Aliases for SLC15A3 Gene

Aliases for SLC15A3 Gene

  • Solute Carrier Family 15 Member 3 2 3 4 5
  • PHT2 2 3 4
  • Solute Carrier Family 15 (Oligopeptide Transporter), Member 3 2 3
  • Peptide/Histidine Transporter 2 3 4
  • Osteoclast Transporter 3 4
  • Peptide Transporter 3 3 4
  • OCTP 3 4
  • PTR3 3 4
  • Solute Carrier Family 15, Member 3 2
  • SLC15A3 5
  • HPTR3 2

External Ids for SLC15A3 Gene

Previous GeneCards Identifiers for SLC15A3 Gene

  • GC11M060955
  • GC11M060480
  • GC11M060481
  • GC11M060461
  • GC11M060704
  • GC11M057050
  • GC11M060962
  • GC11M061334
  • GC11M063799

Summaries for SLC15A3 Gene

GeneCards Summary for SLC15A3 Gene

SLC15A3 (Solute Carrier Family 15 Member 3) is a Protein Coding gene. Diseases associated with SLC15A3 include Hypotrichosis 4 and Permanent Neonatal Diabetes Mellitus. Among its related pathways are Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds. Gene Ontology (GO) annotations related to this gene include transporter activity and symporter activity. An important paralog of this gene is SLC15A4.

UniProtKB/Swiss-Prot Summary for SLC15A3 Gene

  • Proton-coupled amino-acid transporter that transports free histidine and certain di- and tripeptides, and is involved in innate immune response (By similarity). Also able to transport carnosine (PubMed:31073693). Involved in the detection of microbial pathogens by toll-like receptors (TLRs) and NOD-like receptors (NLRs), probably by mediating transport of bacterial peptidoglycans across the endolysosomal membrane: catalyzes the transport of certain bacterial peptidoglycans, such as muramyl dipeptide (MDP), the NOD2 ligand (By similarity).

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for SLC15A3 Gene

Genomics for SLC15A3 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for SLC15A3 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around SLC15A3 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for SLC15A3

Top Transcription factor binding sites by QIAGEN in the SLC15A3 gene promoter:
  • AML1a
  • AP-1
  • Arnt
  • ATF-2
  • c-Jun
  • NF-kappaB
  • NF-kappaB1

Genomic Locations for SLC15A3 Gene

Latest Assembly
chr11:60,937,060-60,952,653
(GRCh38/hg38)
Size:
15,594 bases
Orientation:
Minus strand

Previous Assembly
chr11:60,704,556-60,719,648
(GRCh37/hg19 by Entrez Gene)
Size:
15,093 bases
Orientation:
Minus strand

chr11:60,704,556-60,720,002
(GRCh37/hg19 by Ensembl)
Size:
15,447 bases
Orientation:
Minus strand

Genomic View for SLC15A3 Gene

Genes around SLC15A3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SLC15A3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SLC15A3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SLC15A3 Gene

Proteins for SLC15A3 Gene

  • Protein details for SLC15A3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8IY34-S15A3_HUMAN
    Recommended name:
    Solute carrier family 15 member 3
    Protein Accession:
    Q8IY34
    Secondary Accessions:
    • Q9P2X9

    Protein attributes for SLC15A3 Gene

    Size:
    581 amino acids
    Molecular mass:
    63560 Da
    Quaternary structure:
    No Data Available

neXtProt entry for SLC15A3 Gene

Post-translational modifications for SLC15A3 Gene

  • Glycosylation at Asn61, Asn66, Asn178, Asn223, Asn356, and Asn439
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for SLC15A3 Gene

Domains & Families for SLC15A3 Gene

Gene Families for SLC15A3 Gene

HGNC:
IUPHAR :
Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Predicted membrane proteins
  • Transporters

Protein Domains for SLC15A3 Gene

InterPro:
Blocks:
  • TGF-beta receptor, type I/II extracellular region

Suggested Antigen Peptide Sequences for SLC15A3 Gene

GenScript: Design optimal peptide antigens:
  • Peptide/histidine transporter 2 (S15A3_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q8IY34

UniProtKB/Swiss-Prot:

S15A3_HUMAN :
  • Belongs to the major facilitator superfamily. Proton-dependent oligopeptide transporter (POT/PTR) (TC 2.A.17) family.
Family:
  • Belongs to the major facilitator superfamily. Proton-dependent oligopeptide transporter (POT/PTR) (TC 2.A.17) family.
genes like me logo Genes that share domains with SLC15A3: view

Function for SLC15A3 Gene

Molecular function for SLC15A3 Gene

UniProtKB/Swiss-Prot Function:
Proton-coupled amino-acid transporter that transports free histidine and certain di- and tripeptides, and is involved in innate immune response (By similarity). Also able to transport carnosine (PubMed:31073693). Involved in the detection of microbial pathogens by toll-like receptors (TLRs) and NOD-like receptors (NLRs), probably by mediating transport of bacterial peptidoglycans across the endolysosomal membrane: catalyzes the transport of certain bacterial peptidoglycans, such as muramyl dipeptide (MDP), the NOD2 ligand (By similarity).
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=H(+)(out) + L-histidine(out) = H(+)(in) + L-histidine(in); Xref=Rhea:RHEA:37047, ChEBI:CHEBI:15378, ChEBI:CHEBI:57595; Evidence={ECO:0000250|UniProtKB:Q924V4};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=a dipeptide(out) + H(+)(out) = a dipeptide(in) + H(+)(in); Xref=Rhea:RHEA:64392, ChEBI:CHEBI:15378, ChEBI:CHEBI:90799; Evidence={ECO:0000250|UniProtKB:Q924V4};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=H(+)(out) + N-acetylmuramyl-L-alanyl-D-isoglutamine(out) = H(+)(in) + N-acetylmuramyl-L-alanyl-D-isoglutamine(in); Xref=Rhea:RHEA:64408, ChEBI:CHEBI:15378, ChEBI:CHEBI:155830; Evidence={ECO:0000250|UniProtKB:Q8BPX9};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=carnosine(out) + H(+)(out) = carnosine(in) + H(+)(in); Xref=Rhea:RHEA:64404, ChEBI:CHEBI:15378, ChEBI:CHEBI:57485; Evidence={ECO:0000269|PubMed:31073693};.

Phenotypes From GWAS Catalog for SLC15A3 Gene

Gene Ontology (GO) - Molecular Function for SLC15A3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 24695226
GO:0015293 symporter activity IEA --
GO:0015647 peptidoglycan transmembrane transporter activity IEA,ISS --
GO:0022857 transmembrane transporter activity IEA --
GO:0071916 dipeptide transmembrane transporter activity IDA 31073693
genes like me logo Genes that share ontologies with SLC15A3: view
genes like me logo Genes that share phenotypes with SLC15A3: view

Animal Models for SLC15A3 Gene

MGI Knock Outs for SLC15A3:

Animal Models for research

  • Taconic Biosciences Mouse Models for SLC15A3

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for SLC15A3

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for SLC15A3 Gene

Localization for SLC15A3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SLC15A3 Gene

Lysosome membrane. Multi-pass membrane protein. Endosome membrane. Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SLC15A3 gene
Compartment Confidence
endosome 4
lysosome 4
plasma membrane 3
cytosol 2
extracellular 1
cytoskeleton 1
mitochondrion 1
peroxisome 1
nucleus 1
endoplasmic reticulum 1
golgi apparatus 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for SLC15A3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005764 lysosome IEA --
GO:0005765 lysosomal membrane TAS --
GO:0005768 endosome IEA --
GO:0010008 endosome membrane ISS --
GO:0016020 membrane IEA --
genes like me logo Genes that share ontologies with SLC15A3: view

Pathways & Interactions for SLC15A3 Gene

genes like me logo Genes that share pathways with SLC15A3: view

Gene Ontology (GO) - Biological Process for SLC15A3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002376 immune system process IEA --
GO:0006811 ion transport TAS --
GO:0015031 protein transport IEA --
GO:0015833 peptide transport IEA --
GO:0015835 peptidoglycan transport IEA,ISS --
genes like me logo Genes that share ontologies with SLC15A3: view

No data available for SIGNOR curated interactions for SLC15A3 Gene

Drugs & Compounds for SLC15A3 Gene

(2) Drugs for SLC15A3 Gene - From: DGIdb and IUPHAR

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
[<sup>14</sup>C]histidine Pharma 0
[<sup>3</sup>H]histidine Pharma 0
genes like me logo Genes that share compounds with SLC15A3: view

Transcripts for SLC15A3 Gene

mRNA/cDNA for SLC15A3 Gene

1 REFSEQ mRNAs :
6 NCBI additional mRNA sequence :
14 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for SLC15A3

Alternative Splicing Database (ASD) splice patterns (SP) for SLC15A3 Gene

ExUns: 1 ^ 2a · 2b ^ 3a · 3b ^ 4 ^ 5a · 5b ^ 6a · 6b ^ 7 ^ 8 ^ 9a · 9b
SP1: -
SP2: - -
SP3: -
SP4: -
SP5:

Relevant External Links for SLC15A3 Gene

GeneLoc Exon Structure for
SLC15A3

Expression for SLC15A3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for SLC15A3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SLC15A3 Gene

This gene is overexpressed in Whole Blood (x10.1).

Protein differential expression in normal tissues from HIPED for SLC15A3 Gene

This gene is overexpressed in Spleen (30.7), Monocytes (27.6), and Retina (6.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for SLC15A3 Gene



Protein tissue co-expression partners for SLC15A3 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for SLC15A3

SOURCE GeneReport for Unigene cluster for SLC15A3 Gene:

Hs.237856

Evidence on tissue expression from TISSUES for SLC15A3 Gene

  • Blood(4.4)
  • Pancreas(4.2)
  • Intestine(2.6)
  • Spleen(2.5)
  • Lymph node(2.3)
  • Lung(2.2)
  • Bone marrow(2)
  • Nervous system(2)
genes like me logo Genes that share expression patterns with SLC15A3: view

Primer products for research

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for SLC15A3 Gene

Orthologs for SLC15A3 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for SLC15A3 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia SLC15A3 29 30
  • 98.86 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia SLC15A3 29 30
  • 85.89 (n)
OneToOne
Mouse
(Mus musculus)
Mammalia Slc15a3 29 16 30
  • 81.66 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Slc15a3 29
  • 81.15 (n)
Dog
(Canis familiaris)
Mammalia SLC15A3 30
  • 78 (a)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia SLC15A3 30
  • 72 (a)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia SLC15A3 30
  • 62 (a)
OneToOne
Baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes PTR2 30
  • 21 (a)
OneToMany
Sea Squirt
(Ciona savignyi)
Ascidiacea -- 30
  • 12 (a)
OneToMany
Species where no ortholog for SLC15A3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)
  • Zebrafish (Danio rerio)

Evolution for SLC15A3 Gene

ENSEMBL:
Gene Tree for SLC15A3 (if available)
TreeFam:
Gene Tree for SLC15A3 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for SLC15A3: view image
Alliance of Genome Resources:
Additional Orthologs for SLC15A3

Paralogs for SLC15A3 Gene

Paralogs for SLC15A3 Gene

(1) SIMAP similar genes for SLC15A3 Gene using alignment to 7 proteins:

  • S15A3_HUMAN
  • F5GZ36_HUMAN
  • F5H1C8_HUMAN
  • F5H251_HUMAN
  • H0YFC1_HUMAN
  • H0YG40_HUMAN
  • Q05CH4_HUMAN
genes like me logo Genes that share paralogs with SLC15A3: view

Variants for SLC15A3 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for SLC15A3 Gene

SNP ID Clinical significance and condition Chr 11 pos Variation AA Info Type
rs17855607 -- p.Ile349Phe

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for SLC15A3 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for SLC15A3 Gene

Variant ID Type Subtype PubMed ID
nsv1122626 CNV deletion 24896259

Variation tolerance for SLC15A3 Gene

Residual Variation Intolerance Score: 73.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.80; 58.36% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for SLC15A3 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
SLC15A3
Leiden Open Variation Database (LOVD)
SLC15A3

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SLC15A3 Gene

Disorders for SLC15A3 Gene

MalaCards: The human disease database

(2) MalaCards diseases for SLC15A3 Gene - From: COP

Disorder Aliases PubMed IDs
hypotrichosis 4
  • hypt4
permanent neonatal diabetes mellitus
  • pdmi
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for SLC15A3

genes like me logo Genes that share disorders with SLC15A3: view

No data available for UniProtKB/Swiss-Prot and Genatlas for SLC15A3 Gene

Publications for SLC15A3 Gene

  1. The proton-coupled oligopeptide transporters PEPT2, PHT1 and PHT2 mediate the uptake of carnosine in glioblastoma cells. (PMID: 31073693) Oppermann H … Gaunitz F (Amino acids 2019) 3 4
  2. Integral and associated lysosomal membrane proteins. (PMID: 17897319) Schröder B … Hasilik A (Traffic (Copenhagen, Denmark) 2007) 3 4
  3. The proton oligopeptide cotransporter family SLC15 in physiology and pharmacology. (PMID: 12905028) Daniel H … Kottra G (Pflugers Archiv : European journal of physiology 2004) 3 22
  4. Cloning of a lymphatic peptide/histidine transporter. (PMID: 11336635) Sakata K … Tohyama M (The Biochemical journal 2001) 2 3
  5. Human proton/oligopeptide transporter (POT) genes: identification of putative human genes using bioinformatics. (PMID: 11741232) Botka CW … Sadée W (AAPS pharmSci 2000) 2 3

Products for SLC15A3 Gene

Sources for SLC15A3 Gene