This gene encodes a member of the SLAP family of adapter proteins. The encoded protein may play an important receptor-proximal role in downregulating T and B cell-mediated responses and inhibits antigen receptor-induced calcium mobilization. This protein interacts with Cas-Br-M (murine) ecotropic retroviral transforming sequence c. Two transcript variants encoding distinct isof... See more...

Aliases for SLA2 Gene

Aliases for SLA2 Gene

  • Src Like Adaptor 2 2 3 5
  • SLAP-2 2 3 4
  • Modulator Of Antigen Receptor Signaling 3 4
  • Src-Like-Adapter 2 3 4
  • C20orf156 3 4
  • SLAP2 3 4
  • MARS 3 4
  • Src-Like Adapter Protein-2 3
  • Src-Like Adapter Protein 2 4
  • Src-Like-Adaptor 2 2
  • FLJ21992 2
  • SLA2 5

External Ids for SLA2 Gene

Previous HGNC Symbols for SLA2 Gene

  • C20orf156

Previous GeneCards Identifiers for SLA2 Gene

  • GC20M034969
  • GC20M035879
  • GC20M035926
  • GC20M034657
  • GC20M034674
  • GC20M035240
  • GC20M031976

Summaries for SLA2 Gene

Entrez Gene Summary for SLA2 Gene

  • This gene encodes a member of the SLAP family of adapter proteins. The encoded protein may play an important receptor-proximal role in downregulating T and B cell-mediated responses and inhibits antigen receptor-induced calcium mobilization. This protein interacts with Cas-Br-M (murine) ecotropic retroviral transforming sequence c. Two transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Jul 2008]

GeneCards Summary for SLA2 Gene

SLA2 (Src Like Adaptor 2) is a Protein Coding gene. Diseases associated with SLA2 include Phaeohyphomycosis and Lobomycosis. Among its related pathways are TCR signaling in naive CD4+ T cells. Gene Ontology (GO) annotations related to this gene include protein N-terminus binding and SH3/SH2 adaptor activity. An important paralog of this gene is SLA.

UniProtKB/Swiss-Prot Summary for SLA2 Gene

  • Adapter protein, which negatively regulates T-cell receptor (TCR) signaling. Inhibits T-cell antigen-receptor induced activation of nuclear factor of activated T-cells. May act by linking signaling proteins such as ZAP70 with CBL, leading to a CBL dependent degradation of signaling proteins.

Gene Wiki entry for SLA2 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for SLA2 Gene

Genomics for SLA2 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for SLA2 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH20J036643 Promoter/Enhancer 1.8 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 612.5 +0.3 258 4.1 GATAD2A ZNF7 POLR2A CEBPA KMT2B EED SOX13 RUNX3 TGIF2 KAT7 SLA2 NDRG3 RAB5IF RBL1 SAMHD1 TGIF2 KR153194-107 RF00017-3573
GH20J036942 Enhancer 1.1 FANTOM5 ENCODE dbSUPER 9.1 -298.1 -298113 3.1 RCOR2 SP1 FOXJ2 CEBPA RFX1 CEBPB FOXA2 OSR2 EP300 ZNF205 lnc-RBL1-3 SLA2 SAMHD1 MANBAL RBL1 TGIF2 TLDC2
GH20J036627 Enhancer 1 FANTOM5 ENCODE dbSUPER 8.8 +16.9 16925 3.5 SP1 CREB1 ATF7 ZNF24 CEBPA SCRT2 CEBPB RUNX3 FOXA2 ZBTB40 KR153194-107 RAB5IF NDRG3 MYL9 SLA2 RBL1 RF00017-3573
GH20J036973 Enhancer 0.9 FANTOM5 ENCODE dbSUPER 2.8 -328.6 -328638 1.8 SCRT2 RUNX3 SCRT1 PRDM6 TCF7 CBFA2T3 piR-49732-348 piR-46662-406 piR-54764-393 SAMHD1 MROH8 RPN2 SLA2 RBL1 piR-43105-378
GH20J036988 Enhancer 0.9 FANTOM5 ENCODE dbSUPER 1.7 -342.5 -342489 1.1 SOX6 SCRT2 ZSCAN5C NFIC ZNF366 ZNF146 JUN NFIA GLIS1 YY2 RPN2 RBL1 SAMHD1 GHRH SLA2 lnc-TLDC2-3 piR-36393-317
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around SLA2 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for SLA2

Top Transcription factor binding sites by QIAGEN in the SLA2 gene promoter:
  • AREB6
  • E2F
  • E2F-1
  • E2F-2
  • E2F-3a
  • E2F-4
  • E2F-5
  • Pax-3
  • POU2F1
  • POU2F1a

Genomic Locations for SLA2 Gene

Genomic Locations for SLA2 Gene
chr20:36,612,318-36,646,207
(GRCh38/hg38)
Size:
33,890 bases
Orientation:
Minus strand
chr20:35,240,721-35,274,619
(GRCh37/hg19)
Size:
33,899 bases
Orientation:
Minus strand

Genomic View for SLA2 Gene

Genes around SLA2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SLA2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SLA2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SLA2 Gene

Proteins for SLA2 Gene

  • Protein details for SLA2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9H6Q3-SLAP2_HUMAN
    Recommended name:
    Src-like-adapter 2
    Protein Accession:
    Q9H6Q3
    Secondary Accessions:
    • A8K648
    • E1P5U1
    • E1P5U2
    • Q5TH27
    • Q5TH28
    • Q8WY18
    • Q96QI4
    • Q9H135

    Protein attributes for SLA2 Gene

    Size:
    261 amino acids
    Molecular mass:
    28585 Da
    Quaternary structure:
    • Interacts (via SH2 domain) with ZAP70 (phosphorylated) and CD3Z (phosphorylated). Interacts (via SH2 domain) with CSF1R (phosphorylated) (By similarity). Interacts (via its C-terminal domain) with CBL (phosphorylated).
    Miscellaneous:
    • [Isoform 3]: Produced by alternative initiation at Met-28 of isoform 1.
    • [Isoform 4]: Produced by alternative initiation at Met-28 of isoform 2.

    Three dimensional structures from OCA and Proteopedia for SLA2 Gene

    Alternative splice isoforms for SLA2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SLA2 Gene

Post-translational modifications for SLA2 Gene

Other Protein References for SLA2 Gene

No data available for DME Specific Peptides for SLA2 Gene

Domains & Families for SLA2 Gene

Gene Families for SLA2 Gene

HGNC:
Human Protein Atlas (HPA):
  • Plasma proteins
  • Predicted intracellular proteins

Protein Domains for SLA2 Gene

InterPro:
Blocks:
  • SH2 domain signature
  • SH3 domain signature
ProtoNet:

Suggested Antigen Peptide Sequences for SLA2 Gene

GenScript: Design optimal peptide antigens:
  • Src-like adapter protein 2 (SLAP2_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q9H6Q3

UniProtKB/Swiss-Prot:

SLAP2_HUMAN :
  • The loss of the C-terminal domain partially abolishes the inhibitory function, but can be partially compensated by higher level of protein expression.
Domain:
  • The loss of the C-terminal domain partially abolishes the inhibitory function, but can be partially compensated by higher level of protein expression.
genes like me logo Genes that share domains with SLA2: view

Function for SLA2 Gene

Molecular function for SLA2 Gene

UniProtKB/Swiss-Prot Function:
Adapter protein, which negatively regulates T-cell receptor (TCR) signaling. Inhibits T-cell antigen-receptor induced activation of nuclear factor of activated T-cells. May act by linking signaling proteins such as ZAP70 with CBL, leading to a CBL dependent degradation of signaling proteins.

Phenotypes From GWAS Catalog for SLA2 Gene

Gene Ontology (GO) - Molecular Function for SLA2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005070 SH3/SH2 adaptor activity IDA --
GO:0005515 protein binding IPI 11891219
GO:0035591 signaling adaptor activity IDA 11891219
GO:0046935 1-phosphatidylinositol-3-kinase regulator activity IBA 21873635
GO:0047485 protein N-terminus binding IPI 11891219
genes like me logo Genes that share ontologies with SLA2: view
genes like me logo Genes that share phenotypes with SLA2: view

Animal Models for SLA2 Gene

MGI Knock Outs for SLA2:
  • Sla2 Sla2<tm1Amch>

Animal Model Products

CRISPR Products

miRNA for SLA2 Gene

miRTarBase miRNAs that target SLA2

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for SLA2

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for SLA2 Gene

Localization for SLA2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SLA2 Gene

Cytoplasm.
[Isoform 1]: Cell membrane. Cytoplasmic vesicle. Note=Localized to the plasma membrane and intracellular vesicles, including late endosomal vesicles.
[Isoform 2]: Cytoplasm. Note=May be cytoplasmic and is not localized to membranes.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SLA2 gene
Compartment Confidence
plasma membrane 5
endosome 5
nucleus 4
golgi apparatus 4
cytosol 3
cytoskeleton 2
mitochondrion 2
extracellular 1
endoplasmic reticulum 1
lysosome 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Golgi apparatus (2)
  • Nucleoplasm (2)
  • Vesicles (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for SLA2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005654 nucleoplasm IDA --
GO:0005737 cytoplasm TAS 11696592
GO:0005770 late endosome IEA --
GO:0005794 Golgi apparatus IDA --
GO:0005886 plasma membrane TAS 11891219
genes like me logo Genes that share ontologies with SLA2: view

Pathways & Interactions for SLA2 Gene

PathCards logo

SuperPathways for SLA2 Gene

genes like me logo Genes that share pathways with SLA2: view

Pathways by source for SLA2 Gene

1 BioSystems pathway for SLA2 Gene

SIGNOR curated interactions for SLA2 Gene

Inactivates:

Gene Ontology (GO) - Biological Process for SLA2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription by RNA polymerase II IDA 11696592
GO:0009966 regulation of signal transduction IEA --
GO:0009967 positive regulation of signal transduction IEA --
GO:0019724 B cell mediated immunity TAS 11891219
GO:0030522 intracellular receptor signaling pathway TAS --
genes like me logo Genes that share ontologies with SLA2: view

Drugs & Compounds for SLA2 Gene

(3) Drugs for SLA2 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
genes like me logo Genes that share compounds with SLA2: view

Transcripts for SLA2 Gene

mRNA/cDNA for SLA2 Gene

2 REFSEQ mRNAs :
10 NCBI additional mRNA sequence :
2 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for SLA2

Alternative Splicing Database (ASD) splice patterns (SP) for SLA2 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7a · 7b ^ 8a · 8b · 8c
SP1:
SP2: -
SP3:
SP4:

Relevant External Links for SLA2 Gene

GeneLoc Exon Structure for
SLA2

Expression for SLA2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for SLA2 Gene

mRNA differential expression in normal tissues according to GTEx for SLA2 Gene

This gene is overexpressed in Whole Blood (x34.2).

Protein differential expression in normal tissues from HIPED for SLA2 Gene

This gene is overexpressed in Platelet (52.9) and Peripheral blood mononuclear cells (16.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for SLA2 Gene



Protein tissue co-expression partners for SLA2 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for SLA2

SOURCE GeneReport for Unigene cluster for SLA2 Gene:

Hs.713578

mRNA Expression by UniProt/SwissProt for SLA2 Gene:

Q9H6Q3-SLAP2_HUMAN
Tissue specificity: Predominantly expressed in immune system, with highest levels in peripheral blood leukocytes. Expressed in spleen, thymus and lymph nodes. Expressed in T-cells as well as in monocytes, and at low level in B-cells. Also detected in placenta, prostate, skin, retina and colon.

Evidence on tissue expression from TISSUES for SLA2 Gene

  • Blood(2)
genes like me logo Genes that share expression patterns with SLA2: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and Phenotype-based relationships between genes and organs from Gene ORGANizer for SLA2 Gene

Orthologs for SLA2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for SLA2 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia SLA2 30 31
  • 99.23 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia SLA2 30 31
  • 88.08 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia SLA2 30 31
  • 86.03 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Sla2 30
  • 81.67 (n)
Mouse
(Mus musculus)
Mammalia Sla2 30 17 31
  • 81.52 (n)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia SLA2 31
  • 58 (a)
OneToOne
Chicken
(Gallus gallus)
Aves SLA2 30 31
  • 66.83 (n)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia SLA2 31
  • 45 (a)
OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia sla2 30
  • 59.08 (n)
African clawed frog
(Xenopus laevis)
Amphibia MGC68984 30
Zebrafish
(Danio rerio)
Actinopterygii sla2 30 31
  • 57.41 (n)
OneToOne
Species where no ortholog for SLA2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for SLA2 Gene

ENSEMBL:
Gene Tree for SLA2 (if available)
TreeFam:
Gene Tree for SLA2 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for SLA2: view image

Paralogs for SLA2 Gene

Paralogs for SLA2 Gene

(9) SIMAP similar genes for SLA2 Gene using alignment to 1 proteins:

  • SLAP2_HUMAN
genes like me logo Genes that share paralogs with SLA2: view

Variants for SLA2 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for SLA2 Gene

SNP ID Clinical significance and condition Chr 20 pos Variation AA Info Type
781498 Benign: not provided 36,614,342(-) C/T MISSENSE_VARIANT
781751 Benign: not provided 36,634,550(-) G/A MISSENSE_VARIANT
rs34834764 - p.Val210Met

Additional dbSNP identifiers (rs#s) for SLA2 Gene

Structural Variations from Database of Genomic Variants (DGV) for SLA2 Gene

Variant ID Type Subtype PubMed ID
esv2554197 CNV insertion 19546169
esv3575371 CNV gain 25503493
nsv1057192 CNV loss 25217958
nsv1119489 CNV insertion 24896259
nsv477320 CNV novel sequence insertion 20440878
nsv833967 CNV loss 17160897
nsv962575 CNV duplication 23825009

Variation tolerance for SLA2 Gene

Residual Variation Intolerance Score: 50.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.66; 56.92% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for SLA2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
SLA2

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SLA2 Gene

Disorders for SLA2 Gene

MalaCards: The human disease database

(3) MalaCards diseases for SLA2 Gene - From: DISEASES

Disorder Aliases PubMed IDs
phaeohyphomycosis
  • infection by dematiacious fungi
lobomycosis
  • cutaneous blastomycosis
tinea pedis
  • athlete's foot
- elite association - COSMIC cancer census association via MalaCards
Search SLA2 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for SLA2

genes like me logo Genes that share disorders with SLA2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for SLA2 Gene

Publications for SLA2 Gene

  1. Functional cloning of Src-like adapter protein-2 (SLAP-2), a novel inhibitor of antigen receptor signaling. (PMID: 11696592) Holland SJ … Wu J (The Journal of experimental medicine 2001) 2 3 4 23
  2. Cloning and characterization of human Src-like adaptor protein 2 and a novel splice isoform, SLAP-2-v. (PMID: 12527895) Loreto MP … McGlade CJ (Oncogene 2003) 3 4 23
  3. A novel Src homology 2 domain-containing molecule, Src-like adapter protein-2 (SLAP-2), which negatively regulates T cell receptor signaling. (PMID: 11891219) Pandey A … Mann M (The Journal of biological chemistry 2002) 3 4 23
  4. The Emerging and Diverse Roles of Src-Like Adaptor Proteins in Health and Disease. (PMID: 26339145) Marton N … Nagy G (Mediators of inflammation 2015) 2 3
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4

Products for SLA2 Gene

  • Signalway Proteins for SLA2

Sources for SLA2 Gene