Aliases for SLC16A11 Gene

Aliases for SLC16A11 Gene

  • Solute Carrier Family 16 Member 11 2 3 4 5
  • Solute Carrier Family 16 (Monocarboxylic Acid Transporters), Member 11 2 3
  • Monocarboxylic Acid Transporter 11 2 3
  • Monocarboxylate Transporter 11 3 4
  • MCT 11 3 4
  • MCT11 3 4
  • Solute Carrier Family 16, Member 11 2

External Ids for SLC16A11 Gene

Previous GeneCards Identifiers for SLC16A11 Gene

  • GC17M006889
  • GC17M007145
  • GC17M006885
  • GC17M006944
  • GC17M006838

Summaries for SLC16A11 Gene

GeneCards Summary for SLC16A11 Gene

SLC16A11 (Solute Carrier Family 16 Member 11) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include symporter activity and monocarboxylic acid transmembrane transporter activity. An important paralog of this gene is SLC16A13.

UniProtKB/Swiss-Prot Summary for SLC16A11 Gene

  • Proton-linked monocarboxylate transporter. It catalyzes the transport of pyruvate across the plasma membrane (PubMed:28666119). Probably involved in hepatic lipid metabolism: overexpression results in an increase of triacylglycerol(TAG) levels, small increases in intracellular diacylglycerols and decreases in lysophosphatidylcholine, cholesterol ester and sphingomyelin lipids (PubMed:24390345).

Additional gene information for SLC16A11 Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for SLC16A11 Gene

Genomics for SLC16A11 Gene

GeneHancer (GH) Regulatory Elements for SLC16A11 Gene

Promoters and enhancers for SLC16A11 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH17J007045 Promoter/Enhancer 1.5 FANTOM5 Ensembl ENCODE 500.7 -1.8 -1840 3.3 ZBTB40 ZNF217 CTCF POLR2G USF1 NCOR1 ZIC2 KDM6A TCF7 AFF1 SLC16A11 piR-31462-017 piR-38429-013 KIAA0753 ACAP1 POLR2A MED31 ZBTB4
GH17J007041 Promoter/Enhancer 1.5 EPDnew Ensembl ENCODE 500.7 +1.8 1799 3.2 USF1 SP1 ZIC2 ZNF423 ZBTB26 ZNF341 FOXA2 EZH2 OSR2 TCF12 SLC16A11 KIAA0753 SLC16A13
GH17J007113 Promoter/Enhancer 1.8 EPDnew Ensembl ENCODE dbSUPER 11.5 -70.5 -70468 2.9 EP300 FOXK2 POLR2G NCOR1 NONO ZBTB5 KDM6A FOXA1 ZBTB25 SP1 ASGR2 WRAP53 NLGN2 CNTROB ELP5 ATP1B2 DLG4 ENSG00000233223 POLR2A SLC16A11
GH17J007176 Promoter/Enhancer 1.6 Ensembl ENCODE CraniofacialAtlas 12.3 -133.1 -133101 2.6 EP300 CTCF POLR2G ZNF300 ZIC2 ZBTB10 ZBTB26 ZNF740 TGIF2 RAD21 lnc-DLG4-2 DVL2 NLGN2 CNTROB SNORD10 SNORA48 MIR324 ELP5 DLG4 EIF4A1
GH17J007130 Enhancer 1.5 FANTOM5 ENCODE CraniofacialAtlas dbSUPER 12.7 -87.8 -87792 3.9 CTCF SP1 EP300 TCF7 RELA RCOR1 POLR2A HDAC2 BCL11A NR2F2 LOC105371512 piR-31655-002 CLEC10A SLC16A11 ASGR1 BCL6B EIF5A RPL7AP64 TRAPPC1 CD68
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around SLC16A11 on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for SLC16A11

Top Transcription factor binding sites by QIAGEN in the SLC16A11 gene promoter:
  • Bach2
  • Elk-1
  • Sp1
  • SREBP-1a
  • SRF
  • SRF (504 AA)
  • USF-1
  • USF-1:USF-2
  • USF1
  • USF2

Genomic Locations for SLC16A11 Gene

Genomic Locations for SLC16A11 Gene
chr17:7,041,617-7,044,400
(GRCh38/hg38)
Size:
2,784 bases
Orientation:
Minus strand
chr17:6,944,949-6,947,242
(GRCh37/hg19)
Size:
2,294 bases
Orientation:
Minus strand

Genomic View for SLC16A11 Gene

Genes around SLC16A11 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SLC16A11 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SLC16A11 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SLC16A11 Gene

Proteins for SLC16A11 Gene

  • Protein details for SLC16A11 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8NCK7-MOT11_HUMAN
    Recommended name:
    Monocarboxylate transporter 11
    Protein Accession:
    Q8NCK7

    Protein attributes for SLC16A11 Gene

    Size:
    471 amino acids
    Molecular mass:
    47791 Da
    Quaternary structure:
    • Interacts with BSG.

neXtProt entry for SLC16A11 Gene

Post-translational modifications for SLC16A11 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for SLC16A11 Gene

No data available for DME Specific Peptides for SLC16A11 Gene

Domains & Families for SLC16A11 Gene

Gene Families for SLC16A11 Gene

HGNC:
IUPHAR :
Human Protein Atlas (HPA):
  • Disease related genes
  • Potential drug targets
  • Predicted membrane proteins
  • Transporters

Protein Domains for SLC16A11 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for SLC16A11 Gene

GenScript: Design optimal peptide antigens:
  • Solute carrier family 16 member 11 (MOT11_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q8NCK7

UniProtKB/Swiss-Prot:

MOT11_HUMAN :
  • Belongs to the major facilitator superfamily. Monocarboxylate porter (TC 2.A.1.13) family.
Family:
  • Belongs to the major facilitator superfamily. Monocarboxylate porter (TC 2.A.1.13) family.
genes like me logo Genes that share domains with SLC16A11: view

Function for SLC16A11 Gene

Molecular function for SLC16A11 Gene

UniProtKB/Swiss-Prot Function:
Proton-linked monocarboxylate transporter. It catalyzes the transport of pyruvate across the plasma membrane (PubMed:28666119). Probably involved in hepatic lipid metabolism: overexpression results in an increase of triacylglycerol(TAG) levels, small increases in intracellular diacylglycerols and decreases in lysophosphatidylcholine, cholesterol ester and sphingomyelin lipids (PubMed:24390345).

Phenotypes From GWAS Catalog for SLC16A11 Gene

Gene Ontology (GO) - Molecular Function for SLC16A11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 28666119
GO:0008028 monocarboxylic acid transmembrane transporter activity IBA 21873635
GO:0015293 symporter activity IEA --
GO:0050833 pyruvate transmembrane transporter activity IDA 28666119
genes like me logo Genes that share ontologies with SLC16A11: view
genes like me logo Genes that share phenotypes with SLC16A11: view

Animal Model Products

CRISPR Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for SLC16A11 Gene

Localization for SLC16A11 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SLC16A11 Gene

Endoplasmic reticulum membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SLC16A11 gene
Compartment Confidence
plasma membrane 5
endoplasmic reticulum 5
extracellular 1
cytoskeleton 1
mitochondrion 1
nucleus 1
cytosol 1
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for SLC16A11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005783 endoplasmic reticulum IEA --
GO:0005789 endoplasmic reticulum membrane IEA,IDA 24390345
GO:0005886 plasma membrane IDA,IEA 28666119
GO:0005887 integral component of plasma membrane IEA --
GO:0016020 membrane IEA --
genes like me logo Genes that share ontologies with SLC16A11: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for SLC16A11 Gene

Pathways & Interactions for SLC16A11 Gene

PathCards logo

SuperPathways for SLC16A11 Gene

No Data Available

Gene Ontology (GO) - Biological Process for SLC16A11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006629 lipid metabolic process IDA,IEA 24390345
GO:0015718 monocarboxylic acid transport IEA --
GO:0055085 transmembrane transport IEA --
GO:1901475 pyruvate transmembrane transport IEA --
genes like me logo Genes that share ontologies with SLC16A11: view

No data available for Pathways by source and SIGNOR curated interactions for SLC16A11 Gene

Drugs & Compounds for SLC16A11 Gene

No Compound Related Data Available

Transcripts for SLC16A11 Gene

mRNA/cDNA for SLC16A11 Gene

3 REFSEQ mRNAs :
4 NCBI additional mRNA sequence :
5 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for SLC16A11 Gene

No ASD Table

Relevant External Links for SLC16A11 Gene

GeneLoc Exon Structure for
SLC16A11

Expression for SLC16A11 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for SLC16A11 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SLC16A11 Gene

This gene is overexpressed in Thyroid (x4.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for SLC16A11 Gene



Transcriptomic regulation report from SPP (The Signaling Pathways Project) for SLC16A11

SOURCE GeneReport for Unigene cluster for SLC16A11 Gene:

Hs.336564

mRNA Expression by UniProt/SwissProt for SLC16A11 Gene:

Q8NCK7-MOT11_HUMAN
Tissue specificity: Expressed in liver, salivary gland and thyroid.

Evidence on tissue expression from TISSUES for SLC16A11 Gene

  • Lung(4.1)
  • Heart(4)
genes like me logo Genes that share expression patterns with SLC16A11: view

No data available for Protein differential expression in normal tissues , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for SLC16A11 Gene

Orthologs for SLC16A11 Gene

This gene was present in the common ancestor of chordates.

Orthologs for SLC16A11 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SLC16A11 31 30
  • 99.08 (n)
OneToOne
dog
(Canis familiaris)
Mammalia SLC16A11 31 30
  • 86.13 (n)
OneToOne
cow
(Bos Taurus)
Mammalia SLC16A11 31 30
  • 84.43 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Slc16a11 17 31 30
  • 84.12 (n)
rat
(Rattus norvegicus)
Mammalia Slc16a11 30
  • 83.82 (n)
oppossum
(Monodelphis domestica)
Mammalia SLC16A11 31
  • 78 (a)
OneToOne
chicken
(Gallus gallus)
Aves SLC16A9 31
  • 23 (a)
ManyToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 31
  • 26 (a)
OneToMany
Species where no ortholog for SLC16A11 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for SLC16A11 Gene

ENSEMBL:
Gene Tree for SLC16A11 (if available)
TreeFam:
Gene Tree for SLC16A11 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for SLC16A11: view image

Paralogs for SLC16A11 Gene

(7) SIMAP similar genes for SLC16A11 Gene using alignment to 3 proteins:

  • MOT11_HUMAN
  • C9JRM8_HUMAN
  • I3L431_HUMAN
genes like me logo Genes that share paralogs with SLC16A11: view

Variants for SLC16A11 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for SLC16A11 Gene

SNP ID Clinical significance and condition Chr 17 pos Variation AA Info Type
rs117767867 - p.Val113Ile
rs13342692 - p.Asp127Gly
rs75418188 - p.Gly340Ser
rs75493593 - p.Pro443Thr

Additional dbSNP identifiers (rs#s) for SLC16A11 Gene

Structural Variations from Database of Genomic Variants (DGV) for SLC16A11 Gene

Variant ID Type Subtype PubMed ID
esv2422288 CNV deletion 17116639
nsv457659 CNV loss 19166990
nsv482199 CNV gain 20164927
nsv574322 CNV loss 21841781

Variation tolerance for SLC16A11 Gene

Residual Variation Intolerance Score: 86.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 10.04; 90.09% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for SLC16A11 Gene

Human Gene Mutation Database (HGMD)
SLC16A11
SNPedia medical, phenotypic, and genealogical associations of SNPs for
SLC16A11

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SLC16A11 Gene

Disorders for SLC16A11 Gene

UniProtKB/Swiss-Prot

MOT11_HUMAN
  • Diabetes mellitus, non-insulin-dependent (NIDDM) [MIM:125853]: A multifactorial disorder of glucose homeostasis caused by a lack of sensitivity to the body's own insulin. Affected individuals usually have an obese body habitus and manifestations of a metabolic syndrome characterized by diabetes, insulin resistance, hypertension and hypertriglyceridemia. The disease results in long-term complications that affect the eyes, kidneys, nerves, and blood vessels. {ECO:0000269 PubMed:24390345}. Note=Disease susceptibility is associated with variations affecting the gene represented in this entry. A risk haplotype spanning SLC16A11 is associated with a 20% increased risk for NIDDM. The haplotype includes 5 SLC16A11 variants in strong linkage disequilibrium: variants Ile-113, Gly-127, Ser-340, Thr-443 and a silent variant. This risk haplotype probably derives from H.sapiens neanderthalensis (Neanderthal) introgression and is present at 50% frequency in Native-American samples, 10% in east Asian, while it is rare in European and African samples populations. The risk haplotype contains a cis-eQTL that is responsible for reduced SLC16A11 expression in liver (PubMed:28666119). {ECO:0000269 PubMed:24390345, ECO:0000269 PubMed:28666119}.

Additional Disease Information for SLC16A11

No disorders were found for SLC16A11 Gene.

No data available for MalaCards and Genatlas for SLC16A11 Gene

Publications for SLC16A11 Gene

  1. Type 2 Diabetes Variants Disrupt Function of SLC16A11 through Two Distinct Mechanisms. (PMID: 28666119) Rusu V … Lander ES (Cell 2017) 3 4 54
  2. Sequence variants in SLC16A11 are a common risk factor for type 2 diabetes in Mexico. (PMID: 24390345) SIGMA Type 2 Diabetes Consortium … Altshuler D (Nature 2014) 3 4 54
  3. The SLC16A11 risk haplotype is associated with decreased insulin action, higher transaminases and large-size adipocytes. (PMID: 30475225) Almeda-Valdes P … Aguilar-Salinas CA (European journal of endocrinology 2019) 3 54
  4. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 54
  5. Associations of common variants in the SLC16A11, TCF7L2, and ABCA1 genes with pediatric-onset type 2 diabetes and related glycemic traits in families: A case-control and case-parent trio study. (PMID: 28101933) Miranda-Lora AL … Klünder-Klünder M (Pediatric diabetes 2017) 3 54

Products for SLC16A11 Gene

Sources for SLC16A11 Gene