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Aliases for SLC15A3 Gene

Aliases for SLC15A3 Gene

  • Solute Carrier Family 15 Member 3 2 3 5
  • Solute Carrier Family 15 (Oligopeptide Transporter), Member 3 2 3
  • Peptide/Histidine Transporter 2 3 4
  • Osteoclast Transporter 3 4
  • Peptide Transporter 3 3 4
  • OCTP 3 4
  • PHT2 3 4
  • PTR3 3 4
  • Solute Carrier Family 15, Member 3 2

External Ids for SLC15A3 Gene

Previous GeneCards Identifiers for SLC15A3 Gene

  • GC11M060480
  • GC11M060481
  • GC11M060461
  • GC11M060704
  • GC11M057050

Summaries for SLC15A3 Gene

GeneCards Summary for SLC15A3 Gene

SLC15A3 (Solute Carrier Family 15 Member 3) is a Protein Coding gene. Diseases associated with SLC15A3 include Diabetes Mellitus, Permanent Neonatal. Among its related pathways are Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds. Gene Ontology (GO) annotations related to this gene include transporter activity and symporter activity. An important paralog of this gene is SLC15A4.

UniProtKB/Swiss-Prot for SLC15A3 Gene

  • Proton oligopeptide cotransporter. Transports free histidine and certain di- and tripeptides (By similarity).

Additional gene information for SLC15A3 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SLC15A3 Gene

Genomics for SLC15A3 Gene

GeneHancer (GH) Regulatory Elements for SLC15A3 Gene

Promoters and enhancers for SLC15A3 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH11I060950 Promoter/Enhancer 2.1 EPDnew FANTOM5 Ensembl ENCODE 569.1 +0.0 34 4.9 HDGF PKNOX1 SMAD1 RB1 YBX1 BATF IRF4 YY1 ZNF207 ZNF143 SLC15A3 VPS37C RNU6-933P CPSF7 MS4A18 PTGDR2 PRPF19 MS4A2 CYB561A3 SDHAF2
GH11I061157 Promoter/Enhancer 2.6 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 9.4 -209.2 -209227 8.2 HDGF PKNOX1 CLOCK FOXA2 SMAD1 MLX ARNT ARID4B NEUROD1 SIN3A VPS37C CD5 CD6 SLC15A3 CYB561A3 SDHAF2 CPSF7 PTGDR2 GC11P061168
GH11I060970 Promoter/Enhancer 1.7 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 12 -20.3 -20318 4.5 CTCF RB1 TRIM22 REST ZNF2 RAD21 ZNF143 SMC3 ZNF444 RUNX3 CD6 CD5 SLC15A3 TMEM132A VPS37C CCDC86 FTH1 SDHAF2 RNU6-933P
GH11I061040 Enhancer 1.4 FANTOM5 Ensembl ENCODE dbSUPER 11.2 -89.9 -89932 3 HDGF PKNOX1 SMAD1 BACH1 PAX8 EBF1 KLF5 RELA POLR2A ATF7 CD6 CD5 SLC15A3 TMEM132A SDHAF2 ENSG00000256733 LOC105369326 LOC105369325
GH11I060909 Promoter/Enhancer 2.7 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 5.3 +38.8 38790 8.8 HDGF PKNOX1 SMAD1 SIN3A FEZF1 IRF4 YY1 POLR2B ZNF766 ZNF416 TMEM109 GC11M060911 LOC105369323 CD6 CD5 PRPF19 PTGDR2 SLC15A3 CYB561A3 VPS37C
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around SLC15A3 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the SLC15A3 gene promoter:

Genomic Locations for SLC15A3 Gene

Genomic Locations for SLC15A3 Gene
15,448 bases
Minus strand

Genomic View for SLC15A3 Gene

Genes around SLC15A3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SLC15A3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SLC15A3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SLC15A3 Gene

Proteins for SLC15A3 Gene

  • Protein details for SLC15A3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Solute carrier family 15 member 3
    Protein Accession:
    Secondary Accessions:
    • Q9P2X9

    Protein attributes for SLC15A3 Gene

    581 amino acids
    Molecular mass:
    63560 Da
    Quaternary structure:
    No Data Available

neXtProt entry for SLC15A3 Gene

Post-translational modifications for SLC15A3 Gene

  • Glycosylation at posLast=6161, isoforms=66, posLast=178178, isoforms=223, posLast=356356, and posLast=439439
  • Modification sites at PhosphoSitePlus

Other Protein References for SLC15A3 Gene

No data available for DME Specific Peptides for SLC15A3 Gene

Domains & Families for SLC15A3 Gene

Gene Families for SLC15A3 Gene

Human Protein Atlas (HPA):
  • Predicted membrane proteins
  • Predicted secreted proteins
  • Transporters

Protein Domains for SLC15A3 Gene

Suggested Antigen Peptide Sequences for SLC15A3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the PTR2/POT transporter (TC 2.A.17) family.
  • Belongs to the PTR2/POT transporter (TC 2.A.17) family.
genes like me logo Genes that share domains with SLC15A3: view

Function for SLC15A3 Gene

Molecular function for SLC15A3 Gene

UniProtKB/Swiss-Prot Function:
Proton oligopeptide cotransporter. Transports free histidine and certain di- and tripeptides (By similarity).

Phenotypes From GWAS Catalog for SLC15A3 Gene

Gene Ontology (GO) - Molecular Function for SLC15A3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 24695226
GO:0015293 symporter activity IEA --
GO:0015333 peptide:proton symporter activity TAS --
GO:0022857 transmembrane transporter activity IEA --
genes like me logo Genes that share ontologies with SLC15A3: view
genes like me logo Genes that share phenotypes with SLC15A3: view

Animal Models for SLC15A3 Gene

MGI Knock Outs for SLC15A3:

Animal Model Products

  • Taconic Biosciences Mouse Models for SLC15A3

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for SLC15A3 Gene

Localization for SLC15A3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SLC15A3 Gene

Lysosome membrane; Multi-pass membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SLC15A3 gene
Compartment Confidence
lysosome 5
plasma membrane 3
peroxisome 1
endoplasmic reticulum 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for SLC15A3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005764 lysosome IEA --
GO:0005765 lysosomal membrane TAS --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
GO:0043231 intracellular membrane-bounded organelle IDA --
genes like me logo Genes that share ontologies with SLC15A3: view

Pathways & Interactions for SLC15A3 Gene

genes like me logo Genes that share pathways with SLC15A3: view

Gene Ontology (GO) - Biological Process for SLC15A3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006810 transport IEA --
GO:0006811 ion transport TAS --
GO:0015031 protein transport IEA --
GO:0015833 peptide transport IEA --
GO:0015992 proton transport IEA --
genes like me logo Genes that share ontologies with SLC15A3: view

No data available for SIGNOR curated interactions for SLC15A3 Gene

Drugs & Compounds for SLC15A3 Gene

(2) Drugs for SLC15A3 Gene - From: DGIdb and IUPHAR

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
[<sup>14</sup>C]histidine Pharma 0
[<sup>3</sup>H]histidine Pharma 0
genes like me logo Genes that share compounds with SLC15A3: view

Transcripts for SLC15A3 Gene

Unigene Clusters for SLC15A3 Gene

Solute carrier family 15, member 3:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for SLC15A3 Gene

ExUns: 1 ^ 2a · 2b ^ 3a · 3b ^ 4 ^ 5a · 5b ^ 6a · 6b ^ 7 ^ 8 ^ 9a · 9b
SP1: -
SP2: - -
SP3: -
SP4: -

Relevant External Links for SLC15A3 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for SLC15A3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for SLC15A3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SLC15A3 Gene

This gene is overexpressed in Whole Blood (x10.1).

Protein differential expression in normal tissues from HIPED for SLC15A3 Gene

This gene is overexpressed in Spleen (30.7), Monocytes (27.6), and Retina (6.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for SLC15A3 Gene

Protein tissue co-expression partners for SLC15A3 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of SLC15A3 Gene:


SOURCE GeneReport for Unigene cluster for SLC15A3 Gene:


Evidence on tissue expression from TISSUES for SLC15A3 Gene

  • Blood(4.3)
  • Pancreas(4.1)
  • Intestine(2.1)
  • Spleen(2.1)
genes like me logo Genes that share expression patterns with SLC15A3: view

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for SLC15A3 Gene

Orthologs for SLC15A3 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for SLC15A3 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia SLC15A3 33 34
  • 98.86 (n)
(Bos Taurus)
Mammalia SLC15A3 33 34
  • 85.89 (n)
(Mus musculus)
Mammalia Slc15a3 33 16 34
  • 81.66 (n)
(Rattus norvegicus)
Mammalia Slc15a3 33
  • 81.15 (n)
(Canis familiaris)
Mammalia SLC15A3 34
  • 78 (a)
(Monodelphis domestica)
Mammalia SLC15A3 34
  • 72 (a)
(Anolis carolinensis)
Reptilia SLC15A3 34
  • 62 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes PTR2 34
  • 21 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 12 (a)
Species where no ortholog for SLC15A3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for SLC15A3 Gene

Gene Tree for SLC15A3 (if available)
Gene Tree for SLC15A3 (if available)

Paralogs for SLC15A3 Gene

Paralogs for SLC15A3 Gene

(1) SIMAP similar genes for SLC15A3 Gene using alignment to 7 proteins:

genes like me logo Genes that share paralogs with SLC15A3: view

Variants for SLC15A3 Gene

Sequence variations from dbSNP and Humsavar for SLC15A3 Gene

SNP ID Clin Chr 11 pos Variation AA Info Type
rs1000073951 -- 60,944,643(-) T/C intron_variant
rs1000239315 -- 60,938,416(-) T/G intron_variant
rs1000377494 -- 60,940,713(-) A/G intron_variant
rs1000901961 -- 60,948,621(-) C/T intron_variant
rs1001007311 -- 60,952,387(-) TTTTTT/TTTTT/TTTTTTT upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for SLC15A3 Gene

Variant ID Type Subtype PubMed ID
nsv1122626 CNV deletion 24896259

Variation tolerance for SLC15A3 Gene

Residual Variation Intolerance Score: 73.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.80; 58.36% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for SLC15A3 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SLC15A3 Gene

Disorders for SLC15A3 Gene

MalaCards: The human disease database

(1) MalaCards diseases for SLC15A3 Gene - From: DISEASES

Disorder Aliases PubMed IDs
diabetes mellitus, permanent neonatal
  • pndm
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for SLC15A3

genes like me logo Genes that share disorders with SLC15A3: view

No data available for UniProtKB/Swiss-Prot and Genatlas for SLC15A3 Gene

Publications for SLC15A3 Gene

  1. Integral and associated lysosomal membrane proteins. (PMID: 17897319) Schröder B … Hasilik A (Traffic (Copenhagen, Denmark) 2007) 3 4 58
  2. The proton oligopeptide cotransporter family SLC15 in physiology and pharmacology. (PMID: 12905028) Daniel H … Kottra G (Pflugers Archiv : European journal of physiology 2004) 3 22 58
  3. Cloning of a lymphatic peptide/histidine transporter. (PMID: 11336635) Sakata K … Tohyama M (The Biochemical journal 2001) 2 3 58
  4. Human proton/oligopeptide transporter (POT) genes: identification of putative human genes using bioinformatics. (PMID: 11741232) Botka CW … Sadée W (AAPS pharmSci 2000) 2 3 58
  5. Endosomes are specialized platforms for bacterial sensing and NOD2 signalling. (PMID: 24695226) Nakamura N … Mellman I (Nature 2014) 3 58

Products for SLC15A3 Gene

Sources for SLC15A3 Gene

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