This gene encodes an intestinal hydrogen peptide cotransporter that is a member of the solute carrier family 15. The encoded protein is localized to the brush border membrane of the intestinal epithelium and mediates the uptake of di- and tripeptides from the lumen into the enterocytes. This protein plays an important role in the uptake and digestion of dietary proteins. This p... See more...

Aliases for SLC15A1 Gene

Aliases for SLC15A1 Gene

  • Solute Carrier Family 15 Member 1 2 3 4 5
  • Solute Carrier Family 15 (Oligopeptide Transporter), Member 1 2 3
  • Oligopeptide Transporter, Small Intestine Isoform 3 4
  • Peptide Transporter 1 3 4
  • PEPT1 3 4
  • BA551M18.1.1 (Solute Carrier Family 15 (Oligopeptide Transporter) Member 1) 2
  • Solute Carrier Family 15 Oligopeptide Transporter Member 1 2
  • Macrophage Oligopeptide Transporter PEPT1 3
  • Intestinal H(+)/Peptide Cotransporter 4
  • Intestinal H+/Peptide Cotransporter 3
  • Caco-2 Oligopeptide Transporter 3
  • Peptide Transporter HPEPT1 2
  • HPECT1 3
  • HPEPT1 3

External Ids for SLC15A1 Gene

Previous GeneCards Identifiers for SLC15A1 Gene

  • GC13M097696
  • GC13M093724
  • GC13M098172
  • GC13M097034
  • GC13M098134
  • GC13M099336
  • GC13M079930

Summaries for SLC15A1 Gene

Entrez Gene Summary for SLC15A1 Gene

  • This gene encodes an intestinal hydrogen peptide cotransporter that is a member of the solute carrier family 15. The encoded protein is localized to the brush border membrane of the intestinal epithelium and mediates the uptake of di- and tripeptides from the lumen into the enterocytes. This protein plays an important role in the uptake and digestion of dietary proteins. This protein also facilitates the absorption of numerous peptidomimetic drugs. [provided by RefSeq, Apr 2010]

GeneCards Summary for SLC15A1 Gene

SLC15A1 (Solute Carrier Family 15 Member 1) is a Protein Coding gene. Diseases associated with SLC15A1 include Short Bowel Syndrome and Hartnup Disorder. Among its related pathways are Statin Pathway - Generalized, Pharmacokinetics and Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds. Gene Ontology (GO) annotations related to this gene include transporter activity. An important paralog of this gene is SLC15A2.

UniProtKB/Swiss-Prot Summary for SLC15A1 Gene

  • Proton-coupled intake of oligopeptides of 2 to 4 amino acids with a preference for dipeptides. May constitute a major route for the absorption of protein digestion end-products.

Gene Wiki entry for SLC15A1 Gene

Additional gene information for SLC15A1 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for SLC15A1 Gene

Genomics for SLC15A1 Gene

GeneHancer (GH) Regulatory Elements for SLC15A1 Gene

Promoters and enhancers for SLC15A1 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH13J098737 Promoter/Enhancer 2 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 511.5 +7.3 7313 15.7 NCOR1 TEAD4 ZIC2 ZNF423 ATF2 EZH2 ZNF585B CREB1 CEBPB ZBTB17 SLC15A1 DOCK9-DT RF00017-1476
GH13J098775 Enhancer 1.1 Ensembl ENCODE dbSUPER 20.5 -23.8 -23753 1.9 TCF12 JUND TCF7 TEAD1 MAFF FOS SAP130 FOSL2 MAFK CEBPB SLC15A1 DOCK9-AS1 DOCK9 LOC105370330 lnc-SLC15A1-2
GH13J098688 Enhancer 0.7 Ensembl ENCODE 18.8 +64.6 64574 1.8 ZNF316 MAFF MAFK ATF2 MAX POU5F1 NANOG EMSY SLC15A1 lnc-FARP1-8 RF00017-1476
GH13J098886 Enhancer 1.2 Ensembl ENCODE CraniofacialAtlas dbSUPER 9.4 -137.7 -137726 8 ZNF316 MAFF IRF1 FOS NR3C1 MAFK PBX2 SPI1 USF1 ZFHX2 DOCK9 RNU6-83P DOCK9-DT DOCK9-AS1 SLC15A1 lnc-SLC15A1-3 piR-43105-150
GH13J098813 Enhancer 1 Ensembl ENCODE dbSUPER 10.9 -61.1 -61125 3.6 ZSCAN5C TRIM28 OSR2 BCL11A WT1 ZBTB17 OVOL3 ZNF189 ZNF843 PRDM6 SLC15A1 DOCK9-DT lnc-SLC15A1-2 LOC105370330 DOCK9
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around SLC15A1 on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for SLC15A1

Top Transcription factor binding sites by QIAGEN in the SLC15A1 gene promoter:
  • C/EBPbeta
  • Evi-1
  • FOXF2
  • FOXO4
  • GATA-1
  • GATA-6
  • GR
  • GR-alpha
  • SRF
  • SRF (504 AA)

Genomic Locations for SLC15A1 Gene

Genomic Locations for SLC15A1 Gene
chr13:98,683,801-98,752,675
(GRCh38/hg38)
Size:
68,875 bases
Orientation:
Minus strand
chr13:99,336,055-99,404,929
(GRCh37/hg19)
Size:
68,875 bases
Orientation:
Minus strand

Genomic View for SLC15A1 Gene

Genes around SLC15A1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SLC15A1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SLC15A1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SLC15A1 Gene

Proteins for SLC15A1 Gene

  • Protein details for SLC15A1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P46059-S15A1_HUMAN
    Recommended name:
    Solute carrier family 15 member 1
    Protein Accession:
    P46059
    Secondary Accessions:
    • Q5VW82

    Protein attributes for SLC15A1 Gene

    Size:
    708 amino acids
    Molecular mass:
    78806 Da
    Quaternary structure:
    No Data Available

neXtProt entry for SLC15A1 Gene

Post-translational modifications for SLC15A1 Gene

  • Glycosylation at Asn50, Asn404, Asn408, Asn439, Asn509, Asn514, and Asn562
  • Modification sites at PhosphoSitePlus

Other Protein References for SLC15A1 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • Abcam antibodies for SLC15A1
  • Boster Bio Antibodies for SLC15A1
  • Santa Cruz Biotechnology (SCBT) Antibodies for SLC15A1

No data available for DME Specific Peptides for SLC15A1 Gene

Domains & Families for SLC15A1 Gene

Gene Families for SLC15A1 Gene

Protein Domains for SLC15A1 Gene

Blocks:
  • TGF-beta receptor, type I/II extracellular region
InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for SLC15A1 Gene

GenScript: Design optimal peptide antigens:
  • Caco-2 oligopeptide transporter (O43641_HUMAN)
  • Solute carrier family 15 (Oligopeptide transporter), member 1 (Q4VAL9_HUMAN)
  • Peptide transporter 1 (S15A1_HUMAN)

Graphical View of Domain Structure for InterPro Entry

P46059

UniProtKB/Swiss-Prot:

S15A1_HUMAN :
  • Belongs to the PTR2/POT transporter (TC 2.A.17) family.
Family:
  • Belongs to the PTR2/POT transporter (TC 2.A.17) family.
genes like me logo Genes that share domains with SLC15A1: view

Function for SLC15A1 Gene

Molecular function for SLC15A1 Gene

UniProtKB/Swiss-Prot Function:
Proton-coupled intake of oligopeptides of 2 to 4 amino acids with a preference for dipeptides. May constitute a major route for the absorption of protein digestion end-products.
GENATLAS Biochemistry:
solute carrier family 15 (oligopeptide transport),member 1,expressed in small intestine

Phenotypes From GWAS Catalog for SLC15A1 Gene

Gene Ontology (GO) - Molecular Function for SLC15A1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005427 proton-dependent oligopeptide secondary active transmembrane transporter activity IEA --
GO:0015293 symporter activity IEA --
GO:0015333 peptide:proton symporter activity IDA 7896779
GO:0022857 transmembrane transporter activity IEA --
GO:0035673 oligopeptide transmembrane transporter activity IEA,IBA 21873635
genes like me logo Genes that share ontologies with SLC15A1: view
genes like me logo Genes that share phenotypes with SLC15A1: view

Animal Models for SLC15A1 Gene

MGI Knock Outs for SLC15A1:

Animal Model Products

  • Taconic Biosciences Mouse Models for SLC15A1

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for SLC15A1 Gene

Localization for SLC15A1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SLC15A1 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SLC15A1 gene
Compartment Confidence
plasma membrane 5
nucleus 3
cytosol 3
extracellular 2
mitochondrion 2
lysosome 2
cytoskeleton 1
peroxisome 1
endoplasmic reticulum 1
endosome 1
golgi apparatus 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (2)
  • Nucleoplasm (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for SLC15A1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane IBA 21873635
GO:0005903 brush border IEA --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IBA 21873635
genes like me logo Genes that share ontologies with SLC15A1: view

Pathways & Interactions for SLC15A1 Gene

genes like me logo Genes that share pathways with SLC15A1: view

Gene Ontology (GO) - Biological Process for SLC15A1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006811 ion transport TAS --
GO:0006857 oligopeptide transport IEA --
GO:0015031 protein transport IEA --
GO:0015833 peptide transport IEA --
GO:0035442 dipeptide transmembrane transport IEA --
genes like me logo Genes that share ontologies with SLC15A1: view

No data available for SIGNOR curated interactions for SLC15A1 Gene

Drugs & Compounds for SLC15A1 Gene

(82) Drugs for SLC15A1 Gene - From: DrugBank, DGIdb, IUPHAR, HMDB, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Amoxicillin Approved, Vet_approved Pharma Transporter, inhibitor 632
Ampicillin Approved, Vet_approved Pharma Target, Transporter, inhibitor 73
Cefaclor Approved Pharma Transporter, inhibitor 5
Cefadroxil Approved, Vet_approved, Withdrawn Pharma Transporter, substrate, inhibitor 12
Cefepime Approved, Investigational Pharma Transporter, inhibitor 64

(18) Additional Compounds for SLC15A1 Gene - From: HMDB and Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
2-Hydroxychlorpropamide
36892-36-1
genes like me logo Genes that share compounds with SLC15A1: view

Transcripts for SLC15A1 Gene

mRNA/cDNA for SLC15A1 Gene

1 REFSEQ mRNAs :
13 NCBI additional mRNA sequence :
2 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for SLC15A1 Gene

No ASD Table

Relevant External Links for SLC15A1 Gene

GeneLoc Exon Structure for
SLC15A1

Expression for SLC15A1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for SLC15A1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SLC15A1 Gene

This gene is overexpressed in Small Intestine - Terminal Ileum (x22.8), Skin - Not Sun Exposed (Suprapubic) (x7.2), Skin - Sun Exposed (Lower leg) (x6.2), and Liver (x4.0).

Protein differential expression in normal tissues from HIPED for SLC15A1 Gene

This gene is overexpressed in Fetal gut (63.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for SLC15A1 Gene



Protein tissue co-expression partners for SLC15A1 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for SLC15A1

SOURCE GeneReport for Unigene cluster for SLC15A1 Gene:

Hs.436893

Evidence on tissue expression from TISSUES for SLC15A1 Gene

  • Intestine(4.6)
  • Kidney(2.6)
  • Liver(2.2)
genes like me logo Genes that share expression patterns with SLC15A1: view

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for SLC15A1 Gene

Orthologs for SLC15A1 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for SLC15A1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SLC15A1 31 30
  • 99.15 (n)
OneToOne
dog
(Canis familiaris)
Mammalia SLC15A1 31 30
  • 85.05 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Slc15a1 17 31 30
  • 83.24 (n)
cow
(Bos Taurus)
Mammalia SLC15A1 30
  • 83.12 (n)
PEPT-1 31
  • 83 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Slc15a1 30
  • 82.34 (n)
oppossum
(Monodelphis domestica)
Mammalia SLC15A1 31
  • 74 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia SLC15A1 31
  • 72 (a)
OneToOne
chicken
(Gallus gallus)
Aves SLC15A1 31 30
  • 67.6 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia SLC15A1 31
  • 62 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia slc15a1 30
  • 64.86 (n)
zebrafish
(Danio rerio)
Actinopterygii slc15a1b 31 30
  • 64.19 (n)
OneToMany
slc15a1a 31
  • 55 (a)
OneToMany
slc15a1 30
fruit fly
(Drosophila melanogaster)
Insecta CG2930 31 30
  • 52.14 (n)
ManyToMany
BcDNA:GH06717 32
  • 40 (a)
yin 31
  • 35 (a)
ManyToMany
CG9444 32
  • 31 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP010383 30
  • 50.94 (n)
worm
(Caenorhabditis elegans)
Secernentea pept-1 31 30
  • 54.74 (n)
ManyToMany
opt-2 32
  • 44 (a)
opt-1 32
  • 44 (a)
pept-3 31
  • 34 (a)
ManyToMany
pept-2 31
  • 33 (a)
ManyToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes PTR2 31 30
  • 47.01 (n)
OneToMany
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0E12915g 30
  • 45.52 (n)
thale cress
(Arabidopsis thaliana)
eudicotyledons PTR2 30
  • 47.41 (n)
rice
(Oryza sativa)
Liliopsida Os03g0719900 30
  • 48.48 (n)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes SPBC13A2.04c 30
  • 45.49 (n)
sea squirt
(Ciona savignyi)
Ascidiacea -- 31
  • 42 (a)
ManyToMany
-- 31
  • 36 (a)
ManyToMany
-- 31
  • 33 (a)
ManyToMany
Species where no ortholog for SLC15A1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SLC15A1 Gene

ENSEMBL:
Gene Tree for SLC15A1 (if available)
TreeFam:
Gene Tree for SLC15A1 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for SLC15A1: view image

Paralogs for SLC15A1 Gene

Paralogs for SLC15A1 Gene

(3) SIMAP similar genes for SLC15A1 Gene using alignment to 3 proteins:

  • S15A1_HUMAN
  • Q4VAL9_HUMAN
  • Q9BZ22_HUMAN
genes like me logo Genes that share paralogs with SLC15A1: view

Variants for SLC15A1 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for SLC15A1 Gene

SNP ID Clinical significance and condition Chr 13 pos Variation AA Info Type
719990 Benign: not provided 98,706,263(-) A/G INTRON_VARIANT
730415 Benign: not provided 98,724,019(-) C/T SYNONYMOUS_VARIANT
776806 Benign: not provided 98,702,500(-) T/C SYNONYMOUS_VARIANT
776807 Benign: not provided 98,706,224(-) G/A SYNONYMOUS_VARIANT
781266 Benign: not provided 98,723,913(-) C/T MISSENSE_VARIANT

Additional dbSNP identifiers (rs#s) for SLC15A1 Gene

Structural Variations from Database of Genomic Variants (DGV) for SLC15A1 Gene

Variant ID Type Subtype PubMed ID
esv2747861 CNV deletion 23290073
esv3391339 CNV insertion 20981092
nsv1038016 CNV gain 25217958
nsv518082 CNV gain 19592680

Variation tolerance for SLC15A1 Gene

Residual Variation Intolerance Score: 50.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.95; 68.03% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for SLC15A1 Gene

Human Gene Mutation Database (HGMD)
SLC15A1
SNPedia medical, phenotypic, and genealogical associations of SNPs for
SLC15A1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SLC15A1 Gene

Disorders for SLC15A1 Gene

MalaCards: The human disease database

(3) MalaCards diseases for SLC15A1 Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
short bowel syndrome
  • acquired short bowel syndrome
hartnup disorder
  • hnd
inflammatory bowel disease
  • inflammatory bowel diseases
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for SLC15A1

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with SLC15A1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for SLC15A1 Gene

Publications for SLC15A1 Gene

  1. Human intestinal H+/peptide cotransporter. Cloning, functional expression, and chromosomal localization. (PMID: 7896779) Liang R … Leibach FH (The Journal of biological chemistry 1995) 2 3 4 26 54
  2. Oseltamivir (tamiflu) is a substrate of peptide transporter 1. (PMID: 19439487) Ogihara T … Tamai I (Drug metabolism and disposition: the biological fate of chemicals 2009) 3 23 26 54
  3. PepT1 oligopeptide transporter (SLC15A1) gene polymorphism in inflammatory bowel disease. (PMID: 19462432) Zucchelli M … D'Amato M (Inflammatory bowel diseases 2009) 3 23 41 54
  4. Transport of angiotensin-converting enzyme inhibitors by H+/peptide transporters revisited. (PMID: 18713951) Knütter I … Brandsch M (The Journal of pharmacology and experimental therapeutics 2008) 3 23 26 54
  5. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 41 54

Products for SLC15A1 Gene

Sources for SLC15A1 Gene