Aliases for SLC16A3 Gene
- Solute Carrier Family 16 Member 3 2 3 4 5
- Solute Carrier Family 16, Member 3 (Monocarboxylic Acid Transporter 4) 2 3
- Solute Carrier Family 16 (Monocarboxylic Acid Transporters), Member 3 2 3
- Solute Carrier Family 16 (Monocarboxylate Transporter), Member 3 2 3
- Monocarboxylate Transporter 4 3 4
- MCT 4 3 4
- MCT4 3 4
External Ids for SLC16A3 Gene
Previous GeneCards Identifiers for SLC16A3 Gene
Lactic acid and pyruvate transport across plasma membranes is catalyzed by members of the proton-linked monocarboxylate transporter (MCT) family, which has been designated solute carrier family-16. Each MCT appears to have slightly different substrate and inhibitor specificities and transport kinetics, which are related to the metabolic requirements of the tissues in which it is found. The MCTs, which include MCT1 (SLC16A1; MIM 600682) and MCT2 (SLC16A7; MIM 603654), are characterized by 12 predicted transmembrane domains (Price et al., 1998 [PubMed 9425115]).[supplied by OMIM, Mar 2008]
GeneCards Summary for SLC16A3 Gene
SLC16A3 (Solute Carrier Family 16 Member 3) is a Protein Coding gene. Diseases associated with SLC16A3 include Breast Papillary Carcinoma and Breast Mucinous Carcinoma. Among its related pathways are Central carbon metabolism in cancer and Pyruvate metabolism and Citric Acid (TCA) cycle. Gene Ontology (GO) annotations related to this gene include monocarboxylic acid transmembrane transporter activity. An important paralog of this gene is SLC16A8.
UniProtKB/Swiss-Prot for SLC16A3 Gene
Proton-linked monocarboxylate transporter. Catalyzes the rapid transport across the plasma membrane of many monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and the ketone bodies acetoacetate, beta-hydroxybutyrate and acetate (By similarity).
Monocarboxylate transporters (MCT) catalyze the bidirectional proton-linked transport of short-chain monocarboxylates such as L-lactate, ketone bodies and pyruvate across the plasma membrane of mammalian cells. MCT1-4 are key in the regulation of many cellular processes.