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SLC15A3 (Solute Carrier Family 15 Member 3) is a Protein Coding gene. Diseases associated with SLC15A3 include Hypotrichosis 4 and Diabetes Mellitus, Permanent Neonatal 4. Among its related pathways are Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds. Gene Ontology (GO) annotations related to this gene include transporter activity and symporter activity. An important paralog of this gene is SLC15A4.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005515 | protein binding | IPI | 24695226 |
GO:0015293 | symporter activity | IEA | -- |
GO:0015333 | peptide:proton symporter activity | IBA | -- |
GO:0022857 | transmembrane transporter activity | IEA | -- |
GO:0035673 | oligopeptide transmembrane transporter activity | IBA | -- |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005764 | lysosome | IEA | -- |
GO:0005765 | lysosomal membrane | TAS | -- |
GO:0016020 | membrane | IEA | -- |
GO:0016021 | integral component of membrane | IEA | -- |
GO:0043231 | intracellular membrane-bounded organelle | IDA | -- |
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0006811 | ion transport | TAS | -- |
GO:0015031 | protein transport | IEA | -- |
GO:0015833 | peptide transport | IEA | -- |
GO:0035672 | oligopeptide transmembrane transport | IEA | -- |
GO:0055085 | transmembrane transport | IEA | -- |
ExUns: | 1 | ^ | 2a | · | 2b | ^ | 3a | · | 3b | ^ | 4 | ^ | 5a | · | 5b | ^ | 6a | · | 6b | ^ | 7 | ^ | 8 | ^ | 9a | · | 9b |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
SP1: | - | ||||||||||||||||||||||||||
SP2: | - | - | |||||||||||||||||||||||||
SP3: | - | ||||||||||||||||||||||||||
SP4: | - | ||||||||||||||||||||||||||
SP5: |
This gene was present in the common ancestor of animals and fungi.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Chimpanzee (Pan troglodytes) |
Mammalia | SLC15A3 30 31 |
|
OneToOne | |
Cow (Bos Taurus) |
Mammalia | SLC15A3 30 31 |
|
OneToOne | |
Mouse (Mus musculus) |
Mammalia | Slc15a3 30 17 31 |
|
OneToOne | |
Rat (Rattus norvegicus) |
Mammalia | Slc15a3 30 |
|
||
Dog (Canis familiaris) |
Mammalia | SLC15A3 31 |
|
OneToOne | |
Oppossum (Monodelphis domestica) |
Mammalia | SLC15A3 31 |
|
OneToOne | |
Lizard (Anolis carolinensis) |
Reptilia | SLC15A3 31 |
|
OneToOne | |
Baker's yeast (Saccharomyces cerevisiae) |
Saccharomycetes | PTR2 31 |
|
OneToMany | |
Sea Squirt (Ciona savignyi) |
Ascidiacea | -- 31 |
|
OneToMany |
SNP ID | Clinical significance and condition | Chr 11 pos | Variation | AA Info | Type |
---|---|---|---|---|---|
rs17855607 | - | p.Ile349Phe |
Variant ID | Type | Subtype | PubMed ID |
---|---|---|---|
nsv1122626 | CNV | deletion | 24896259 |
Disorder | Aliases | PubMed IDs |
---|---|---|
hypotrichosis 4 |
|
|
diabetes mellitus, permanent neonatal 4 |
|
|