Aliases for SLAMF1 Gene

Aliases for SLAMF1 Gene

  • Signaling Lymphocytic Activation Molecule Family Member 1 2 3 5
  • Signaling Lymphocytic Activation Molecule 2 3 4
  • SLAM Family Member 1 3 4
  • CDw150 3 4
  • IPO-3 3 4
  • SLAM 3 4
  • CD150 Antigen 4
  • CD150 3

External Ids for SLAMF1 Gene

Previous HGNC Symbols for SLAMF1 Gene

  • SLAM

Previous GeneCards Identifiers for SLAMF1 Gene

  • GC01M157796
  • GC01M157392
  • GC01M158844
  • GC01M160577
  • GC01M131936

Summaries for SLAMF1 Gene

GeneCards Summary for SLAMF1 Gene

SLAMF1 (Signaling Lymphocytic Activation Molecule Family Member 1) is a Protein Coding gene. Diseases associated with SLAMF1 include Measles and Subacute Sclerosing Panencephalitis. Among its related pathways are Dendritic Cells Developmental Lineage Pathway and T Cell Co-Signaling Pathway: Ligand-Receptor Interactions. Gene Ontology (GO) annotations related to this gene include antigen binding. An important paralog of this gene is LY9.

UniProtKB/Swiss-Prot Summary for SLAMF1 Gene

  • Self-ligand receptor of the signaling lymphocytic activation molecule (SLAM) family. SLAM receptors triggered by homo- or heterotypic cell-cell interactions are modulating the activation and differentiation of a wide variety of immune cells and thus are involved in the regulation and interconnection of both innate and adaptive immune response. Activities are controlled by presence or absence of small cytoplasmic adapter proteins, SH2D1A/SAP and/or SH2D1B/EAT-2. SLAMF1-induced signal-transduction events in T-lymphocytes are different from those in B-cells. Two modes of SLAMF1 signaling seem to exist: one depending on SH2D1A (and perhaps SH2D1B) and another in which protein-tyrosine phosphatase 2C (PTPN11)-dependent signal transduction operates. Initially it has been proposed that association with SH2D1A prevents binding to inhibitory effectors including INPP5D/SHIP1 and PTPN11/SHP-2 (PubMed:11806999). However, signaling is also regulated by SH2D1A which can simultaneously interact with and recruit FYN which subsequently phosphorylates and activates SLAMF1 (PubMed:12458214). Mediates IL-2-independent proliferation of activated T-cells during immune responses and induces IFN-gamma production (By similarity). Downstreaming signaling involves INPP5D, DOK1 and DOK2 leading to inhibited IFN-gamma production in T-cells, and PRKCQ, BCL10 and NFKB1 leading to increased T-cell activation and Th2 cytokine production (By similarity). Promotes T-cell receptor-induced IL-4 secretion by CD4(+) cells (By similarity). Inhibits antigen receptor-mediated production of IFN-gamma, but not IL-2, in CD4(-)/CD8(-) T-cells (By similarity). Required for IL-4 production by germinal centers T follicular helper (T(Fh))cells (By similarity). May inhibit CD40-induced signal transduction in monocyte-derived dendritic cells (PubMed:16317102). May play a role in allergic responses and may regulate allergen-induced Th2 cytokine and Th1 cytokine secretion (By similarity). In conjunction with SLAMF6 controls the transition between positive selection and the subsequent expansion and differentiation of the thymocytic natural killer T (NKT) cell lineage. Involved in the peripheral differentiation of indifferent natural killer T (iNKT) cells toward a regulatory NKT2 type (By similarity). In macrophages involved in down-regulation of IL-12, TNF-alpha and nitric oxide in response to lipopolysaccharide (LPS) (By similarity). In B-cells activates the ERK signaling pathway independently of SH2D1A but implicating both, SYK and INPP5D, and activates Akt signaling dependent on SYK and SH2D1A (By similarity). In B-cells also activates p38 MAPK and JNK1 and JNK2 (PubMed:20231852). In conjunction with CD84/SLAMF5 and SLAMF6 may be a negative regulator of the humoral immune response (By similarity). Involved in innate immune response against Gram-negative bacteria in macrophages; probably recognizes OmpC and/or OmpF on the bacterial surface, regulates phagosome maturation and recruitment of the PI3K complex II (PI3KC3-C2) leading to accumulation of PdtIns(3)P and NOX2 activity in the phagosomes (PubMed:20818396).
  • (Microbial infection) Acts as a receptor for Measles virus; also including isoform 4.

Gene Wiki entry for SLAMF1 Gene

Additional gene information for SLAMF1 Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for SLAMF1 Gene

Genomics for SLAMF1 Gene

GeneHancer (GH) Regulatory Elements for SLAMF1 Gene

Promoters and enhancers for SLAMF1 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH01J160635 Promoter/Enhancer 1.9 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 506.4 +5.4 5363 12.9 SIN3A SP1 POLR2A RELA RCOR1 TRIM22 TEAD1 NFYB TCF12 CBFB SLAMF1 ENSG00000228863 SETP9 ENSG00000237409 PPOX SLAMF6 CD48 piR-50968-010
GH01J160538 Promoter/Enhancer 1.7 FANTOM5 Ensembl ENCODE dbSUPER 16.3 +105.9 105912 7.2 ZBTB40 CTCF SIN3A SP1 NCOR1 GTF2E2 PHB2 EP300 ZBTB11 AFF1 CD84 SLAMF1 VANGL2 PPOX ENSG00000228863 SLAMF8 TSTD1 SLAMF6 CD48 DCAF8
GH01J160703 Promoter/Enhancer 2 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 11 -62.0 -62004 11.8 SIN3A SP1 ZNF623 CTCF RELA MEF2C RCOR1 TRIM22 POLR2A MCM3 CD48 SLAMF7 CD244 DEDD NCSTN ENSG00000228863 SLAMF1 LY9 LINC01133 ITLN1
GH01J160573 Promoter/Enhancer 1.9 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 10.4 +70.5 70494 6.3 SIN3A JUND ZBTB11 POLR2A ZNF316 ARNT CREB3L1 ZKSCAN1 FOS IRF1 CD84 SLAMF7 VANGL2 SLAMF6 SLAMF1 CD48 CD244 ATP1A4 piR-32810-007
GH01J160399 Promoter/Enhancer 1.8 Ensembl ENCODE CraniofacialAtlas 9.8 +246.0 246026 4.2 HNRNPK EP300 JUND ZNF639 ZIC2 ZBTB10 ZNF423 ZBTB26 REST ZNF740 VANGL2 NCSTN SLAMF1 IGSF8 HSALNG0007839 LOC105371466
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around SLAMF1 on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for SLAMF1

Top Transcription factor binding sites by QIAGEN in the SLAMF1 gene promoter:
  • AP-2alpha
  • AP-2alpha isoform 2
  • AP-2alpha isoform 3
  • AP-2alpha isoform 4
  • AREB6
  • ATF-2
  • CRE-BP1
  • IRF-7A
  • MyoD

Genomic Locations for SLAMF1 Gene

Genomic Locations for SLAMF1 Gene
chr1:160,608,106-160,647,537
(GRCh38/hg38)
Size:
39,432 bases
Orientation:
Minus strand
chr1:160,577,890-160,617,085
(GRCh37/hg19)
Size:
39,196 bases
Orientation:
Minus strand

Genomic View for SLAMF1 Gene

Genes around SLAMF1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SLAMF1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SLAMF1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SLAMF1 Gene

Proteins for SLAMF1 Gene

  • Protein details for SLAMF1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q13291-SLAF1_HUMAN
    Recommended name:
    Signaling lymphocytic activation molecule
    Protein Accession:
    Q13291
    Secondary Accessions:
    • Q5W172
    • Q9HBE8
    • W0HKK7

    Protein attributes for SLAMF1 Gene

    Size:
    335 amino acids
    Molecular mass:
    37231 Da
    Quaternary structure:
    • Interacts (via cytoplasmic domain) with SH2D1A and SH2D1B; SH2D1A mediates association with FYN; SH2D1A binds to phosphorylated and not phosphorylated ITSM 1 (PubMed:9774102, PubMed:11313386, PubMed:11806999, PubMed:12458214). Interacts (via cytoplasmic domain phosphorylated on tyrosine residues) with INPP5D and PTPN11; presence of SH2D1A facilitates binding to INPP5D (PubMed:11313386, PubMed:12458214). Interacts with MAP4K1 (PubMed:20231852). Interacts with PIK3C3, BECN1 and UVRAG; indicative for an association with PI3K complex II (PI3KC3-C2) (PubMed:20818396).
    • (Microbial infection) Interacts with measles hemagglutinin protein.

    Three dimensional structures from OCA and Proteopedia for SLAMF1 Gene

    Alternative splice isoforms for SLAMF1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SLAMF1 Gene

Post-translational modifications for SLAMF1 Gene

  • Phosphorylated on tyrosine residues by FYN.
  • Glycosylation at Asn53, Asn57, Asn102, Asn125, Asn150, Asn155, Asn189, and Asn217
  • Modification sites at PhosphoSitePlus

Other Protein References for SLAMF1 Gene

Antibody Products

Assay Products

  • Boster Bio ELISA Kits for SLAMF1
  • Signalway ELISA kits for SLAMF1

No data available for DME Specific Peptides for SLAMF1 Gene

Domains & Families for SLAMF1 Gene

Gene Families for SLAMF1 Gene

HGNC:
Human Protein Atlas (HPA):
  • CD markers
  • Predicted membrane proteins
  • Predicted secreted proteins

Protein Domains for SLAMF1 Gene

Suggested Antigen Peptide Sequences for SLAMF1 Gene

GenScript: Design optimal peptide antigens:
  • cDNA FLJ57169, highly similar to Signaling lymphocytic activation molecule (B4E2E4_HUMAN)
  • Signaling lymphocytic activation molecule (Q9HBE7_HUMAN)
  • Signaling lymphocytic activation molecule (Q9HBE8_HUMAN)
  • Signaling lymphocytic activation molecule (Q9HBE9_HUMAN)
  • IPO-3 (SLAF1_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q13291

UniProtKB/Swiss-Prot:

SLAF1_HUMAN :
  • The ITSMs (immunoreceptor tyrosine-based switch motifs) with the consensus sequence T-X-Y-X-X-[VI] present in SLAM family receptors have overlapping specificity for activating and inhibitory SH2 domain-containing binding partners. Especially they mediate the interaction with the SH2 domain of SH2D1A and SH2D1B. For SLAMF1 a 'two-out-of-three-pronged' mechanism is proposed involving threonine (position -2), phosphorylated tyrosine (position 0) and valine/isoleucine (position +3). SH2D1A binding is mediated by either three 'prongs' (for high affinity binding involving ITSM 1) or a combination of any two also including non-phosphorylated Tyr-281 of ITSM 1 thus providing a positive feedback loop implicating SH2D1A-dependent recruitment of activating FYN. ITSM 2 needs to be phosphorylated on Tyr-327 for SH2D1A binding.
Domain:
  • The ITSMs (immunoreceptor tyrosine-based switch motifs) with the consensus sequence T-X-Y-X-X-[VI] present in SLAM family receptors have overlapping specificity for activating and inhibitory SH2 domain-containing binding partners. Especially they mediate the interaction with the SH2 domain of SH2D1A and SH2D1B. For SLAMF1 a 'two-out-of-three-pronged' mechanism is proposed involving threonine (position -2), phosphorylated tyrosine (position 0) and valine/isoleucine (position +3). SH2D1A binding is mediated by either three 'prongs' (for high affinity binding involving ITSM 1) or a combination of any two also including non-phosphorylated Tyr-281 of ITSM 1 thus providing a positive feedback loop implicating SH2D1A-dependent recruitment of activating FYN. ITSM 2 needs to be phosphorylated on Tyr-327 for SH2D1A binding.
genes like me logo Genes that share domains with SLAMF1: view

Function for SLAMF1 Gene

Molecular function for SLAMF1 Gene

UniProtKB/Swiss-Prot Function:
Self-ligand receptor of the signaling lymphocytic activation molecule (SLAM) family. SLAM receptors triggered by homo- or heterotypic cell-cell interactions are modulating the activation and differentiation of a wide variety of immune cells and thus are involved in the regulation and interconnection of both innate and adaptive immune response. Activities are controlled by presence or absence of small cytoplasmic adapter proteins, SH2D1A/SAP and/or SH2D1B/EAT-2. SLAMF1-induced signal-transduction events in T-lymphocytes are different from those in B-cells. Two modes of SLAMF1 signaling seem to exist: one depending on SH2D1A (and perhaps SH2D1B) and another in which protein-tyrosine phosphatase 2C (PTPN11)-dependent signal transduction operates. Initially it has been proposed that association with SH2D1A prevents binding to inhibitory effectors including INPP5D/SHIP1 and PTPN11/SHP-2 (PubMed:11806999). However, signaling is also regulated by SH2D1A which can simultaneously interact with and recruit FYN which subsequently phosphorylates and activates SLAMF1 (PubMed:12458214). Mediates IL-2-independent proliferation of activated T-cells during immune responses and induces IFN-gamma production (By similarity). Downstreaming signaling involves INPP5D, DOK1 and DOK2 leading to inhibited IFN-gamma production in T-cells, and PRKCQ, BCL10 and NFKB1 leading to increased T-cell activation and Th2 cytokine production (By similarity). Promotes T-cell receptor-induced IL-4 secretion by CD4(+) cells (By similarity). Inhibits antigen receptor-mediated production of IFN-gamma, but not IL-2, in CD4(-)/CD8(-) T-cells (By similarity). Required for IL-4 production by germinal centers T follicular helper (T(Fh))cells (By similarity). May inhibit CD40-induced signal transduction in monocyte-derived dendritic cells (PubMed:16317102). May play a role in allergic responses and may regulate allergen-induced Th2 cytokine and Th1 cytokine secretion (By similarity). In conjunction with SLAMF6 controls the transition between positive selection and the subsequent expansion and differentiation of the thymocytic natural killer T (NKT) cell lineage. Involved in the peripheral differentiation of indifferent natural killer T (iNKT) cells toward a regulatory NKT2 type (By similarity). In macrophages involved in down-regulation of IL-12, TNF-alpha and nitric oxide in response to lipopolysaccharide (LPS) (By similarity). In B-cells activates the ERK signaling pathway independently of SH2D1A but implicating both, SYK and INPP5D, and activates Akt signaling dependent on SYK and SH2D1A (By similarity). In B-cells also activates p38 MAPK and JNK1 and JNK2 (PubMed:20231852). In conjunction with CD84/SLAMF5 and SLAMF6 may be a negative regulator of the humoral immune response (By similarity). Involved in innate immune response against Gram-negative bacteria in macrophages; probably recognizes OmpC and/or OmpF on the bacterial surface, regulates phagosome maturation and recruitment of the PI3K complex II (PI3KC3-C2) leading to accumulation of PdtIns(3)P and NOX2 activity in the phagosomes (PubMed:20818396).
UniProtKB/Swiss-Prot Function:
(Microbial infection) Acts as a receptor for Measles virus; also including isoform 4.

Phenotypes From GWAS Catalog for SLAMF1 Gene

Gene Ontology (GO) - Molecular Function for SLAMF1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001618 virus receptor activity IEA --
GO:0003823 antigen binding TAS 7617038
GO:0004888 transmembrane signaling receptor activity TAS 7617038
GO:0005515 protein binding IPI 9774102
GO:0038023 signaling receptor activity IEA --
genes like me logo Genes that share ontologies with SLAMF1: view
genes like me logo Genes that share phenotypes with SLAMF1: view

Animal Models for SLAMF1 Gene

MGI Knock Outs for SLAMF1:

Animal Model Products

CRISPR Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for SLAMF1 Gene

Localization for SLAMF1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SLAMF1 Gene

Cell membrane; Single-pass type I membrane protein. Note=Present on the surface of B-cells and T-cells. Located at the plasma membrane contacts between neighboring T-cells (PubMed:11806999). {ECO:0000269 PubMed:11806999}.
[Isoform 3]: Secreted.
[Isoform 4]: Cell membrane. Note=Overexpressed isoform 4 is detected on the cell surface. In glioma cell lines endogenuous isoform 4 is detetced predominantly in the cytoplasm and colocalized with endoplasmic reticulum and Golgi markers. {ECO:0000269 PubMed:25710480}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SLAMF1 gene
Compartment Confidence
plasma membrane 5
extracellular 2
cytoskeleton 2
mitochondrion 2
nucleus 2
endoplasmic reticulum 2
endosome 2
cytosol 2
lysosome 2
peroxisome 1
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for SLAMF1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
GO:0005886 plasma membrane IEA --
GO:0009986 cell surface IEA --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with SLAMF1: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for SLAMF1 Gene

Pathways & Interactions for SLAMF1 Gene

genes like me logo Genes that share pathways with SLAMF1: view

SIGNOR curated interactions for SLAMF1 Gene

Is activated by:
Other effect:

Gene Ontology (GO) - Biological Process for SLAMF1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002250 adaptive immune response IEA --
GO:0002277 myeloid dendritic cell activation involved in immune response IDA 16317102
GO:0002376 immune system process IEA --
GO:0006909 phagocytosis IEA --
GO:0007155 cell adhesion IEA --
genes like me logo Genes that share ontologies with SLAMF1: view

Drugs & Compounds for SLAMF1 Gene

(2) Drugs for SLAMF1 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(1) Additional Compounds for SLAMF1 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with SLAMF1: view

Transcripts for SLAMF1 Gene

mRNA/cDNA for SLAMF1 Gene

2 REFSEQ mRNAs :
15 NCBI additional mRNA sequence :
4 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for SLAMF1 Gene

ExUns: 1a · 1b ^ 2a · 2b · 2c ^ 3a · 3b ^ 4 ^ 5 ^ 6a · 6b ^ 7a · 7b · 7c
SP1: - -
SP2: - - - -
SP3: -
SP4:
SP5:

Relevant External Links for SLAMF1 Gene

GeneLoc Exon Structure for
SLAMF1

Expression for SLAMF1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for SLAMF1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for SLAMF1 Gene

This gene is overexpressed in Plasma (38.6), Peripheral blood mononuclear cells (9.2), CD8 Tcells (8.4), and Blymphocyte (6.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for SLAMF1 Gene



Protein tissue co-expression partners for SLAMF1 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for SLAMF1

SOURCE GeneReport for Unigene cluster for SLAMF1 Gene:

Hs.523660

mRNA Expression by UniProt/SwissProt for SLAMF1 Gene:

Q13291-SLAF1_HUMAN
Tissue specificity: Constitutively expressed on peripheral blood memory T-cells, T-cell clones, immature thymocytes and a proportion of B-cells, and is rapidly induced on naive T-cells after activation (PubMed:7617038). Activated B-cells express isoform 1, isoform 3 and a cytoplasmic isoform (PubMed:9091591). Isoform 4 is expressed in B-cells, primary T-cells, dendritic cells and macrophages. Isoform 4 is expressed in tumors of the central nervous system (PubMed:25710480).

Evidence on tissue expression from TISSUES for SLAMF1 Gene

  • Blood(4.5)
  • Lymph node(2.7)
  • Spleen(2.5)
  • Bone marrow(2.2)
genes like me logo Genes that share expression patterns with SLAMF1: view

No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for SLAMF1 Gene

Orthologs for SLAMF1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for SLAMF1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SLAMF1 31 30
  • 99.8 (n)
OneToOne
cow
(Bos Taurus)
Mammalia SLAMF1 31 30
  • 78.64 (n)
OneToOne
dog
(Canis familiaris)
Mammalia SLAMF1 30
  • 78.41 (n)
SLAM 31
  • 65 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Slamf1 17 31 30
  • 74.83 (n)
rat
(Rattus norvegicus)
Mammalia Slamf1 30
  • 72.94 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia SLAMF1 31
  • 31 (a)
OneToOne
chicken
(Gallus gallus)
Aves SLAMF1 31 30
  • 47.12 (n)
OneToOne
Species where no ortholog for SLAMF1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for SLAMF1 Gene

ENSEMBL:
Gene Tree for SLAMF1 (if available)
TreeFam:
Gene Tree for SLAMF1 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for SLAMF1: view image

Paralogs for SLAMF1 Gene

Paralogs for SLAMF1 Gene

(1) SIMAP similar genes for SLAMF1 Gene using alignment to 4 proteins:

  • SLAF1_HUMAN
  • B4E2E4_HUMAN
  • E7ET99_HUMAN
  • W0HKK7_HUMAN
genes like me logo Genes that share paralogs with SLAMF1: view

Variants for SLAMF1 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for SLAMF1 Gene

SNP ID Clinical significance and condition Chr 01 pos Variation AA Info Type
717815 Benign: not provided 160,612,502(-) G/A MISSENSE_VARIANT,NON_CODING_TRANSCRIPT_VARIANT,SYNONYMOUS_VARIANT
720023 Benign: not provided 160,612,529(-) T/C MISSENSE_VARIANT,NON_CODING_TRANSCRIPT_VARIANT,SYNONYMOUS_VARIANT
726708 Likely Benign: not provided 160,637,394(-) T/C MISSENSE_VARIANT,NON_CODING_TRANSCRIPT_VARIANT
rs1373814964 A breast cancer sample p.Leu81Phe
rs2295612 - p.Phe11Leu

Additional dbSNP identifiers (rs#s) for SLAMF1 Gene

Structural Variations from Database of Genomic Variants (DGV) for SLAMF1 Gene

Variant ID Type Subtype PubMed ID
nsv831703 CNV gain 17160897
nsv831714 CNV gain 17160897

Variation tolerance for SLAMF1 Gene

Residual Variation Intolerance Score: 41.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.99; 68.28% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for SLAMF1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
SLAMF1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SLAMF1 Gene

Disorders for SLAMF1 Gene

MalaCards: The human disease database

(18) MalaCards diseases for SLAMF1 Gene - From: DISEASES, Novoseek, and GeneCards

- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for SLAMF1

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with SLAMF1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for SLAMF1 Gene

Publications for SLAMF1 Gene

  1. SLAM/SLAM interactions inhibit CD40-induced production of inflammatory cytokines in monocyte-derived dendritic cells. (PMID: 16317102) Réthi B … Lányi A (Blood 2006) 3 4 23 54
  2. Dual functional roles for the X-linked lymphoproliferative syndrome gene product SAP/SH2D1A in signaling through the signaling lymphocyte activation molecule (SLAM) family of immune receptors. (PMID: 12458214) Li C … Li SS (The Journal of biological chemistry 2003) 3 4 23 54
  3. SAP couples Fyn to SLAM immune receptors. (PMID: 12545174) Chan B … Eck MJ (Nature cell biology 2003) 3 4 23 54
  4. Absence of SLAM mutations in EBV-associated lymphoproliferative disease patients. (PMID: 12629654) Ferrand V … Yin L (Journal of medical virology 2003) 3 4 41 54
  5. Molecular dissection of the signaling and costimulatory functions of CD150 (SLAM): CD150/SAP binding and CD150-mediated costimulation. (PMID: 11806999) Howie D … Terhorst C (Blood 2002) 3 4 23 54

Products for SLAMF1 Gene

Sources for SLAMF1 Gene