Aliases for SLC13A3 Gene
External Ids for SLC13A3 Gene
Previous GeneCards Identifiers for SLC13A3 Gene
Mammalian sodium-dicarboxylate cotransporters transport succinate and other Krebs cycle intermediates. They fall into 2 categories based on their substrate affinity: low affinity and high affinity. Both the low- and high-affinity transporters play an important role in the handling of citrate by the kidneys. The protein encoded by this gene represents the high-affinity form. Alternatively spliced transcript variants encoding different isoforms have been found for this gene, although the full-length nature of some of them have not been characterized yet. [provided by RefSeq, Jul 2008]
GeneCards Summary for SLC13A3 Gene
SLC13A3 (Solute Carrier Family 13 Member 3) is a Protein Coding gene. Diseases associated with SLC13A3 include Leukoencephalopathy, Acute Reversible, With Increased Urinary Alpha-Ketoglutarate and N-Acetylglutamate Synthase Deficiency. Among its related pathways are Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds. Gene Ontology (GO) annotations related to this gene include transporter activity and high-affinity sodium:dicarboxylate symporter activity. An important paralog of this gene is SLC13A2.
UniProtKB/Swiss-Prot Summary for SLC13A3 Gene
High-affinity sodium-dicarboxylate cotransporter that accepts a range of substrates with 4-6 carbon atoms, including succinate, alpha-ketoglutarate and N-acetylaspartate (PubMed:30635937). The stoichiometry is probably 3 Na(+) for 1 divalent succinate.