Aliases for SLC15A5 Gene

Aliases for SLC15A5 Gene

  • Solute Carrier Family 15 Member 5 2 3 4 5
  • Peptide/Histidine Transporter ENSP00000340402 3
  • Solute Carrier Family 15, Member 5 2
  • SLC15A5 5

External Ids for SLC15A5 Gene

Previous GeneCards Identifiers for SLC15A5 Gene

  • GC12M016235
  • GC12M016343
  • GC12M016110

Summaries for SLC15A5 Gene

GeneCards Summary for SLC15A5 Gene

SLC15A5 (Solute Carrier Family 15 Member 5) is a Protein Coding gene. Diseases associated with SLC15A5 include Dicarboxylic Aminoaciduria and Hydranencephaly. Gene Ontology (GO) annotations related to this gene include transporter activity and symporter activity. An important paralog of this gene is SLC15A3.

UniProtKB/Swiss-Prot Summary for SLC15A5 Gene

Additional gene information for SLC15A5 Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for SLC15A5 Gene

Genomics for SLC15A5 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for SLC15A5 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH12J016346 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER 15.6 -72.4 -72426 6.9 REST LEF1 POLR2A JUND FOXA1 RBFOX2 RXRB PATZ1 SMAD5 SP1 MGST1 NONHSAG010597.2 SLC15A5 SUPT16HP1 HSALNG0089581 lnc-DERA-4 LMO3
GH12J016148 Enhancer 0.4 Ensembl 10.2 +127.8 127784 3 PRDM1 POLR2A SPI1 SLC15A5 LOC101928362 piR-49573 DERA
GH12J016176 Enhancer 0.3 FANTOM5 Ensembl 1.4 +101.8 101784 2.6 MGST1 SLC15A5 piR-49573 LOC101928362 DERA
GH12J016280 Enhancer 0.6 ENCODE 0.7 -3.7 -3693 1.3 SP1 ATF3 YY1 GABPA JUND RAD21 HNF4A RXRA MAX REST MGST1 SLC15A5 lnc-MGST1-6
GH12J016299 Enhancer 0.4 Ensembl ENCODE 0.4 -22.6 -22614 1.5 SCRT2 MGST1 lnc-MGST1-6 SLC15A5
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around SLC15A5 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for SLC15A5

Genomic Locations for SLC15A5 Gene

Genomic Locations for SLC15A5 Gene
chr12:16,188,485-16,277,685
(GRCh38/hg38)
Size:
89,201 bases
Orientation:
Minus strand
chr12:16,341,419-16,430,619
(GRCh37/hg19)
Size:
89,201 bases
Orientation:
Minus strand

Genomic View for SLC15A5 Gene

Genes around SLC15A5 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SLC15A5 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SLC15A5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SLC15A5 Gene

Proteins for SLC15A5 Gene

  • Protein details for SLC15A5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    A6NIM6-S15A5_HUMAN
    Recommended name:
    Solute carrier family 15 member 5
    Protein Accession:
    A6NIM6

    Protein attributes for SLC15A5 Gene

    Size:
    579 amino acids
    Molecular mass:
    65263 Da
    Quaternary structure:
    No Data Available

neXtProt entry for SLC15A5 Gene

Post-translational modifications for SLC15A5 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for SLC15A5 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for SLC15A5 Gene

Domains & Families for SLC15A5 Gene

Gene Families for SLC15A5 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted membrane proteins
  • Transporters

Protein Domains for SLC15A5 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for SLC15A5 Gene

GenScript: Design optimal peptide antigens:
  • Solute carrier family 15 member 5 (S15A5_HUMAN)

Graphical View of Domain Structure for InterPro Entry

A6NIM6

UniProtKB/Swiss-Prot:

S15A5_HUMAN :
  • Belongs to the major facilitator superfamily. Proton-dependent oligopeptide transporter (POT/PTR) (TC 2.A.17) family.
Family:
  • Belongs to the major facilitator superfamily. Proton-dependent oligopeptide transporter (POT/PTR) (TC 2.A.17) family.
genes like me logo Genes that share domains with SLC15A5: view

Function for SLC15A5 Gene

Molecular function for SLC15A5 Gene

UniProtKB/Swiss-Prot Function:
Proton oligopeptide cotransporter.

Phenotypes From GWAS Catalog for SLC15A5 Gene

Gene Ontology (GO) - Molecular Function for SLC15A5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 24550280
GO:0015293 symporter activity IEA --
GO:0015333 peptide:proton symporter activity IBA --
GO:0022857 transmembrane transporter activity IEA --
GO:0035673 oligopeptide transmembrane transporter activity IBA --
genes like me logo Genes that share ontologies with SLC15A5: view

Phenotypes for SLC15A5 Gene

GenomeRNAi human phenotypes for SLC15A5:
genes like me logo Genes that share phenotypes with SLC15A5: view

Animal Model Products

CRISPR Products

miRNA for SLC15A5 Gene

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for SLC15A5

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for SLC15A5 Gene

Localization for SLC15A5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SLC15A5 Gene

Membrane. Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SLC15A5 gene
Compartment Confidence
plasma membrane 3

Gene Ontology (GO) - Cellular Components for SLC15A5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IBA --
genes like me logo Genes that share ontologies with SLC15A5: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for SLC15A5 Gene

Pathways & Interactions for SLC15A5 Gene

PathCards logo

SuperPathways for SLC15A5 Gene

No Data Available

Interacting Proteins for SLC15A5 Gene

Gene Ontology (GO) - Biological Process for SLC15A5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0015031 protein transport IEA --
GO:0015833 peptide transport IEA --
GO:0035672 oligopeptide transmembrane transport IEA --
GO:0055085 transmembrane transport IEA --
GO:1902600 proton transmembrane transport IEA --
genes like me logo Genes that share ontologies with SLC15A5: view

No data available for Pathways by source and SIGNOR curated interactions for SLC15A5 Gene

Drugs & Compounds for SLC15A5 Gene

No Compound Related Data Available

Transcripts for SLC15A5 Gene

mRNA/cDNA for SLC15A5 Gene

1 REFSEQ mRNAs :
1 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for SLC15A5

Alternative Splicing Database (ASD) splice patterns (SP) for SLC15A5 Gene

No ASD Table

Relevant External Links for SLC15A5 Gene

GeneLoc Exon Structure for
SLC15A5

Expression for SLC15A5 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for SLC15A5 Gene

mRNA differential expression in normal tissues according to GTEx for SLC15A5 Gene

This gene is overexpressed in Brain - Substantia nigra (x5.5), Brain - Amygdala (x5.4), and Brain - Anterior cingulate cortex (BA24) (x5.1).

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for SLC15A5

SOURCE GeneReport for Unigene cluster for SLC15A5 Gene:

Hs.692712

Evidence on tissue expression from TISSUES for SLC15A5 Gene

  • Nervous system(4.2)
genes like me logo Genes that share expression patterns with SLC15A5: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for SLC15A5 Gene

Orthologs for SLC15A5 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for SLC15A5 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia SLC15A5 30 31
  • 98.96 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia SLC15A5 30 31
  • 87.89 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia SLC15A5 30 31
  • 83.79 (n)
OneToOne
Mouse
(Mus musculus)
Mammalia Slc15a5 30 17 31
  • 75.77 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Slc15a5 30
  • 75.44 (n)
Oppossum
(Monodelphis domestica)
Mammalia SLC15A5 31
  • 65 (a)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia -- 31
  • 19 (a)
ManyToMany
Chicken
(Gallus gallus)
Aves SLC15A5 30 31
  • 65.66 (n)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia SLC15A5 31
  • 56 (a)
OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia LOC101733983 30
  • 62.14 (n)
Zebrafish
(Danio rerio)
Actinopterygii LOC799543 30
  • 59.54 (n)
SLC15A5 31
  • 52 (a)
OneToOne
Fruit Fly
(Drosophila melanogaster)
Insecta CG9444 31
  • 15 (a)
ManyToMany
Baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes PTR2 31
  • 16 (a)
OneToMany
Sea Squirt
(Ciona savignyi)
Ascidiacea -- 31
  • 4 (a)
OneToMany
Species where no ortholog for SLC15A5 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for SLC15A5 Gene

ENSEMBL:
Gene Tree for SLC15A5 (if available)
TreeFam:
Gene Tree for SLC15A5 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for SLC15A5: view image

Paralogs for SLC15A5 Gene

Paralogs for SLC15A5 Gene

genes like me logo Genes that share paralogs with SLC15A5: view

Variants for SLC15A5 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for SLC15A5 Gene

SNP ID Clinical significance and condition Chr 12 pos Variation AA Info Type
rs1527014 - p.Pro271Leu
rs1671511 - p.Asp494Glu
rs1799516 - p.His141Gln
rs3946358 - p.Glu508Lys

Additional dbSNP identifiers (rs#s) for SLC15A5 Gene

Structural Variations from Database of Genomic Variants (DGV) for SLC15A5 Gene

Variant ID Type Subtype PubMed ID
dgv2392n54 CNV loss 21841781
dgv2393n54 CNV gain+loss 21841781
dgv274n67 CNV loss 20364138
dgv43n73 CNV deletion 24416366
dgv776n106 CNV deletion 24896259
esv1001083 CNV loss 20482838
esv1003486 CNV loss 20482838
esv2661182 CNV deletion 23128226
esv26884 CNV gain+loss 19812545
esv2745595 CNV deletion 23290073
esv2759881 CNV gain 17122850
esv3253718 CNV deletion 24192839
esv3548814 CNV deletion 23714750
esv3580162 CNV loss 25503493
esv3628686 CNV loss 21293372
esv3628687 CNV loss 21293372
esv3628688 CNV loss 21293372
esv3892149 CNV loss 25118596
esv999691 CNV deletion 20482838
nsv1036638 CNV loss 25217958
nsv1038946 CNV loss 25217958
nsv1039831 CNV loss 25217958
nsv1068261 CNV deletion 25765185
nsv1119936 CNV deletion 24896259
nsv1151534 CNV deletion 26484159
nsv428273 CNV loss 18775914
nsv512257 CNV loss 21212237
nsv52662 CNV deletion 16902084
nsv557639 CNV loss 21841781
nsv557641 CNV gain 21841781
nsv557644 CNV gain 21841781
nsv557645 CNV loss 21841781
nsv821614 CNV deletion 20802225
nsv826267 CNV loss 20364138
nsv832336 CNV gain 17160897

Variation tolerance for SLC15A5 Gene

Gene Damage Index Score: 5.07; 68.86% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for SLC15A5 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
SLC15A5

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SLC15A5 Gene

Disorders for SLC15A5 Gene

MalaCards: The human disease database

(2) MalaCards diseases for SLC15A5 Gene - From: DISEASES

Disorder Aliases PubMed IDs
dicarboxylic aminoaciduria
  • dcbxa
hydranencephaly
  • hydroanencephaly
- elite association - COSMIC cancer census association via MalaCards
genes like me logo Genes that share disorders with SLC15A5: view

No data available for UniProtKB/Swiss-Prot and Genatlas for SLC15A5 Gene

Publications for SLC15A5 Gene

  1. Long evolutionary conservation and considerable tissue specificity of several atypical solute carrier transporters. (PMID: 21044875) Sreedharan S … Fredriksson R (Gene 2011) 2 3
  2. The finished DNA sequence of human chromosome 12. (PMID: 16541075) Scherer SE … Baylor College of Medicine Human Genome Sequencing Center Sequence Production Team (Nature 2006) 3 4
  3. Proteome-wide analysis of phospho-regulated PDZ domain interactions. (PMID: 30126976) Sundell GN … Ivarsson Y (Molecular systems biology 2018) 3
  4. Large-scale interaction profiling of PDZ domains through proteomic peptide-phage display using human and viral phage peptidomes. (PMID: 24550280) Ivarsson Y … Kim PM (Proceedings of the National Academy of Sciences of the United States of America 2014) 3
  5. Genome-wide association for abdominal subcutaneous and visceral adipose reveals a novel locus for visceral fat in women. (PMID: 22589738) Fox CS … Borecki IB (PLoS genetics 2012) 3

Products for SLC15A5 Gene

Sources for SLC15A5 Gene