Aliases for SLC15A3 Gene
Aliases for SLC15A3 Gene
External Ids for SLC15A3 Gene
- HGNC: 18068
- Entrez Gene: 51296
- Ensembl: ENSG00000110446
- OMIM: 610408
- UniProtKB: Q8IY34
Previous GeneCards Identifiers for SLC15A3 Gene
- GC11M060480
- GC11M060481
- GC11M060461
- GC11M060704
- GC11M057050
Summaries for SLC15A3 Gene
GeneCards Summary for SLC15A3 Gene
SLC15A3 (Solute Carrier Family 15 Member 3) is a Protein Coding gene. Diseases associated with SLC15A3 include Diabetes Mellitus, Permanent Neonatal. Among its related pathways are Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds. Gene Ontology (GO) annotations related to this gene include transporter activity and symporter activity. An important paralog of this gene is SLC15A4.
UniProtKB/Swiss-Prot for SLC15A3 Gene
-
Proton oligopeptide cotransporter. Transports free histidine and certain di- and tripeptides (By similarity).
Additional gene information for SLC15A3 Gene
No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SLC15A3 Gene
Genomics for SLC15A3 Gene
GeneHancer (GH) Regulatory Elements for SLC15A3 Gene
Promoters and enhancers for SLC15A3 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data dump
GeneHancers around SLC15A3 on UCSC Golden Path with GeneCards custom track
- Top Transcription factor binding sites by QIAGEN in the SLC15A3 gene promoter:
Regulatory Element Products
Genomic Locations for SLC15A3 Gene
Genomic Locations for SLC15A3 Gene
- chr11:60,937,083-60,952,530
- (GRCh38/hg38)
- Size:
- 15,448 bases
- Orientation:
- Minus strand
- chr11:60,704,555-60,720,002
- (GRCh37/hg19)
Genomic View for SLC15A3 Gene
Genes around SLC15A3 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 11q12.2 by Ensembl
- 11q12.2 by Entrez Gene
- 11q12.2 by HGNC
SLC15A3 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for SLC15A3 Gene
Proteins for SLC15A3 Gene
-
Protein details for SLC15A3 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q8IY34-S15A3_HUMAN
- Recommended name:
- Solute carrier family 15 member 3
- Protein Accession:
- Q8IY34
- Q9P2X9
Protein attributes for SLC15A3 Gene
- Size:
- 581 amino acids
- Molecular mass:
- 63560 Da
- Quaternary structure:
- No Data Available
Protein Expression for SLC15A3 Gene
Post-translational modifications for SLC15A3 Gene
Other Protein References for SLC15A3 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- Novus Biologicals Antibodies for SLC15A3
- Invitrogen Antibodies for SLC15A3
- Search GeneTex for Antibodies for SLC15A3
Protein Products
- Search Origene for Purified Proteins, MassSpec and Protein Over-expression Lysates for SLC15A3
- Origene Custom Protein Services for SLC15A3
- Search GeneTex for Proteins for SLC15A3
Assay Products
No data available for DME Specific Peptides for SLC15A3 Gene
Domains & Families for SLC15A3 Gene
Gene Families for SLC15A3 Gene
- HGNC:
- IUPHAR :
- Human Protein Atlas (HPA):
-
- Predicted membrane proteins
- Predicted secreted proteins
- Transporters
Protein Domains for SLC15A3 Gene
- InterPro:
- Blocks:
- ProtoNet:
Suggested Antigen Peptide Sequences for SLC15A3 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
Q8IY34- Family:
-
- Belongs to the PTR2/POT transporter (TC 2.A.17) family.
Function for SLC15A3 Gene
Molecular function for SLC15A3 Gene
- UniProtKB/Swiss-Prot Function:
- Proton oligopeptide cotransporter. Transports free histidine and certain di- and tripeptides (By similarity).
Phenotypes From GWAS Catalog for SLC15A3 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005515 | protein binding | IPI | 24695226 |
| GO:0015293 | symporter activity | IEA | -- |
| GO:0015333 | peptide:proton symporter activity | TAS | -- |
| GO:0022857 | transmembrane transporter activity | IEA | -- |
Phenotypes for SLC15A3 Gene
- MGI mutant phenotypes for SLC15A3:
- inferred from 1 alleles
- GenomeRNAi human phenotypes for SLC15A3:
Animal Models for SLC15A3 Gene
- MGI Knock Outs for SLC15A3:
-
- Slc15a3 tm1b(KOMP)Wtsi
Animal Model Products
-
Taconic Biosciences Mouse Models for SLC15A3
- Cyagen custom Knockout/knockin (KOKI) mouse models for SLC15A3
-
-
ViGene Biosciences lentiviral particle packaged cDNA for SLC15A3 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for SLC15A3 gene
- Search ViGene Biosciences for SLC15A3
CRISPR Products
-
OriGene CRISPR knockouts for SLC15A3
- genomics-online: gRNA clones - Search results for 80 available SLC15A3 gene related products
- Overview of 80 available SLC15A3 gene related products
- Applied Biological Materials CRISPR for SLC15A3
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for SLC15A3
- GenScript: Design CRISPR guide RNA sequences for SLC15A3
miRNA Products
- Search ViGene Biosciences for SLC15A3
Inhibitory RNA Products
- Origene RNAi, sirna, and shrna products in human, mouse, rat for SLC15A3
- Browse OriGene Inhibitory RNA Products For SLC15A3
- genomics-online: shRNA clones - Search results for 80 available SLC15A3 gene related products
- Overview of 80 available SLC15A3 gene related products
-
ViGene Biosciences ready-to-package AAV shRNAs for SLC15A3 gene
Clone Products
- VectorBuilder custom plasmid, inducible vectors for SLC15A3
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for SLC15A3
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Applied Biological Materials Clones for SLC15A3
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
- R&D Systems cDNA Clones for SLC15A3
Cell Line Products
-
Horizon Cell Lines for SLC15A3
-
ViGene Biosciences adenoviral particle packaged cDNA for SLC15A3 gene
-
ViGene Biosciences lentiviral particle packaged cDNA for SLC15A3 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for SLC15A3 gene
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for SLC15A3 Gene
Localization for SLC15A3 Gene
Subcellular locations from UniProtKB/Swiss-Prot for SLC15A3 Gene
- Lysosome membrane; Multi-pass membrane protein.
| Compartment | Confidence |
|---|---|
| lysosome | 5 |
| plasma membrane | 3 |
| peroxisome | 1 |
| endoplasmic reticulum | 1 |
- Vesicles (3)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005764 | lysosome | IEA | -- |
| GO:0005765 | lysosomal membrane | TAS | -- |
| GO:0016020 | membrane | IEA | -- |
| GO:0016021 | integral component of membrane | IEA | -- |
| GO:0043231 | intracellular membrane-bounded organelle | IDA | -- |
Pathways & Interactions for SLC15A3 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds | ||
Pathways by source for SLC15A3 Gene
Interacting Proteins for SLC15A3 Gene
Selected Interacting proteins:
Q8IY34-S15A3_HUMAN
ENSP00000227880
for SLC15A3 Gene via
IID
STRING
UniProtKB
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0006810 | transport | IEA | -- |
| GO:0006811 | ion transport | TAS | -- |
| GO:0015031 | protein transport | IEA | -- |
| GO:0015833 | peptide transport | IEA | -- |
| GO:0015992 | proton transport | IEA | -- |
No data available for SIGNOR curated interactions for SLC15A3 Gene
Transcripts for SLC15A3 Gene
mRNA/cDNA for SLC15A3 Gene
- (2) REFSEQ mRNAs :
- (5) Additional mRNA sequences :
- (93) Selected AceView cDNA sequences:
- (9) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for SLC15A3 Gene
CRISPR Products
-
OriGene CRISPR knockouts for SLC15A3
- genomics-online: gRNA clones - Search results for 80 available SLC15A3 gene related products
- Overview of 80 available SLC15A3 gene related products
- Applied Biological Materials CRISPR for SLC15A3
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for SLC15A3
- GenScript: Design CRISPR guide RNA sequences for SLC15A3
miRNA Products
- Search ViGene Biosciences for SLC15A3
Inhibitory RNA Products
- Origene RNAi, sirna, and shrna products in human, mouse, rat for SLC15A3
- Browse OriGene Inhibitory RNA Products For SLC15A3
- genomics-online: shRNA clones - Search results for 80 available SLC15A3 gene related products
- Overview of 80 available SLC15A3 gene related products
-
ViGene Biosciences ready-to-package AAV shRNAs for SLC15A3 gene
Clone Products
- VectorBuilder custom plasmid, inducible vectors for SLC15A3
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for SLC15A3
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Applied Biological Materials Clones for SLC15A3
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
- R&D Systems cDNA Clones for SLC15A3
| ExUns: | 1 | ^ | 2a | · | 2b | ^ | 3a | · | 3b | ^ | 4 | ^ | 5a | · | 5b | ^ | 6a | · | 6b | ^ | 7 | ^ | 8 | ^ | 9a | · | 9b |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | ||||||||||||||||||||||||||
| SP2: | - | - | |||||||||||||||||||||||||
| SP3: | - | ||||||||||||||||||||||||||
| SP4: | - | ||||||||||||||||||||||||||
| SP5: |
Expression for SLC15A3 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
-
Eye (Sensory Organs)
- Lens Vesicle Cells Lens Vesicle
- Lens
-
Skeletal Muscle (Muscoskeletal System)
- Muscle Progenitor Cells Mandibular Arch Muscles
- Muscle Progenitor Cells Hyoid Arch Muscles
-
Lateral Plate Mesoderm (Gastrulation Derivatives)
- Hematopoietic Stem Cells Aorta-Gonad-Mesonephros
-
Blood (Cardiovascular System)
- Hematopoietic Stem Cells Aorta-Gonad-Mesonephros
- Bone (Muscoskeletal System)
- Liver (Hepatobiliary System)
- Brain (Nervous System)
-
Spleen (Hematopoietic System)
-
Lung (Respiratory System)
mRNA differential expression in normal tissues according to GTEx for SLC15A3 Gene
This gene is overexpressed in Whole Blood (x10.1).
This gene is overexpressed in Spleen (30.7), Monocytes (27.6), and Retina (6.1).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for SLC15A3 Gene
NURSA nuclear receptor signaling pathways regulating expression of SLC15A3 Gene:
SLC15A3SOURCE GeneReport for Unigene cluster for SLC15A3 Gene:
Hs.237856Evidence on tissue expression from TISSUES for SLC15A3 Gene
- Blood(4.3)
- Pancreas(4.1)
- Intestine(2.1)
- Spleen(2.1)
Primer Products
-
OriGene qPCR primer pairs for SLC15A3
-
OriGene qPCR primer pairs and template standards for SLC15A3
- genomics-online: primer clones - Search results for 80 available SLC15A3 gene related products
- Overview of 80 available SLC15A3 gene related products
Gene Expression Assay Products
No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for SLC15A3 Gene
Orthologs for SLC15A3 Gene
This gene was present in the common ancestor of animals and fungi.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | SLC15A3 33 34 |
|
||
| cow (Bos Taurus) |
Mammalia | SLC15A3 33 34 |
|
||
| mouse (Mus musculus) |
Mammalia | Slc15a3 33 16 34 |
|
||
| rat (Rattus norvegicus) |
Mammalia | Slc15a3 33 |
|
||
| dog (Canis familiaris) |
Mammalia | SLC15A3 34 |
|
OneToOne | |
| oppossum (Monodelphis domestica) |
Mammalia | SLC15A3 34 |
|
OneToOne | |
| lizard (Anolis carolinensis) |
Reptilia | SLC15A3 34 |
|
OneToOne | |
| baker's yeast (Saccharomyces cerevisiae) |
Saccharomycetes | PTR2 34 |
|
OneToMany | |
| sea squirt (Ciona savignyi) |
Ascidiacea | -- 34 |
|
OneToMany |
- Species where no ortholog for SLC15A3 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- chicken (Gallus gallus)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- fruit fly (Drosophila melanogaster)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- platypus (Ornithorhynchus anatinus)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- tropical clawed frog (Silurana tropicalis)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
- zebrafish (Danio rerio)
Paralogs for SLC15A3 Gene
(1) SIMAP similar genes for SLC15A3 Gene using alignment to 7 proteins:
Variants for SLC15A3 Gene
| SNP ID | Clin | Chr 11 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs1000073951 | -- | 60,944,643(-) | T/C | intron_variant | |
| rs1000239315 | -- | 60,938,416(-) | T/G | intron_variant | |
| rs1000377494 | -- | 60,940,713(-) | A/G | intron_variant | |
| rs1000901961 | -- | 60,948,621(-) | C/T | intron_variant | |
| rs1001007311 | -- | 60,952,387(-) | TTTTTT/TTTTT/TTTTTTT | upstream_transcript_variant |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| nsv1122626 | CNV | deletion | 24896259 |
Residual Variation Intolerance Score:
73.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
3.80;
58.36% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for SLC15A3 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- SLC15A3
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SLC15A3 Gene
Disorders for SLC15A3 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| diabetes mellitus, permanent neonatal |
|
|
Search SLC15A3 in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for SLC15A3
No data available for UniProtKB/Swiss-Prot and Genatlas for SLC15A3 Gene
Publications for SLC15A3 Gene
- Integral and associated lysosomal membrane proteins. (PMID: 17897319) Schröder B … Hasilik A (Traffic (Copenhagen, Denmark) 2007) 3 4 58
- The proton oligopeptide cotransporter family SLC15 in physiology and pharmacology. (PMID: 12905028) Daniel H … Kottra G (Pflugers Archiv : European journal of physiology 2004) 3 22 58
- Cloning of a lymphatic peptide/histidine transporter. (PMID: 11336635) Sakata K … Tohyama M (The Biochemical journal 2001) 2 3 58
- Human proton/oligopeptide transporter (POT) genes: identification of putative human genes using bioinformatics. (PMID: 11741232) Botka CW … Sadée W (AAPS pharmSci 2000) 2 3 58
- Endosomes are specialized platforms for bacterial sensing and NOD2 signalling. (PMID: 24695226) Nakamura N … Mellman I (Nature 2014) 3 58
Products for SLC15A3 Gene
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- Taconic Biosciences Mouse Models for SLC15A3
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- Humanized Mice
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- VectorBuilder custom plasmid, inducible vectors for SLC15A3
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for SLC15A3
- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Search GeneTex for Antibodies for SLC15A3
- Search GeneTex for Proteins for SLC15A3
- ViGene Biosciences adenoviral particle packaged cDNA for SLC15A3 gene
- ViGene Biosciences lentiviral particle packaged cDNA for SLC15A3 gene
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- Browse Santa Cruz Biotechnology (SCBT) Antibodies
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- genomics-online: cdna clones - Search results for 80 available SLC15A3 gene related products
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- Overview of 80 available SLC15A3 gene related products
Sources for SLC15A3 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) ASD
- (29) ECgene
- (30) GeneAnnot
- (31) CGAP SAGE
- (32) SOURCE
- (33) HomoloGene
- (34) PanEnsembl
- (35) euGenes
- (36) SGD
- (37) FlyBase
- (38) WormBase
- (39) Pseudogene
- (40) DGV
- (41) dbSNP
- (42) GenAtlas
- (43) HGMD
- (44) GAD
- (45) BGMUT
- (46) HuGE
- (47) Atlas
- (48) Cell Signaling Technology
- (49) GenBank
- (50) H-invDB
- (51) HORDE
- (52) HUGE
- (53) IMGT
- (54) Leiden
- (55) miRBase
- (56) DME
- (57) OriGene
- (58) PubMed
- (59) R&D Systems
- (60) TGDB
- (61) Tocris
- (62) Abcam
- (63) Novus Biologicals
- (64) ProSpec
- (65) Sino Biological
- (66) GenScript
- (67) Qiagen
- (68) Cloud-Clone Corp.
- (69) OCA
- (70) Proteopedia
- (71) MOPED
- (72) neXtProt
- (73) Reactome
- (74) GeneGo (Thomson Reuters)
- (75) fRNAdb
- (76) DISEASES
- (77) SIMAP
- (78) GenomeRNAi
- (79) LifeMap
- (80) miRTarBase
- (81) MalaCards
- (82) Invitrogen
- (83) BitterDB
- (84) Vector BioLabs
- (85) ESI-BIO
- (86) RefSeq
- (87) BioSystems
- (88) MaxQB
- (89) IUPHAR
- (90) BioGPS
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