Free for academic non-profit institutions. Other users need a Commercial license

Aliases for SLAIN2 Gene

Aliases for SLAIN2 Gene

  • SLAIN Motif Family Member 2 2 3 5
  • KIAA1458 2 3 4
  • SLAIN Motif-Containing Protein 2 3

External Ids for SLAIN2 Gene

Previous HGNC Symbols for SLAIN2 Gene

  • KIAA1458

Previous GeneCards Identifiers for SLAIN2 Gene

  • GC04P047991
  • GC04P047663

Summaries for SLAIN2 Gene

GeneCards Summary for SLAIN2 Gene

SLAIN2 (SLAIN Motif Family Member 2) is a Protein Coding gene. An important paralog of this gene is SLAIN1.

UniProtKB/Swiss-Prot for SLAIN2 Gene

  • Binds to the plus end of microtubules and regulates microtubule dynamics and microtubule organization. Promotes cytoplasmic microtubule nucleation and elongation. Required for normal structure of the microtubule cytoskeleton during interphase.

Additional gene information for SLAIN2 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SLAIN2 Gene

Genomics for SLAIN2 Gene

GeneHancer (GH) Regulatory Elements for SLAIN2 Gene

Promoters and enhancers for SLAIN2 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH04J048336 Promoter/Enhancer 2.3 EPDnew FANTOM5 Ensembl ENCODE 658.2 -1.0 -1035 6.9 HDGF SMAD1 ARNT ARID4B SIN3A DMAP1 YY1 POLR2B ZNF766 ZNF143 SLAIN2 TEC ZAR1 TXK SLC10A4 GC04M048339 GC04M048291
GH04J048267 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE dbSUPER 654.8 -71.8 -71765 4.1 HDGF PKNOX1 SMAD1 ARID4B SIN3A DMAP1 ZNF2 IRF4 YY1 POLR2B TEC SLAIN2 LOC105374445 GC04M048219
GH04J048775 Promoter/Enhancer 2.4 EPDnew Ensembl ENCODE dbSUPER 23.6 +437.1 437112 6.8 PKNOX1 FOXA2 SMAD1 ARID4B SIN3A FEZF1 YY1 POLR2B ZNF766 ZNF207 FRYL OCIAD1 SLAIN2 NFXL1 TEC SLC10A4 GC04P048658
GH04J048209 Enhancer 1.3 Ensembl ENCODE dbSUPER 6.3 -129.7 -129694 3.6 HDGF ATF1 PKNOX1 SMAD1 ARNT IRF4 YY1 TCF12 ZNF766 CBX5 TEC SLAIN2 NFXL1 PIR56443 GC04M048219
GH04J048234 Enhancer 0.6 dbSUPER 12.9 -106.4 -106350 0.9 ZNF639 ZNF687 ZNF740 CAVIN1 SOX6 DPF2 ZBTB40 GTF2A2 ZNF592 GABPB1 SLAIN2 TXK TEC GC04M048219
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around SLAIN2 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the SLAIN2 gene promoter:
  • Nkx2-2
  • E2F-5
  • E2F-4
  • E2F-3a
  • E2F-2
  • E2F-1
  • E2F
  • HOXA5
  • Pbx1a
  • ARP-1

Genomic Locations for SLAIN2 Gene

Genomic Locations for SLAIN2 Gene
chr4:48,341,322-48,426,212
(GRCh38/hg38)
Size:
84,891 bases
Orientation:
Plus strand
chr4:48,343,339-48,428,229
(GRCh37/hg19)
Size:
84,891 bases
Orientation:
Plus strand

Genomic View for SLAIN2 Gene

Genes around SLAIN2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SLAIN2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SLAIN2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SLAIN2 Gene

Proteins for SLAIN2 Gene

  • Protein details for SLAIN2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9P270-SLAI2_HUMAN
    Recommended name:
    SLAIN motif-containing protein 2
    Protein Accession:
    Q9P270
    Secondary Accessions:
    • A8K4P1
    • Q8N5R3

    Protein attributes for SLAIN2 Gene

    Size:
    581 amino acids
    Molecular mass:
    62543 Da
    Quaternary structure:
    • Interacts with CLIP1, CLIP2, CKAP5, CLASP1, MAPRE1 and MAPRE3.
    SequenceCaution:
    • Sequence=AAH31691.2; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAA95982.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for SLAIN2 Gene

neXtProt entry for SLAIN2 Gene

Post-translational modifications for SLAIN2 Gene

  • Is highly phosphorylated during mitosis, but not during interphase. The highly phosphorylated form does not localize at microtubule plus ends and does not interact with MAPRE1 or CKAP5.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for SLAIN2 Gene

No data available for DME Specific Peptides for SLAIN2 Gene

Domains & Families for SLAIN2 Gene

Gene Families for SLAIN2 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for SLAIN2 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for SLAIN2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9P270

UniProtKB/Swiss-Prot:

SLAI2_HUMAN :
  • The N-terminus forms a two-stranded coiled coil.
  • Belongs to the SLAIN motif-containing family.
Domain:
  • The N-terminus forms a two-stranded coiled coil.
Family:
  • Belongs to the SLAIN motif-containing family.
genes like me logo Genes that share domains with SLAIN2: view

Function for SLAIN2 Gene

Molecular function for SLAIN2 Gene

UniProtKB/Swiss-Prot Function:
Binds to the plus end of microtubules and regulates microtubule dynamics and microtubule organization. Promotes cytoplasmic microtubule nucleation and elongation. Required for normal structure of the microtubule cytoskeleton during interphase.

Phenotypes From GWAS Catalog for SLAIN2 Gene

Gene Ontology (GO) - Molecular Function for SLAIN2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 21646404
genes like me logo Genes that share ontologies with SLAIN2: view

Phenotypes for SLAIN2 Gene

genes like me logo Genes that share phenotypes with SLAIN2: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for SLAIN2

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for SLAIN2 Gene

Localization for SLAIN2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SLAIN2 Gene

Cytoplasm, cytoskeleton. Note=Colocalizes with microtubules. Detected at the plus end of growing microtubules.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SLAIN2 gene
Compartment Confidence
cytoskeleton 5
cytosol 5
nucleus 4

Subcellular locations from the

Human Protein Atlas (HPA)
  • Centrosome (4)
  • Cytosol (4)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for SLAIN2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
GO:0005813 centrosome IDA 21399614
GO:0005829 cytosol IDA --
GO:0005856 cytoskeleton IEA --
GO:0015630 microtubule cytoskeleton IDA 21646404
genes like me logo Genes that share ontologies with SLAIN2: view

Pathways & Interactions for SLAIN2 Gene

SuperPathways for SLAIN2 Gene

No Data Available

Gene Ontology (GO) - Biological Process for SLAIN2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007020 microtubule nucleation IMP 21646404
GO:0031113 regulation of microtubule polymerization IEA --
GO:0031116 positive regulation of microtubule polymerization IMP 21646404
GO:0031122 cytoplasmic microtubule organization IMP 21646404
genes like me logo Genes that share ontologies with SLAIN2: view

No data available for Pathways by source and SIGNOR curated interactions for SLAIN2 Gene

Drugs & Compounds for SLAIN2 Gene

No Compound Related Data Available

Transcripts for SLAIN2 Gene

mRNA/cDNA for SLAIN2 Gene

Unigene Clusters for SLAIN2 Gene

SLAIN motif family, member 2:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for SLAIN2

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for SLAIN2 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6a · 6b · 6c ^ 7 ^ 8a · 8b ^ 9
SP1: - - - -
SP2: -
SP3:

Relevant External Links for SLAIN2 Gene

GeneLoc Exon Structure for
SLAIN2
ECgene alternative splicing isoforms for
SLAIN2

Expression for SLAIN2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for SLAIN2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for SLAIN2 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (30.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for SLAIN2 Gene



Protein tissue co-expression partners for SLAIN2 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of SLAIN2 Gene:

SLAIN2

SOURCE GeneReport for Unigene cluster for SLAIN2 Gene:

Hs.479677

mRNA Expression by UniProt/SwissProt for SLAIN2 Gene:

Q9P270-SLAI2_HUMAN
Tissue specificity: Widely expressed with highest levels in adult liver, testis and ovary, and lowest levels in adult pancreas and spleen and in fetal brain.

Evidence on tissue expression from TISSUES for SLAIN2 Gene

  • Liver(4.4)
  • Nervous system(4.4)
  • Skin(4.3)
  • Heart(2)
  • Muscle(2)
genes like me logo Genes that share expression patterns with SLAIN2: view

No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for SLAIN2 Gene

Orthologs for SLAIN2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for SLAIN2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SLAIN2 34 33
  • 99.83 (n)
OneToOne
cow
(Bos Taurus)
Mammalia SLAIN2 34 33
  • 96.1 (n)
OneToOne
dog
(Canis familiaris)
Mammalia SLAIN2 34 33
  • 92.03 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Slain2 16 34 33
  • 91.03 (n)
rat
(Rattus norvegicus)
Mammalia Slain2 33
  • 90.92 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia SLAIN2 34
  • 87 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia SLAIN2 34
  • 79 (a)
OneToOne
chicken
(Gallus gallus)
Aves SLAIN2 34 33
  • 78.53 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia SLAIN2 34
  • 70 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100491488 33
  • 70.28 (n)
zebrafish
(Danio rerio)
Actinopterygii slain2 34 33
  • 63.97 (n)
OneToOne
wufd58c02 33
Species where no ortholog for SLAIN2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for SLAIN2 Gene

ENSEMBL:
Gene Tree for SLAIN2 (if available)
TreeFam:
Gene Tree for SLAIN2 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for SLAIN2: view image

Paralogs for SLAIN2 Gene

Paralogs for SLAIN2 Gene

(1) SIMAP similar genes for SLAIN2 Gene using alignment to 4 proteins:

  • SLAI2_HUMAN
  • D6REM5_HUMAN
  • D6RIF6_HUMAN
  • H0Y9L2_HUMAN
genes like me logo Genes that share paralogs with SLAIN2: view

Variants for SLAIN2 Gene

Sequence variations from dbSNP and Humsavar for SLAIN2 Gene

SNP ID Clin Chr 04 pos Variation AA Info Type
rs1000027730 -- 48,380,483(+) A/G intron_variant
rs10000288 -- 48,355,510(+) A/G intron_variant
rs1000090387 -- 48,347,898(+) G/A intron_variant
rs10001054 -- 48,406,804(+) A/G intron_variant
rs1000185279 -- 48,384,355(+) G/A intron_variant

Structural Variations from Database of Genomic Variants (DGV) for SLAIN2 Gene

Variant ID Type Subtype PubMed ID
dgv2789n106 CNV deletion 24896259
esv2662770 CNV deletion 23128226
esv3563835 CNV deletion 23714750
esv3600463 CNV loss 21293372
nsv470034 CNV gain 18288195
nsv509896 OTHER sequence alteration 20534489
nsv528084 CNV loss 19592680
nsv594121 CNV gain 21841781
nsv956878 CNV deletion 24416366

Variation tolerance for SLAIN2 Gene

Residual Variation Intolerance Score: 11.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.80; 16.82% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for SLAIN2 Gene

Human Gene Mutation Database (HGMD)
SLAIN2
SNPedia medical, phenotypic, and genealogical associations of SNPs for
SLAIN2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SLAIN2 Gene

Disorders for SLAIN2 Gene

Additional Disease Information for SLAIN2

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for SLAIN2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SLAIN2 Gene

Publications for SLAIN2 Gene

  1. SLAIN2 links microtubule plus end-tracking proteins and controls microtubule growth in interphase. (PMID: 21646404) van der Vaart B … Akhmanova A (The Journal of cell biology 2011) 3 4 58
  2. Polymorphisms in innate immunity genes and patients response to dendritic cell-based HIV immuno-treatment. (PMID: 20056178) Segat L … Crovella S (Vaccine 2010) 3 44 58
  3. Transcriptional profiling of mouse and human ES cells identifies SLAIN1, a novel stem cell gene. (PMID: 16546155) Hirst CE … Elefanty AG (Developmental biology 2006) 2 3 58
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  5. Prediction of the coding sequences of unidentified human genes. XVII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 10819331) Nagase T … Ohara O (DNA research : an international journal for rapid publication of reports on genes and genomes 2000) 3 4 58

Products for SLAIN2 Gene

Sources for SLAIN2 Gene

Content
Loading form....