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The protein encoded by this gene is a proton-linked monocarboxylate transporter that catalyzes the movement of many monocarboxylates, such as lactate and pyruvate, across the plasma membrane. Mutations in this gene are associated with erythrocyte lactate transporter defect. Alternatively spliced transcript variants have been found for this gene.[provided by RefSeq, Oct 2009] See more...
Aliases for SLC16A1 Gene
Aliases for SLC16A1 Gene
External Ids for SLC16A1 Gene
- HGNC: 10922
- Entrez Gene: 6566
- Ensembl: ENSG00000155380
- OMIM: 600682
- UniProtKB: P53985
Previous GeneCards Identifiers for SLC16A1 Gene
- GC01M113870
- GC01M112339
- GC01M112557
- GC01M112753
- GC01M113166
- GC01M113255
- GC01M113454
- GC01M111313
- GC01M112912
Summaries for SLC16A1 Gene
-
The protein encoded by this gene is a proton-linked monocarboxylate transporter that catalyzes the movement of many monocarboxylates, such as lactate and pyruvate, across the plasma membrane. Mutations in this gene are associated with erythrocyte lactate transporter defect. Alternatively spliced transcript variants have been found for this gene.[provided by RefSeq, Oct 2009]
GeneCards Summary for SLC16A1 Gene
SLC16A1 (Solute Carrier Family 16 Member 1) is a Protein Coding gene. Diseases associated with SLC16A1 include Erythrocyte Lactate Transporter Defect and Hyperinsulinemic Hypoglycemia, Familial, 7. Among its related pathways are Pyruvate metabolism and Citric Acid (TCA) cycle and Cell surface interactions at the vascular wall. Gene Ontology (GO) annotations related to this gene include protein homodimerization activity and monocarboxylic acid transmembrane transporter activity. An important paralog of this gene is SLC16A7.
UniProtKB/Swiss-Prot Summary for SLC16A1 Gene
-
Proton-coupled monocarboxylate transporter. Catalyzes the rapid transport across the plasma membrane of many monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and the ketone bodies acetoacetate, beta-hydroxybutyrate and acetate. Depending on the tissue and on cicumstances, mediates the import or export of lactic acid and ketone bodies. Required for normal nutrient assimilation, increase of white adipose tissue and body weight gain when on a high-fat diet. Plays a role in cellular responses to a high-fat diet by modulating the cellular levels of lactate and pyruvate, small molecules that contribute to the regulation of central metabolic pathways and insulin secretion, with concomitant effects on plasma insulin levels and blood glucose homeostasis.
-
Monocarboxylate transporters (MCT) catalyze the bidirectional proton-linked transport of short-chain monocarboxylates such as L-lactate, ketone bodies and pyruvate across the plasma membrane of mammalian cells. MCT1-4 are key in the regulation of many cellular processes.
Additional gene information for SLC16A1 Gene
- HGNC(10922)
- Entrez Gene(6566)
- Ensembl(ENSG00000155380)
- OMIM(600682)
- UniProtKB(P53985)
- Open Targets Platform(ENSG00000155380)
- Monarch Initiative
- Search for SLC16A1 at DataMed
- Search for SLC16A1 at HumanCyc
No data available for CIViC Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for SLC16A1 Gene
Genomics for SLC16A1 Gene
GeneHancer (GH) Regulatory Elements Pubs
Promoters and enhancers for SLC16A1 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around SLC16A1 on the GeneHancer Hub at the UCSC Golden Path
Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for SLC16A1
- Top Transcription factor binding sites by QIAGEN in the SLC16A1 gene promoter:
-
- AP-4
- Cart-1
- Egr-4
- FOXJ2
- FOXJ2 (long isoform)
- MAZR
- Pax-4a
- SREBP-1a
- SREBP-1b
- SREBP-1c
Genomic Locations for SLC16A1 Gene
Genomic Locations for SLC16A1 Gene
- chr1:112,911,847-112,957,013
- (GRCh38/hg38)
- Size:
- 45,167 bases
- Orientation:
- Minus strand
- chr1:113,454,469-113,499,635
- (GRCh37/hg19)
- Size:
- 45,167 bases
- Orientation:
- Minus strand
Genomic View for SLC16A1 Gene
Genes around SLC16A1 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 1p13.2 by HGNC
- 1p13.2 by Entrez Gene
- 1p13.2 by Ensembl
SLC16A1 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for SLC16A1 Gene
Proteins for SLC16A1 Gene
-
Protein details for SLC16A1 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- P53985-MOT1_HUMAN
- Recommended name:
- Monocarboxylate transporter 1
- Protein Accession:
- P53985
- Q49A45
- Q5T8R6
- Q9NSJ9
Protein attributes for SLC16A1 Gene
- Size:
- 500 amino acids
- Molecular mass:
- 53944 Da
- Quaternary structure:
-
- Interacts with EMB. Interaction with either BSG or EMB is required for expression at the cell membrane (By similarity). Interacts with BSG; this is required for expression at the cell membrane.
- Miscellaneous:
-
- Overexpression in pancreatic beta-cells triggers insulin secretion in response to pyruvate, causing hyperinsulemia and hypoglycemia during strenuous exercise.
Protein Expression for SLC16A1 Gene
Post-translational modifications for SLC16A1 Gene
Other Protein References for SLC16A1 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- G Biosciences Immunotag™ SLC16A1 Antibody
- GeneTex Anti-MCT1 antibody [GT14612] and Anti-MCT1 antibody
-
Custom Antibody ServicesOriGene Antibodies for SLC16A1
- Novus Biologicals Antibodies for SLC16A1
-
Abcam antibodies for SLC16A1
- Invitrogen Antibodies for SLC16A1 (AFLGC-SLC16A1)
-
Boster Bio Antibodies for SLC16A1
-
Santa Cruz Biotechnology (SCBT) Antibodies for SLC16A1
Protein Products
-
OriGene Purified Proteins for SLC16A1
- Search Origene for MassSpec and Protein Over-expression Lysates for SLC16A1
- Origene Custom Protein Services for SLC16A1
- antibodies-online: Show 6 available SLC16A1 Proteins ranked by validation data
- Compare Top SLC16A1 Proteins
-
Quality Products:
-
Signalway Proteins for SLC16A1
-
Abcam proteins for SLC16A1
Assay Products
- G Biosciences Immunotag™ Monocarboxylate transporter 1 ELISA Kit
- antibodies-online: Show 24 available SLC16A1 Elisa Kits ranked by validation data
- Compare Top SLC16A1 Elisa Kits
-
Quality Products:
No data available for DME Specific Peptides for SLC16A1 Gene
Domains & Families for SLC16A1 Gene
Gene Families for SLC16A1 Gene
- HGNC:
- IUPHAR :
- Human Protein Atlas (HPA):
-
- Disease related genes
- Potential drug targets
- Predicted membrane proteins
- Transporters
Suggested Antigen Peptide Sequences for SLC16A1 Gene
- GenScript: Design optimal peptide antigens:
-
- Solute carrier family 16 member 1 (MOT1_HUMAN)
Graphical View of Domain Structure for InterPro Entry
P53985UniProtKB/Swiss-Prot:
MOT1_HUMAN :- Belongs to the major facilitator superfamily. Monocarboxylate porter (TC 2.A.1.13) family.
- Family:
-
- Belongs to the major facilitator superfamily. Monocarboxylate porter (TC 2.A.1.13) family.
Function for SLC16A1 Gene
Molecular function for SLC16A1 Gene
- UniProtKB/Swiss-Prot Function:
- Proton-coupled monocarboxylate transporter. Catalyzes the rapid transport across the plasma membrane of many monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and the ketone bodies acetoacetate, beta-hydroxybutyrate and acetate. Depending on the tissue and on cicumstances, mediates the import or export of lactic acid and ketone bodies. Required for normal nutrient assimilation, increase of white adipose tissue and body weight gain when on a high-fat diet. Plays a role in cellular responses to a high-fat diet by modulating the cellular levels of lactate and pyruvate, small molecules that contribute to the regulation of central metabolic pathways and insulin secretion, with concomitant effects on plasma insulin levels and blood glucose homeostasis.
- GENATLAS Biochemistry:
- solute carrier family 16,member A1,monocarboxylic acids transporter,mediating movement of lactate and pyruvate across membranes
Phenotypes From GWAS Catalog for SLC16A1 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0008028 | monocarboxylic acid transmembrane transporter activity | TAS,IBA | 21873635 |
| GO:0015129 | lactate transmembrane transporter activity | IEA | -- |
| GO:0015130 | mevalonate transmembrane transporter activity | TAS | 1429658 |
| GO:0015293 | symporter activity | IEA | -- |
| GO:0042802 | identical protein binding | IEA | -- |
Phenotypes for SLC16A1 Gene
- MGI mutant phenotypes for SLC16A1:
- inferred from 1 alleles
- GenomeRNAi human phenotypes for SLC16A1:
-
- Increased vaccinia virus (VACV) infection
- no effect
- Decreased viability
- shRNA abundance <= 50%
- Decreased epidermal growth factor (EGF) endocytosis, decreased transferrin (TF) endocytosis
- Increased shRNA abundance (Z-score > 2)
- Decreased shRNA abundance (Z-score < -2)
- Decreased interferon-beta reporter expression
- Large nuclei
Animal Models for SLC16A1 Gene
- MGI Knock Outs for SLC16A1:
-
- Slc16a1 Slc16a1<tm1.1Geno>
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for SLC16A1 - Select products 50% OFF >
- * SLC16A1 CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for SLC16A1
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for SLC16A1
-
Santa Cruz Biotechnology (SCBT) CRISPR for SLC16A1
miRNA for SLC16A1 Gene
- miRTarBase miRNAs that target SLC16A1
-
- hsa-miR-376a-5p (MIRT001745)
- hsa-miR-124-3p (MIRT002665)
- hsa-miR-484 (MIRT016624)
- hsa-miR-376a-3p (MIRT019664)
- hsa-miR-128-3p (MIRT021959)
- hsa-miR-615-3p (MIRT040070)
- hsa-miR-320a (MIRT044631)
- hsa-miR-23b-3p (MIRT046336)
- hsa-miR-5003-3p (MIRT058696)
- hsa-miR-6074 (MIRT058706)
- hsa-miR-552-5p (MIRT241355)
- hsa-miR-374a-5p (MIRT241358)
- hsa-miR-374b-5p (MIRT241363)
- hsa-miR-33a-5p (MIRT265218)
- hsa-miR-33b-5p (MIRT265221)
- hsa-miR-302a-5p (MIRT265226)
- hsa-miR-190a-3p (MIRT265243)
- hsa-miR-5011-5p (MIRT265246)
- hsa-miR-129-5p (MIRT332037)
- hsa-miR-3978 (MIRT332051)
- hsa-miR-488-3p (MIRT467939)
- hsa-miR-6730-5p (MIRT467940)
- hsa-miR-5681a (MIRT467941)
- hsa-miR-4719 (MIRT467942)
- hsa-miR-3936 (MIRT467943)
- hsa-miR-3680-3p (MIRT467944)
- hsa-miR-30e-3p (MIRT467945)
- hsa-miR-30d-3p (MIRT467946)
- hsa-miR-30a-3p (MIRT467947)
- hsa-miR-3942-3p (MIRT467948)
- hsa-miR-6783-3p (MIRT467949)
- hsa-miR-1343-3p (MIRT467950)
- hsa-miR-7154-5p (MIRT467951)
- hsa-miR-5100 (MIRT467952)
- hsa-miR-7151-3p (MIRT467953)
- hsa-miR-5095 (MIRT467954)
- hsa-miR-376a-2-5p (MIRT467955)
- hsa-miR-4451 (MIRT467956)
- hsa-miR-379-5p (MIRT467957)
- hsa-miR-3529-5p (MIRT467958)
- hsa-miR-4650-3p (MIRT467959)
- hsa-miR-3663-3p (MIRT467960)
- hsa-miR-6742-3p (MIRT467961)
- hsa-miR-6852-5p (MIRT467962)
- hsa-miR-939-3p (MIRT467963)
- hsa-miR-8060 (MIRT467964)
- hsa-miR-936 (MIRT467965)
- hsa-miR-1972 (MIRT467966)
- hsa-miR-6504-3p (MIRT467967)
- hsa-miR-4438 (MIRT467968)
- hsa-miR-29a-3p (MIRT467969)
- hsa-miR-29c-3p (MIRT467970)
- hsa-miR-29b-3p (MIRT467971)
- hsa-miR-656-3p (MIRT505628)
- hsa-miR-5582-5p (MIRT505629)
- hsa-miR-3910 (MIRT505630)
- hsa-miR-5582-3p (MIRT505631)
- hsa-miR-3714 (MIRT505632)
- hsa-miR-548f-3p (MIRT505633)
- hsa-miR-548e-3p (MIRT505634)
- hsa-miR-548az-3p (MIRT505635)
- hsa-miR-548ar-3p (MIRT505636)
- hsa-miR-548a-3p (MIRT505637)
- hsa-miR-506-3p (MIRT505638)
- hsa-miR-506-5p (MIRT534244)
- hsa-miR-892c-5p (MIRT534245)
- hsa-miR-6866-3p (MIRT534246)
- hsa-miR-188-5p (MIRT534247)
- hsa-miR-7109-3p (MIRT534248)
- hsa-miR-605-5p (MIRT534249)
- hsa-miR-6124 (MIRT561579)
- hsa-miR-3148 (MIRT561580)
- hsa-miR-5002-5p (MIRT561581)
- hsa-miR-33a-3p (MIRT561582)
- hsa-miR-4307 (MIRT565627)
- hsa-miR-576-5p (MIRT565628)
- hsa-miR-563 (MIRT565629)
- hsa-miR-380-5p (MIRT565630)
- hsa-miR-6738-5p (MIRT565631)
- hsa-miR-5194 (MIRT565632)
- hsa-miR-1914-3p (MIRT565633)
- hsa-miR-6761-5p (MIRT565634)
- hsa-miR-4324 (MIRT565635)
- hsa-miR-6814-5p (MIRT565636)
- hsa-miR-4733-5p (MIRT565637)
- hsa-miR-548m (MIRT565638)
- hsa-miR-3117-5p (MIRT565639)
- hsa-miR-425-5p (MIRT565640)
- mmu-miR-3073a-3p (MIRT595215)
- mmu-miR-654-3p (MIRT595216)
- mmu-miR-30a-5p (MIRT595217)
- mmu-miR-30c-5p (MIRT595218)
- mmu-miR-30e-5p (MIRT595219)
- mmu-miR-30b-5p (MIRT595220)
- mmu-miR-30d-5p (MIRT595221)
- mmu-miR-384-5p (MIRT595222)
- hsa-miR-4503 (MIRT630798)
- hsa-miR-6792-5p (MIRT630799)
- hsa-miR-6815-3p (MIRT630800)
- hsa-miR-890 (MIRT630801)
- hsa-miR-8055 (MIRT674737)
- hsa-miR-744-3p (MIRT674738)
- hsa-miR-6805-3p (MIRT674739)
- hsa-miR-5691 (MIRT674740)
- hsa-miR-5006-5p (MIRT674741)
- hsa-miR-3972 (MIRT674742)
- hsa-miR-1202 (MIRT674743)
- hsa-miR-6864-3p (MIRT674744)
- hsa-miR-3672 (MIRT674745)
- hsa-miR-4423-5p (MIRT674746)
- hsa-miR-6501-5p (MIRT674747)
- hsa-miR-431-5p (MIRT674748)
- hsa-miR-4294 (MIRT674749)
- hsa-miR-3194-3p (MIRT674750)
- hsa-miR-4755-3p (MIRT674751)
- hsa-miR-924 (MIRT674752)
- hsa-miR-367-5p (MIRT674753)
- hsa-miR-1267 (MIRT674754)
- hsa-miR-302c-5p (MIRT710074)
- hsa-miR-216a-3p (MIRT739026)
- hsa-miR-27a-3p (MIRT739446)
- hsa-miR-27b-3p (MIRT739465)
- hsa-miR-3681-3p (MIRT742197)
- hsa-miR-377-5p (MIRT742716)
- hsa-miR-513a-5p (MIRT749770)
- hsa-miR-548ae-3p (MIRT750501)
- hsa-miR-548ah-3p (MIRT750514)
- hsa-miR-548aj-3p (MIRT750522)
- hsa-miR-548am-3p (MIRT750541)
- hsa-miR-548aq-3p (MIRT750573)
- hsa-miR-548j-3p (MIRT750750)
- hsa-miR-548x-3p (MIRT750824)
- hsa-miR-6086 (MIRT751869)
- hsa-miR-655-5p (MIRT753486)
- hsa-miR-7162-3p (MIRT759344)
- hsa-miR-7850-5p (MIRT759881)
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for SLC16A1
- Browse OriGene Inhibitory RNA Products For SLC16A1
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for SLC16A1
Clone Products
- Applied Biological Materials (abm): Clones for SLC16A1 - Select products 50% OFF >
- * SLC16A1 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
- Sino Biological Human cDNA Clone for SLC16A1
- Addgene plasmids for SLC16A1
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for SLC16A1
Cell Line Products
-
Horizon Cell Lines for SLC16A1
No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targets and HOMER Transcription for SLC16A1 Gene
Localization for SLC16A1 Gene
Subcellular locations from UniProtKB/Swiss-Prot for SLC16A1 Gene
- Cell membrane. Multi-pass membrane protein.
| Compartment | Confidence |
|---|---|
| plasma membrane | 5 |
| cytoskeleton | 5 |
| extracellular | 4 |
| mitochondrion | 2 |
| nucleus | 2 |
| cytosol | 2 |
| peroxisome | 1 |
| endoplasmic reticulum | 1 |
| endosome | 1 |
| lysosome | 1 |
| golgi apparatus | 1 |
- Cell Junctions (4)
- Plasma membrane (4)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005813 | centrosome | IDA | 23816619 |
| GO:0005886 | plasma membrane | TAS | -- |
| GO:0005887 | integral component of plasma membrane | IBA,ISS | -- |
| GO:0016020 | membrane | TAS,HDA | 19946888 |
| GO:0016021 | integral component of membrane | TAS,IBA | 21873635 |
Pathways & Interactions for SLC16A1 Gene
Pathways by source for SLC16A1 Gene
1 BioSystems pathway for SLC16A1 Gene
11 Reactome pathways for SLC16A1 Gene
2 R&D Systems pathways for SLC16A1 Gene
Interacting Proteins for SLC16A1 Gene
GPS-Prot Interaction Network for SLC16A1
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0006090 | pyruvate metabolic process | TAS | -- |
| GO:0006629 | lipid metabolic process | IEA | -- |
| GO:0007098 | centrosome cycle | IMP | 23816619 |
| GO:0015718 | monocarboxylic acid transport | IBA | 21873635 |
| GO:0015728 | mevalonate transport | TAS | 1429658 |
No data available for SIGNOR curated interactions for SLC16A1 Gene
Drugs & Compounds for SLC16A1 Gene
| Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
|---|---|---|---|---|---|---|
| acetic acid | Approved | Pharma | Agonist, Full agonist, Transporter, substrate | 139 | ||
| Nateglinide | Approved, Investigational | Pharma | Transporter, substrate | Insulin secretagog agent | 24 | |
| Salicylic acid | Approved, Investigational, Vet_approved | Pharma | Channel blocker, Transporter, substrate | 292 | ||
| 4-Hydroxybutyric acid | Approved, Illicit, Investigational | Pharma | Transporter, inhibitor | 0 | ||
| Foscarnet | Approved | Pharma | Transporter, substrate | 34 |
| Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs | |
|---|---|---|---|---|---|---|
| 4-ene-Valproic acid |
|
|||||
| SR 13800 |
|
227321-12-2 |
|
|
(4) Tocris Compounds for SLC16A1 Gene
| Compound | Action | Cas Number |
|---|---|---|
| AR-C155858 | MCT1 and MCT2 inhibitor; inhibits glycolysis in cancer cells | 496791-37-8 |
| CHC | MCT inhibitor; decreases glycoloysis | 28166-41-8 |
| SR 13800 | Potent MCT1 inhibitor | 227321-12-2 |
| UK 5099 | MCT inhibitor; also inhibits of pyruvate transport | 56396-35-1 |
(3) ApexBio Compounds for SLC16A1 Gene
| Compound | Action | Cas Number |
|---|---|---|
| 7ACC1 | 50995-74-9 | |
| 7ACC2 | 1472624-85-3 | |
| AR-C155858 | MCT1 and MCT2 inhibitor | 496791-37-8 |
Transcripts for SLC16A1 Gene
mRNA/cDNA for SLC16A1 Gene
- 2 REFSEQ mRNAs :
- 16 NCBI additional mRNA sequence :
- 7 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000369626 3753 nts (view in UCSC)
- ENST00000429288 865 nts (view in UCSC)
- ENST00000443580 1099 nts (view in UCSC)
- ENST00000458229 2201 nts (view in UCSC)
- ENST00000478835 452 nts (view in UCSC)
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for SLC16A1 - Select products 50% OFF >
- * SLC16A1 CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for SLC16A1
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for SLC16A1
-
Santa Cruz Biotechnology (SCBT) CRISPR for SLC16A1
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for SLC16A1
- Browse OriGene Inhibitory RNA Products For SLC16A1
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for SLC16A1
Clone Products
- Applied Biological Materials (abm): Clones for SLC16A1 - Select products 50% OFF >
- * SLC16A1 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
- Sino Biological Human cDNA Clone for SLC16A1
- Addgene plasmids for SLC16A1
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for SLC16A1
| ExUns: | 1a | · | 1b | ^ | 2 | ^ | 3a | · | 3b | ^ | 4 | ^ | 5a | · | 5b | ^ | 6 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | |||||||||||||||||
| SP2: | |||||||||||||||||
| SP3: | - |
Relevant External Links for SLC16A1 Gene
- GeneLoc Exon Structure for
- SLC16A1
Expression for SLC16A1 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
-
Brain (Nervous System)
- Mature Choroid Plexus Cells Choroid Plexus
- Mature Endothelial Cells Blood Brain Barrier
- Endothelial Cells Blood Brain Barrier
- Adult Endothelial Cells Blood Brain Barrier
- Striatum
-
Endothelium (Cardiovascular System)
- Mature Endothelial Cells Blood Brain Barrier
- Endothelial Cells Blood Brain Barrier
- Adult Endothelial Cells Blood Brain Barrier
- Mature brain microvascular endothelial cells (Lippmann ES et. al. 2012)
-
Epithelial Cells
- Outer Root Sheath Cells Outer Root Sheath
- Basal Cells Respiratory Bronchioles
- Mature Choroid Plexus Cells Choroid Plexus
-
Blood (Hematopoietic System)
- Proerythroblasts Hematopoietic Bone Marrow
- Erythroblasts Hematopoietic Bone Marrow
- Double Negative 2 Thymocytes Thymus
- Adipose (Muscoskeletal System)
-
Hair (Integumentary System)
- Outer Root Sheath Cells Outer Root Sheath
-
Lung (Respiratory System)
- Basal Cells Respiratory Bronchioles
-
Thymus (Hematopoietic System)
- Double Negative 2 Thymocytes Thymus
- Gut Tube (Gastrointestinal Tract)
- Neural Tube (Nervous System)
- Lower Urinary Tract (Urinary System)
- Kidney (Urinary System)
- Liver (Hepatobiliary System)
This gene is overexpressed in Retina (10.5).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for SLC16A1 Gene
Transcriptomic regulation report from SPP (The Signaling Pathways Project) for SLC16A1
SOURCE GeneReport for Unigene cluster for SLC16A1 Gene:
Hs.75231mRNA Expression by UniProt/SwissProt for SLC16A1 Gene:
P53985-MOT1_HUMAN
Tissue specificity:
Detected in heart and in blood lymphocytes and monocytes (at protein level). Widely expressed.
Evidence on tissue expression from TISSUES for SLC16A1 Gene
- Nervous system(5)
- Liver(4.7)
- Heart(4.6)
- Intestine(4.6)
- Muscle(3)
- Skin(2.8)
- Kidney(2.7)
- Blood(2.5)
- Stomach(2.5)
- Eye(2.2)
- Pancreas(2.1)
- Thyroid gland(2.1)
Phenotype-based relationships between genes and organs from Gene ORGANizer for SLC16A1 Gene
Germ Layers:
- ectoderm
- endoderm
- mesoderm
Systems:
- cardiovascular
- digestive
- endocrine
- integumentary
- nervous
- skeletal muscle
Regions:
Head and neck:
- brain
- ear
- head
- mouth
- salivary gland
Thorax:
- esophagus
- heart
Abdomen:
- adrenal gland
- intestine
- large intestine
- pancreas
- small intestine
- stomach
General:
- blood vessel
- peripheral nerve
- peripheral nervous system
- skin
- sweat gland
Primer Products
-
OriGene qPCR primer pairs for SLC16A1
-
OriGene qPCR primer pairs and template standards for SLC16A1
Gene Expression Assay Products
No data available for mRNA differential expression in normal tissues for SLC16A1 Gene
Orthologs for SLC16A1 Gene
This gene was present in the common ancestor of chordates.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| Chimpanzee (Pan troglodytes) |
Mammalia | SLC16A1 30 31 |
|
OneToOne | |
| Dog (Canis familiaris) |
Mammalia | SLC16A1 30 |
|
||
| MCT1 31 |
|
OneToOne | |||
| Cow (Bos Taurus) |
Mammalia | SLC16A1 30 31 |
|
OneToOne | |
| Rat (Rattus norvegicus) |
Mammalia | Slc16a1 30 |
|
||
| Mouse (Mus musculus) |
Mammalia | Slc16a1 30 17 31 |
|
OneToOne | |
| Platypus (Ornithorhynchus anatinus) |
Mammalia | SLC16A1 31 |
|
OneToOne | |
| Oppossum (Monodelphis domestica) |
Mammalia | SLC16A1 31 |
|
OneToOne | |
| Chicken (Gallus gallus) |
Aves | SLC16A1 30 31 |
|
OneToOne | |
| Lizard (Anolis carolinensis) |
Reptilia | SLC16A1 31 |
|
OneToOne | |
| Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | slc16a1 30 |
|
||
| African clawed frog (Xenopus laevis) |
Amphibia | slc16a1-prov 30 |
|
||
| Zebrafish (Danio rerio) |
Actinopterygii | SLC16A1 (1 of 2) 31 |
|
OneToMany | |
| slc16a1 30 31 |
|
OneToMany |
- Species where no ortholog for SLC16A1 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Eremothecium gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- Alpha proteobacteria (Wolbachia pipientis)
- Amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- Baker's yeast (Saccharomyces cerevisiae)
- Barley (Hordeum vulgare)
- Beta proteobacteria (Neisseria meningitidis)
- Bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- Common water flea (Daphnia pulex)
- Corn (Zea mays)
- E. coli (Escherichia coli)
- Filamentous fungi (Aspergillus nidulans)
- Firmicute Bacteria (Streptococcus pneumoniae)
- Fission Yeast (Schizosaccharomyces pombe)
- Fruit Fly (Drosophila melanogaster)
- Green Algae (Chlamydomonas reinhardtii)
- Honey Bee (Apis mellifera)
- K. Lactis Yeast (Kluyveromyces lactis)
- Loblloly Pine (Pinus taeda)
- Malaria Parasite (Plasmodium falciparum)
- Medicago Trunc (Medicago Truncatula)
- Moss (Physcomitrella patens)
- Orangutan (Pongo pygmaeus)
- Pig (Sus scrofa)
- Rainbow Trout (Oncorhynchus mykiss)
- Rice (Oryza sativa)
- Rice Blast Fungus (Magnaporthe grisea)
- Schistosome Parasite (Schistosoma mansoni)
- Sea Anemone (Nematostella vectensis)
- Sea Vase (Ciona intestinalis)
- Sea Squirt (Ciona savignyi)
- Sea Urchin (Strongylocentrotus purpuratus)
- Sorghum (Sorghum bicolor)
- Soybean (Glycine max)
- Stem Rust Fungus (Puccinia graminis)
- Sugarcane (Saccharum officinarum)
- Thale Cress (Arabidopsis thaliana)
- Tomato (Lycopersicon esculentum)
- Toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- Wheat (Triticum aestivum)
- Worm (Caenorhabditis elegans)
Evolution for SLC16A1 Gene
- ENSEMBL:
- Gene Tree for SLC16A1 (if available)
- TreeFam:
- Gene Tree for SLC16A1 (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for SLC16A1: view image
Paralogs for SLC16A1 Gene
Paralogs for SLC16A1 Gene
(10) SIMAP similar genes for SLC16A1 Gene using alignment to 5 proteins:
- MOT1_HUMAN
- Q49A45_HUMAN
- Q5T8R3_HUMAN
- Q5T8R4_HUMAN
- Q5T8R5_HUMAN
Pseudogenes.org Pseudogenes for SLC16A1 Gene
Variants for SLC16A1 Gene
Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for SLC16A1 Gene
| SNP ID | Clinical significance and condition | Chr 01 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| 712920 | Benign: not provided | 112,917,433(-) | T/C | MISSENSE_VARIANT | |
| 713802 | Likely Benign: not provided | 112,922,027(-) | G/A | SYNONYMOUS_VARIANT | |
| 717692 | Likely Benign: not provided | 112,917,551(-) | A/G | SYNONYMOUS_VARIANT | |
| 727984 | Likely Benign: not provided | 112,917,425(-) | A/C | SYNONYMOUS_VARIANT | |
| 733619 | Benign/Likely Benign: Exercise-induced hyperinsulinism; not provided | 112,914,112(-) | C/T | MISSENSE_VARIANT |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| dgv83e212 | CNV | gain | 25503493 |
| esv24626 | CNV | loss | 19812545 |
| esv3584026 | CNV | gain | 25503493 |
| esv3894045 | CNV | gain | 25118596 |
| nsv1004102 | CNV | gain | 25217958 |
| nsv946145 | CNV | duplication | 23825009 |
| nsv999915 | CNV | gain | 25217958 |
Residual Variation Intolerance Score:
55.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
0.83;
17.45% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for SLC16A1 Gene
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SLC16A1 Gene
Disorders for SLC16A1 Gene
(10) MalaCards diseases for SLC16A1 Gene - From: UniProtKB/Swiss-Prot, OMIM, ClinVar, GTR, Orphanet, DISEASES, Novoseek, and GeneCards
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| erythrocyte lactate transporter defect |
|
|
| hyperinsulinemic hypoglycemia, familial, 7 |
|
|
| monocarboxylate transporter 1 deficiency |
|
|
| hypoglycemia |
|
|
| hyperinsulinism |
|
|
Search SLC16A1 in MalaCards
View complete list of genes associated with diseases
UniProtKB/Swiss-Prot
MOT1_HUMAN- Symptomatic deficiency in lactate transport (SDLT) [MIM:245340]: Deficiency of lactate transporter may result in an acidic intracellular environment created by muscle activity with consequent degeneration of muscle and release of myoglobin and creatine kinase. This defect might compromise extreme performance in otherwise healthy individuals. {ECO:0000269 PubMed:10590411}. Note=The disease is caused by mutations affecting the gene represented in this entry.
- Familial hyperinsulinemic hypoglycemia 7 (HHF7) [MIM:610021]: Dominantly inherited hypoglycemic disorder characterized by inappropriate insulin secretion during anaerobic exercise or on pyruvate load. {ECO:0000269 PubMed:17701893}. Note=The disease is caused by mutations affecting the gene represented in this entry.
- Monocarboxylate transporter 1 deficiency (MCT1D) [MIM:616095]: A metabolic disorder characterized by recurrent ketoacidosis, a pathologic state due to ketone formation exceeding ketone utilization. The clinical consequences of ketoacidosis are vomiting, osmotic diuresis, dehydration, and Kussmaul breathing. The condition may progress to decreased consciousness and, ultimately, death. {ECO:0000269 PubMed:25390740}. Note=The disease is caused by mutations affecting the gene represented in this entry.
Additional Disease Information for SLC16A1
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
- Open Targets Platform
No data available for Genatlas for SLC16A1 Gene
Publications for SLC16A1 Gene
- cDNA cloning of the human monocarboxylate transporter 1 and chromosomal localization of the SLC16A1 locus to 1p13.2-p12. (PMID: 7835905) Garcia CK … Francke U (Genomics 1994) 2 3 4 23
- Genetic variations in the MCT1 (SLC16A1) gene in the Chinese population of Singapore. (PMID: 19881260) Lean CB … Lee EJ (Drug metabolism and pharmacokinetics 2009) 3 23 41
- Physical exercise-induced hypoglycemia caused by failed silencing of monocarboxylate transporter 1 in pancreatic beta cells. (PMID: 17701893) Otonkoski T … Kere J (American journal of human genetics 2007) 3 4 23
- Presence and localization of three lactic acid transporters (MCT1, -2, and -4) in separated human granulocytes, lymphocytes, and monocytes. (PMID: 15505343) Merezhinskaya N … Fishbein WN (The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society 2004) 3 4 23
- The human monocarboxylate transporter, MCT1: genomic organization and promoter analysis. (PMID: 11944921) Cuff MA … Shirazi-Beechey SP (Biochemical and biophysical research communications 2002) 3 4 23
ExternalLinks
Products for SLC16A1 Gene
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- Novus Biologicals proteins and lysates for SLC16A1
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- VectorBuilder Viral vectors for SLC16A1 (ie. lentivirus, AAV, adenovirus)
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- Boster Bio Antibodies for SLC16A1
- Browse Boster Bio ELISA Kits
Sources for SLC16A1 Gene
- (1) GeneCards
- (2) HGNC
- (3) NCBI Entrez Gene
- (4) UniProtKB/Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) Cell Signaling Technology
- (12) GO
- (13) UniProtKB/TrEMBL
- (14) InterPro
- (15) ProtoNet
- (16) Blocks
- (17) MGI
- (18) IUBMB
- (19) KEGG
- (20) MINT
- (21) STRING
- (22) IntAct
- (23) Novoseek
- (24) PharmGKB
- (25) DrugBank
- (26) HMDB
- (27) ASD
- (28) SAGE
- (29) SOURCE
- (30) HomoloGene
- (31) PanEnsembl
- (32) euGenes
- (33) SGD
- (34) FlyBase
- (35) WormBase
- (36) Pseudogene
- (37) DGV
- (38) dbSNP
- (39) GenAtlas
- (40) HGMD
- (41) GAD
- (42) BGMUT
- (43) HuGE
- (44) Atlas
- (45) GenBank
- (46) HORDE
- (47) HUGE
- (48) IMGT
- (49) Leiden
- (50) miRBase
- (51) DME
- (52) OriGene
- (53) PubMed
- (54) R&D Systems
- (55) TGDB
- (56) Tocris
- (57) Abcam
- (58) Novus Biologicals
- (59) ProSpec
- (60) Sino Biological
- (61) GenScript
- (62) Qiagen
- (63) OCA
- (64) Proteopedia
- (65) MOPED
- (66) neXtProt
- (67) Reactome
- (68) GeneGo (Thomson Reuters)
- (69) DISEASES
- (70) SIMAP
- (71) GenomeRNAi
- (72) LifeMap
- (73) miRTarBase
- (74) MalaCards
- (75) Invitrogen
- (76) BitterDB
- (77) ESI-BIO
- (78) RefSeq
- (79) BioSystems
- (80) MaxQB
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- (84) COMPARTMENTS
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- (89) antibodies-online
- (90) CYP
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- (93) PathCards
- (94) GeneReviews
- (95) GeneTex
- (96) Taconic Biosciences
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- (98) ProteomicsDB
- (99) SCBT
- (100) DGIdb
- (101) ClinicalTrials
- (102) RVIS
- (103) SIGNOR
- (104) diseasecard
- (105) NIH Rare Diseases
- (106) Orphanet
- (107) UMLS
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- (109) Disease Ontology
- (110) Genetics Home Reference
- (111) MeSH
- (112) MedlinePlus
- (113) CDC
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- (115) NCBI Bookshelf
- (116) ClinVar
- (117) Gene Damage Index
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- (133) TISSUES
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- (135) abm
- (136) Human Protein Atlas
- (137) GWAS Catalog
- (138) Monarch Initiative
- (139) DataMed
- (140) HumanCyc
- (141) UCNEbase
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- (143) Applied Biosystems
- (144) GlyConnect
- (145) Aminode
- (146) GeneCopoeia
- (147) GPS-Prot
- (148) RNACentral
- (149) LncRNADisease
- (150) LOVD
- (151) miR2Disease
- (152) DiseaseEnhancer
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- (154) Biorbyt
- (155) Biocompare
- (156) Mastermind
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