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SLC16A10 is a member of a family of plasma membrane amino acid transporters that mediate the Na(+)-independent transport of aromatic amino acids across the plasma membrane.[supplied by OMIM, Apr 2004]
SLC16A10 (Solute Carrier Family 16 Member 10) is a Protein Coding gene. Diseases associated with SLC16A10 include Allan-Herndon-Dudley Syndrome and Thyroid Crisis. Among its related pathways are Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds and Collagen chain trimerization. Gene Ontology (GO) annotations related to this gene include transporter activity. An important paralog of this gene is SLC16A2.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0008028 | monocarboxylic acid transmembrane transporter activity | IBA | -- |
GO:0015171 | amino acid transmembrane transporter activity | TAS | -- |
GO:0015173 | aromatic amino acid transmembrane transporter activity | IEA | -- |
GO:0015349 | thyroid hormone transmembrane transporter activity | IEA | -- |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005886 | plasma membrane | TAS | -- |
GO:0005887 | integral component of plasma membrane | IEA | -- |
GO:0016020 | membrane | IEA | -- |
GO:0016021 | integral component of membrane | IEA,IBA | 21873635 |
GO:0016323 | basolateral plasma membrane | TAS | 15918515 |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0003333 | amino acid transmembrane transport | IEA | -- |
GO:0006590 | thyroid hormone generation | IEA | -- |
GO:0006865 | amino acid transport | TAS | -- |
GO:0015718 | monocarboxylic acid transport | IEA | -- |
GO:0015801 | aromatic amino acid transport | IEA,TAS | 15918515 |
Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
---|---|---|---|---|---|---|
Droxidopa | Approved, Investigational | Pharma | Transporter, inhibitor | 36 | ||
Levodopa | Approved | Pharma | Agonist, Transporter, inhibitor | 470 | ||
Aspartic acid | Approved | Nutra | Transporter, inhibitor | 182 | ||
Cysteine | Approved | Nutra | Transporter, inhibitor | 250 | ||
cystine | Approved | Nutra | Transporter, inhibitor | 0 |
Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs | |
---|---|---|---|---|---|---|
sodium |
|
7440-23-5 |
|
This gene was present in the common ancestor of animals.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Chimpanzee (Pan troglodytes) |
Mammalia | SLC16A10 30 31 |
|
OneToOne | |
Cow (Bos Taurus) |
Mammalia | SLC16A10 30 31 |
|
OneToOne | |
Dog (Canis familiaris) |
Mammalia | SLC16A10 30 31 |
|
OneToOne | |
Mouse (Mus musculus) |
Mammalia | Slc16a10 30 17 31 |
|
OneToOne | |
Rat (Rattus norvegicus) |
Mammalia | Slc16a10 30 |
|
||
Platypus (Ornithorhynchus anatinus) |
Mammalia | SLC16A10 31 |
|
OneToOne | |
Oppossum (Monodelphis domestica) |
Mammalia | SLC16A10 31 |
|
OneToOne | |
Chicken (Gallus gallus) |
Aves | SLC16A10 30 31 |
|
OneToOne | |
Lizard (Anolis carolinensis) |
Reptilia | SLC16A10 31 |
|
OneToOne | |
Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | slc16a10 30 |
|
||
Zebrafish (Danio rerio) |
Actinopterygii | slc16a10 30 31 |
|
OneToOne | |
Fruit Fly (Drosophila melanogaster) |
Insecta | kar 30 31 32 |
|
OneToMany | |
African malaria mosquito (Anopheles gambiae) |
Insecta | AgaP_AGAP007743 30 |
|
||
Worm (Caenorhabditis elegans) |
Secernentea | CELE_Y19D10A.12 30 |
|
||
mct-1 31 |
|
ManyToMany | |||
mct-2 31 |
|
ManyToMany | |||
mct-3 31 |
|
ManyToMany | |||
mct-6 31 |
|
ManyToMany | |||
mct-5 31 |
|
ManyToMany | |||
mct-4 31 |
|
ManyToMany | |||
Sea Squirt (Ciona savignyi) |
Ascidiacea | CSA.3504 31 |
|
ManyToMany | |
-- 31 |
|
ManyToMany | |||
-- 31 |
|
ManyToMany | |||
CSA.4076 31 |
|
ManyToMany |
SNP ID | Clinical significance and condition | Chr 06 pos | Variation | AA Info | Type |
---|---|---|---|---|---|
713154 | Benign: not provided | 111,177,285(+) | T/C | SYNONYMOUS_VARIANT | |
737124 | Likely Benign: not provided | 111,088,004(+) | G/A | SYNONYMOUS_VARIANT | |
761212 | Likely Benign: not provided | 111,218,838(+) | C/T | SYNONYMOUS_VARIANT | |
782253 | Benign: not provided | 111,177,461(+) | G/C | SYNONYMOUS_VARIANT | |
rs17072442 | - | p.Lys508Gln |
Variant ID | Type | Subtype | PubMed ID |
---|---|---|---|
esv2661859 | CNV | deletion | 23128226 |
esv2732574 | CNV | deletion | 23290073 |
esv3431181 | CNV | duplication | 20981092 |
esv3610375 | CNV | loss | 21293372 |
nsv1020627 | CNV | gain | 25217958 |
nsv1028349 | CNV | gain | 25217958 |
nsv1128270 | CNV | deletion | 24896259 |
nsv480856 | CNV | novel sequence insertion | 20440878 |
nsv509149 | CNV | insertion | 20534489 |
nsv5440 | CNV | insertion | 18451855 |
nsv5441 | CNV | insertion | 18451855 |
nsv604517 | CNV | gain | 21841781 |
Disorder | Aliases | PubMed IDs |
---|---|---|
allan-herndon-dudley syndrome |
|
|
thyroid crisis |
|
|
euthyroid sick syndrome |
|
|