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Aliases for SLC13A4 Gene

Aliases for SLC13A4 Gene

  • Solute Carrier Family 13 Member 4 2 3 5
  • Solute Carrier Family 13 (Sodium/Sulphate Symporters), Member 4 2 3
  • Solute Carrier Family 13 (Sodium/Sulfate Symporter), Member 4 2 3
  • Na(+)/Sulfate Cotransporter SUT-1 3 4
  • Sulphate Transporter 1 2 3
  • NAS2 3 4
  • SUT1 3 4
  • Solute Carrier Family 13 (Sodium/Sulfate Symporters), Member 4 3
  • SUT-1 3

External Ids for SLC13A4 Gene

Previous GeneCards Identifiers for SLC13A4 Gene

  • GC07M133708
  • GC07M134768
  • GC07M134782
  • GC07M134823
  • GC07M135016
  • GC07M135365
  • GC07M129668

Summaries for SLC13A4 Gene

GeneCards Summary for SLC13A4 Gene

SLC13A4 (Solute Carrier Family 13 Member 4) is a Protein Coding gene. Among its related pathways are Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds. Gene Ontology (GO) annotations related to this gene include transporter activity and sodium:sulfate symporter activity. An important paralog of this gene is SLC13A1.

UniProtKB/Swiss-Prot for SLC13A4 Gene

  • Sodium/sulfate cotransporter that mediates sulfate reabsorption in the high endothelial venules (HEV).

Additional gene information for SLC13A4 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SLC13A4 Gene

Genomics for SLC13A4 Gene

GeneHancer (GH) Regulatory Elements for SLC13A4 Gene

Promoters and enhancers for SLC13A4 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH07I135728 Promoter/Enhancer 1.4 EPDnew Ensembl ENCODE 550.8 +0.8 770 1 ZNF449 ZIC2 ZNF335 ZNF316 ZNF213 ZNF366 ZSCAN5C SCRT2 FOS ZNF600 SLC13A4 STMP1 FAM180A ENSG00000273219
GH07I135727 Promoter 0.6 EPDnew 550.8 +1.4 1440 0.1 BRD4 SLC13A4 FAM180A STMP1 ENSG00000273219
GH07I135706 Enhancer 0.8 ENCODE 13.8 +21.9 21945 2.4 PKNOX1 FEZF1 ZNF2 ZBTB40 ELK1 ZNF366 ZSCAN5C KLF7 FOS RCOR1 RPL15P11 SLC13A4 ENSG00000273219 STMP1 LOC105375521
GH07I135771 Enhancer 1.6 VISTA FANTOM5 Ensembl ENCODE dbSUPER 5.4 -44.0 -43979 3.2 CTCF FOXA2 CEBPG ZIC2 ZNF2 RAD21 FOSL1 ZNF335 CTBP1 GATA3 FAM180A STMP1 SLC13A4 LOC105375522 GC07M135854
GH07I135712 Enhancer 1.1 Ensembl ENCODE 5.7 +15.2 15157 4.2 HDGF PKNOX1 ARNT YBX1 FEZF1 GLI4 ZNF2 FOS ZNF488 REST STMP1 NUP205 RPL15P11 C7orf49 FAM180A WDR91 SLC13A4 ENSG00000224746 ENSG00000273219
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around SLC13A4 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the SLC13A4 gene promoter:

Genomic Locations for SLC13A4 Gene

Genomic Locations for SLC13A4 Gene
chr7:135,681,231-135,729,258
(GRCh38/hg38)
Size:
48,028 bases
Orientation:
Minus strand
chr7:135,365,985-135,414,006
(GRCh37/hg19)

Genomic View for SLC13A4 Gene

Genes around SLC13A4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SLC13A4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SLC13A4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SLC13A4 Gene

Proteins for SLC13A4 Gene

  • Protein details for SLC13A4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9UKG4-S13A4_HUMAN
    Recommended name:
    Solute carrier family 13 member 4
    Protein Accession:
    Q9UKG4
    Secondary Accessions:
    • A4D1Q4
    • Q8N631

    Protein attributes for SLC13A4 Gene

    Size:
    626 amino acids
    Molecular mass:
    69358 Da
    Quaternary structure:
    No Data Available
    Miscellaneous:
    • Transport is inhibited by thiosulfate, phosphate, molybdate, selenate and tungstate. Not inhibited by oxalate, citrate, succinate, phenol red or 4,4-diisothiocyanostilbene-2,2-disulfonic acid (DIDS).

neXtProt entry for SLC13A4 Gene

Post-translational modifications for SLC13A4 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for SLC13A4 Gene

No data available for DME Specific Peptides for SLC13A4 Gene

Domains & Families for SLC13A4 Gene

Gene Families for SLC13A4 Gene

HGNC:
IUPHAR :
Human Protein Atlas (HPA):
  • Predicted membrane proteins
  • Transporters

Protein Domains for SLC13A4 Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for SLC13A4 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9UKG4

UniProtKB/Swiss-Prot:

S13A4_HUMAN :
  • Belongs to the SLC13A/DASS transporter (TC 2.A.47) family. NADC subfamily.
Family:
  • Belongs to the SLC13A/DASS transporter (TC 2.A.47) family. NADC subfamily.
genes like me logo Genes that share domains with SLC13A4: view

Function for SLC13A4 Gene

Molecular function for SLC13A4 Gene

UniProtKB/Swiss-Prot Function:
Sodium/sulfate cotransporter that mediates sulfate reabsorption in the high endothelial venules (HEV).

Phenotypes From GWAS Catalog for SLC13A4 Gene

Gene Ontology (GO) - Molecular Function for SLC13A4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005215 transporter activity IBA --
GO:0015293 symporter activity IEA --
GO:0015382 sodium:sulfate symporter activity TAS --
genes like me logo Genes that share ontologies with SLC13A4: view
genes like me logo Genes that share phenotypes with SLC13A4: view

Animal Models for SLC13A4 Gene

MGI Knock Outs for SLC13A4:

Animal Model Products

  • Taconic Biosciences Mouse Models for SLC13A4

CRISPR Products

Inhibitory RNA Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for SLC13A4 Gene

Localization for SLC13A4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SLC13A4 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SLC13A4 gene
Compartment Confidence
plasma membrane 5
cytoskeleton 2
nucleus 2
cytosol 2

Gene Ontology (GO) - Cellular Components for SLC13A4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane TAS 10535998
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with SLC13A4: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for SLC13A4 Gene

Pathways & Interactions for SLC13A4 Gene

genes like me logo Genes that share pathways with SLC13A4: view

Interacting Proteins for SLC13A4 Gene

Gene Ontology (GO) - Biological Process for SLC13A4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006810 transport IEA --
GO:0006811 ion transport IEA --
GO:0006814 sodium ion transport IEA --
GO:0008272 sulfate transport TAS 10535998
GO:0035725 sodium ion transmembrane transport IEA --
genes like me logo Genes that share ontologies with SLC13A4: view

No data available for SIGNOR curated interactions for SLC13A4 Gene

Drugs & Compounds for SLC13A4 Gene

(1) Drugs for SLC13A4 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Phenol Approved, Experimental Pharma 52

(2) Additional Compounds for SLC13A4 Gene - From: Novoseek and HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Sulfate
  • Sulfate (ion 2-)
  • Sulfate anion
  • Sulfate anion(2-)
  • Sulfate dianion
  • Sulfate ion
14808-79-8
sodium
  • Sodium
  • Sodium ion
7440-23-5
genes like me logo Genes that share compounds with SLC13A4: view

Transcripts for SLC13A4 Gene

Unigene Clusters for SLC13A4 Gene

Solute carrier family 13 (sodium/sulfate symporters), member 4:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for SLC13A4 Gene

ExUns: 1a · 1b ^ 2a · 2b · 2c · 2d ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17
SP1:
SP2:
SP3: - - -
SP4: - -

Relevant External Links for SLC13A4 Gene

GeneLoc Exon Structure for
SLC13A4
ECgene alternative splicing isoforms for
SLC13A4

Expression for SLC13A4 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for SLC13A4 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SLC13A4 Gene

This gene is overexpressed in Brain - Cerebellum (x7.5), Testis (x5.3), and Esophagus - Mucosa (x4.2).

Protein differential expression in normal tissues from HIPED for SLC13A4 Gene

This gene is overexpressed in Placenta (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for SLC13A4 Gene



Protein tissue co-expression partners for SLC13A4 Gene

NURSA nuclear receptor signaling pathways regulating expression of SLC13A4 Gene:

SLC13A4

SOURCE GeneReport for Unigene cluster for SLC13A4 Gene:

Hs.490241

mRNA Expression by UniProt/SwissProt for SLC13A4 Gene:

Q9UKG4-S13A4_HUMAN
Tissue specificity: Highly expressed in placenta and testis with intermediate levels in brain and lower levels in heart, thymus and liver.

Evidence on tissue expression from TISSUES for SLC13A4 Gene

  • Nervous system(4.7)
  • Heart(4.1)
genes like me logo Genes that share expression patterns with SLC13A4: view

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for SLC13A4 Gene

Orthologs for SLC13A4 Gene

This gene was present in the common ancestor of animals.

Orthologs for SLC13A4 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SLC13A4 33 34
  • 99.41 (n)
dog
(Canis familiaris)
Mammalia SLC13A4 33 34
  • 90.88 (n)
cow
(Bos Taurus)
Mammalia SLC13A4 33 34
  • 89.55 (n)
rat
(Rattus norvegicus)
Mammalia Slc13a4 33
  • 87.78 (n)
mouse
(Mus musculus)
Mammalia Slc13a4 33 16 34
  • 86.55 (n)
oppossum
(Monodelphis domestica)
Mammalia SLC13A4 34
  • 86 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia SLC13A4 34
  • 79 (a)
OneToOne
chicken
(Gallus gallus)
Aves SLC13A4 33 34
  • 76.58 (n)
lizard
(Anolis carolinensis)
Reptilia SLC13A4 34
  • 65 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100495139 33
  • 72.29 (n)
African clawed frog
(Xenopus laevis)
Amphibia MGC53521 33
zebrafish
(Danio rerio)
Actinopterygii slc13a4 33 34
  • 69.37 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG33934 34
  • 28 (a)
ManyToMany
worm
(Caenorhabditis elegans)
Secernentea nac-1 34
  • 34 (a)
ManyToMany
nac-3 34
  • 34 (a)
ManyToMany
F31F6.6 35
  • 33 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 36 (a)
ManyToMany
-- 34
  • 35 (a)
ManyToMany
Species where no ortholog for SLC13A4 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SLC13A4 Gene

ENSEMBL:
Gene Tree for SLC13A4 (if available)
TreeFam:
Gene Tree for SLC13A4 (if available)

Paralogs for SLC13A4 Gene

Paralogs for SLC13A4 Gene

(5) SIMAP similar genes for SLC13A4 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with SLC13A4: view

Variants for SLC13A4 Gene

Sequence variations from dbSNP and Humsavar for SLC13A4 Gene

SNP ID Clin Chr 07 pos Variation AA Info Type
rs1000093884 -- 135,728,099(-) G/T 5_prime_UTR_variant, genic_upstream_transcript_variant, upstream_transcript_variant
rs1000250279 -- 135,703,720(-) AGAGAG/AG intron_variant
rs1000304512 -- 135,713,802(-) C/A genic_upstream_transcript_variant, intron_variant
rs1000357611 -- 135,710,274(-) A/C genic_upstream_transcript_variant, intron_variant
rs1000399103 -- 135,721,697(-) A/C genic_upstream_transcript_variant, intron_variant

Structural Variations from Database of Genomic Variants (DGV) for SLC13A4 Gene

Variant ID Type Subtype PubMed ID
esv3395242 CNV duplication 20981092
nsv473042 CNV novel sequence insertion 20440878
nsv608460 CNV gain 21841781

Variation tolerance for SLC13A4 Gene

Residual Variation Intolerance Score: 12.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.67; 45.93% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for SLC13A4 Gene

Human Gene Mutation Database (HGMD)
SLC13A4
SNPedia medical, phenotypic, and genealogical associations of SNPs for
SLC13A4

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SLC13A4 Gene

Disorders for SLC13A4 Gene

Additional Disease Information for SLC13A4

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for SLC13A4 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SLC13A4 Gene

Publications for SLC13A4 Gene

  1. Molecular cloning and functional analysis of SUT-1, a sulfate transporter from human high endothelial venules. (PMID: 10535998) Girard JP … Amalric F (Proceedings of the National Academy of Sciences of the United States of America 1999) 2 3 4 22 58
  2. Functional characterization and genomic organization of the human Na(+)-sulfate cotransporter hNaS2 gene (SLC13A4). (PMID: 15607730) Markovich D … Dawson PA (Biochemical and biophysical research communications 2005) 3 4 22 58
  3. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 44 58
  4. Human chromosome 7: DNA sequence and biology. (PMID: 12690205) Scherer SW … Tsui LC (Science (New York, N.Y.) 2003) 3 4 58
  5. Human placental sulfate transporter mRNA profiling from term pregnancies identifies abundant SLC13A4 in syncytiotrophoblasts and SLC26A2 in cytotrophoblasts. (PMID: 23453247) Simmons DG … Dawson PA (Placenta 2013) 3 58

Products for SLC13A4 Gene

Sources for SLC13A4 Gene

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