This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-... See more...

Aliases for SKP2 Gene

Aliases for SKP2 Gene

  • S-Phase Kinase Associated Protein 2 2 3 5
  • S-Phase Kinase-Associated Protein 2, E3 Ubiquitin Protein Ligase 2 3
  • S-Phase Kinase-Associated Protein 2 3 4
  • F-Box/LRR-Repeat Protein 1 3 4
  • P45skp2 3 4
  • FBXL1 3 4
  • S-Phase Kinase-Associated Protein 2 (P45) 2
  • CDK2/Cyclin A-Associated Protein P45 3
  • Cyclin-A/CDK2-Associated Protein P45 4
  • F-Box Protein Skp2 4
  • FBL1 3
  • FLB1 3
  • P45 3

External Ids for SKP2 Gene

Previous GeneCards Identifiers for SKP2 Gene

  • GC05P036333
  • GC05P037218
  • GC05P036152
  • GC05P036197
  • GC05P036187

Summaries for SKP2 Gene

Entrez Gene Summary for SKP2 Gene

  • This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbls class; in addition to an F-box, this protein contains 10 tandem leucine-rich repeats. This protein is an essential element of the cyclin A-CDK2 S-phase kinase. It specifically recognizes phosphorylated cyclin-dependent kinase inhibitor 1B (CDKN1B, also referred to as p27 or KIP1) predominantly in S phase and interacts with S-phase kinase-associated protein 1 (SKP1 or p19). In addition, this gene is established as a protooncogene causally involved in the pathogenesis of lymphomas. Alternative splicing of this gene generates three transcript variants encoding different isoforms. [provided by RefSeq, Jul 2011]

GeneCards Summary for SKP2 Gene

SKP2 (S-Phase Kinase Associated Protein 2) is a Protein Coding gene. Diseases associated with SKP2 include Lung Cancer and Hepatitis C Virus. Among its related pathways are Metabolism of proteins and FoxO family signaling. Gene Ontology (GO) annotations related to this gene include identical protein binding and ubiquitin-protein transferase activity. An important paralog of this gene is FBXL7.

UniProtKB/Swiss-Prot Summary for SKP2 Gene

  • Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins involved in cell cycle progression, signal transduction and transcription. Specifically recognizes phosphorylated CDKN1B/p27kip and is involved in regulation of G1/S transition. Degradation of CDKN1B/p27kip also requires CKS1. Recognizes target proteins ORC1, CDT1, RBL2, KMT2A/MLL1, CDK9, RAG2, FOXO1, UBP43, and probably MYC, TOB1 and TAL1. Degradation of TAL1 also requires STUB1. Recognizes CDKN1A in association with CCNE1 or CCNE2 and CDK2. Promotes ubiquitination and destruction of CDH1 in a CK1-Dependent Manner, thereby regulating cell migration.
  • Through the ubiquitin-mediated proteasomal degradation of hepatitis C virus non-structural protein 5A, has an antiviral activity towards that virus.

Gene Wiki entry for SKP2 Gene

Additional gene information for SKP2 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for SKP2 Gene

Genomics for SKP2 Gene

GeneHancer (GH) Regulatory Elements for SKP2 Gene

Promoters and enhancers for SKP2 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH05J036150 Promoter/Enhancer 2.3 EPDnew FANTOM5 Ensembl ENCODE CraniofacialAtlas 507.6 +3.1 3059 9.7 EP300 RXRA FOXK2 ZBTB40 ZNF217 ZSCAN5C TCF12 SIN3A NRF1 USF1 LMBRD2 SKP2 RF00026-857 RNU6-1305P NIPBL UGT3A2 ENSG00000251591 NADK2
GH05J035185 Enhancer 0.8 Ensembl ENCODE 11.1 -964.9 -964875 4.1 ZNF217 CTBP1 SIN3A SAP130 MBD1 JUND GATA3 FOXA1 MYC DPF2 BRIX1 ENSG00000215158 SKP2 RAI14 PRLR L13713-186 piR-34093-030
GH05J036180 Enhancer 0.8 ENCODE 4.6 +28.6 28625 0.2 ZNF217 ZBTB25 TGIF2 SKI CTBP1 FOXA2 SAP130 ZBTB33 MIER3 HDAC1 RNU6-1305P RANBP3L SKP2 piR-40110-561 piR-30599
GH05J036073 Enhancer 0.7 Ensembl ENCODE 5.2 -78.0 -77989 0.8 CTCF RAD21 TCF12 ZNF654 SMC3 ZNF143 SCRT2 ENSG00000251591 lnc-UGT3A2-2 LMBRD2 RNU6-1305P RANBP3L UGT3A2 SKP2 lnc-UGT3A2-3
GH05J035189 Enhancer 0.3 Ensembl 11.1 -962.7 -962688 0.2 ZNF26 BRIX1 ENSG00000215158 SKP2 RAI14 L13713-186 piR-34093-030 PRLR
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around SKP2 on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for SKP2

Top Transcription factor binding sites by QIAGEN in the SKP2 gene promoter:
  • AREB6
  • CUTL1
  • PPAR-gamma1
  • PPAR-gamma2
  • STAT3

Genomic Locations for SKP2 Gene

Genomic Locations for SKP2 Gene
chr5:36,151,989-36,192,788
(GRCh38/hg38)
Size:
40,800 bases
Orientation:
Plus strand
chr5:36,152,091-36,184,421
(GRCh37/hg19)
Size:
32,331 bases
Orientation:
Plus strand

Genomic View for SKP2 Gene

Genes around SKP2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SKP2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SKP2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SKP2 Gene

Proteins for SKP2 Gene

  • Protein details for SKP2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q13309-SKP2_HUMAN
    Recommended name:
    S-phase kinase-associated protein 2
    Protein Accession:
    Q13309
    Secondary Accessions:
    • A8K5E0
    • B4DJT4
    • Q8TDZ0
    • Q8TDZ1
    • Q9BV69

    Protein attributes for SKP2 Gene

    Size:
    424 amino acids
    Molecular mass:
    47761 Da
    Quaternary structure:
    • Part of a SCF(SKP2) complex consisting of CUL1, RBX1, SKP1 and SKP2. Component of a SCF(SKP2)-like complex containing CUL1, SKP1, TRIM21 and SKP2. Interacts directly with CUL1 and SKP1. Interacts with CKS1. Interacts with the cyclin-A-CDK2 complex. Interacts with ORC1, phosphorylated CDT1, phosphorylated RBL2, ELF4, phosphorylated RAG2, FOXO1, UBP43, MYC, TOB1, TAL1 and KMT2A/MLL1. Interacts with TRIM21. Interacts with IFI27; promotes the ubiquitin-mediated proteasomal degradation of NS5A (PubMed:27194766). Interacts with hepatitis C virus/HCV non-structural protein NS5A; promotes the ubiquitin-mediated proteasomal degradation of NS5A (PubMed:27194766).
    SequenceCaution:
    • Sequence=AAC50242.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305}; Sequence=BAB87202.1; Type=Miscellaneous discrepancy; Note=Probable cloning artifact.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for SKP2 Gene

    Alternative splice isoforms for SKP2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SKP2 Gene

Post-translational modifications for SKP2 Gene

  • Ubiquitinated by the APC/C complex, leading to its degradation by the proteasome. Deubiquitinated by USP13.
  • Acetylation at Lys-68 and Lys-71 increases stability through impairment of APC/C-mediated proteolysis and promotes cytoplasmic retention. Deacetylated by SIRT3.
  • Ubiquitination at Lys299, Lys145, and Lys228
  • Modification sites at PhosphoSitePlus

Antibody Products

  • Abcam antibodies for SKP2

No data available for DME Specific Peptides for SKP2 Gene

Domains & Families for SKP2 Gene

Gene Families for SKP2 Gene

HGNC:
Human Protein Atlas (HPA):
  • Cancer-related genes
  • Predicted intracellular proteins

Protein Domains for SKP2 Gene

Blocks:
  • Leucine-rich repeat signature
InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for SKP2 Gene

GenScript: Design optimal peptide antigens:
  • cDNA FLJ60606, highly similar to S-phase kinase-associated protein 2 (B4DJT4_HUMAN)
  • p45skp2 (SKP2_HUMAN)
genes like me logo Genes that share domains with SKP2: view

No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for SKP2 Gene

Function for SKP2 Gene

Molecular function for SKP2 Gene

UniProtKB/Swiss-Prot Function:
Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins involved in cell cycle progression, signal transduction and transcription. Specifically recognizes phosphorylated CDKN1B/p27kip and is involved in regulation of G1/S transition. Degradation of CDKN1B/p27kip also requires CKS1. Recognizes target proteins ORC1, CDT1, RBL2, KMT2A/MLL1, CDK9, RAG2, FOXO1, UBP43, and probably MYC, TOB1 and TAL1. Degradation of TAL1 also requires STUB1. Recognizes CDKN1A in association with CCNE1 or CCNE2 and CDK2. Promotes ubiquitination and destruction of CDH1 in a CK1-Dependent Manner, thereby regulating cell migration.
UniProtKB/Swiss-Prot Function:
Through the ubiquitin-mediated proteasomal degradation of hepatitis C virus non-structural protein 5A, has an antiviral activity towards that virus.
GENATLAS Biochemistry:
S phase kinase associated protein 2 (p45),involved in regulation of cell cycle

Phenotypes From GWAS Catalog for SKP2 Gene

Gene Ontology (GO) - Molecular Function for SKP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI,IEA 11931757
GO:0016301 kinase activity IEA --
GO:0042802 identical protein binding IPI 22770219
GO:0061630 contributes_to ubiquitin protein ligase activity IBA 21873635
genes like me logo Genes that share ontologies with SKP2: view
genes like me logo Genes that share phenotypes with SKP2: view

Animal Models for SKP2 Gene

MGI Knock Outs for SKP2:

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for SKP2

Clone Products

  • Addgene plasmids for SKP2

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for SKP2 Gene

Localization for SKP2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SKP2 Gene

Cytoplasm. Nucleus.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SKP2 gene
Compartment Confidence
nucleus 5
cytosol 5
plasma membrane 2
extracellular 2
cytoskeleton 2
mitochondrion 2
lysosome 2
peroxisome 1
endoplasmic reticulum 1
endosome 1
golgi apparatus 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (3)
  • Nucleoplasm (3)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for SKP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IBA,IDA 21873635
GO:0005654 nucleoplasm TAS --
GO:0005730 nucleolus IDA --
GO:0005737 cytoplasm IEA --
GO:0005829 cytosol IDA,TAS --
genes like me logo Genes that share ontologies with SKP2: view

Pathways & Interactions for SKP2 Gene

genes like me logo Genes that share pathways with SKP2: view

Pathways by source for SKP2 Gene

6 GeneGo (Thomson Reuters) pathways for SKP2 Gene
  • Cell cycle ESR1 regulation of G1/S transition
  • Cell cycle Regulation of G1/S transition (part 1)
  • Cell cycle Role of SCF complex in cell cycle regulation
  • Cell cycle_Role of APC in cell cycle regulation
  • Immune response MIF-JAB1 signaling
1 Qiagen pathway for SKP2 Gene
  • Estrogen-mediated S-Phase Entry
1 Cell Signaling Technology pathway for SKP2 Gene

UniProtKB/Swiss-Prot Q13309-SKP2_HUMAN

  • Pathway: Protein modification; protein ubiquitination.

SIGNOR curated interactions for SKP2 Gene

Inactivates:
Is activated by:
Is inactivated by:

Gene Ontology (GO) - Biological Process for SKP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000082 G1/S transition of mitotic cell cycle IEA --
GO:0000086 G2/M transition of mitotic cell cycle IBA 21873635
GO:0000209 protein polyubiquitination TAS --
GO:0002376 immune system process IEA --
GO:0006511 ubiquitin-dependent protein catabolic process IEA --
genes like me logo Genes that share ontologies with SKP2: view

Drugs & Compounds for SKP2 Gene

(10) Drugs for SKP2 Gene - From: ApexBio and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Skp2 Inhibitor C1 Pharma 0

(7) Additional Compounds for SKP2 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs

(1) ApexBio Compounds for SKP2 Gene

Compound Action Cas Number
Skp2 Inhibitor C1 432001-69-9
genes like me logo Genes that share compounds with SKP2: view

Transcripts for SKP2 Gene

mRNA/cDNA for SKP2 Gene

3 REFSEQ mRNAs :
13 NCBI additional mRNA sequence :
9 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for SKP2

Clone Products

  • Addgene plasmids for SKP2

Alternative Splicing Database (ASD) splice patterns (SP) for SKP2 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3a · 3b ^ 4a · 4b ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10 ^ 11a · 11b ^ 12a · 12b
SP1: - - -
SP2: -
SP3: - -
SP4: -
SP5: - - - - - - - - -
SP6: - -
SP7: -
SP8:

Relevant External Links for SKP2 Gene

GeneLoc Exon Structure for
SKP2

Expression for SKP2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for SKP2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for SKP2 Gene

This gene is overexpressed in Platelet (68.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for SKP2 Gene



Protein tissue co-expression partners for SKP2 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for SKP2

SOURCE GeneReport for Unigene cluster for SKP2 Gene:

Hs.23348

Evidence on tissue expression from TISSUES for SKP2 Gene

  • Liver(4.5)
  • Nervous system(4.5)
  • Lymph node(2)
genes like me logo Genes that share expression patterns with SKP2: view

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for SKP2 Gene

Orthologs for SKP2 Gene

This gene was present in the common ancestor of animals.

Orthologs for SKP2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SKP2 31 30
  • 99.84 (n)
OneToOne
dog
(Canis familiaris)
Mammalia SKP2 31 30
  • 90.8 (n)
OneToOne
cow
(Bos Taurus)
Mammalia SKP2 31 30
  • 89.23 (n)
OneToMany
-- 31
  • 87 (a)
OneToMany
-- 31
  • 78 (a)
OneToMany
-- 31
  • 74 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Skp2 30
  • 85.15 (n)
mouse
(Mus musculus)
Mammalia Skp2 17 31 30
  • 84.83 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia -- 31
  • 72 (a)
OneToMany
-- 31
  • 54 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia SKP2 31
  • 69 (a)
OneToOne
chicken
(Gallus gallus)
Aves SKP2 31 30
  • 66.26 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia SKP2 31
  • 62 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia skp2 30
  • 60.52 (n)
African clawed frog
(Xenopus laevis)
Amphibia Xl.12754 30
zebrafish
(Danio rerio)
Actinopterygii skp2 31 30
  • 55.29 (n)
OneToOne
wufa10b08 30
fruit fly
(Drosophila melanogaster)
Insecta Skp2 31 30
  • 43.94 (n)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP005297 30
  • 43.66 (n)
worm
(Caenorhabditis elegans)
Secernentea skpt-1 31 30
  • 42.18 (n)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea -- 31
  • 28 (a)
OneToOne
Species where no ortholog for SKP2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SKP2 Gene

ENSEMBL:
Gene Tree for SKP2 (if available)
TreeFam:
Gene Tree for SKP2 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for SKP2: view image

Paralogs for SKP2 Gene

Pseudogenes.org Pseudogenes for SKP2 Gene

genes like me logo Genes that share paralogs with SKP2: view

Variants for SKP2 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for SKP2 Gene

SNP ID Clinical significance and condition Chr 05 pos Variation AA Info Type
rs3913486 - p.Pro85Leu
rs3913487 - p.Leu87Ile

Additional dbSNP identifiers (rs#s) for SKP2 Gene

Structural Variations from Database of Genomic Variants (DGV) for SKP2 Gene

Variant ID Type Subtype PubMed ID
esv3604707 CNV gain 21293372
nsv524075 CNV loss 19592680
nsv524991 CNV gain 19592680
nsv830262 CNV gain 17160897
nsv968165 CNV duplication 23825009

Variation tolerance for SKP2 Gene

Residual Variation Intolerance Score: 16.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.27; 5.95% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for SKP2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
SKP2

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SKP2 Gene

Disorders for SKP2 Gene

MalaCards: The human disease database

(16) MalaCards diseases for SKP2 Gene - From: LncRNADisease, DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
lung cancer
  • adenocarcinoma of lung
hepatitis c virus
  • hepatitis c virus, susceptibility to
cervical squamous cell carcinoma
  • squamous cell carcinoma of cervix
pancreatic intraductal papillary-mucinous adenoma
laryngeal squamous cell carcinoma
  • epidermoid carcinoma of the larynx
- elite association - COSMIC cancer census association via MalaCards
Search SKP2 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for SKP2

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with SKP2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for SKP2 Gene

Publications for SKP2 Gene

  1. The F-box protein Skp2 participates in c-Myc proteosomal degradation and acts as a cofactor for c-Myc-regulated transcription. (PMID: 12769844) von der Lehr N … Larsson LG (Molecular cell 2003) 3 4 23 54
  2. ISG12a Restricts Hepatitis C Virus Infection through the Ubiquitination-Dependent Degradation Pathway. (PMID: 27194766) Xue B … Zhu H (Journal of virology 2016) 3 4 54
  3. Acetylation-dependent regulation of Skp2 function. (PMID: 22770219) Inuzuka H … Wei W (Cell 2012) 3 4 54
  4. Centrosome-related genes, genetic variation, and risk of breast cancer. (PMID: 20508983) Olson JE … Couch FJ (Breast cancer research and treatment 2011) 3 41 54
  5. Ubiquitin-recognition protein Ufd1 couples the endoplasmic reticulum (ER) stress response to cell cycle control. (PMID: 21571647) Chen M … Ronai ZA (Proceedings of the National Academy of Sciences of the United States of America 2011) 3 4 54

Products for SKP2 Gene

Sources for SKP2 Gene