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Aliases for SLAMF9 Gene

Aliases for SLAMF9 Gene

  • SLAM Family Member 9 2 3 5
  • CD2 Family Member 10 3 4
  • CD84 Homolog 1 3 4
  • CD2F-10 3 4
  • CD84-H1 3 4
  • CD2F10 3 4
  • Signaling Lymphocytic Activation Molecule Family Member 2001 3
  • Signaling Lymphocytic Activation Molecule Family Member 9 3
  • Cluster Of Differentiation 2 Antigen Family Member 10 3
  • Cluster Of Differentiation 84 Homolog 1 3
  • CD84H1 3
  • SF2001 3

External Ids for SLAMF9 Gene

Previous GeneCards Identifiers for SLAMF9 Gene

  • GC01M157138
  • GC01M156734
  • GC01M158187
  • GC01M159923
  • GC01M131277

Summaries for SLAMF9 Gene

Entrez Gene Summary for SLAMF9 Gene

  • This gene encodes a member of the signaling lymphocytic activation molecule family. The encoded protein is a cell surface molecule that consists of two extracellular immunoglobulin domains, a transmembrane domain and a short cytoplasmic tail that lacks the signal transduction motifs found in other family members. Alternative splicing results in multiple transcript variants.[provided by RefSeq, Apr 2009]

GeneCards Summary for SLAMF9 Gene

SLAMF9 (SLAM Family Member 9) is a Protein Coding gene. Diseases associated with SLAMF9 include Taeniasis. Gene Ontology (GO) annotations related to this gene include receptor activity. An important paralog of this gene is CD84.

UniProtKB/Swiss-Prot for SLAMF9 Gene

  • May play a role in the immune response.

Additional gene information for SLAMF9 Gene

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SLAMF9 Gene

Genomics for SLAMF9 Gene

GeneHancer (GH) Regulatory Elements for SLAMF9 Gene

Promoters and enhancers for SLAMF9 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH01I159953 Promoter/Enhancer 1 EPDnew Ensembl 550.8 +0.2 153 1 FOSL1 PKNOX1 IKZF1 CBFA2T3 CREM SLAMF9 LINC01133 IGSF9
GH01I159888 Enhancer 1.7 FANTOM5 Ensembl ENCODE dbSUPER 5.8 +63.8 63771 3 HDGF ATF1 SIN3A ZNF2 IRF4 GLIS2 ARID2 ZNF207 ZNF143 ATF7 ENSG00000272668 SLAMF8 SNHG28 FCRL6 VSIG8 ENSG00000212161 IGSF9 DUSP23 PIGM SLAMF9
GH01I159881 Enhancer 1.6 FANTOM5 Ensembl ENCODE dbSUPER 5.5 +72.1 72119 1.7 PKNOX1 SMAD1 ATF7 FOS DEK ZNF491 ZNF518A ZNF592 MAFF SMARCA4 RPSAP18 ENSG00000272668 SNHG28 LOC100287049 SLAMF8 PIGM DCAF8 CADM3 CADM3-AS1 COPA
GH01I160427 Enhancer 1.6 FANTOM5 Ensembl ENCODE dbSUPER 3.3 -476.4 -476386 6 HDGF HDAC1 PKNOX1 SMAD1 BATF IRF4 RAD21 ZBTB40 ZNF766 ARID2 VANGL2 SLAMF7 SLAMF1 NCSTN ENSG00000228863 NHLH1 ITLN1 CD48 CD244 LY9
GH01I159848 Enhancer 1.1 FANTOM5 Ensembl ENCODE dbSUPER 4.4 +104.7 104727 1.9 CEBPB FOS ENSG00000272668 SLAMF9 SLAMF8 TAGLN2 ENSG00000212161 GC01M159852 GC01M159841 SNHG28
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around SLAMF9 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the SLAMF9 gene promoter:

Genomic Locations for SLAMF9 Gene

Genomic Locations for SLAMF9 Gene
2,763 bases
Minus strand

Genomic View for SLAMF9 Gene

Genes around SLAMF9 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SLAMF9 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SLAMF9 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SLAMF9 Gene

Proteins for SLAMF9 Gene

  • Protein details for SLAMF9 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    SLAM family member 9
    Protein Accession:
    Secondary Accessions:
    • Q5JRQ9
    • Q5JRR0
    • Q6UWG1

    Protein attributes for SLAMF9 Gene

    289 amino acids
    Molecular mass:
    32436 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for SLAMF9 Gene


neXtProt entry for SLAMF9 Gene

Post-translational modifications for SLAMF9 Gene

  • Glycosylation at posLast=9999 and isoforms=208

Other Protein References for SLAMF9 Gene

Antibody Products

  • R&D Systems Antibodies for SLAMF9 (CD2F-10/SLAMF9)
  • Abcam antibodies for SLAMF9

No data available for DME Specific Peptides for SLAMF9 Gene

Domains & Families for SLAMF9 Gene

Gene Families for SLAMF9 Gene

Human Protein Atlas (HPA):
  • Predicted membrane proteins

Protein Domains for SLAMF9 Gene

Suggested Antigen Peptide Sequences for SLAMF9 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with SLAMF9: view

No data available for UniProtKB/Swiss-Prot for SLAMF9 Gene

Function for SLAMF9 Gene

Molecular function for SLAMF9 Gene

UniProtKB/Swiss-Prot Function:
May play a role in the immune response.

Phenotypes From GWAS Catalog for SLAMF9 Gene

Gene Ontology (GO) - Molecular Function for SLAMF9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
genes like me logo Genes that share ontologies with SLAMF9: view
genes like me logo Genes that share phenotypes with SLAMF9: view

Animal Model Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for SLAMF9 Gene

Localization for SLAMF9 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SLAMF9 Gene

Membrane; Single-pass type I membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SLAMF9 gene
Compartment Confidence
plasma membrane 3
extracellular 2
peroxisome 1
endoplasmic reticulum 1

Gene Ontology (GO) - Cellular Components for SLAMF9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with SLAMF9: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for SLAMF9 Gene

Pathways & Interactions for SLAMF9 Gene

SuperPathways for SLAMF9 Gene

No Data Available

Gene Ontology (GO) - Biological Process for SLAMF9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008150 biological_process ND --
genes like me logo Genes that share ontologies with SLAMF9: view

No data available for Pathways by source and SIGNOR curated interactions for SLAMF9 Gene

Drugs & Compounds for SLAMF9 Gene

No Compound Related Data Available

Transcripts for SLAMF9 Gene

Unigene Clusters for SLAMF9 Gene

SLAM family member 9:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for SLAMF9 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3 ^ 4a · 4b · 4c
SP2: -
SP3: - -

Relevant External Links for SLAMF9 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for SLAMF9 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for SLAMF9 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SLAMF9 Gene

This gene is overexpressed in Liver (x9.8), Whole Blood (x6.5), and Testis (x6.5).

NURSA nuclear receptor signaling pathways regulating expression of SLAMF9 Gene:


SOURCE GeneReport for Unigene cluster for SLAMF9 Gene:


mRNA Expression by UniProt/SwissProt for SLAMF9 Gene:

Tissue specificity: Expression is predominantly restricted in hematopoietic tissues. Expressed in heart, spleen, liver, intestine, muscle and testis. Expressed in immune cells, including monocytes, dendritic, B- and T-cells. No expression was seen in peripheral blood leukocytes. Expressed in the leukocyte cell line THP-1.
genes like me logo Genes that share expression patterns with SLAMF9: view

No data available for Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for SLAMF9 Gene

Orthologs for SLAMF9 Gene

This gene was present in the common ancestor of mammals.

Orthologs for SLAMF9 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia SLAMF9 33 34
  • 97.46 (n)
(Bos Taurus)
Mammalia SLAMF9 33 34
  • 81.14 (n)
(Rattus norvegicus)
Mammalia Slamf9 33
  • 75.13 (n)
(Canis familiaris)
Mammalia SLAMF9 33 34
  • 74.87 (n)
(Mus musculus)
Mammalia Slamf9 33 16 34
  • 74.74 (n)
(Monodelphis domestica)
Mammalia SLAMF9 34
  • 36 (a)
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 29 (a)
Species where no ortholog for SLAMF9 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for SLAMF9 Gene

Gene Tree for SLAMF9 (if available)
Gene Tree for SLAMF9 (if available)

Paralogs for SLAMF9 Gene

Paralogs for SLAMF9 Gene

(3) SIMAP similar genes for SLAMF9 Gene using alignment to 2 proteins: Pseudogenes for SLAMF9 Gene

genes like me logo Genes that share paralogs with SLAMF9: view

Variants for SLAMF9 Gene

Sequence variations from dbSNP and Humsavar for SLAMF9 Gene

SNP ID Clin Chr 01 pos Variation AA Info Type
rs1000112455 -- 159,959,215(-) A/C genic_upstream_transcript_variant, intron_variant
rs1000185291 -- 159,956,047(-) C/T genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant
rs1000303860 -- 159,957,499(-) C/T genic_upstream_transcript_variant, intron_variant
rs1000322597 -- 159,951,494(-) G/A 3_prime_UTR_variant
rs1000359271 -- 159,961,602(-) A/C genic_upstream_transcript_variant, intron_variant

Structural Variations from Database of Genomic Variants (DGV) for SLAMF9 Gene

Variant ID Type Subtype PubMed ID
nsv548055 CNV loss 21841781
nsv524006 CNV gain 19592680
nsv520773 CNV loss 19592680
esv3587705 CNV loss 21293372
esv3578219 CNV loss 25503493

Variation tolerance for SLAMF9 Gene

Residual Variation Intolerance Score: 56.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.21; 69.85% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for SLAMF9 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SLAMF9 Gene

Disorders for SLAMF9 Gene

MalaCards: The human disease database

(1) MalaCards diseases for SLAMF9 Gene - From: DISEASES

Disorder Aliases PubMed IDs
  • beef tapeworm infection
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for SLAMF9

genes like me logo Genes that share disorders with SLAMF9: view

No data available for UniProtKB/Swiss-Prot and Genatlas for SLAMF9 Gene

Publications for SLAMF9 Gene

  1. CD2F-10: a new member of the CD2 subset of the immunoglobulin superfamily. (PMID: 11685473) Fennelly JA … Evans EJ (Immunogenetics 2001) 2 3 4 58
  2. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory SG … Prigmore E (Nature 2006) 3 4 58
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  4. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark HF … Gray A (Genome research 2003) 3 4 58
  5. Genetic approach to insight into the immunobiology of human dendritic cells and identification of CD84-H1, a novel CD84 homologue. (PMID: 11300479) Zhang W … Cao X (Clinical cancer research : an official journal of the American Association for Cancer Research 2001) 3 4 58

Products for SLAMF9 Gene

Sources for SLAMF9 Gene

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