Aliases for SLA Gene
External Ids for SLA Gene
Previous GeneCards Identifiers for SLA Gene
GeneCards Summary for SLA Gene
SLA (Src Like Adaptor) is a Protein Coding gene. Diseases associated with SLA include Thyroid Dyshormonogenesis 3 and Familial Thyroid Dyshormonogenesis. Among its related pathways are EPH-Ephrin signaling and PDGFR-beta signaling pathway. Gene Ontology (GO) annotations related to this gene include SH3/SH2 adaptor activity. An important paralog of this gene is SLA2.
UniProtKB/Swiss-Prot Summary for SLA Gene
Adapter protein, which negatively regulates T-cell receptor (TCR) signaling. Inhibits T-cell antigen-receptor induced activation of nuclear factor of activated T-cells. Involved in the negative regulation of positive selection and mitosis of T-cells. May act by linking signaling proteins such as ZAP70 with CBL, leading to a CBL dependent degradation of signaling proteins.