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Aliases for SLC10A3 Gene

Aliases for SLC10A3 Gene

  • Solute Carrier Family 10 Member 3 2 3 4 5
  • DXS253E 3 4
  • P3 3 4
  • Solute Carrier Family 10 (Sodium/Bile Acid Cotransporter Family), Member 3 3
  • Solute Carrier Family 10, Member 3 2
  • P3 Protein 3
  • Protein P3 3

External Ids for SLC10A3 Gene

Previous GeneCards Identifiers for SLC10A3 Gene

  • GC0XM151301
  • GC0XM152183
  • GC0XM153279
  • GC0XM153368
  • GC0XM153715
  • GC0XM142292

Summaries for SLC10A3 Gene

Entrez Gene Summary for SLC10A3 Gene

  • This gene maps to a GC-rich region of the X chromosome and was identified by its proximity to a CpG island. It is thought to be a housekeeping gene. Alternative splicing results in multiple transcript variants encoding distinct isoforms.[provided by RefSeq, Dec 2008]

GeneCards Summary for SLC10A3 Gene

SLC10A3 (Solute Carrier Family 10 Member 3) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include bile acid:sodium symporter activity. An important paralog of this gene is SLC10A5.

UniProtKB/Swiss-Prot for SLC10A3 Gene

  • The ubiquitous expression and the conservation of the sequence in distant animal species suggest that the gene codes for a protein with housekeeping functions.

Gene Wiki entry for SLC10A3 Gene

Additional gene information for SLC10A3 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SLC10A3 Gene

Genomics for SLC10A3 Gene

GeneHancer (GH) Regulatory Elements for SLC10A3 Gene

Promoters and enhancers for SLC10A3 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH0XI154488 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 550.8 +0.4 408 2.8 PKNOX1 ATF1 ARID4B NEUROD1 SIN3A YY1 POLR2B GLIS2 ELK1 ATF7 SLC10A3 FAM3A H2AFB1 TMEM187 PIR45081
GH0XI153965 Promoter/Enhancer 2.6 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 23.3 +520.2 520174 10 HDGF PKNOX1 CLOCK FOXA2 ARNT ZFP64 SIN3A FEZF1 DMAP1 ZNF2 TMEM187 HCFC1 HCFC1-AS1 SNORA70 SLC10A3 SNORA56 DKC1 EMD FAM3A ABCD1
GH0XI154396 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 25.2 +91.2 91210 6.2 HNRNPUL1 PKNOX1 CLOCK SMAD1 MLX ARNT ZFP64 ARID4B SIN3A DMAP1 SNORA70 ENSG00000280195 GC0XP154402 GC0XP154401 RPL10 PLXNA3 HCFC1 DKC1 SNORA56 EMD
GH0XI153922 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 16.4 +563.9 563875 7.7 HDGF HNRNPUL1 PKNOX1 CLOCK SMAD1 ARNT ARID4B SIN3A DMAP1 ZNF2 ARHGAP4 TMEM187 HCFC1 SNORA70 DKC1 SLC10A3 EMD HCFC1-AS1 FLNA GC0XP153923
GH0XI154723 Enhancer 1.6 FANTOM5 Ensembl ENCODE dbSUPER 21.4 -240.7 -240735 16 FOXA2 ZFP64 IRF4 YY1 ZNF213 FOS RUNX3 RXRA JUNB ZC3H11A DKC1 SNORA70 HCFC1 SNORA56 F8A1 EMD GAB3 PLXNA3 F8A2 SLC10A3
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around SLC10A3 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the SLC10A3 gene promoter:

Genomic Locations for SLC10A3 Gene

Genomic Locations for SLC10A3 Gene
chrX:154,487,306-154,490,690
(GRCh38/hg38)
Size:
3,385 bases
Orientation:
Minus strand
chrX:153,715,645-153,719,016
(GRCh37/hg19)

Genomic View for SLC10A3 Gene

Genes around SLC10A3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SLC10A3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SLC10A3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SLC10A3 Gene

Proteins for SLC10A3 Gene

  • Protein details for SLC10A3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P09131-P3_HUMAN
    Recommended name:
    P3 protein
    Protein Accession:
    P09131
    Secondary Accessions:
    • Q5HY79
    • Q9BSL2

    Protein attributes for SLC10A3 Gene

    Size:
    477 amino acids
    Molecular mass:
    50333 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for SLC10A3 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SLC10A3 Gene

Post-translational modifications for SLC10A3 Gene

No Post-translational modifications

No data available for DME Specific Peptides for SLC10A3 Gene

Domains & Families for SLC10A3 Gene

Gene Families for SLC10A3 Gene

HGNC:
IUPHAR :
Human Protein Atlas (HPA):
  • Predicted membrane proteins
  • Predicted secreted proteins
  • Transporters

Protein Domains for SLC10A3 Gene

Suggested Antigen Peptide Sequences for SLC10A3 Gene

Graphical View of Domain Structure for InterPro Entry

P09131

UniProtKB/Swiss-Prot:

P3_HUMAN :
  • Belongs to the bile acid:sodium symporter (BASS) (TC 2.A.28) family.
Family:
  • Belongs to the bile acid:sodium symporter (BASS) (TC 2.A.28) family.
genes like me logo Genes that share domains with SLC10A3: view

Function for SLC10A3 Gene

Molecular function for SLC10A3 Gene

UniProtKB/Swiss-Prot Function:
The ubiquitous expression and the conservation of the sequence in distant animal species suggest that the gene codes for a protein with housekeeping functions.

Phenotypes From GWAS Catalog for SLC10A3 Gene

Gene Ontology (GO) - Molecular Function for SLC10A3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008508 bile acid:sodium symporter activity IBA --
GO:0015293 symporter activity IEA --
genes like me logo Genes that share ontologies with SLC10A3: view
genes like me logo Genes that share phenotypes with SLC10A3: view

Animal Model Products

miRNA for SLC10A3 Gene

miRTarBase miRNAs that target SLC10A3

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for SLC10A3 Gene

Localization for SLC10A3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SLC10A3 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SLC10A3 gene
Compartment Confidence
plasma membrane 3
cytoskeleton 3
endoplasmic reticulum 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Intermediate filaments (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for SLC10A3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with SLC10A3: view

Pathways & Interactions for SLC10A3 Gene

SuperPathways for SLC10A3 Gene

No Data Available

Interacting Proteins for SLC10A3 Gene

Gene Ontology (GO) - Biological Process for SLC10A3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0010033 response to organic substance IEA --
GO:0015721 bile acid and bile salt transport IEA --
GO:0032526 response to retinoic acid IEA --
GO:0055085 transmembrane transport IEA --
genes like me logo Genes that share ontologies with SLC10A3: view

No data available for Pathways by source and SIGNOR curated interactions for SLC10A3 Gene

Drugs & Compounds for SLC10A3 Gene

(1) Additional Compounds for SLC10A3 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
sodium
  • Sodium
  • Sodium ion
7440-23-5
genes like me logo Genes that share compounds with SLC10A3: view

Transcripts for SLC10A3 Gene

Unigene Clusters for SLC10A3 Gene

Solute carrier family 10 (sodium/bile acid cotransporter family), member 3:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for SLC10A3 Gene

No ASD Table

Relevant External Links for SLC10A3 Gene

GeneLoc Exon Structure for
SLC10A3
ECgene alternative splicing isoforms for
SLC10A3

Expression for SLC10A3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for SLC10A3 Gene

NURSA nuclear receptor signaling pathways regulating expression of SLC10A3 Gene:

SLC10A3

SOURCE GeneReport for Unigene cluster for SLC10A3 Gene:

Hs.522826

Evidence on tissue expression from TISSUES for SLC10A3 Gene

  • Nervous system(4.2)
genes like me logo Genes that share expression patterns with SLC10A3: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for SLC10A3 Gene

Orthologs for SLC10A3 Gene

This gene was present in the common ancestor of animals.

Orthologs for SLC10A3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SLC10A3 33
  • 98.95 (n)
dog
(Canis familiaris)
Mammalia SLC10A3 33 34
  • 89.1 (n)
cow
(Bos Taurus)
Mammalia SLC10A3 33 34
  • 86.65 (n)
rat
(Rattus norvegicus)
Mammalia Slc10a3 33
  • 84.07 (n)
mouse
(Mus musculus)
Mammalia Slc10a3 33 16 34
  • 83.44 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia SLC10A3 34
  • 69 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia SLC10A3 34
  • 62 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia SLC10A3 34
  • 60 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia slc10a3 33
  • 59.27 (n)
African clawed frog
(Xenopus laevis)
Amphibia Xl.9703 33
zebrafish
(Danio rerio)
Actinopterygii slc10a3 33 34
  • 66.35 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG11655 34
  • 22 (a)
ManyToMany
CG9903 34
  • 19 (a)
ManyToMany
worm
(Caenorhabditis elegans)
Secernentea Y71G10AR.4 34
  • 18 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 31 (a)
ManyToMany
-- 34
  • 31 (a)
ManyToMany
Species where no ortholog for SLC10A3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SLC10A3 Gene

ENSEMBL:
Gene Tree for SLC10A3 (if available)
TreeFam:
Gene Tree for SLC10A3 (if available)

Paralogs for SLC10A3 Gene

Paralogs for SLC10A3 Gene

(1) SIMAP similar genes for SLC10A3 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with SLC10A3: view

Variants for SLC10A3 Gene

Sequence variations from dbSNP and Humsavar for SLC10A3 Gene

SNP ID Clin Chr 0X pos Variation AA Info Type
rs1000882856 -- 154,487,666(-) G/A coding_sequence_variant, synonymous_variant
rs1001532201 -- 154,492,412(-) G/A upstream_transcript_variant
rs1001759527 -- 154,491,944(-) C/T upstream_transcript_variant
rs1003194654 -- 154,490,729(-) C/T upstream_transcript_variant
rs1003245410 -- 154,491,006(-) C/T upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for SLC10A3 Gene

Variant ID Type Subtype PubMed ID
nsv519042 CNV gain 19592680
esv33784 CNV gain+loss 17666407
esv33199 CNV gain+loss 17666407

Variation tolerance for SLC10A3 Gene

Residual Variation Intolerance Score: 14.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.53; 29.68% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for SLC10A3 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
SLC10A3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SLC10A3 Gene

Disorders for SLC10A3 Gene

Additional Disease Information for SLC10A3

No disorders were found for SLC10A3 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SLC10A3 Gene

Publications for SLC10A3 Gene

  1. Long-range sequence analysis in Xq28: thirteen known and six candidate genes in 219.4 kb of high GC DNA between the RCP/GCP and G6PD loci. (PMID: 8733135) Chen EY … D'Urso M (Human molecular genetics 1996) 2 3 4 58
  2. CpG islands of the X chromosome are gene associated. (PMID: 3186440) Alcalay M … Toniolo D (Nucleic acids research 1988) 3 4 58
  3. Toward an understanding of the protein interaction network of the human liver. (PMID: 21988832) Wang J … Yang X (Molecular systems biology 2011) 3 58
  4. Ubiquitin-mediated proteolysis of HuR by heat shock. (PMID: 19322201) Abdelmohsen K … Gorospe M (The EMBO journal 2009) 3 58
  5. Prominent use of distal 5' transcription start sites and discovery of a large number of additional exons in ENCODE regions. (PMID: 17567994) Denoeud F … Reymond A (Genome research 2007) 3 58

Products for SLC10A3 Gene

Sources for SLC10A3 Gene

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