Lactic acid and pyruvate transport across plasma membranes is catalyzed by members of the proton-linked monocarboxylate transporter (MCT) family, which has been designated solute carrier family-16. Each MCT appears to have slightly different substrate and inhibitor specificities and transport kinetics, which are related to the metabolic requirements of the tissues in which it i... See more...

Aliases for SLC16A3 Gene

Aliases for SLC16A3 Gene

  • Solute Carrier Family 16 Member 3 2 3 4 5
  • MCT4 2 3 4
  • Solute Carrier Family 16, Member 3 (Monocarboxylic Acid Transporter 4) 2 3
  • Solute Carrier Family 16 (Monocarboxylic Acid Transporters), Member 3 2 3
  • Solute Carrier Family 16 (Monocarboxylate Transporter), Member 3 2 3
  • Monocarboxylate Transporter 4 3 4
  • MCT 4 3 4
  • MCT3 2 3
  • Monocarboxylate Transporter 3 3
  • SLC16A3 5
  • MCT 3 3
  • MCT-3 3
  • MCT-4 3

External Ids for SLC16A3 Gene

Previous GeneCards Identifiers for SLC16A3 Gene

  • GC17P079025
  • GC17P082998
  • GC17P080716
  • GC17P080865
  • GC17P077780
  • GC17P080186
  • GC17P075585
  • GC17P082228

Summaries for SLC16A3 Gene

Entrez Gene Summary for SLC16A3 Gene

  • Lactic acid and pyruvate transport across plasma membranes is catalyzed by members of the proton-linked monocarboxylate transporter (MCT) family, which has been designated solute carrier family-16. Each MCT appears to have slightly different substrate and inhibitor specificities and transport kinetics, which are related to the metabolic requirements of the tissues in which it is found. The MCTs, which include MCT1 (SLC16A1; MIM 600682) and MCT2 (SLC16A7; MIM 603654), are characterized by 12 predicted transmembrane domains (Price et al., 1998 [PubMed 9425115]).[supplied by OMIM, Mar 2008]

GeneCards Summary for SLC16A3 Gene

SLC16A3 (Solute Carrier Family 16 Member 3) is a Protein Coding gene. Diseases associated with SLC16A3 include Lacrimal Gland Carcinoma and Lacrimal Gland Adenocarcinoma. Among its related pathways are Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds and Cell surface interactions at the vascular wall. Gene Ontology (GO) annotations related to this gene include monocarboxylic acid transmembrane transporter activity. An important paralog of this gene is SLC16A8.

UniProtKB/Swiss-Prot Summary for SLC16A3 Gene

  • Proton-linked monocarboxylate transporter. Catalyzes the rapid transport across the plasma membrane of many monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and the ketone bodies acetoacetate, beta-hydroxybutyrate and acetate (By similarity).

Tocris Summary for SLC16A3 Gene

  • Monocarboxylate transporters (MCT) catalyze the bidirectional proton-linked transport of short-chain monocarboxylates such as L-lactate, ketone bodies and pyruvate across the plasma membrane of mammalian cells. MCT1-4 are key in the regulation of many cellular processes.

Gene Wiki entry for SLC16A3 Gene

No data available for CIViC Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for SLC16A3 Gene

Genomics for SLC16A3 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for SLC16A3 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around SLC16A3 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for SLC16A3

Top Transcription factor binding sites by QIAGEN in the SLC16A3 gene promoter:
  • c-Myb
  • LUN-1
  • Pax-5
  • PPAR-alpha

Genomic Locations for SLC16A3 Gene

Latest Assembly
chr17:82,217,934-82,261,129
(GRCh38/hg38)
Size:
43,196 bases
Orientation:
Plus strand

Previous Assembly
chr17:80,186,311-80,197,962
(GRCh37/hg19 by Entrez Gene)
Size:
11,652 bases
Orientation:
Plus strand

chr17:80,186,273-80,219,005
(GRCh37/hg19 by Ensembl)
Size:
32,733 bases
Orientation:
Plus strand

Genomic View for SLC16A3 Gene

Genes around SLC16A3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SLC16A3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SLC16A3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SLC16A3 Gene

Proteins for SLC16A3 Gene

  • Protein details for SLC16A3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O15427-MOT4_HUMAN
    Recommended name:
    Monocarboxylate transporter 4
    Protein Accession:
    O15427
    Secondary Accessions:
    • B3KXG8
    • Q2M1P8

    Protein attributes for SLC16A3 Gene

    Size:
    465 amino acids
    Molecular mass:
    49469 Da
    Quaternary structure:
    No Data Available

neXtProt entry for SLC16A3 Gene

Post-translational modifications for SLC16A3 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Antibodies for research

  • Biorbyt antibodies for SLC16A3
  • Boster Bio Antibodies for SLC16A3

No data available for DME Specific Peptides for SLC16A3 Gene

Domains & Families for SLC16A3 Gene

Gene Families for SLC16A3 Gene

Protein Domains for SLC16A3 Gene

Suggested Antigen Peptide Sequences for SLC16A3 Gene

GenScript: Design optimal peptide antigens:
  • Solute carrier family 16 member 3 (MOT4_HUMAN)

Graphical View of Domain Structure for InterPro Entry

O15427

UniProtKB/Swiss-Prot:

MOT4_HUMAN :
  • Belongs to the major facilitator superfamily. Monocarboxylate porter (TC 2.A.1.13) family.
Family:
  • Belongs to the major facilitator superfamily. Monocarboxylate porter (TC 2.A.1.13) family.
genes like me logo Genes that share domains with SLC16A3: view

Function for SLC16A3 Gene

Molecular function for SLC16A3 Gene

UniProtKB/Swiss-Prot Function:
Proton-linked monocarboxylate transporter. Catalyzes the rapid transport across the plasma membrane of many monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and the ketone bodies acetoacetate, beta-hydroxybutyrate and acetate (By similarity).
GENATLAS Biochemistry:
solute carrier family 16 (monocarboxylic acids transport) member 3,expressed only in the retinal pigment epithelium

Phenotypes From GWAS Catalog for SLC16A3 Gene

Gene Ontology (GO) - Molecular Function for SLC16A3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003723 RNA binding HDA 22658674
GO:0005515 protein binding IPI 25416956
GO:0008028 monocarboxylic acid transmembrane transporter activity IEA,IBA 21873635
GO:0015129 lactate transmembrane transporter activity IEA --
GO:0015293 symporter activity IEA --
genes like me logo Genes that share ontologies with SLC16A3: view
genes like me logo Genes that share phenotypes with SLC16A3: view

Animal Models for SLC16A3 Gene

MGI Knock Outs for SLC16A3:

Animal Models for research

  • Taconic Biosciences Mouse Models for SLC16A3

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for SLC16A3

Clone products for research

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for SLC16A3 Gene

Localization for SLC16A3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SLC16A3 Gene

Cell membrane. Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SLC16A3 gene
Compartment Confidence
plasma membrane 5
nucleus 5
cytoskeleton 3
mitochondrion 3
extracellular 2
endoplasmic reticulum 2
cytosol 2
lysosome 2
peroxisome 1
endosome 1
golgi apparatus 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Plasma membrane (3)
  • Nuclear membrane (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for SLC16A3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane IEA,IBA 21873635
GO:0016020 membrane IEA,TAS 9425115
GO:0016021 integral component of membrane IEA,IBA 21873635
GO:0016323 basolateral plasma membrane IDA 31791063
genes like me logo Genes that share ontologies with SLC16A3: view

Pathways & Interactions for SLC16A3 Gene

genes like me logo Genes that share pathways with SLC16A3: view

Pathways by source for SLC16A3 Gene

Gene Ontology (GO) - Biological Process for SLC16A3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006090 pyruvate metabolic process TAS --
GO:0015718 monocarboxylic acid transport IEA,IBA 21873635
GO:0035873 lactate transmembrane transport IEA --
GO:0035879 plasma membrane lactate transport IEA --
GO:0050900 leukocyte migration TAS --
genes like me logo Genes that share ontologies with SLC16A3: view

No data available for SIGNOR curated interactions for SLC16A3 Gene

Drugs & Compounds for SLC16A3 Gene

(16) Drugs for SLC16A3 Gene - From: DrugBank, ApexBio, HMDB, and Tocris

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
4-Hydroxybutyric acid Approved, Illicit, Investigational Pharma Transporter, substrate 0
Pyruvic acid Approved, Investigational Nutra Target, Transporter, substrate 0
Lactic acid Approved, Vet_approved Pharma Transporter, substrate 0
Niacin Approved, Investigational Nutra Transporter 479,479
alpha-ketoisovalerate Experimental Pharma Transporter, substrate 0

(3) Additional Compounds for SLC16A3 Gene - From: Novoseek and Tocris

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
SR 13800
227321-12-2

(4) Tocris Compounds for SLC16A3 Gene

Compound Action Cas Number
AR-C155858 MCT1 and MCT2 inhibitor; inhibits glycolysis in cancer cells 496791-37-8
CHC MCT inhibitor; decreases glycoloysis 28166-41-8
SR 13800 Potent MCT1 inhibitor 227321-12-2
UK 5099 MCT inhibitor; also inhibits of pyruvate transport 56396-35-1

(2) ApexBio Compounds for SLC16A3 Gene

Compound Action Cas Number
7ACC1 50995-74-9
7ACC2 1472624-85-3
genes like me logo Genes that share compounds with SLC16A3: view

Drug products for research

Transcripts for SLC16A3 Gene

mRNA/cDNA for SLC16A3 Gene

6 REFSEQ mRNAs :
13 NCBI additional mRNA sequence :
19 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for SLC16A3

Clone products for research

Alternative Splicing Database (ASD) splice patterns (SP) for SLC16A3 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b · 7c ^ 8a · 8b · 8c · 8d · 8e · 8f ^ 9
SP1: - - - -
SP2: - - -
SP3: -
SP4: -
SP5: -
SP6: - -
SP7: - -
SP8:

Relevant External Links for SLC16A3 Gene

GeneLoc Exon Structure for
SLC16A3

Expression for SLC16A3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for SLC16A3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SLC16A3 Gene

This gene is overexpressed in Whole Blood (x21.2) and Muscle - Skeletal (x4.3).

Protein differential expression in normal tissues from HIPED for SLC16A3 Gene

This gene is overexpressed in Nasal epithelium (32.8) and Breast (26.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for SLC16A3 Gene



Protein tissue co-expression partners for SLC16A3 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for SLC16A3

SOURCE GeneReport for Unigene cluster for SLC16A3 Gene:

Hs.500761

mRNA Expression by UniProt/SwissProt for SLC16A3 Gene:

O15427-MOT4_HUMAN
Tissue specificity: Highly expressed in skeletal muscle.

Evidence on tissue expression from TISSUES for SLC16A3 Gene

  • Nervous system(4.6)
  • Blood(4.5)
  • Kidney(4)
  • Lung(4)
  • Intestine(3.3)
  • Eye(2.9)
  • Muscle(2.5)
  • Skin(2.5)
  • Heart(2.5)
  • Stomach(2.4)
  • Pancreas(2.4)
  • Liver(2.1)
  • Spleen(2.1)
  • Bone marrow(2)
genes like me logo Genes that share expression patterns with SLC16A3: view

Primer products for research

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for SLC16A3 Gene

Orthologs for SLC16A3 Gene

This gene was present in the common ancestor of animals.

Orthologs for SLC16A3 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia SLC16A3 29 30
  • 99.06 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia SLC16A3 29 30
  • 86.1 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia SLC16A3 29 30
  • 85.93 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Slc16a3 29
  • 84.66 (n)
Mouse
(Mus musculus)
Mammalia Slc16a3 29 16 30
  • 84.27 (n)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia SLC16A3 30
  • 81 (a)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia SLC16A3 30
  • 76 (a)
OneToOne
Chicken
(Gallus gallus)
Aves SLC16A3 29 30
  • 71.13 (n)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia SLC16A3 30
  • 78 (a)
OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia slc16a3 29
  • 68.39 (n)
Str.19 29
African clawed frog
(Xenopus laevis)
Amphibia mct3-prov 29
Zebrafish
(Danio rerio)
Actinopterygii slc16a3 29 30
  • 68.64 (n)
OneToMany
SLC16A3 (1 of 2) 30
  • 67 (a)
OneToMany
Dr.7337 29
Fruit Fly
(Drosophila melanogaster)
Insecta CG8271 31
  • 35 (a)
Species where no ortholog for SLC16A3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for SLC16A3 Gene

ENSEMBL:
Gene Tree for SLC16A3 (if available)
TreeFam:
Gene Tree for SLC16A3 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for SLC16A3: view image
Alliance of Genome Resources:
Additional Orthologs for SLC16A3

Paralogs for SLC16A3 Gene

(28) SIMAP similar genes for SLC16A3 Gene using alignment to 11 proteins:

  • MOT4_HUMAN
  • J3KT83_HUMAN
  • J3KTI8_HUMAN
  • J3KTM6_HUMAN
  • J3QLE3_HUMAN
  • J3QQS9_HUMAN
  • J3QQV2_HUMAN
  • J3QRA0_HUMAN
  • J3QRP8_HUMAN
  • J3QRU2_HUMAN
  • J3QSC3_HUMAN
genes like me logo Genes that share paralogs with SLC16A3: view

Variants for SLC16A3 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for SLC16A3 Gene

SNP ID Clinical significance and condition Chr 17 pos Variation AA Info Type
rs144588703 Benign: not provided 82,236,052(+) C/T
NM_001042422.2(SLC16A3):c.44C>T (p.Ala15Val)
MISSENSE
rs200551682 Likely Benign: not provided 82,236,772(+) C/T
NM_001042422.2(SLC16A3):c.267C>T (p.Pro89=)
SYNONYMOUS
rs527273390 Benign: not provided 82,237,601(+) G/A
NM_001042422.2(SLC16A3):c.831G>A (p.Ala277=)
SYNONYMOUS

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for SLC16A3 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for SLC16A3 Gene

Variant ID Type Subtype PubMed ID
esv21913 CNV gain+loss 19812545
esv995451 CNV deletion 20482838
nsv1071417 CNV deletion 25765185
nsv2166 CNV insertion 18451855
nsv428351 CNV gain 18775914
nsv476004 CNV novel sequence insertion 20440878
nsv576193 CNV loss 21841781
nsv833572 CNV loss 17160897

Variation tolerance for SLC16A3 Gene

Residual Variation Intolerance Score: 23.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.79; 47.35% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for SLC16A3 Gene

Human Gene Mutation Database (HGMD)
SLC16A3
SNPedia medical, phenotypic, and genealogical associations of SNPs for
SLC16A3
Leiden Open Variation Database (LOVD)
SLC16A3

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SLC16A3 Gene

Disorders for SLC16A3 Gene

MalaCards: The human disease database

(3) MalaCards diseases for SLC16A3 Gene - From: COP

Disorder Aliases PubMed IDs
lacrimal gland carcinoma
  • carcinoma of the lacrimal gland
lacrimal gland adenocarcinoma
  • adenocarcinoma of lacrimal gland
breast papillary carcinoma
  • breast solid papillary carcinoma
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for SLC16A3

Human Genome Epidemiology Navigator
(HuGE)
Atlas
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
Open Targets Platform
genes like me logo Genes that share disorders with SLC16A3: view

No data available for UniProtKB/Swiss-Prot and Genatlas for SLC16A3 Gene

Publications for SLC16A3 Gene

  1. Cloning and sequencing of four new mammalian monocarboxylate transporter (MCT) homologues confirms the existence of a transporter family with an ancient past. (PMID: 9425115) Price NT … Halestrap AP (The Biochemical journal 1998) 2 3 4
  2. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey SD … DREAM investigators (Diabetes care 2010) 3 40
  3. The role of monocarboxylate transporter 2 and 4 in the transport of gamma-hydroxybutyric acid in mammalian cells. (PMID: 17502341) Wang Q … Morris ME (Drug metabolism and disposition: the biological fate of chemicals 2007) 3 22
  4. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PMID: 17081983) Olsen JV … Mann M (Cell 2006) 3 4
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4

Products for SLC16A3 Gene

  • Biorbyt antibodies for SLC16A3

Sources for SLC16A3 Gene