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SLC10A6 (Solute Carrier Family 10 Member 6) is a Protein Coding gene. Diseases associated with SLC10A6 include Intraductal Breast Benign Neoplasm and Intraductal Papilloma. Among its related pathways are Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds. Gene Ontology (GO) annotations related to this gene include bile acid:sodium symporter activity and sodium-dependent organic anion transmembrane transporter activity. An important paralog of this gene is SLC10A2.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005515 | protein binding | IPI | 32296183 |
GO:0008508 | bile acid:sodium symporter activity | TAS | -- |
GO:0015293 | symporter activity | IEA | -- |
GO:0043250 | sodium-dependent organic anion transmembrane transporter activity | IEA | -- |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005886 | plasma membrane | TAS | -- |
GO:0016020 | membrane | IEA | -- |
GO:0016021 | integral component of membrane | IEA | -- |
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0006811 | ion transport | IEA | -- |
GO:0006814 | sodium ion transport | IEA | -- |
GO:0015721 | bile acid and bile salt transport | IBA | 21873635 |
GO:0043251 | sodium-dependent organic anion transport | IEA | -- |
GO:0055085 | transmembrane transport | TAS | -- |
Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs | |
---|---|---|---|---|---|---|
sodium |
|
7440-23-5 |
|
This gene was present in the common ancestor of animals.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Chimpanzee (Pan troglodytes) |
Mammalia | SLC10A6 30 31 |
|
OneToOne | |
Dog (Canis familiaris) |
Mammalia | SLC10A6 30 31 |
|
OneToOne | |
Cow (Bos Taurus) |
Mammalia | SLC10A6 30 31 31 |
|
OneToMany | |
Mouse (Mus musculus) |
Mammalia | Slc10a6 30 17 31 |
|
OneToOne | |
Rat (Rattus norvegicus) |
Mammalia | Slc10a6 30 |
|
||
Oppossum (Monodelphis domestica) |
Mammalia | SLC10A6 31 |
|
OneToOne | |
Platypus (Ornithorhynchus anatinus) |
Mammalia | SLC10A6 31 |
|
OneToOne | |
Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | slc10a6 30 |
|
||
Fruit Fly (Drosophila melanogaster) |
Insecta | CG11655 31 |
|
ManyToMany | |
CG9903 31 |
|
ManyToMany | |||
Worm (Caenorhabditis elegans) |
Secernentea | Y71G10AR.4 31 |
|
OneToMany | |
Sea Squirt (Ciona savignyi) |
Ascidiacea | -- 31 |
|
OneToMany |
SNP ID | Clinical significance and condition | Chr 04 pos | Variation | AA Info | Type |
---|---|---|---|---|---|
rs13106574 | - |
p.Ile114Val |
|||
rs17694522 | - |
p.Ser6Phe |
Variant ID | Type | Subtype | PubMed ID |
---|---|---|---|
dgv1510e212 | CNV | loss | 25503493 |
esv2727934 | CNV | deletion | 23290073 |
esv3564194 | CNV | deletion | 23714750 |
nsv1013308 | CNV | gain | 25217958 |
nsv594787 | CNV | gain | 21841781 |
nsv830001 | CNV | loss | 17160897 |
Disorder | Aliases | PubMed IDs |
---|---|---|
intraductal breast benign neoplasm |
|
|
intraductal papilloma |
|
|
ichthyosis, x-linked |
|
|