Aliases for SLA2 Gene
External Ids for SLA2 Gene
Previous HGNC Symbols for SLA2 Gene
Previous GeneCards Identifiers for SLA2 Gene
This gene encodes a member of the SLAP family of adapter proteins. The encoded protein may play an important receptor-proximal role in downregulating T and B cell-mediated responses and inhibits antigen receptor-induced calcium mobilization. This protein interacts with Cas-Br-M (murine) ecotropic retroviral transforming sequence c. Two transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Jul 2008]
GeneCards Summary for SLA2 Gene
SLA2 (Src Like Adaptor 2) is a Protein Coding gene. Diseases associated with SLA2 include Phaeohyphomycosis and Tinea Manuum. Among its related pathways are TCR signaling in naive CD4+ T cells. Gene Ontology (GO) annotations related to this gene include protein N-terminus binding and SH3/SH2 adaptor activity. An important paralog of this gene is SLA.
UniProtKB/Swiss-Prot Summary for SLA2 Gene
Adapter protein, which negatively regulates T-cell receptor (TCR) signaling. Inhibits T-cell antigen-receptor induced activation of nuclear factor of activated T-cells. May act by linking signaling proteins such as ZAP70 with CBL, leading to a CBL dependent degradation of signaling proteins.