The protein encoded by this gene belongs to the sodium/bile acid cotransporter family, which are integral membrane glycoproteins that participate in the enterohepatic circulation of bile acids. Two homologous transporters are involved in the reabsorption of bile acids; the ileal sodium/bile acid cotransporter with an apical cell localization that absorbs bile acids from the int... See more...

Aliases for SLC10A1 Gene

Aliases for SLC10A1 Gene

  • Solute Carrier Family 10 Member 1 2 3 4 5
  • Solute Carrier Family 10 (Sodium/Bile Acid Cotransporter), Member 1 2 3
  • Sodium/Taurocholate Cotransporting Polypeptide 3 4
  • Cell Growth-Inhibiting Gene 29 Protein 3 4
  • Na(+)/Taurocholate Transport Protein 3 4
  • Sodium/Bile Acid Cotransporter 3 4
  • Na(+)/Bile Acid Cotransporter 3 4
  • NTCP 3 4
  • Solute Carrier Family 10 (Sodium/Bile Acid Cotransporter Family), Member 1 3
  • Na+/Taurocholate Cotransporting Polypeptide 2
  • Na/Taurocholate Cotransporting Polypeptide 3
  • Sodium/Taurocholate Cotransporter 3
  • Growth-Inhibiting Protein 29 3

External Ids for SLC10A1 Gene

Previous GeneCards Identifiers for SLC10A1 Gene

  • GC14M067747
  • GC14M064038
  • GC14M068232
  • GC14M069312
  • GC14M070242
  • GC14M050411

Summaries for SLC10A1 Gene

Entrez Gene Summary for SLC10A1 Gene

  • The protein encoded by this gene belongs to the sodium/bile acid cotransporter family, which are integral membrane glycoproteins that participate in the enterohepatic circulation of bile acids. Two homologous transporters are involved in the reabsorption of bile acids; the ileal sodium/bile acid cotransporter with an apical cell localization that absorbs bile acids from the intestinal lumen, bile duct and kidney, and the liver-specific sodium/bile acid cotransporter, represented by this protein, that is found in the basolateral membranes of hepatocytes. Bile acids are the catabolic product of cholesterol metabolism, hence this protein is important for cholesterol homeostasis. [provided by RefSeq, Oct 2011]

GeneCards Summary for SLC10A1 Gene

SLC10A1 (Solute Carrier Family 10 Member 1) is a Protein Coding gene. Diseases associated with SLC10A1 include Biliary Atresia and Hepatitis B. Among its related pathways are Metabolism and Drug Induction of Bile Acid Pathway. Gene Ontology (GO) annotations related to this gene include bile acid:sodium symporter activity and bile acid transmembrane transporter activity. An important paralog of this gene is SLC10A4.

UniProtKB/Swiss-Prot Summary for SLC10A1 Gene

  • The hepatic sodium/bile acid uptake system exhibits broad substrate specificity and transports various non-bile acid organic compounds as well. It is strictly dependent on the extracellular presence of sodium.
  • (Microbial infection) Acts as a receptor for hepatitis B virus.

Gene Wiki entry for SLC10A1 Gene

Additional gene information for SLC10A1 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for SLC10A1 Gene

Genomics for SLC10A1 Gene

GeneHancer (GH) Regulatory Elements for SLC10A1 Gene

Promoters and enhancers for SLC10A1 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH14J069797 Promoter/Enhancer 0.9 EPDnew Ensembl 750.6 -0.3 -312 1.6 HLF SP1 CEBPG CEBPA RXRA SOX13 JUND YY1 CEBPB NFIL3 lnc-CCDC177-5 SLC10A1 lnc-SRSF5-3
GH14J069995 Enhancer 1.5 FANTOM5 Ensembl ENCODE dbSUPER 10.3 -201.1 -201130 6.8 SREBF1 POLR2A CTBP1 ZNF362 RAD21 MNT NFIB BCL6B SP1 NCOA3 SMOC1 MED6 ADAM20 SRSF5 DCAF5 ERH SLC10A1 TTC9 SNORD169-001 lnc-SLC10A1-2
GH14J069573 Promoter/Enhancer 1.4 Ensembl ENCODE CraniofacialAtlas 10 +223.2 223157 1.7 CTCF RAD21 NKRF GLIS2 ZIC2 GATAD2A CTBP1 ZEB2 PATZ1 POLR2A CCDC177 SUSD6 SRSF5 SLC10A1 lnc-CCDC177-1 lnc-SUSD6-2
GH14J069739 Enhancer 1.1 Ensembl ENCODE dbSUPER 11.1 +56.6 56588 2.2 FOXA1 MLX NR2F6 ZNF217 MNT ELF3 SP1 KAT8 FOSL2 CREB1 HSALNG0102188 SUSD6 SLC10A1 ENSG00000221060 SYNJ2BP SRSF5
GH14J070002 Enhancer 1.1 Ensembl ENCODE dbSUPER 10.3 -205.6 -205563 0.3 ZBTB6 CTBP1 ZNF362 ZNF121 SP7 ZSCAN21 HNF1A ZNF644 PKNOX1 ZIC2 SMOC1 SLC10A1 EXD2 SNORD169-001 lnc-SLC10A1-2
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around SLC10A1 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the SLC10A1 gene promoter:
  • AP-1
  • ATF-2
  • c-Fos
  • c-Jun
  • c-Myc
  • Max1
  • PPAR-gamma1
  • STAT3

Genomic Locations for SLC10A1 Gene

Genomic Locations for SLC10A1 Gene
chr14:69,775,416-69,797,289
(GRCh38/hg38)
Size:
21,874 bases
Orientation:
Minus strand
chr14:70,242,134-70,264,006
(GRCh37/hg19)
Size:
21,873 bases
Orientation:
Minus strand

Genomic View for SLC10A1 Gene

Genes around SLC10A1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SLC10A1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SLC10A1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SLC10A1 Gene

Proteins for SLC10A1 Gene

  • Protein details for SLC10A1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q14973-NTCP_HUMAN
    Recommended name:
    Sodium/bile acid cotransporter
    Protein Accession:
    Q14973
    Secondary Accessions:
    • B9EGB6
    • Q2TU29

    Protein attributes for SLC10A1 Gene

    Size:
    349 amino acids
    Molecular mass:
    38119 Da
    Quaternary structure:
    • (Microbial infection) Interacts with hepatitis B virus large envelope protein.

neXtProt entry for SLC10A1 Gene

Post-translational modifications for SLC10A1 Gene

  • Glycosylation at Asn5, Asn11, Asn117, and Asn336
  • Modification sites at PhosphoSitePlus

Other Protein References for SLC10A1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for SLC10A1 Gene

Domains & Families for SLC10A1 Gene

Gene Families for SLC10A1 Gene

Protein Domains for SLC10A1 Gene

Suggested Antigen Peptide Sequences for SLC10A1 Gene

GenScript: Design optimal peptide antigens:
  • Solute carrier family 10 member 1 (NTCP_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q14973

UniProtKB/Swiss-Prot:

NTCP_HUMAN :
  • Belongs to the bile acid:sodium symporter (BASS) (TC 2.A.28) family.
Family:
  • Belongs to the bile acid:sodium symporter (BASS) (TC 2.A.28) family.
genes like me logo Genes that share domains with SLC10A1: view

Function for SLC10A1 Gene

Molecular function for SLC10A1 Gene

UniProtKB/Swiss-Prot Function:
The hepatic sodium/bile acid uptake system exhibits broad substrate specificity and transports various non-bile acid organic compounds as well. It is strictly dependent on the extracellular presence of sodium.
UniProtKB/Swiss-Prot Function:
(Microbial infection) Acts as a receptor for hepatitis B virus.
GENATLAS Biochemistry:
solute carrier family 10,38kDa,(sodium/taurocholate cotransport),member 1,hepatic

Phenotypes From GWAS Catalog for SLC10A1 Gene

Gene Ontology (GO) - Molecular Function for SLC10A1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001618 virus receptor activity IEA --
GO:0008508 bile acid:sodium symporter activity TAS --
GO:0015125 bile acid transmembrane transporter activity IEA --
GO:0015293 symporter activity IEA --
genes like me logo Genes that share ontologies with SLC10A1: view
genes like me logo Genes that share phenotypes with SLC10A1: view

Animal Model Products

  • Taconic Biosciences Mouse Models for SLC10A1

CRISPR Products

miRNA for SLC10A1 Gene

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for SLC10A1

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for SLC10A1 Gene

Localization for SLC10A1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SLC10A1 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SLC10A1 gene
Compartment Confidence
plasma membrane 5
nucleus 2
extracellular 1
cytoskeleton 1
endoplasmic reticulum 1
endosome 1
cytosol 1

Gene Ontology (GO) - Cellular Components for SLC10A1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane TAS 8132774
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
GO:0016323 basolateral plasma membrane IEA --
genes like me logo Genes that share ontologies with SLC10A1: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for SLC10A1 Gene

Pathways & Interactions for SLC10A1 Gene

genes like me logo Genes that share pathways with SLC10A1: view

Pathways by source for SLC10A1 Gene

2 KEGG pathways for SLC10A1 Gene
1 Qiagen pathway for SLC10A1 Gene
  • Hepatic ABC Transporters

Interacting Proteins for SLC10A1 Gene

Gene Ontology (GO) - Biological Process for SLC10A1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006811 ion transport IEA --
GO:0006814 sodium ion transport IEA --
GO:0015721 bile acid and bile salt transport TAS --
GO:0016032 viral process IEA --
GO:0046718 viral entry into host cell IEA --
genes like me logo Genes that share ontologies with SLC10A1: view

No data available for SIGNOR curated interactions for SLC10A1 Gene

Drugs & Compounds for SLC10A1 Gene

(29) Drugs for SLC10A1 Gene - From: DrugBank, DGIdb, IUPHAR, HMDB, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Cyclosporin A Approved, Investigational, Vet_approved Pharma Antagonist, Inhibition, Inhibitor, Transporter, inhibitor Immunosuppressive agent, Calcineurin inhibitor 0
Bumetanide Approved Pharma Agonist, Inhibition, Inhibitor, Transporter, substrate, inhibitor NKCC cotransporter inhibitor, Na+/2Cl-/K+ (NKCC) symporter inhibitor 25
cholic acid Approved Pharma Full agonist, Agonist, Transporter, substrate, inhibitor 0
deoxycholic acid Approved Pharma Antagonist, Full agonist, Agonist, Transporter, substrate 47
Ethinyl Estradiol Approved Pharma Transporter, inducer Oral contraceptive 823

(81) Additional Compounds for SLC10A1 Gene - From: HMDB, IUPHAR, and Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
sodium
  • Na(+)
  • Na+
  • SODIUM ion
7440-23-5
chenodeoxycholyl-N<sup>epsilon</sup>-nitrobenzoxadiazol-lysine
(3a,5b,7a)-23-Carboxy-7-hydroxy-24-norcholan-3-yl-b-D-Glucopyranosiduronic acid
  • Chenodeoxycholic acid 3-glucuronide
  • Chenodeoxycholic acid-3-b-D-glucuronide
  • Chenodeoxycholic acid-3-beta-delta-glucuronide
58814-71-4
1,3,12-Trihydroxycholan-24-oic acid
  • 1,3,12-Trihydroxy-5b-cholanoate
  • 1,3,12-Trihydroxy-5b-cholanoic acid
  • 1,3,12-Trihydroxy-cholan-24-Oate
  • 1,3,12-Trihydroxy-cholan-24-Oic acid
  • 1,3,12-Trihydroxycholan-24-Oate
63266-91-1
1,3,7,12-Tetrahydroxycholan-24-oic acid
  • 1,3,7,12-Tetrahydroxy-cholan-24-Oate
  • 1,3,7,12-Tetrahydroxy-cholan-24-Oic acid
  • 1,3,7,12-Tetrahydroxycholan-24-Oate
  • 1,3,7,12-Tetrahydroxycholanoate
  • 1,3,7,12-Tetrahydroxycholanoic acid
63266-89-7
genes like me logo Genes that share compounds with SLC10A1: view

Transcripts for SLC10A1 Gene

mRNA/cDNA for SLC10A1 Gene

(1) REFSEQ mRNAs :
(9) Additional mRNA sequences :
(19) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for SLC10A1

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for SLC10A1 Gene

No ASD Table

Relevant External Links for SLC10A1 Gene

GeneLoc Exon Structure for
SLC10A1
ECgene alternative splicing isoforms for
SLC10A1

Expression for SLC10A1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for SLC10A1 Gene

mRNA differential expression in normal tissues according to GTEx for SLC10A1 Gene

This gene is overexpressed in Liver (x51.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for SLC10A1 Gene



Protein tissue co-expression partners for SLC10A1 Gene

NURSA nuclear receptor signaling pathways regulating expression of SLC10A1 Gene:

SLC10A1

SOURCE GeneReport for Unigene cluster for SLC10A1 Gene:

Hs.952

Evidence on tissue expression from TISSUES for SLC10A1 Gene

  • Liver(4.9)
  • Nervous system(4.3)
  • Intestine(2.4)
  • Kidney(2.2)
genes like me logo Genes that share expression patterns with SLC10A1: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for SLC10A1 Gene

Orthologs for SLC10A1 Gene

This gene was present in the common ancestor of animals.

Orthologs for SLC10A1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SLC10A1 33 32
  • 99.14 (n)
OneToOne
dog
(Canis familiaris)
Mammalia SLC10A1 33 32
  • 86.82 (n)
OneToOne
cow
(Bos Taurus)
Mammalia SLC10A1 33 32
  • 85.99 (n)
OneToOne
rat
(Rattus norvegicus)
Mammalia Slc10a1 32
  • 82.46 (n)
mouse
(Mus musculus)
Mammalia Slc10a1 17 33 32
  • 81.63 (n)
oppossum
(Monodelphis domestica)
Mammalia SLC10A1 33
  • 75 (a)
OneToOne
chicken
(Gallus gallus)
Aves SLC10A1 33
  • 47 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia SLC10A1 33
  • 56 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100489580 32
  • 58.54 (n)
zebrafish
(Danio rerio)
Actinopterygii slc10a1 33 32
  • 60.37 (n)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG11655 33
  • 15 (a)
ManyToMany
CG9903 33
  • 14 (a)
ManyToMany
worm
(Caenorhabditis elegans)
Secernentea Y71G10AR.4 33
  • 17 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 33
  • 47 (a)
OneToOne
Species where no ortholog for SLC10A1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SLC10A1 Gene

ENSEMBL:
Gene Tree for SLC10A1 (if available)
TreeFam:
Gene Tree for SLC10A1 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for SLC10A1: view image

Paralogs for SLC10A1 Gene

Paralogs for SLC10A1 Gene

(3) SIMAP similar genes for SLC10A1 Gene using alignment to 2 proteins:

  • NTCP_HUMAN
  • K7PFC0_HUMAN
genes like me logo Genes that share paralogs with SLC10A1: view

Variants for SLC10A1 Gene

Sequence variations from dbSNP and Humsavar for SLC10A1 Gene

SNP ID Clin Chr 14 pos Variation AA Info Type
rs1566634876 uncertain-significance, Cholestasis, hepatic fibrosis, high serum bile salts, normal GGT 69,779,317(-) ACTGTGACGGC/ coding_sequence_variant, frameshift
rs2296651 benign, not specified, - 69,778,476(-) G/A coding_sequence_variant, missense_variant
rs76966244 uncertain-significance, not provided, Cholestasis, hepatic fibrosis, high serum bile salts, normal GGT 69,779,183(-) G/A/T coding_sequence_variant, missense_variant, synonymous_variant
rs148467625 likely-benign, not specified 69,796,893(-) A/G coding_sequence_variant, missense_variant
rs1020894026 uncertain-significance, not provided 69,779,341(-) A/G coding_sequence_variant, missense_variant

Structural Variations from Database of Genomic Variants (DGV) for SLC10A1 Gene

Variant ID Type Subtype PubMed ID
nsv456336 CNV gain 19166990
nsv565007 CNV gain 21841781

Variation tolerance for SLC10A1 Gene

Residual Variation Intolerance Score: 72.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.40; 54.32% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for SLC10A1 Gene

Human Gene Mutation Database (HGMD)
SLC10A1
SNPedia medical, phenotypic, and genealogical associations of SNPs for
SLC10A1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SLC10A1 Gene

Disorders for SLC10A1 Gene

MalaCards: The human disease database

(8) MalaCards diseases for SLC10A1 Gene - From: HGMD, DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
biliary atresia
  • atresia of bile duct
hepatitis b
  • chronic hepatitis b
hepatitis
  • hepatitis a
cholestasis
  • bile occlusion
pericholangitis
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for SLC10A1

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with SLC10A1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for SLC10A1 Gene

Publications for SLC10A1 Gene

  1. Molecular cloning, chromosomal localization, and functional characterization of a human liver Na+/bile acid cotransporter. (PMID: 8132774) Hagenbuch B … Meier PJ (The Journal of clinical investigation 1994) 2 3 4 56
  2. Sodium taurocholate cotransporting polypeptide is a functional receptor for human hepatitis B and D virus. (PMID: 23150796) Yan H … Li W (eLife 2012) 3 4 56
  3. Genetic risk factors for hepatopulmonary syndrome in patients with advanced liver disease. (PMID: 20346360) Roberts KE … Pulmonary Vascular Complications of Liver Disease Study Group (Gastroenterology 2010) 3 43 56
  4. L-type voltage-dependent calcium channel alpha subunit 1C is a novel candidate gene associated with secondary hyperparathyroidism: an application of haplotype-based analysis for multiple linked single nucleotide polymorphisms. (PMID: 20424473) Yokoyama K … Hosoya T (Nephron. Clinical practice 2010) 3 43 56
  5. Association study between single-nucleotide polymorphisms in 199 drug-related genes and commonly measured quantitative traits of 752 healthy Japanese subjects. (PMID: 19343046) Saito A … Kamatani N (Journal of human genetics 2009) 3 43 56

Products for SLC10A1 Gene

Sources for SLC10A1 Gene