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SLC16A10 is a member of a family of plasma membrane amino acid transporters that mediate the Na(+)-independent transport of aromatic amino acids across the plasma membrane.[supplied by OMIM, Apr 2004] See more...
Aliases for SLC16A10 Gene
Aliases for SLC16A10 Gene
External Ids for SLC16A10 Gene
- HGNC: 17027
- Entrez Gene: 117247
- Ensembl: ENSG00000112394
- OMIM: 607550
- UniProtKB: Q8TF71
Previous GeneCards Identifiers for SLC16A10 Gene
- GC06P111244
- GC06P111431
- GC06P111454
- GC06P111515
- GC06P108979
Summaries for SLC16A10 Gene
-
SLC16A10 is a member of a family of plasma membrane amino acid transporters that mediate the Na(+)-independent transport of aromatic amino acids across the plasma membrane.[supplied by OMIM, Apr 2004]
GeneCards Summary for SLC16A10 Gene
SLC16A10 (Solute Carrier Family 16 Member 10) is a Protein Coding gene. Diseases associated with SLC16A10 include Allan-Herndon-Dudley Syndrome and Thyroid Crisis. Among its related pathways are Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds and Collagen chain trimerization. Gene Ontology (GO) annotations related to this gene include transporter activity. An important paralog of this gene is SLC16A2.
UniProtKB/Swiss-Prot Summary for SLC16A10 Gene
-
Sodium-independent transporter that mediates the uptake of aromatic acids. Can function as a net efflux pathway for aromatic amino acids in the basosolateral epithelial cells (By similarity).
Additional gene information for SLC16A10 Gene
- HGNC(17027)
- Entrez Gene(117247)
- Ensembl(ENSG00000112394)
- OMIM(607550)
- UniProtKB(Q8TF71)
- Open Targets Platform(ENSG00000112394)
- Search for SLC16A10 at DataMed
- Search for SLC16A10 at HumanCyc
No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for SLC16A10 Gene
Genomics for SLC16A10 Gene
GeneHancer (GH) Regulatory Elements Pubs
Promoters and enhancers for SLC16A10 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around SLC16A10 on the GeneHancer Hub at the UCSC Golden Path
Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for SLC16A10
- Top Transcription factor binding sites by QIAGEN in the SLC16A10 gene promoter:
-
- AML1a
- C/EBPalpha
- FOXD3
- FOXI1
- HFH-3
- HNF-1
- HNF-1A
- YY1
- ZID
Genomic Locations for SLC16A10 Gene
Genomic Locations for SLC16A10 Gene
- chr6:111,087,503-111,231,194
- (GRCh38/hg38)
- Size:
- 143,692 bases
- Orientation:
- Plus strand
- chr6:111,408,781-111,552,397
- (GRCh37/hg19)
- Size:
- 143,617 bases
- Orientation:
- Plus strand
Genomic View for SLC16A10 Gene
Genes around SLC16A10 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 6q21 by HGNC
- 6q21 by Entrez Gene
- 6q21 by Ensembl
SLC16A10 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for SLC16A10 Gene
Proteins for SLC16A10 Gene
-
Protein details for SLC16A10 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q8TF71-MOT10_HUMAN
- Recommended name:
- Monocarboxylate transporter 10
- Protein Accession:
- Q8TF71
- B3KWY0
- Q6ZMG0
- Q8WVI5
Protein attributes for SLC16A10 Gene
- Size:
- 515 amino acids
- Molecular mass:
- 55493 Da
- Quaternary structure:
- No Data Available
- SequenceCaution:
-
- Sequence=AAH17968.1; Type=Erroneous initiation; Evidence={ECO:0000305};
Protein Expression for SLC16A10 Gene
Post-translational modifications for SLC16A10 Gene
- Not N-glycosylated.
- Modification sites at PhosphoSitePlus
- Modification sites at neXtProt
Other Protein References for SLC16A10 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- Novus Biologicals Antibodies for SLC16A10
- Invitrogen Antibodies for SLC16A10 (AFLGC-SLC16A10)
-
Biorbyt antibodies for SLC16A10
Protein Products
-
OriGene Purified Proteins for SLC16A10
- Search Origene for MassSpec and Protein Over-expression Lysates for SLC16A10
- Origene Custom Protein Services for SLC16A10
- Novus Biologicals proteins for SLC16A10
No data available for DME Specific Peptides for SLC16A10 Gene
Domains & Families for SLC16A10 Gene
Gene Families for SLC16A10 Gene
- HGNC:
- IUPHAR :
- Human Protein Atlas (HPA):
-
- Predicted membrane proteins
- Transporters
Protein Domains for SLC16A10 Gene
- InterPro:
- ProtoNet:
Suggested Antigen Peptide Sequences for SLC16A10 Gene
- GenScript: Design optimal peptide antigens:
-
- T-type amino acid transporter 1 (MOT10_HUMAN)
- SLC16A10 protein (Q05BR4_HUMAN)
- Solute carrier family 16, member 10 (Aromatic amino acid transporter) (Q5VWW7_HUMAN)
- Solute carrier family 16, member 10 (Aromatic amino acid transporter) (Q5VWW8_HUMAN)
Graphical View of Domain Structure for InterPro Entry
Q8TF71UniProtKB/Swiss-Prot:
MOT10_HUMAN :- Belongs to the major facilitator superfamily. Monocarboxylate porter (TC 2.A.1.13) family.
- Family:
-
- Belongs to the major facilitator superfamily. Monocarboxylate porter (TC 2.A.1.13) family.
Function for SLC16A10 Gene
Molecular function for SLC16A10 Gene
- UniProtKB/Swiss-Prot Function:
- Sodium-independent transporter that mediates the uptake of aromatic acids. Can function as a net efflux pathway for aromatic amino acids in the basosolateral epithelial cells (By similarity).
Phenotypes From GWAS Catalog for SLC16A10 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0008028 | monocarboxylic acid transmembrane transporter activity | IBA | -- |
| GO:0015171 | amino acid transmembrane transporter activity | TAS | -- |
| GO:0015173 | aromatic amino acid transmembrane transporter activity | IEA | -- |
| GO:0015349 | thyroid hormone transmembrane transporter activity | IEA | -- |
Phenotypes for SLC16A10 Gene
- MGI mutant phenotypes for SLC16A10:
- inferred from 2 alleles
- GenomeRNAi human phenotypes for SLC16A10:
Animal Model Products
-
Taconic Biosciences Mouse Models for SLC16A10
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for SLC16A10 - Select products 50% OFF >
- * SLC16A10 CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for SLC16A10
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for SLC16A10
-
Santa Cruz Biotechnology (SCBT) CRISPR for SLC16A10
miRNA for SLC16A10 Gene
- miRTarBase miRNAs that target SLC16A10
-
- hsa-miR-21-5p (MIRT002409)
- hsa-miR-590-3p (MIRT244041)
- hsa-miR-379-5p (MIRT315444)
- hsa-miR-4451 (MIRT315450)
- hsa-miR-4650-3p (MIRT315452)
- hsa-miR-3529-5p (MIRT315453)
- hsa-miR-548s (MIRT496804)
- hsa-miR-6807-5p (MIRT496805)
- hsa-miR-566 (MIRT496806)
- hsa-miR-3926 (MIRT496807)
- hsa-miR-6720-3p (MIRT496808)
- hsa-miR-3190-5p (MIRT496809)
- hsa-miR-4428 (MIRT496810)
- hsa-miR-5195-3p (MIRT497438)
- hsa-miR-145-5p (MIRT497439)
- hsa-miR-2115-5p (MIRT497440)
- hsa-miR-199b-5p (MIRT497441)
- hsa-miR-199a-5p (MIRT497442)
- hsa-miR-1825 (MIRT497443)
- hsa-miR-3149 (MIRT521108)
- hsa-miR-6832-5p (MIRT521109)
- hsa-miR-1273f (MIRT521110)
- hsa-miR-7151-3p (MIRT521111)
- hsa-miR-5095 (MIRT521112)
- hsa-miR-4537 (MIRT521113)
- hsa-miR-4717-3p (MIRT521114)
- hsa-miR-6746-3p (MIRT521115)
- hsa-miR-6504-3p (MIRT521116)
- hsa-miR-942-3p (MIRT521117)
- hsa-miR-4438 (MIRT521118)
- hsa-miR-4643 (MIRT521119)
- mmu-miR-466m-3p (MIRT603337)
- mmu-miR-466o-3p (MIRT603338)
- mmu-miR-466f-3p (MIRT603339)
- mmu-miR-329-3p (MIRT603340)
- mmu-miR-466i-3p (MIRT603341)
- mmu-miR-362-3p (MIRT603342)
- mmu-miR-466d-3p (MIRT603343)
- mmu-miR-297b-3p (MIRT603344)
- mmu-miR-466e-3p (MIRT603345)
- mmu-miR-467g (MIRT603346)
- mmu-miR-466a-3p (MIRT603347)
- mmu-miR-1b-5p (MIRT603348)
- mmu-miR-466p-3p (MIRT603349)
- mmu-miR-466c-3p (MIRT603350)
- mmu-miR-466b-3p (MIRT603351)
- hsa-miR-3674 (MIRT653742)
- hsa-miR-6758-3p (MIRT653743)
- hsa-miR-153-5p (MIRT653744)
- hsa-miR-1250-3p (MIRT653745)
- hsa-miR-624-3p (MIRT653746)
- hsa-miR-5698 (MIRT666313)
- hsa-miR-143-5p (MIRT666314)
- hsa-miR-6879-3p (MIRT666315)
- hsa-miR-4430 (MIRT666316)
- hsa-miR-3652 (MIRT666317)
- hsa-miR-504-3p (MIRT666318)
- hsa-miR-3135b (MIRT666319)
- hsa-miR-6499-3p (MIRT666320)
- hsa-miR-500b-3p (MIRT666321)
- hsa-miR-140-3p (MIRT666322)
- hsa-miR-6722-5p (MIRT666323)
- hsa-miR-122-5p (MIRT666324)
- hsa-miR-1304-3p (MIRT666325)
- hsa-miR-1281 (MIRT666326)
- hsa-miR-5693 (MIRT666327)
- hsa-miR-6890-3p (MIRT666328)
- hsa-miR-1273h-3p (MIRT706744)
- hsa-miR-4771 (MIRT706745)
- hsa-miR-3166 (MIRT706746)
- hsa-miR-3158-5p (MIRT706747)
- hsa-miR-499b-5p (MIRT706748)
- hsa-miR-509-5p (MIRT706749)
- hsa-miR-509-3-5p (MIRT706750)
- hsa-miR-4418 (MIRT706751)
- hsa-miR-4772-3p (MIRT786714)
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for SLC16A10
- Browse OriGene Inhibitory RNA Products For SLC16A10
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for SLC16A10
Clone Products
- Applied Biological Materials (abm): Clones for SLC16A10 - Select products 50% OFF >
- * SLC16A10 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
- MG206388
- MG217280
- MG218642
- MR206388
- MR206388L3
- MR206388L4
- MR217280
- MR217280L3
- MR217280L4
- MR218642
- MR218642L3
- MR218642L4
- RC209881
- RC209881L3
- RC209881L4
- RG209881
- RR212630
- RR212630L3
- RR212630L4
- MR206388L3V
- MR206388L4V
- MR217280L3V
- MR217280L4V
- MR218642L3V
- MR218642L4V
- RC209881L3V
- RC209881L4V
- RR212630L3V
- RR212630L4V
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for SLC16A10
- Addgene plasmids for SLC16A10
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for SLC16A10
Cell Line Products
-
Horizon Cell Lines for SLC16A10
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for SLC16A10 Gene
Localization for SLC16A10 Gene
Subcellular locations from UniProtKB/Swiss-Prot for SLC16A10 Gene
- Cell membrane. Multi-pass membrane protein. Basolateral cell membrane.
| Compartment | Confidence |
|---|---|
| plasma membrane | 5 |
| nucleus | 2 |
| extracellular | 1 |
| cytoskeleton | 1 |
| mitochondrion | 1 |
| peroxisome | 1 |
| endoplasmic reticulum | 1 |
| endosome | 1 |
| cytosol | 1 |
| lysosome | 1 |
- Cell Junctions (3)
- Vesicles (2)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005886 | plasma membrane | TAS | -- |
| GO:0005887 | integral component of plasma membrane | IEA | -- |
| GO:0016020 | membrane | IEA | -- |
| GO:0016021 | integral component of membrane | IEA,IBA | 21873635 |
| GO:0016323 | basolateral plasma membrane | TAS | 15918515 |
Pathways & Interactions for SLC16A10 Gene
Pathways by source for SLC16A10 Gene
2 KEGG pathways for SLC16A10 Gene
Interacting Proteins for SLC16A10 Gene
Selected Interacting proteins:
Q8TF71-MOT10_HUMAN
ENSP00000357844
for SLC16A10 Gene via
UniProtKB
STRING
IID
GPS-Prot Interaction Network for SLC16A10
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0003333 | amino acid transmembrane transport | IEA | -- |
| GO:0006590 | thyroid hormone generation | IEA | -- |
| GO:0006865 | amino acid transport | TAS | -- |
| GO:0015718 | monocarboxylic acid transport | IEA | -- |
| GO:0015801 | aromatic amino acid transport | IEA,TAS | 15918515 |
No data available for SIGNOR curated interactions for SLC16A10 Gene
Drugs & Compounds for SLC16A10 Gene
| Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
|---|---|---|---|---|---|---|
| Droxidopa | Approved, Investigational | Pharma | Transporter, inhibitor | 36 | ||
| Levodopa | Approved | Pharma | Agonist, Transporter, inhibitor | 470 | ||
| Aspartic acid | Approved | Nutra | Transporter, inhibitor | 182 | ||
| Cysteine | Approved | Nutra | Transporter, inhibitor | 250 | ||
| cystine | Approved | Nutra | Transporter, inhibitor | 0 |
| Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs | |
|---|---|---|---|---|---|---|
| sodium |
|
7440-23-5 |
|
Transcripts for SLC16A10 Gene
mRNA/cDNA for SLC16A10 Gene
- 1 REFSEQ mRNAs :
- 7 NCBI additional mRNA sequence :
- 6 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000368850 10051 nts (view in UCSC)
- ENST00000368851 10757 nts (view in UCSC)
- ENST00000419619 912 nts (view in UCSC)
- ENST00000439288 646 nts (view in UCSC)
- ENST00000465319 734 nts (view in UCSC)
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for SLC16A10 - Select products 50% OFF >
- * SLC16A10 CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for SLC16A10
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for SLC16A10
-
Santa Cruz Biotechnology (SCBT) CRISPR for SLC16A10
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for SLC16A10
- Browse OriGene Inhibitory RNA Products For SLC16A10
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for SLC16A10
Clone Products
- Applied Biological Materials (abm): Clones for SLC16A10 - Select products 50% OFF >
- * SLC16A10 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
- MG206388
- MG217280
- MG218642
- MR206388
- MR206388L3
- MR206388L4
- MR217280
- MR217280L3
- MR217280L4
- MR218642
- MR218642L3
- MR218642L4
- RC209881
- RC209881L3
- RC209881L4
- RG209881
- RR212630
- RR212630L3
- RR212630L4
- MR206388L3V
- MR206388L4V
- MR217280L3V
- MR217280L4V
- MR218642L3V
- MR218642L4V
- RC209881L3V
- RC209881L4V
- RR212630L3V
- RR212630L4V
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for SLC16A10
- Addgene plasmids for SLC16A10
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for SLC16A10
Relevant External Links for SLC16A10 Gene
- GeneLoc Exon Structure for
- SLC16A10
Expression for SLC16A10 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
-
Blood (Hematopoietic System)
- Proerythroblasts Hematopoietic Bone Marrow
- T Helper Cells Peripheral Blood
- T-Cytotoxic Cells Peripheral Blood
- Inner Cell Mass (Early Embryonic Tissues)
-
Brain (Nervous System)
- Choroid Plexus Progenitor Cells Choroid Plexus
- Choroid Plexus
mRNA differential expression in normal tissues according to GTEx for SLC16A10 Gene
This gene is overexpressed in Muscle - Skeletal (x17.2) and Pancreas (x6.2).
This gene is overexpressed in Pancreas (28.4), Fetal Liver (13.9), Fetal ovary (9.5), and Placenta (7.0).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for SLC16A10 Gene
Transcriptomic regulation report from SPP (The Signaling Pathways Project) for SLC16A10
SOURCE GeneReport for Unigene cluster for SLC16A10 Gene:
Hs.591327mRNA Expression by UniProt/SwissProt for SLC16A10 Gene:
Q8TF71-MOT10_HUMAN
Tissue specificity:
Strongly expressed in kidney and skeletal muscle and at lower level in placenta and heart.
Evidence on tissue expression from TISSUES for SLC16A10 Gene
- Liver(4.4)
- Thyroid gland(2.9)
- Muscle(2.3)
- Kidney(2.2)
- Nervous system(2.2)
- Heart(2.2)
- Pancreas(2.1)
Primer Products
-
OriGene qPCR primer pairs for SLC16A10
-
OriGene qPCR primer pairs and template standards for SLC16A10
Gene Expression Assay Products
No data available for Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for SLC16A10 Gene
Orthologs for SLC16A10 Gene
This gene was present in the common ancestor of animals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| Chimpanzee (Pan troglodytes) |
Mammalia | SLC16A10 30 31 |
|
OneToOne | |
| Cow (Bos Taurus) |
Mammalia | SLC16A10 30 31 |
|
OneToOne | |
| Dog (Canis familiaris) |
Mammalia | SLC16A10 30 31 |
|
OneToOne | |
| Mouse (Mus musculus) |
Mammalia | Slc16a10 30 17 31 |
|
OneToOne | |
| Rat (Rattus norvegicus) |
Mammalia | Slc16a10 30 |
|
||
| Platypus (Ornithorhynchus anatinus) |
Mammalia | SLC16A10 31 |
|
OneToOne | |
| Oppossum (Monodelphis domestica) |
Mammalia | SLC16A10 31 |
|
OneToOne | |
| Chicken (Gallus gallus) |
Aves | SLC16A10 30 31 |
|
OneToOne | |
| Lizard (Anolis carolinensis) |
Reptilia | SLC16A10 31 |
|
OneToOne | |
| Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | slc16a10 30 |
|
||
| Zebrafish (Danio rerio) |
Actinopterygii | slc16a10 30 31 |
|
OneToOne | |
| Fruit Fly (Drosophila melanogaster) |
Insecta | kar 30 31 32 |
|
OneToMany | |
| African malaria mosquito (Anopheles gambiae) |
Insecta | AgaP_AGAP007743 30 |
|
||
| Worm (Caenorhabditis elegans) |
Secernentea | CELE_Y19D10A.12 30 |
|
||
| mct-1 31 |
|
ManyToMany | |||
| mct-2 31 |
|
ManyToMany | |||
| mct-3 31 |
|
ManyToMany | |||
| mct-6 31 |
|
ManyToMany | |||
| mct-5 31 |
|
ManyToMany | |||
| mct-4 31 |
|
ManyToMany | |||
| Sea Squirt (Ciona savignyi) |
Ascidiacea | CSA.3504 31 |
|
ManyToMany | |
| -- 31 |
|
ManyToMany | |||
| -- 31 |
|
ManyToMany | |||
| CSA.4076 31 |
|
ManyToMany |
- Species where no ortholog for SLC16A10 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Eremothecium gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- Alicante grape (Vitis vinifera)
- Alpha proteobacteria (Wolbachia pipientis)
- Amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- Baker's yeast (Saccharomyces cerevisiae)
- Barley (Hordeum vulgare)
- Beta proteobacteria (Neisseria meningitidis)
- Bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- Common water flea (Daphnia pulex)
- Corn (Zea mays)
- E. coli (Escherichia coli)
- Filamentous fungi (Aspergillus nidulans)
- Firmicute Bacteria (Streptococcus pneumoniae)
- Fission Yeast (Schizosaccharomyces pombe)
- Green Algae (Chlamydomonas reinhardtii)
- Honey Bee (Apis mellifera)
- K. Lactis Yeast (Kluyveromyces lactis)
- Loblloly Pine (Pinus taeda)
- Malaria Parasite (Plasmodium falciparum)
- Medicago Trunc (Medicago Truncatula)
- Moss (Physcomitrella patens)
- Orangutan (Pongo pygmaeus)
- Pig (Sus scrofa)
- Rainbow Trout (Oncorhynchus mykiss)
- Rice (Oryza sativa)
- Rice Blast Fungus (Magnaporthe grisea)
- Schistosome Parasite (Schistosoma mansoni)
- Sea Anemone (Nematostella vectensis)
- Sea Vase (Ciona intestinalis)
- Sea Urchin (Strongylocentrotus purpuratus)
- Sorghum (Sorghum bicolor)
- Soybean (Glycine max)
- Stem Rust Fungus (Puccinia graminis)
- Sugarcane (Saccharum officinarum)
- Thale Cress (Arabidopsis thaliana)
- Tomato (Lycopersicon esculentum)
- Toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- Wheat (Triticum aestivum)
Evolution for SLC16A10 Gene
- ENSEMBL:
- Gene Tree for SLC16A10 (if available)
- TreeFam:
- Gene Tree for SLC16A10 (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for SLC16A10: view image
Paralogs for SLC16A10 Gene
Paralogs for SLC16A10 Gene
(9) SIMAP similar genes for SLC16A10 Gene using alignment to 5 proteins:
- MOT10_HUMAN
- H0Y3W8_HUMAN
- H0Y5M8_HUMAN
- Q05BR4_HUMAN
- Q9P1I2_HUMAN
Variants for SLC16A10 Gene
Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for SLC16A10 Gene
| SNP ID | Clinical significance and condition | Chr 06 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| 713154 | Benign: not provided | 111,177,285(+) | T/C | SYNONYMOUS_VARIANT | |
| 737124 | Likely Benign: not provided | 111,088,004(+) | G/A | SYNONYMOUS_VARIANT | |
| 761212 | Likely Benign: not provided | 111,218,838(+) | C/T | SYNONYMOUS_VARIANT | |
| 782253 | Benign: not provided | 111,177,461(+) | G/C | SYNONYMOUS_VARIANT | |
| rs17072442 | - | p.Lys508Gln |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| esv2661859 | CNV | deletion | 23128226 |
| esv2732574 | CNV | deletion | 23290073 |
| esv3431181 | CNV | duplication | 20981092 |
| esv3610375 | CNV | loss | 21293372 |
| nsv1020627 | CNV | gain | 25217958 |
| nsv1028349 | CNV | gain | 25217958 |
| nsv1128270 | CNV | deletion | 24896259 |
| nsv480856 | CNV | novel sequence insertion | 20440878 |
| nsv509149 | CNV | insertion | 20534489 |
| nsv5440 | CNV | insertion | 18451855 |
| nsv5441 | CNV | insertion | 18451855 |
| nsv604517 | CNV | gain | 21841781 |
Residual Variation Intolerance Score:
30.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
3.17;
51.85% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for SLC16A10 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- SLC16A10
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SLC16A10 Gene
Disorders for SLC16A10 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| allan-herndon-dudley syndrome |
|
|
| thyroid crisis |
|
|
| euthyroid sick syndrome |
|
|
Search SLC16A10 in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for SLC16A10
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
- Open Targets Platform
No data available for UniProtKB/Swiss-Prot and Genatlas for SLC16A10 Gene
Publications for SLC16A10 Gene
- The human T-type amino acid transporter-1: characterization, gene organization, and chromosomal location. (PMID: 11827462) Kim DK … Endou H (Genomics 2002) 2 3 4 23 26
- Expression cloning of a Na+-independent aromatic amino acid transporter with structural similarity to H+/monocarboxylate transporters. (PMID: 11278508) Kim DK … Endou H (The Journal of biological chemistry 2001) 2 3 26
- Reabsorption of neutral amino acids mediated by amino acid transporter LAT2 and TAT1 in the basolateral membrane of proximal tubule. (PMID: 15918515) Park SY … Kim DK (Archives of pharmacal research 2005) 3 23
- The SLC16 gene family-from monocarboxylate transporters (MCTs) to aromatic amino acid transporters and beyond. (PMID: 12739169) Halestrap AP … Meredith D (Pflugers Archiv : European journal of physiology 2004) 3 23
- A reference map of the human binary protein interactome. (PMID: 32296183) Luck K … Calderwood MA (Nature 2020) 3
ExternalLinks
Products for SLC16A10 Gene
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