecular mass:
    54022 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for SLC16A4 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SLC16A4 Gene

Post-translational modifications for SLC16A4 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for SLC16A4 Gene

Domains & Families for SLC16A4 Gene

Gene Families for SLC16A4 Gene

Protein Domains for SLC16A4 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for SLC16A4 Gene

GenScript: Design optimal peptide antigens:
  • cDNA FLJ60583, highly similar to Monocarboxylate transporter 5 (B4DJ67_HUMAN)
  • Solute carrier family 16 member 4 (MOT5_HUMAN)

Graphical View of Domain Structure for InterPro Entry

O15374

UniProtKB/Swiss-Prot:

MOT5_HUMAN :
  • Belongs to the major facilitator superfamily. Monocarboxylate porter (TC 2.A.1.13) family.
Family:
  • Belongs to the major facilitator superfamily. Monocarboxylate porter (TC 2.A.1.13) family.
genes like me logo Genes that share domains with SLC16A4: view

Function for SLC16A4 Gene

Molecular function for SLC16A4 Gene

UniProtKB/Swiss-Prot Function:
Proton-linked monocarboxylate transporter. Catalyzes the rapid transport across the plasma membrane of many monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and the ketone bodies acetoacetate, beta-hydroxybutyrate and acetate (By similarity).

Phenotypes From GWAS Catalog for SLC16A4 Gene

Gene Ontology (GO) - Molecular Function for SLC16A4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008028 monocarboxylic acid transmembrane transporter activity TAS,IBA 21873635
GO:0015293 symporter activity IEA --
genes like me logo Genes that share ontologies with SLC16A4: view
genes like me logo Genes that share phenotypes with SLC16A4: view

Animal Models for SLC16A4 Gene

MGI Knock Outs for SLC16A4:
  • Slc16a4 Slc16a4<tm2e(EUCOMM)Wtsi>

Animal Model Products

CRISPR Products

miRNA for SLC16A4 Gene

miRTarBase miRNAs that target SLC16A4

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for SLC16A4 Gene

Localization for SLC16A4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SLC16A4 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SLC16A4 gene
Compartment Confidence
plasma membrane 5
extracellular 2
mitochondrion 2
nucleus 1
cytosol 1
endoplasmic reticulum 0

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytokinetic bridge (2)
  • Cytosol (2)
  • Microtubules (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for SLC16A4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005887 integral component of plasma membrane TAS,IBA 21873635
GO:0016020 membrane TAS 9425115
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with SLC16A4: view

Pathways & Interactions for SLC16A4 Gene

PathCards logo

SuperPathways for SLC16A4 Gene

No Data Available

Interacting Proteins for SLC16A4 Gene

Gene Ontology (GO) - Biological Process for SLC16A4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0015718 monocarboxylic acid transport TAS,IBA 21873635
GO:0055085 transmembrane transport IEA --
genes like me logo Genes that share ontologies with SLC16A4: view

No data available for Pathways by source and SIGNOR curated interactions for SLC16A4 Gene

Drugs & Compounds for SLC16A4 Gene

(1) Drugs for SLC16A4 Gene - From: DrugBank and HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Pyruvic acid Approved, Investigational Nutra Target 0

(2) Additional Compounds for SLC16A4 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with SLC16A4: view

Transcripts for SLC16A4 Gene

CRISPR Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for SLC16A4 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3a · 3b ^ 4 ^ 5a · 5b ^ 6 ^ 7a · 7b · 7c ^ 8 ^ 9a · 9b ^ 10a · 10b ^ 11
SP1: - -
SP2: -
SP3: - - -
SP4: - - - - - -
SP5: - - - -
SP6: - - - -
SP7: -
SP8: - - - - -
SP9:

Relevant External Links for SLC16A4 Gene

GeneLoc Exon Structure for
SLC16A4
ECgene alternative splicing isoforms for
SLC16A4

Expression for SLC16A4 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for SLC16A4 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SLC16A4 Gene

This gene is overexpressed in Kidney - Cortex (x9.3).

Protein differential expression in normal tissues from HIPED for SLC16A4 Gene

This gene is overexpressed in Urine (35.4), Kidney (19.9), and Placenta (13.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for SLC16A4 Gene



Protein tissue co-expression partners for SLC16A4 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of SLC16A4 Gene:

SLC16A4

SOURCE GeneReport for Unigene cluster for SLC16A4 Gene:

Hs.351306

Evidence on tissue expression from TISSUES for SLC16A4 Gene

  • Kidney(4.4)
  • Lung(4.2)
  • Nervous system(4.2)
genes like me logo Genes that share expression patterns with SLC16A4: view

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for SLC16A4 Gene

Orthologs for SLC16A4 Gene

This gene was present in the common ancestor of chordates.

Orthologs for SLC16A4 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SLC16A4 33 32
  • 96.76 (n)
OneToOne
cow
(Bos Taurus)
Mammalia SLC16A4 33 32
  • 88.13 (n)
OneToOne
dog
(Canis familiaris)
Mammalia SLC16A4 33 32
  • 86.39 (n)
OneToOne
rat
(Rattus norvegicus)
Mammalia Slc16a4 32
  • 86.27 (n)
mouse
(Mus musculus)
Mammalia Slc16a4 17 33 32
  • 84.57 (n)
oppossum
(Monodelphis domestica)
Mammalia SLC16A4 33
  • 61 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia SLC16A4 33
  • 54 (a)
OneToOne
chicken
(Gallus gallus)
Aves SLC16A4 33 32
  • 61.12 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia SLC16A4 33
  • 57 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii slc16a4 33 32
  • 57.85 (n)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea -- 33
  • 29 (a)
OneToMany
Species where no ortholog for SLC16A4 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for SLC16A4 Gene

ENSEMBL:
Gene Tree for SLC16A4 (if available)
TreeFam:
Gene Tree for SLC16A4 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for SLC16A4: view image

Paralogs for SLC16A4 Gene

(5) SIMAP similar genes for SLC16A4 Gene using alignment to 4 proteins:

  • MOT5_HUMAN
  • E9PKZ1_HUMAN
  • E9PRV1_HUMAN
  • H0YEG4_HUMAN
genes like me logo Genes that share paralogs with SLC16A4: view

Variants for SLC16A4 Gene

Sequence variations from dbSNP and Humsavar for SLC16A4 Gene

SNP ID Clin Chr 01 pos Variation AA Info Type
rs1000032405 -- 110,372,348(-) T/TT intron_variant
rs1000037350 -- 110,364,078(-) A/C/T intron_variant
rs1000110280 -- 110,370,928(-) A/G intron_variant
rs1000141406 -- 110,370,596(-) C/T intron_variant
rs1000153275 -- 110,381,666(-) A/G coding_sequence_variant, intron_variant, missense_variant

Structural Variations from Database of Genomic Variants (DGV) for SLC16A4 Gene

Variant ID Type Subtype PubMed ID
esv3346908 CNV insertion 20981092

Variation tolerance for SLC16A4 Gene

Residual Variation Intolerance Score: 31.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.73; 57.65% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for SLC16A4 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
SLC16A4

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SLC16A4 Gene

Disorders for SLC16A4 Gene

Additional Disease Information for SLC16A4

No disorders were found for SLC16A4 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SLC16A4 Gene

Publications for SLC16A4 Gene

  1. Cloning and sequencing of four new mammalian monocarboxylate transporter (MCT) homologues confirms the existence of a transporter family with an ancient past. (PMID: 9425115) Price NT … Halestrap AP (The Biochemical journal 1998) 2 3 4 56
  2. Hypoxia stimulates lactate release and modulates monocarboxylate transporter (MCT1, MCT2, and MCT4) expression in human adipocytes. (PMID: 19876643) Pérez de Heredia F … Trayhurn P (Pflugers Archiv : European journal of physiology 2010) 3 23 56
  3. Expression of monocarboxylate transporters 1, 2, and 4 in human tumours and their association with CD147 and CD44. (PMID: 20454640) Pinheiro C … Baltazar F (Journal of biomedicine & biotechnology 2010) 3 23 56
  4. Interaction of monocarboxylate transporter 4 with beta1-integrin and its role in cell migration. (PMID: 19073896) Gallagher SM … Philp NJ (American journal of physiology. Cell physiology 2009) 3 23 56
  5. Increased expression of monocarboxylate transporters 1, 2, and 4 in colorectal carcinomas. (PMID: 18188595) Pinheiro C … Baltazar F (Virchows Archiv : an international journal of pathology 2008) 3 23 56

Products for SLC16A4 Gene

Sources for SLC16A4 Gene