Aliases for SLC11A1 Gene
External Ids for SLC11A1 Gene
Previous HGNC Symbols for SLC11A1 Gene
Previous GeneCards Identifiers for SLC11A1 Gene
This gene is a member of the solute carrier family 11 (proton-coupled divalent metal ion transporters) family and encodes a multi-pass membrane protein. The protein functions as a divalent transition metal (iron and manganese) transporter involved in iron metabolism and host resistance to certain pathogens. Mutations in this gene have been associated with susceptibility to infectious diseases such as tuberculosis and leprosy, and inflammatory diseases such as rheumatoid arthritis and Crohn disease. Alternatively spliced variants that encode different protein isoforms have been described but the full-length nature of only one has been determined. [provided by RefSeq, Jul 2008]
GeneCards Summary for SLC11A1 Gene
SLC11A1 (Solute Carrier Family 11 Member 1) is a Protein Coding gene. Diseases associated with SLC11A1 include Buruli Ulcer and Typhoid Fever. Among its related pathways are Lysosome and Validated targets of C-MYC transcriptional repression. Gene Ontology (GO) annotations related to this gene include protein homodimerization activity and manganese ion transmembrane transporter activity. An important paralog of this gene is SLC11A2.
UniProtKB/Swiss-Prot Summary for SLC11A1 Gene
Divalent transition metal (iron and manganese) transporter involved in iron metabolism and host resistance to certain pathogens. Macrophage-specific membrane transport function. Controls natural resistance to infection with intracellular parasites. Pathogen resistance involves sequestration of Fe(2+) and Mn(2+), cofactors of both prokaryotic and eukaryotic catalases and superoxide dismutases, not only to protect the macrophage against its own generation of reactive oxygen species, but to deny the cations to the pathogen for synthesis of its protective enzymes.