SLC16A10 is a member of a family of plasma membrane amino acid transporters that mediate the Na(+)-independent transport of aromatic amino acids across the plasma membrane.[supplied by OMIM, Apr 2004] See more...

Aliases for SLC16A10 Gene

Aliases for SLC16A10 Gene

  • Solute Carrier Family 16 Member 10 2 3 4 5
  • MCT10 2 3 4
  • TAT1 2 3 4
  • Solute Carrier Family 16 (Monocarboxylic Acid Transporters), Member 10 2 3
  • Solute Carrier Family 16 (Aromatic Amino Acid Transporter), Member 10 2 3
  • Aromatic Amino Acid Transporter 1 3 4
  • T-Type Amino Acid Transporter 1 3 4
  • Monocarboxylate Transporter 10 3 4
  • MCT 10 3 4
  • Solute Carrier Family 16, Member 10 (Aromatic Amino Acid Transporter) 3
  • SLC16A10 5
  • PRO0813 3

External Ids for SLC16A10 Gene

Previous GeneCards Identifiers for SLC16A10 Gene

  • GC06P111244
  • GC06P111431
  • GC06P111454
  • GC06P111515
  • GC06P108979

Summaries for SLC16A10 Gene

Entrez Gene Summary for SLC16A10 Gene

  • SLC16A10 is a member of a family of plasma membrane amino acid transporters that mediate the Na(+)-independent transport of aromatic amino acids across the plasma membrane.[supplied by OMIM, Apr 2004]

GeneCards Summary for SLC16A10 Gene

SLC16A10 (Solute Carrier Family 16 Member 10) is a Protein Coding gene. Diseases associated with SLC16A10 include Allan-Herndon-Dudley Syndrome and Thyroid Crisis. Among its related pathways are Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds and Collagen chain trimerization. Gene Ontology (GO) annotations related to this gene include transporter activity. An important paralog of this gene is SLC16A2.

UniProtKB/Swiss-Prot Summary for SLC16A10 Gene

  • Sodium-independent transporter that mediates the uptake of aromatic acids. Can function as a net efflux pathway for aromatic amino acids in the basosolateral epithelial cells (By similarity).

Gene Wiki entry for SLC16A10 Gene

Additional gene information for SLC16A10 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for SLC16A10 Gene

Genomics for SLC16A10 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for SLC16A10 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around SLC16A10 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for SLC16A10

Top Transcription factor binding sites by QIAGEN in the SLC16A10 gene promoter:
  • AML1a
  • C/EBPalpha
  • FOXD3
  • FOXI1
  • HFH-3
  • HNF-1
  • HNF-1A
  • YY1
  • ZID

Genomic Locations for SLC16A10 Gene

Genomic Locations for SLC16A10 Gene
chr6:111,087,503-111,231,194
(GRCh38/hg38)
Size:
143,692 bases
Orientation:
Plus strand
chr6:111,408,781-111,552,397
(GRCh37/hg19)
Size:
143,617 bases
Orientation:
Plus strand

Genomic View for SLC16A10 Gene

Genes around SLC16A10 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SLC16A10 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SLC16A10 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SLC16A10 Gene

Proteins for SLC16A10 Gene

  • Protein details for SLC16A10 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8TF71-MOT10_HUMAN
    Recommended name:
    Monocarboxylate transporter 10
    Protein Accession:
    Q8TF71
    Secondary Accessions:
    • B3KWY0
    • Q6ZMG0
    • Q8WVI5

    Protein attributes for SLC16A10 Gene

    Size:
    515 amino acids
    Molecular mass:
    55493 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAH17968.1; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for SLC16A10 Gene

Post-translational modifications for SLC16A10 Gene

Other Protein References for SLC16A10 Gene

No data available for DME Specific Peptides for SLC16A10 Gene

Domains & Families for SLC16A10 Gene

Gene Families for SLC16A10 Gene

Protein Domains for SLC16A10 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for SLC16A10 Gene

GenScript: Design optimal peptide antigens:
  • T-type amino acid transporter 1 (MOT10_HUMAN)
  • SLC16A10 protein (Q05BR4_HUMAN)
  • Solute carrier family 16, member 10 (Aromatic amino acid transporter) (Q5VWW7_HUMAN)
  • Solute carrier family 16, member 10 (Aromatic amino acid transporter) (Q5VWW8_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q8TF71

UniProtKB/Swiss-Prot:

MOT10_HUMAN :
  • Belongs to the major facilitator superfamily. Monocarboxylate porter (TC 2.A.1.13) family.
Family:
  • Belongs to the major facilitator superfamily. Monocarboxylate porter (TC 2.A.1.13) family.
genes like me logo Genes that share domains with SLC16A10: view

Function for SLC16A10 Gene

Molecular function for SLC16A10 Gene

UniProtKB/Swiss-Prot Function:
Sodium-independent transporter that mediates the uptake of aromatic acids. Can function as a net efflux pathway for aromatic amino acids in the basosolateral epithelial cells (By similarity).

Phenotypes From GWAS Catalog for SLC16A10 Gene

Gene Ontology (GO) - Molecular Function for SLC16A10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008028 monocarboxylic acid transmembrane transporter activity IBA --
GO:0015171 amino acid transmembrane transporter activity TAS --
GO:0015173 aromatic amino acid transmembrane transporter activity IEA --
GO:0015349 thyroid hormone transmembrane transporter activity IEA --
genes like me logo Genes that share ontologies with SLC16A10: view
genes like me logo Genes that share phenotypes with SLC16A10: view

Animal Model Products

  • Taconic Biosciences Mouse Models for SLC16A10

CRISPR Products

miRNA for SLC16A10 Gene

miRTarBase miRNAs that target SLC16A10

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for SLC16A10

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for SLC16A10 Gene

Localization for SLC16A10 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SLC16A10 Gene

Cell membrane. Multi-pass membrane protein. Basolateral cell membrane.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SLC16A10 gene
Compartment Confidence
plasma membrane 5
nucleus 2
extracellular 1
cytoskeleton 1
mitochondrion 1
peroxisome 1
endoplasmic reticulum 1
endosome 1
cytosol 1
lysosome 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cell Junctions (3)
  • Vesicles (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for SLC16A10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane IEA --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA,IBA 21873635
GO:0016323 basolateral plasma membrane TAS 15918515
genes like me logo Genes that share ontologies with SLC16A10: view

Pathways & Interactions for SLC16A10 Gene

genes like me logo Genes that share pathways with SLC16A10: view

Gene Ontology (GO) - Biological Process for SLC16A10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003333 amino acid transmembrane transport IEA --
GO:0006590 thyroid hormone generation IEA --
GO:0006865 amino acid transport TAS --
GO:0015718 monocarboxylic acid transport IEA --
GO:0015801 aromatic amino acid transport IEA,TAS 15918515
genes like me logo Genes that share ontologies with SLC16A10: view

No data available for SIGNOR curated interactions for SLC16A10 Gene

Drugs & Compounds for SLC16A10 Gene

(35) Drugs for SLC16A10 Gene - From: DrugBank and HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Droxidopa Approved, Investigational Pharma Transporter, inhibitor 36
Levodopa Approved Pharma Agonist, Transporter, inhibitor 470
Aspartic acid Approved Nutra Transporter, inhibitor 182
Cysteine Approved Nutra Transporter, inhibitor 250
cystine Approved Nutra Transporter, inhibitor 0

(1) Additional Compounds for SLC16A10 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
sodium
  • Na(+)
  • Na+
  • SODIUM ion
7440-23-5
genes like me logo Genes that share compounds with SLC16A10: view

Transcripts for SLC16A10 Gene

mRNA/cDNA for SLC16A10 Gene

1 REFSEQ mRNAs :
7 NCBI additional mRNA sequence :
6 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for SLC16A10

Alternative Splicing Database (ASD) splice patterns (SP) for SLC16A10 Gene

No ASD Table

Relevant External Links for SLC16A10 Gene

GeneLoc Exon Structure for
SLC16A10

Expression for SLC16A10 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for SLC16A10 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SLC16A10 Gene

This gene is overexpressed in Muscle - Skeletal (x17.2) and Pancreas (x6.2).

Protein differential expression in normal tissues from HIPED for SLC16A10 Gene

This gene is overexpressed in Pancreas (28.4), Fetal Liver (13.9), Fetal ovary (9.5), and Placenta (7.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for SLC16A10 Gene



Transcriptomic regulation report from SPP (The Signaling Pathways Project) for SLC16A10

SOURCE GeneReport for Unigene cluster for SLC16A10 Gene:

Hs.591327

mRNA Expression by UniProt/SwissProt for SLC16A10 Gene:

Q8TF71-MOT10_HUMAN
Tissue specificity: Strongly expressed in kidney and skeletal muscle and at lower level in placenta and heart.

Evidence on tissue expression from TISSUES for SLC16A10 Gene

  • Liver(4.4)
  • Thyroid gland(2.9)
  • Muscle(2.3)
  • Kidney(2.2)
  • Nervous system(2.2)
  • Heart(2.2)
  • Pancreas(2.1)
genes like me logo Genes that share expression patterns with SLC16A10: view

No data available for Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for SLC16A10 Gene

Orthologs for SLC16A10 Gene

This gene was present in the common ancestor of animals.

Orthologs for SLC16A10 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia SLC16A10 30 31
  • 99.74 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia SLC16A10 30 31
  • 89.82 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia SLC16A10 30 31
  • 89.72 (n)
OneToOne
Mouse
(Mus musculus)
Mammalia Slc16a10 30 17 31
  • 85.03 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Slc16a10 30
  • 84.8 (n)
Platypus
(Ornithorhynchus anatinus)
Mammalia SLC16A10 31
  • 78 (a)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia SLC16A10 31
  • 55 (a)
OneToOne
Chicken
(Gallus gallus)
Aves SLC16A10 30 31
  • 75.69 (n)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia SLC16A10 31
  • 70 (a)
OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia slc16a10 30
  • 69.39 (n)
Zebrafish
(Danio rerio)
Actinopterygii slc16a10 30 31
  • 67.46 (n)
OneToOne
Fruit Fly
(Drosophila melanogaster)
Insecta kar 30 31 32
  • 54.56 (n)
OneToMany
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP007743 30
  • 52.74 (n)
Worm
(Caenorhabditis elegans)
Secernentea CELE_Y19D10A.12 30
  • 43.15 (n)
mct-1 31
  • 13 (a)
ManyToMany
mct-2 31
  • 13 (a)
ManyToMany
mct-3 31
  • 11 (a)
ManyToMany
mct-6 31
  • 10 (a)
ManyToMany
mct-5 31
  • 10 (a)
ManyToMany
mct-4 31
  • 8 (a)
ManyToMany
Sea Squirt
(Ciona savignyi)
Ascidiacea CSA.3504 31
  • 15 (a)
ManyToMany
-- 31
  • 13 (a)
ManyToMany
-- 31
  • 12 (a)
ManyToMany
CSA.4076 31
  • 4 (a)
ManyToMany
Species where no ortholog for SLC16A10 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)

Evolution for SLC16A10 Gene

ENSEMBL:
Gene Tree for SLC16A10 (if available)
TreeFam:
Gene Tree for SLC16A10 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for SLC16A10: view image

Paralogs for SLC16A10 Gene

(9) SIMAP similar genes for SLC16A10 Gene using alignment to 5 proteins:

  • MOT10_HUMAN
  • H0Y3W8_HUMAN
  • H0Y5M8_HUMAN
  • Q05BR4_HUMAN
  • Q9P1I2_HUMAN
genes like me logo Genes that share paralogs with SLC16A10: view

Variants for SLC16A10 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for SLC16A10 Gene

SNP ID Clinical significance and condition Chr 06 pos Variation AA Info Type
713154 Benign: not provided 111,177,285(+) T/C SYNONYMOUS_VARIANT
737124 Likely Benign: not provided 111,088,004(+) G/A SYNONYMOUS_VARIANT
761212 Likely Benign: not provided 111,218,838(+) C/T SYNONYMOUS_VARIANT
782253 Benign: not provided 111,177,461(+) G/C SYNONYMOUS_VARIANT
rs17072442 - p.Lys508Gln

Additional dbSNP identifiers (rs#s) for SLC16A10 Gene

Structural Variations from Database of Genomic Variants (DGV) for SLC16A10 Gene

Variant ID Type Subtype PubMed ID
esv2661859 CNV deletion 23128226
esv2732574 CNV deletion 23290073
esv3431181 CNV duplication 20981092
esv3610375 CNV loss 21293372
nsv1020627 CNV gain 25217958
nsv1028349 CNV gain 25217958
nsv1128270 CNV deletion 24896259
nsv480856 CNV novel sequence insertion 20440878
nsv509149 CNV insertion 20534489
nsv5440 CNV insertion 18451855
nsv5441 CNV insertion 18451855
nsv604517 CNV gain 21841781

Variation tolerance for SLC16A10 Gene

Residual Variation Intolerance Score: 30.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.17; 51.85% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for SLC16A10 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
SLC16A10

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SLC16A10 Gene

Disorders for SLC16A10 Gene

MalaCards: The human disease database

(3) MalaCards diseases for SLC16A10 Gene - From: DISEASES

Disorder Aliases PubMed IDs
allan-herndon-dudley syndrome
  • ahds
thyroid crisis
  • thyrotoxic crisis
euthyroid sick syndrome
  • sick-euthyroid syndrome
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for SLC16A10

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
genes like me logo Genes that share disorders with SLC16A10: view

No data available for UniProtKB/Swiss-Prot and Genatlas for SLC16A10 Gene

Publications for SLC16A10 Gene

  1. The human T-type amino acid transporter-1: characterization, gene organization, and chromosomal location. (PMID: 11827462) Kim DK … Endou H (Genomics 2002) 2 3 4 23 26
  2. Expression cloning of a Na+-independent aromatic amino acid transporter with structural similarity to H+/monocarboxylate transporters. (PMID: 11278508) Kim DK … Endou H (The Journal of biological chemistry 2001) 2 3 26
  3. Reabsorption of neutral amino acids mediated by amino acid transporter LAT2 and TAT1 in the basolateral membrane of proximal tubule. (PMID: 15918515) Park SY … Kim DK (Archives of pharmacal research 2005) 3 23
  4. The SLC16 gene family-from monocarboxylate transporters (MCTs) to aromatic amino acid transporters and beyond. (PMID: 12739169) Halestrap AP … Meredith D (Pflugers Archiv : European journal of physiology 2004) 3 23
  5. A reference map of the human binary protein interactome. (PMID: 32296183) Luck K … Calderwood MA (Nature 2020) 3

Products for SLC16A10 Gene

  • Biorbyt antibodies for SLC16A10

Sources for SLC16A10 Gene