Aliases for SLC15A3 Gene
External Ids for SLC15A3 Gene
Previous GeneCards Identifiers for SLC15A3 Gene
GeneCards Summary for SLC15A3 Gene
SLC15A3 (Solute Carrier Family 15 Member 3) is a Protein Coding gene. Diseases associated with SLC15A3 include Hypotrichosis 4 and Permanent Neonatal Diabetes Mellitus. Among its related pathways are Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds. Gene Ontology (GO) annotations related to this gene include transporter activity and symporter activity. An important paralog of this gene is SLC15A4.
UniProtKB/Swiss-Prot Summary for SLC15A3 Gene
Proton-coupled amino-acid transporter that transports free histidine and certain di- and tripeptides, and is involved in innate immune response (By similarity). Also able to transport carnosine (PubMed:31073693). Involved in the detection of microbial pathogens by toll-like receptors (TLRs) and NOD-like receptors (NLRs), probably by mediating transport of bacterial peptidoglycans across the endolysosomal membrane: catalyzes the transport of certain bacterial peptidoglycans, such as muramyl dipeptide (MDP), the NOD2 ligand (By similarity).