Aliases for SLC16A14 Gene

Aliases for SLC16A14 Gene

  • Solute Carrier Family 16 Member 14 2 3 4 5
  • Solute Carrier Family 16 (Monocarboxylic Acid Transporters), Member 14 2 3
  • Monocarboxylic Acid Transporter 14 2 3
  • Monocarboxylate Transporter 14 3 4
  • MCT 14 3 4
  • MCT14 3 4
  • Solute Carrier Family 16, Member 14 2

External Ids for SLC16A14 Gene

Previous GeneCards Identifiers for SLC16A14 Gene

  • GC02M231102
  • GC02M230725
  • GC02M230607
  • GC02M230899
  • GC02M222739

Summaries for SLC16A14 Gene

GeneCards Summary for SLC16A14 Gene

SLC16A14 (Solute Carrier Family 16 Member 14) is a Protein Coding gene. Diseases associated with SLC16A14 include Allan-Herndon-Dudley Syndrome. Gene Ontology (GO) annotations related to this gene include symporter activity and monocarboxylic acid transmembrane transporter activity. An important paralog of this gene is SLC16A9.

UniProtKB/Swiss-Prot Summary for SLC16A14 Gene

  • Proton-linked monocarboxylate transporter. May catalyze the transport of monocarboxylates across the plasma membrane.

Additional gene information for SLC16A14 Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for SLC16A14 Gene

Genomics for SLC16A14 Gene

GeneHancer (GH) Regulatory Elements for SLC16A14 Gene

Promoters and enhancers for SLC16A14 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH02J230066 Promoter/Enhancer 1.9 EPDnew Ensembl ENCODE CraniofacialAtlas 500.7 +0.9 939 2.9 ZNF217 CTCF ZFX ZIC2 ZBTB10 CLOCK ZBTB26 TRIM28 REST RAD21 HSALNG0022851 SLC16A14 RNY4P19 RF00019-072
GH02J230755 Promoter/Enhancer 1.1 Ensembl ENCODE 11.7 -688.7 -688655 4.7 ZNF623 ZNF510 RUNX1 ZNF266 FOXA2 CBFB CEBPG FOS CEBPB ZBTB11 NCL FBXO36 SLC16A14 CAB39 ENSG00000235419 TEX44 TRIP12 RNU6-451P RF00026-621 RNU6-268P
GH02J230599 Enhancer 1.2 FANTOM5 ENCODE dbSUPER 10 -532.8 -532754 5.1 RXRA ZBTB40 SP1 EP300 RELA MEF2C TRIM22 POLR2A BCL11A TCF12 SLC16A14 SP140 SP110 SP140L GPR55 SP100 lnc-SP100-2 MF281430-051
GH02J230614 Enhancer 1.3 FANTOM5 Ensembl ENCODE dbSUPER 9.6 -547.0 -547040 4.1 ZBTB40 POLR2A TCF12 ZNF384 ZNF207 TARDBP NBN NFE2 POU2F2 JUND RNU6-451P SLC16A14 GPR55 SP110 SP140 MF281430-051 lnc-SP100-2
GH02J230010 Enhancer 1 Ensembl ENCODE 11.7 +57.1 57107 2.8 MYC RUNX1 CTBP1 NCOR1 MBD2 NFIC TRIM24 MAX ZNF592 FOSL1 SLC16A14 lnc-SLC16A14-2 RF00017-3445 FBXO36
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around SLC16A14 on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for SLC16A14

Top Transcription factor binding sites by QIAGEN in the SLC16A14 gene promoter:
  • AREB6
  • Brachyury
  • FOXO1
  • FOXO1a
  • HOXA5
  • NF-kappaB1
  • Pax-4a
  • RORalpha2
  • S8
  • YY1

Genomic Locations for SLC16A14 Gene

Genomic Locations for SLC16A14 Gene
chr2:230,034,974-230,068,999
(GRCh38/hg38)
Size:
34,026 bases
Orientation:
Minus strand
chr2:230,899,690-230,933,715
(GRCh37/hg19)
Size:
34,026 bases
Orientation:
Minus strand

Genomic View for SLC16A14 Gene

Genes around SLC16A14 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SLC16A14 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SLC16A14 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SLC16A14 Gene

Proteins for SLC16A14 Gene

  • Protein details for SLC16A14 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q7RTX9-MOT14_HUMAN
    Recommended name:
    Monocarboxylate transporter 14
    Protein Accession:
    Q7RTX9
    Secondary Accessions:
    • A8KA08
    • Q53R92
    • Q96NI7

    Protein attributes for SLC16A14 Gene

    Size:
    510 amino acids
    Molecular mass:
    56254 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for SLC16A14 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SLC16A14 Gene

Post-translational modifications for SLC16A14 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for SLC16A14 Gene

Domains & Families for SLC16A14 Gene

Gene Families for SLC16A14 Gene

HGNC:
IUPHAR :
Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Predicted membrane proteins
  • Transporters

Protein Domains for SLC16A14 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for SLC16A14 Gene

GenScript: Design optimal peptide antigens:
  • Solute carrier family 16 member 14 (MOT14_HUMAN)
  • SLC16A14 protein (Q05BQ4_HUMAN)
  • cDNA FLJ41213 fis, clone BRALZ2016085, weakly similar to MONOCARBOXYLATE TRANSPORTER 3 (Q6ZWE5_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q7RTX9

UniProtKB/Swiss-Prot:

MOT14_HUMAN :
  • Belongs to the major facilitator superfamily. Monocarboxylate porter (TC 2.A.1.13) family.
Family:
  • Belongs to the major facilitator superfamily. Monocarboxylate porter (TC 2.A.1.13) family.
genes like me logo Genes that share domains with SLC16A14: view

Function for SLC16A14 Gene

Molecular function for SLC16A14 Gene

UniProtKB/Swiss-Prot Function:
Proton-linked monocarboxylate transporter. May catalyze the transport of monocarboxylates across the plasma membrane.

Phenotypes From GWAS Catalog for SLC16A14 Gene

Gene Ontology (GO) - Molecular Function for SLC16A14 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008028 monocarboxylic acid transmembrane transporter activity IBA 21873635
GO:0015293 symporter activity IEA --
genes like me logo Genes that share ontologies with SLC16A14: view
genes like me logo Genes that share phenotypes with SLC16A14: view

Animal Model Products

  • Taconic Biosciences Mouse Models for SLC16A14

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for SLC16A14

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for SLC16A14 Gene

Localization for SLC16A14 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SLC16A14 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SLC16A14 gene
Compartment Confidence
plasma membrane 4
endoplasmic reticulum 2
cytosol 2
extracellular 1
cytoskeleton 1
mitochondrion 1
nucleus 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Endoplasmic reticulum (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for SLC16A14 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005887 integral component of plasma membrane IEA --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with SLC16A14: view

Pathways & Interactions for SLC16A14 Gene

PathCards logo

SuperPathways for SLC16A14 Gene

No Data Available

Gene Ontology (GO) - Biological Process for SLC16A14 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0015718 monocarboxylic acid transport IEA --
GO:0055085 transmembrane transport IEA --
genes like me logo Genes that share ontologies with SLC16A14: view

No data available for Pathways by source and SIGNOR curated interactions for SLC16A14 Gene

Drugs & Compounds for SLC16A14 Gene

No Compound Related Data Available

Transcripts for SLC16A14 Gene

mRNA/cDNA for SLC16A14 Gene

1 REFSEQ mRNAs :
11 NCBI additional mRNA sequence :
5 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for SLC16A14

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for SLC16A14 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5a · 5b · 5c ^ 6 ^ 7a · 7b ^ 8
SP1: - - - -
SP2: -
SP3: - -
SP4:

Relevant External Links for SLC16A14 Gene

GeneLoc Exon Structure for
SLC16A14

Expression for SLC16A14 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for SLC16A14 Gene

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for SLC16A14 Gene



Protein tissue co-expression partners for SLC16A14 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for SLC16A14

SOURCE GeneReport for Unigene cluster for SLC16A14 Gene:

Hs.504317

Evidence on tissue expression from TISSUES for SLC16A14 Gene

  • Nervous system(4.8)
  • Lung(4)
  • Thyroid gland(2.1)
genes like me logo Genes that share expression patterns with SLC16A14: view

No data available for mRNA differential expression in normal tissues , Protein differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for SLC16A14 Gene

Orthologs for SLC16A14 Gene

This gene was present in the common ancestor of animals.

Orthologs for SLC16A14 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SLC16A14 31 30
  • 99.48 (n)
OneToOne
cow
(Bos Taurus)
Mammalia SLC16A14 31 30
  • 85.1 (n)
OneToOne
rat
(Rattus norvegicus)
Mammalia Slc16a14 30
  • 84.41 (n)
mouse
(Mus musculus)
Mammalia Slc16a14 17 31 30
  • 82.81 (n)
oppossum
(Monodelphis domestica)
Mammalia SLC16A14 31
  • 82 (a)
OneToOne
dog
(Canis familiaris)
Mammalia SLC16A14 31 30
  • 81.96 (n)
OneToOne
chicken
(Gallus gallus)
Aves SLC16A14 31 30
  • 72.51 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia SLC16A14 31
  • 73 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia slc16a14 30
  • 66.33 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG13907 30
  • 47.82 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP003206 30
  • 46.49 (n)
worm
(Caenorhabditis elegans)
Secernentea pes-22 30
  • 43.06 (n)
sea squirt
(Ciona savignyi)
Ascidiacea -- 31
  • 23 (a)
OneToMany
Species where no ortholog for SLC16A14 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • zebrafish (Danio rerio)

Evolution for SLC16A14 Gene

ENSEMBL:
Gene Tree for SLC16A14 (if available)
TreeFam:
Gene Tree for SLC16A14 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for SLC16A14: view image

Paralogs for SLC16A14 Gene

(7) SIMAP similar genes for SLC16A14 Gene using alignment to 6 proteins:

  • MOT14_HUMAN
  • C9JIV1_HUMAN
  • C9JME4_HUMAN
  • E7EMG7_HUMAN
  • Q05BQ4_HUMAN
  • Q6ZWE5_HUMAN

Pseudogenes.org Pseudogenes for SLC16A14 Gene

genes like me logo Genes that share paralogs with SLC16A14: view

Variants for SLC16A14 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for SLC16A14 Gene

SNP ID Clinical significance and condition Chr 02 pos Variation AA Info Type
767865 Benign: not provided 230,046,220(-) C/T SYNONYMOUS_VARIANT

Additional dbSNP identifiers (rs#s) for SLC16A14 Gene

Structural Variations from Database of Genomic Variants (DGV) for SLC16A14 Gene

Variant ID Type Subtype PubMed ID
dgv164e55 CNV gain 17911159
dgv4179n100 CNV gain 25217958
dgv7330n54 CNV gain 21841781
esv3575337 CNV gain 25503493
esv3594584 CNV loss 21293372
esv3594585 CNV gain 21293372
esv3594594 CNV gain 21293372
esv3594595 CNV loss 21293372
nsv1008431 CNV gain 25217958
nsv460118 CNV gain 19166990
nsv584650 CNV gain 21841781

Variation tolerance for SLC16A14 Gene

Residual Variation Intolerance Score: 49.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.67; 31.96% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for SLC16A14 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
SLC16A14

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SLC16A14 Gene

Disorders for SLC16A14 Gene

MalaCards: The human disease database

(1) MalaCards diseases for SLC16A14 Gene - From: DISEASES

Disorder Aliases PubMed IDs
allan-herndon-dudley syndrome
  • ahds
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for SLC16A14

genes like me logo Genes that share disorders with SLC16A14: view

No data available for UniProtKB/Swiss-Prot and Genatlas for SLC16A14 Gene

Publications for SLC16A14 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 54
  2. The SLC16 gene family-from monocarboxylate transporters (MCTs) to aromatic amino acid transporters and beyond. (PMID: 12739169) Halestrap AP … Meredith D (Pflugers Archiv : European journal of physiology 2004) 3 4 54
  3. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 54
  4. Genome-wide CRISPR screen identifies HNRNPL as a prostate cancer dependency regulating RNA splicing. (PMID: 28611215) Fei T … Brown M (Proceedings of the National Academy of Sciences of the United States of America 2017) 3 54
  5. BRCA2 mediates centrosome cohesion via an interaction with cytoplasmic dynein. (PMID: 27433848) Malik S … Nakanishi A (Cell cycle (Georgetown, Tex.) 2016) 3 54

Products for SLC16A14 Gene

Sources for SLC16A14 Gene