Aliases for SLA Gene

Aliases for SLA Gene

  • Src Like Adaptor 2 3 5
  • Src-Like-Adapter 2 3 4
  • SLAP-1 2 3 4
  • HSLAP 2 3 4
  • SLAP 2 3 4
  • Src-Like-Adapter Protein 1 3 4
  • SLA1 2 3
  • Src-Like-Adaptor 2
  • SLAP1 4
  • SLA 5

External Ids for SLA Gene

Previous GeneCards Identifiers for SLA Gene

  • GC08M132778
  • GC08M134136
  • GC08M133719
  • GC08M134005
  • GC08M134118
  • GC08M129368
  • GC08M134048

Summaries for SLA Gene

GeneCards Summary for SLA Gene

SLA (Src Like Adaptor) is a Protein Coding gene. Diseases associated with SLA include Thyroid Dyshormonogenesis 3 and Familial Thyroid Dyshormonogenesis. Among its related pathways are EPH-Ephrin signaling and PDGFR-beta signaling pathway. Gene Ontology (GO) annotations related to this gene include SH3/SH2 adaptor activity. An important paralog of this gene is SLA2.

UniProtKB/Swiss-Prot Summary for SLA Gene

  • Adapter protein, which negatively regulates T-cell receptor (TCR) signaling. Inhibits T-cell antigen-receptor induced activation of nuclear factor of activated T-cells. Involved in the negative regulation of positive selection and mitosis of T-cells. May act by linking signaling proteins such as ZAP70 with CBL, leading to a CBL dependent degradation of signaling proteins.

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for SLA Gene

Genomics for SLA Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for SLA Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH08J133051 Promoter/Enhancer 1.8 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 265.3 +38.4 38359 25.8 CEBPA CTCF RXRA IRF4 SPI1 MYC ZNF189 PKNOX1 MAX POLR2A SLA TG CCN4 TMEM71 PHF20L1 ENSG00000270137 5MWI_A-169 PTCSC1 lnc-NDRG1-4
GH08J133128 Promoter/Enhancer 1.4 EPDnew FANTOM5 ENCODE dbSUPER 262.3 -26.9 -26856 3.4 CEBPA ATF3 CEBPB ETV4 FOSL2 JUND POLR2A HNF4A HMG20A HBP1 SLA CCN4 TG ST3GAL1 PHF20L1 NDRG1 HSALNG0068720 HSALNG0068723 HSALNG0068721
GH08J133102 Promoter/Enhancer 1 EPDnew Ensembl ENCODE CraniofacialAtlas 250.7 -1.8 -1832 5.8 ZNF623 NR2F2 SLA CCN4 lnc-NDRG1-4 HSALNG0068719 TG
GH08J133080 Promoter/Enhancer 1.3 FANTOM5 Ensembl ENCODE dbSUPER 14 +20.9 20899 3.2 CTCF GABPA RXRA POLR2A RAD21 SP1 NR2F2 CEBPB CEBPG TMEM71 PHF20L1 CCN4 SLA ST3GAL1 TG lnc-NDRG1-4 5MWI_A-169
GH08J133048 Enhancer 0.8 ENCODE dbSUPER 22.5 +52.9 52904 2.3 JUND NFIC CEBPB MAX EP300 TCF7L2 PRDM10 ATF4 NFIB ZFP36 SLA CCN4 MIR7848 PTCSC1 lnc-NDRG1-4 TG
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around SLA on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for SLA

Top Transcription factor binding sites by QIAGEN in the SLA gene promoter:
  • AML1a
  • AREB6
  • E47
  • IRF-1
  • IRF-7A
  • POU2F1
  • POU2F1a
  • POU6F1 (c2)
  • USF-1
  • USF1

Genomic Locations for SLA Gene

Latest Assembly
chr8:133,036,728-133,103,053
(GRCh38/hg38)
Size:
66,326 bases
Orientation:
Minus strand

Previous Assembly
chr8:134,048,973-134,114,846
(GRCh37/hg19 by Entrez Gene)
Size:
65,874 bases
Orientation:
Minus strand

chr8:134,048,973-134,115,298
(GRCh37/hg19 by Ensembl)
Size:
66,326 bases
Orientation:
Minus strand

Genomic View for SLA Gene

Genes around SLA on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SLA Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SLA Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SLA Gene

Proteins for SLA Gene

  • Protein details for SLA Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q13239-SLAP1_HUMAN
    Recommended name:
    Src-like-adapter
    Protein Accession:
    Q13239
    Secondary Accessions:
    • B7Z4J2
    • B7Z4L6
    • Q6FI01
    • Q9UMQ8

    Protein attributes for SLA Gene

    Size:
    276 amino acids
    Molecular mass:
    31156 Da
    Quaternary structure:
    • Interacts with EPHA2, VAV1, LCP2 and PDGFRB (By similarity). Homodimer. Homodimerization and interaction with phosphorylated CBL occurs via its C-terminal domain. Interacts with phosphorylated proteins ZAP70, CD3Z, SYK and LAT via its SH2 domain.
    SequenceCaution:
    • Sequence=AAH07042.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305}; Sequence=BAG35478.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for SLA Gene

    Alternative splice isoforms for SLA Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SLA Gene

Post-translational modifications for SLA Gene

  • Ubiquitination at Lys117, Lys60, Lys93, Lys104, Lys252, and Lys264
  • Modification sites at PhosphoSitePlus

Antibodies for research

  • Boster Bio Antibodies for SLA

No data available for DME Specific Peptides for SLA Gene

Domains & Families for SLA Gene

Gene Families for SLA Gene

Protein Domains for SLA Gene

InterPro:
Blocks:
  • SH2 domain signature

Suggested Antigen Peptide Sequences for SLA Gene

GenScript: Design optimal peptide antigens:
  • cDNA FLJ50391, highly similar to SRC-like-adapter (B7Z4J2_HUMAN)
  • cDNA FLJ59930, highly similar to SRC-like-adapter (B7Z4L6_HUMAN)
  • cDNA, FLJ92959, Homo sapiens Src-like-adaptor (SLA), mRNA (Q6FI01_HUMAN)
  • Src-like-adapter protein 1 (SLAP1_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q13239

UniProtKB/Swiss-Prot:

SLAP1_HUMAN :
  • The C-terminal domain is essential for the homodimerization and the interaction with CBL. While the interaction with CBL is apparently mediated via the hydrophobic region of this domain, the highly charged region is apparently required for the homodimerization.
Domain:
  • The C-terminal domain is essential for the homodimerization and the interaction with CBL. While the interaction with CBL is apparently mediated via the hydrophobic region of this domain, the highly charged region is apparently required for the homodimerization.
genes like me logo Genes that share domains with SLA: view

Function for SLA Gene

Molecular function for SLA Gene

UniProtKB/Swiss-Prot Function:
Adapter protein, which negatively regulates T-cell receptor (TCR) signaling. Inhibits T-cell antigen-receptor induced activation of nuclear factor of activated T-cells. Involved in the negative regulation of positive selection and mitosis of T-cells. May act by linking signaling proteins such as ZAP70 with CBL, leading to a CBL dependent degradation of signaling proteins.
UniProtKB/Swiss-Prot Induction:
By all-trans retinoic acid (ATRA). Induction is indirect and is mediated through other proteins.
GENATLAS Biochemistry:
mouse Src-like adaptor protein (Slap) homolog,binding the Eck receptor protein tyrosine kinase,involved in signal transduction

Phenotypes From GWAS Catalog for SLA Gene

Gene Ontology (GO) - Molecular Function for SLA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004713 protein tyrosine kinase activity IBA 21873635
GO:0004715 non-membrane spanning protein tyrosine kinase activity IBA 21873635
GO:0005102 signaling receptor binding IBA 21873635
GO:0005515 protein binding IEA,IPI 9742401
genes like me logo Genes that share ontologies with SLA: view
genes like me logo Genes that share phenotypes with SLA: view

Animal Models for SLA Gene

MGI Knock Outs for SLA:
  • Sla Sla<tm1Weis>

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for SLA

Clone products for research

  • Addgene plasmids for SLA

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for SLA Gene

Localization for SLA Gene

Subcellular locations from UniProtKB/Swiss-Prot for SLA Gene

Cytoplasm. Endosome. Note=Colocalizes with endosomes. {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SLA gene
Compartment Confidence
plasma membrane 4
endosome 4
cytosol 3
extracellular 2
cytoskeleton 2
mitochondrion 2
nucleus 2
endoplasmic reticulum 1
lysosome 1
golgi apparatus 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (2)
  • Nuclear membrane (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for SLA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
GO:0005768 endosome IEA --
GO:0005925 focal adhesion IBA 21873635
GO:0031234 extrinsic component of cytoplasmic side of plasma membrane IBA 21873635
GO:0043197 dendritic spine IBA 21873635
genes like me logo Genes that share ontologies with SLA: view

Pathways & Interactions for SLA Gene

PathCards logo

SuperPathways for SLA Gene

genes like me logo Genes that share pathways with SLA: view

Pathways by source for SLA Gene

1 Sino Biological pathway for SLA Gene
1 BioSystems pathway for SLA Gene
1 GeneGo (Thomson Reuters) pathway for SLA Gene
  • Cell adhesion Ephrins signaling

SIGNOR curated interactions for SLA Gene

Inactivates:
Is inactivated by:

Gene Ontology (GO) - Biological Process for SLA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway IBA 21873635
GO:0009966 regulation of signal transduction IEA --
GO:0030154 cell differentiation IBA 21873635
GO:0038083 peptidyl-tyrosine autophosphorylation IBA --
GO:0042127 regulation of cell proliferation IBA --
genes like me logo Genes that share ontologies with SLA: view

Drugs & Compounds for SLA Gene

(2) Drugs for SLA Gene - From: ClinicalTrials and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Vaccines Pharma 8734

(1) Additional Compounds for SLA Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with SLA: view

Transcripts for SLA Gene

mRNA/cDNA for SLA Gene

5 REFSEQ mRNAs :
22 NCBI additional mRNA sequence :
23 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for SLA

Clone products for research

  • Addgene plasmids for SLA

Alternative Splicing Database (ASD) splice patterns (SP) for SLA Gene

ExUns: 1a · 1b ^ 2a · 2b · 2c · 2d ^ 3a · 3b ^ 4a · 4b ^ 5 ^ 6 ^ 7a · 7b · 7c ^ 8a · 8b ^ 9a · 9b · 9c ^ 10a · 10b · 10c ^ 11a · 11b ^ 12
SP1: - - - - - -
SP2: - - - - - - - - - - - -
SP3: - - - - - - - - -
SP4: -
SP5: - - - - - -
SP6: - - -
SP7: - - - - -
SP8: - - - - - - - - - - - - -
SP9: - -

Relevant External Links for SLA Gene

GeneLoc Exon Structure for
SLA

Expression for SLA Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for SLA Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SLA Gene

This gene is overexpressed in Whole Blood (x28.9) and Spleen (x4.2).

Protein differential expression in normal tissues from HIPED for SLA Gene

This gene is overexpressed in CD8 Tcells (41.9) and Monocytes (27.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for SLA Gene



Protein tissue co-expression partners for SLA Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for SLA

SOURCE GeneReport for Unigene cluster for SLA Gene:

Hs.75367

mRNA Expression by UniProt/SwissProt for SLA Gene:

Q13239-SLAP1_HUMAN
Tissue specificity: Expressed in lung and fetal brain. Weakly expressed in heart, adult brain, placenta, liver, skeletal muscle, kidney and pancreas.

Evidence on tissue expression from TISSUES for SLA Gene

  • Nervous system(5)
  • Blood(4.7)
  • Bone marrow(4.3)
  • Liver(4.3)
  • Spleen(2.6)
  • Intestine(2.5)
  • Lymph node(2.2)
genes like me logo Genes that share expression patterns with SLA: view

Primer products for research

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for SLA Gene

Orthologs for SLA Gene

This gene was present in the common ancestor of chordates.

Orthologs for SLA Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia SLA 29 30
  • 99.47 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia SLA 29 30
  • 86.23 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia SLA 29 30
  • 84.13 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Sla 29
  • 81.54 (n)
Oppossum
(Monodelphis domestica)
Mammalia SLA 30
  • 81 (a)
OneToOne
Mouse
(Mus musculus)
Mammalia Sla 29 16 30
  • 80.94 (n)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia SLA 30
  • 74 (a)
OneToOne
Chicken
(Gallus gallus)
Aves SLA 29 30
  • 67.27 (n)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia SLA 30
  • 61 (a)
OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia sla 29
  • 65.87 (n)
Zebrafish
(Danio rerio)
Actinopterygii sla1 29 30
  • 57.65 (n)
OneToOne
Species where no ortholog for SLA was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for SLA Gene

ENSEMBL:
Gene Tree for SLA (if available)
TreeFam:
Gene Tree for SLA (if available)
Aminode:
Evolutionary constrained regions (ECRs) for SLA: view image
Alliance of Genome Resources:
Additional Orthologs for SLA

Paralogs for SLA Gene

Paralogs for SLA Gene

(11) SIMAP similar genes for SLA Gene using alignment to 11 proteins:

  • SLAP1_HUMAN
  • B7Z4J2_HUMAN
  • B7Z4L6_HUMAN
  • E5RGG0_HUMAN
  • E5RH80_HUMAN
  • E5RHT2_HUMAN
  • E5RJ69_HUMAN
  • E5RJB0_HUMAN
  • E5RK29_HUMAN
  • E5RK95_HUMAN
  • Q6FI01_HUMAN
genes like me logo Genes that share paralogs with SLA: view

Variants for SLA Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for SLA Gene

SNP ID Clinical significance and condition Chr 08 pos Variation AA Info Type
1031319 Pathogenic: Iodotyrosyl coupling defect 133,096,303(-) G/A
NM_003235.5(TG):c.7502G>A (p.Trp2501Ter)
NONSENSE,INTRON
908349 Uncertain Significance: Iodotyrosyl coupling defect 133,095,167(-) C/T
NM_003235.5(TG):c.7363C>T (p.Arg2455Cys)
MISSENSE_VARIANT,INTRON
908350 Uncertain Significance: Iodotyrosyl coupling defect 133,096,197(-) C/T
NM_003235.5(TG):c.7405-9C>T
INTRON
908351 Uncertain Significance: Iodotyrosyl coupling defect 133,096,215(-) G/A
NM_003235.5(TG):c.7414G>A (p.Val2472Met)
MISSENSE_VARIANT,INTRON
911338 Uncertain Significance: Iodotyrosyl coupling defect 133,095,052(-) C/T
NM_003235.5(TG):c.7248C>T (p.Ser2416=)
SYNONYMOUS_VARIANT,INTRON

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for SLA Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for SLA Gene

Variant ID Type Subtype PubMed ID
esv33548 CNV gain 17666407
esv3573001 CNV loss 25503493
esv3573002 CNV loss 25503493
nsv465818 CNV loss 19166990
nsv482993 CNV loss 15286789
nsv525105 CNV loss 19592680
nsv612328 CNV loss 21841781
nsv6402 CNV insertion 18451855
nsv949988 CNV duplication 24416366

Variation tolerance for SLA Gene

Residual Variation Intolerance Score: 35.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.39; 54.22% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for SLA Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
SLA
Leiden Open Variation Database (LOVD)
SLA

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SLA Gene

Disorders for SLA Gene

MalaCards: The human disease database

(3) MalaCards diseases for SLA Gene - From: CVR and COP

Disorder Aliases PubMed IDs
thyroid dyshormonogenesis 3
  • tdh3
familial thyroid dyshormonogenesis
  • thyroid dyshormonogenesis
cd3zeta deficiency
- elite association - COSMIC cancer census association via MalaCards
Search SLA in MalaCards View complete list of genes associated with diseases

Additional Disease Information for SLA

Human Genome Epidemiology Navigator
(HuGE)
Atlas
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
Open Targets Platform
genes like me logo Genes that share disorders with SLA: view

No data available for UniProtKB/Swiss-Prot and Genatlas for SLA Gene

Publications for SLA Gene

  1. Characterization of promoter region and genomic structure of the murine and human genes encoding Src like adapter protein. (PMID: 11179692) Kratchmarova I … Pandey A (Gene 2001) 2 3 4 22
  2. Chromosomal localization of the mouse Src-like adapter protein (Slap) gene and its putative human homolog SLA. (PMID: 8825655) Angrist M … Pandey A (Genomics 1995) 2 3 4 22
  3. Functional cloning of Src-like adapter protein-2 (SLAP-2), a novel inhibitor of antigen receptor signaling. (PMID: 11696592) Holland SJ … Wu J (The Journal of experimental medicine 2001) 3 4 22
  4. Expression of Src-like adapter protein mRNA is induced by all-trans retinoic acid. (PMID: 9020066) Ohtsuki T … Miura Y (Biochemical and biophysical research communications 1997) 3 4 22
  5. The Emerging and Diverse Roles of Src-Like Adaptor Proteins in Health and Disease. (PMID: 26339145) Marton N … Nagy G (Mediators of inflammation 2015) 2 3

Products for SLA Gene

Sources for SLA Gene