Aliases for SLC12A7 Gene
External Ids for SLC12A7 Gene
Previous GeneCards Identifiers for SLC12A7 Gene
GeneCards Summary for SLC12A7 Gene
SLC12A7 (Solute Carrier Family 12 Member 7) is a Protein Coding gene. Diseases associated with SLC12A7 include Renal Tubular Acidosis and Agenesis Of The Corpus Callosum With Peripheral Neuropathy. Among its related pathways are Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds and Insulin receptor recycling. Gene Ontology (GO) annotations related to this gene include protein kinase binding and potassium:chloride symporter activity. An important paralog of this gene is SLC12A5.
UniProtKB/Swiss-Prot Summary for SLC12A7 Gene
Mediates electroneutral potassium-chloride cotransport when activated by cell swelling. May mediate K(+) uptake into Deiters' cells in the cochlea and contribute to K(+) recycling in the inner ear. Important for the survival of cochlear outer and inner hair cells and the maintenance of the organ of Corti. May be required for basolateral Cl(-) extrusion in the kidney and contribute to renal acidification (By similarity).