Aliases for SKP2 Gene
Aliases for SKP2 Gene
External Ids for SKP2 Gene
- HGNC: 10901
- Entrez Gene: 6502
- Ensembl: ENSG00000145604
- OMIM: 601436
- UniProtKB: Q13309
Previous GeneCards Identifiers for SKP2 Gene
- GC05P036333
- GC05P037218
- GC05P036152
- GC05P036197
- GC05P036187
Summaries for SKP2 Gene
-
This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbls class; in addition to an F-box, this protein contains 10 tandem leucine-rich repeats. This protein is an essential element of the cyclin A-CDK2 S-phase kinase. It specifically recognizes phosphorylated cyclin-dependent kinase inhibitor 1B (CDKN1B, also referred to as p27 or KIP1) predominantly in S phase and interacts with S-phase kinase-associated protein 1 (SKP1 or p19). In addition, this gene is established as a protooncogene causally involved in the pathogenesis of lymphomas. Alternative splicing of this gene generates three transcript variants encoding different isoforms. [provided by RefSeq, Jul 2011]
GeneCards Summary for SKP2 Gene
SKP2 (S-Phase Kinase Associated Protein 2) is a Protein Coding gene. Diseases associated with SKP2 include Lung Cancer and Cervical Squamous Cell Carcinoma. Among its related pathways are Metabolism of proteins and Innate Immune System. Gene Ontology (GO) annotations related to this gene include identical protein binding and ubiquitin-protein transferase activity.
UniProtKB/Swiss-Prot for SKP2 Gene
-
Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins involved in cell cycle progression, signal transduction and transcription. Specifically recognizes phosphorylated CDKN1B/p27kip and is involved in regulation of G1/S transition. Degradation of CDKN1B/p27kip also requires CKS1. Recognizes target proteins ORC1, CDT1, RBL2, KMT2A/MLL1, CDK9, RAG2, FOXO1, UBP43, and probably MYC, TOB1 and TAL1. Degradation of TAL1 also requires STUB1. Recognizes CDKN1A in association with CCNE1 or CCNE2 and CDK2. Promotes ubiquitination and destruction of CDH1 in a CK1-Dependent Manner, thereby regulating cell migration.
Additional gene information for SKP2 Gene
- Monarch Initiative
- Search for SKP2 at DataMed
- Search for SKP2 at HumanCyc
No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SKP2 Gene
Genomics for SKP2 Gene
GeneHancer (GH) Regulatory Elements for SKP2 Gene
Promoters and enhancers for SKP2 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data dump
GeneHancers around SKP2 on UCSC Golden Path with GeneCards custom track
- Top Transcription factor binding sites by QIAGEN in the SKP2 gene promoter:
Regulatory Element Products
Genomic Locations for SKP2 Gene
Genomic Locations for SKP2 Gene
- chr5:36,151,989-36,192,788
- (GRCh38/hg38)
- Size:
- 40,800 bases
- Orientation:
- Plus strand
- chr5:36,152,091-36,184,421
- (GRCh37/hg19)
Genomic View for SKP2 Gene
Genes around SKP2 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 5p13.2 by Ensembl
- 5p13.2 by Entrez Gene
- 5p13.2 by HGNC
SKP2 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for SKP2 Gene
Proteins for SKP2 Gene
-
Protein details for SKP2 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q13309-SKP2_HUMAN
- Recommended name:
- S-phase kinase-associated protein 2
- Protein Accession:
- Q13309
- A8K5E0
- B4DJT4
- Q8TDZ0
- Q8TDZ1
- Q9BV69
Protein attributes for SKP2 Gene
- Size:
- 424 amino acids
- Molecular mass:
- 47761 Da
- Quaternary structure:
-
- Part of a SCF(SKP2) complex consisting of CUL1, RBX1, SKP1 and SKP2. Component of a SCF(SKP2)-like complex containing CUL1, SKP1, TRIM21 and SKP2. Interacts directly with CUL1 and SKP1. Interacts with CKS1. Interacts with the cyclin-A-CDK2 complex. Interacts with ORC1, phosphorylated CDT1, phosphorylated RBL2, ELF4, phosphorylated RAG2, FOXO1, UBP43, MYC, TOB1, TAL1 and KMT2A/MLL1. Interacts with TRIM21.
- SequenceCaution:
-
- Sequence=AAC50242.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=BAB87202.1; Type=Miscellaneous discrepancy; Note=Probable cloning artifact.; Evidence={ECO:0000305};
Three dimensional structures from OCA and Proteopedia for SKP2 Gene
Protein Expression for SKP2 Gene
Post-translational modifications for SKP2 Gene
- Acetylation at Lys-68 and Lys-71 increases stability through impairment of APC/C-mediated proteolysis and promotes cytoplasmic retention. Deacetylated by SIRT3.
- Ubiquitinated by the APC/C complex, leading to its degradation by the proteasome. Deubiquitinated by USP13.
- Ubiquitination at isoforms=2145, isoforms=2228, and posLast=299299
Other Protein References for SKP2 Gene
Antibody Products
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-
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- Novus Biologicals Antibodies for SKP2
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Abcam antibodies for SKP2
-
Cloud-Clone Corp. Antibodies for SKP2
- Invitrogen Antibodies for SKP2
- antibodies-online: Search results for available Skp2 related products ranked by validation data
- Search GeneTex for Antibodies for SKP2
-
Santa Cruz Biotechnology (SCBT) Antibodies for SKP2
Protein Products
-
OriGene Purified Proteins for SKP2
- Search Origene for MassSpec and Protein Over-expression Lysates for SKP2
- Origene Custom Protein Services for SKP2
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Cloud-Clone Corp. Proteins for SKP2
- antibodies-online: Search results for available Skp2 related products ranked by validation data
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-
Abcam proteins for SKP2
Assay Products
-
Cloud-Clone Corp. Assay Kits for SKP2
- antibodies-online: Search results for available Skp2 related products ranked by validation data
No data available for DME Specific Peptides for SKP2 Gene
Domains & Families for SKP2 Gene
Gene Families for SKP2 Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Cancer-related genes
- Predicted intracellular proteins
Protein Domains for SKP2 Gene
- InterPro:
- Blocks:
- ProtoNet:
Suggested Antigen Peptide Sequences for SKP2 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
No data available for UniProtKB/Swiss-Prot for SKP2 Gene
Function for SKP2 Gene
Molecular function for SKP2 Gene
- GENATLAS Biochemistry:
- S phase kinase associated protein 2 (p45),involved in regulation of cell cycle
- UniProtKB/Swiss-Prot Function:
- Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins involved in cell cycle progression, signal transduction and transcription. Specifically recognizes phosphorylated CDKN1B/p27kip and is involved in regulation of G1/S transition. Degradation of CDKN1B/p27kip also requires CKS1. Recognizes target proteins ORC1, CDT1, RBL2, KMT2A/MLL1, CDK9, RAG2, FOXO1, UBP43, and probably MYC, TOB1 and TAL1. Degradation of TAL1 also requires STUB1. Recognizes CDKN1A in association with CCNE1 or CCNE2 and CDK2. Promotes ubiquitination and destruction of CDH1 in a CK1-Dependent Manner, thereby regulating cell migration.
Phenotypes From GWAS Catalog for SKP2 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0004842 | ubiquitin-protein transferase activity | TAS | -- |
| GO:0005515 | protein binding | IPI | 11931757 |
| GO:0016301 | kinase activity | IEA | -- |
| GO:0042802 | identical protein binding | IPI | 22770219 |
| GO:0061630 | ubiquitin protein ligase activity | IEA | -- |
Phenotypes for SKP2 Gene
- MGI mutant phenotypes for SKP2:
- inferred from 1 alleles
- GenomeRNAi human phenotypes for SKP2:
-
- Increased vaccinia virus (VACV) infection
- Decreased NF-kappaB reporter expression
- Increased transferrin (TF) endocytosis
- Increased cell number in S
- Increased cell death in breast cancer cell lines (MCF10A, MDA-MB-435)
- Upregulation of Wnt/beta-catenin pathway after WNT3A stimulation
- Decreased viability
- Increased mitotic index
Animal Models for SKP2 Gene
- MGI Knock Outs for SKP2:
-
- Skp2 tm1Kin
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
- Cyagen custom Knockout/knockin (KOKI) mouse models for SKP2
-
-
ViGene Biosciences lentiviral particle packaged cDNA for SKP2 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for SKP2 gene
- Search ViGene Biosciences for SKP2
CRISPR Products
-
OriGene CRISPR knockouts for SKP2
- genomics-online: gRNA clones - Search results for available Skp2 gene related products
- Applied Biological Materials CRISPR for SKP2
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for SKP2
- GenScript: Design CRISPR guide RNA sequences for SKP2
miRNA for SKP2 Gene
- miRTarBase miRNAs that target SKP2
miRNA Products
- Search ViGene Biosciences for SKP2
Inhibitory RNA Products
- Origene RNAi, sirna, and shrna products in human, mouse, rat for SKP2
- Browse OriGene Inhibitory RNA Products For SKP2
- genomics-online: shRNA clones - Search results for available Skp2 gene related products
-
ViGene Biosciences ready-to-package AAV shRNAs for SKP2 gene
Clone Products
- Sino Biological Human cDNA Clone for SKP2
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- VectorBuilder custom plasmid, inducible vectors for SKP2
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for SKP2
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Addgene plasmids for SKP2
- genomics-online: cdna clones - Search results for available Skp2 gene related products
- orf clones - Search results for available Skp2 gene related products
- Applied Biological Materials Clones for SKP2
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Cell Line Products
-
Horizon Cell Lines for SKP2
-
ViGene Biosciences adenoviral particle packaged cDNA for SKP2 gene
-
ViGene Biosciences lentiviral particle packaged cDNA for SKP2 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for SKP2 gene
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for SKP2 Gene
Localization for SKP2 Gene
Subcellular locations from UniProtKB/Swiss-Prot for SKP2 Gene
- Cytoplasm. Nucleus.
| Compartment | Confidence |
|---|---|
| nucleus | 5 |
| cytosol | 5 |
| plasma membrane | 1 |
| extracellular | 1 |
| cytoskeleton | 1 |
| peroxisome | 1 |
- Cytosol (3)
- Nucleus (3)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005634 | nucleus | IDA | -- |
| GO:0005654 | nucleoplasm | TAS | -- |
| GO:0005730 | nucleolus | IDA | -- |
| GO:0005737 | cytoplasm | IEA | -- |
| GO:0005829 | cytosol | IDA,TAS | -- |
Pathways & Interactions for SKP2 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | CDK-mediated phosphorylation and removal of Cdc6 |
.78
|
|
| 2 | Cell cycle Role of SCF complex in cell cycle regulation | ||
| 3 | Class I MHC mediated antigen processing and presentation | ||
| 4 | Cell cycle |
.58
|
.58
|
| 5 | Cell Cycle, Mitotic |
.83
|
|
Pathways by source for SKP2 Gene
1 Cell Signaling Technology pathway for SKP2 Gene
8 BioSystems pathways for SKP2 Gene
9 KEGG pathways for SKP2 Gene
6 GeneGo (Thomson Reuters) pathways for SKP2 Gene
1 Qiagen pathway for SKP2 Gene
UniProtKB/Swiss-Prot Q13309-SKP2_HUMAN
- Pathway: Protein modification; protein ubiquitination.
Interacting Proteins for SKP2 Gene
Selected Interacting proteins:
ENSP00000274255
Q13309-SKP2_HUMAN
for SKP2 Gene via
STRING
MINT
IID
UniProtKB
SIGNOR curated interactions for SKP2 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000082 | G1/S transition of mitotic cell cycle | IEA | -- |
| GO:0000086 | G2/M transition of mitotic cell cycle | IEA | -- |
| GO:0000209 | protein polyubiquitination | TAS | -- |
| GO:0006511 | ubiquitin-dependent protein catabolic process | IEA | -- |
| GO:0008283 | cell proliferation | TAS | 7553852 |
Drugs & Compounds for SKP2 Gene
| Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
|---|---|---|---|---|---|---|
| Skp2 Inhibitor C1 | Pharma | 0 |
| Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs |
|---|
(1) ApexBio Compounds for SKP2 Gene
| Compound | Action | Cas Number |
|---|---|---|
| Skp2 Inhibitor C1 | 432001-69-9 |
Transcripts for SKP2 Gene
mRNA/cDNA for SKP2 Gene
- (7) REFSEQ mRNAs :
- (11) Additional mRNA sequences :
- (174) Selected AceView cDNA sequences:
- (9) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for SKP2 Gene
CRISPR Products
-
OriGene CRISPR knockouts for SKP2
- genomics-online: gRNA clones - Search results for available Skp2 gene related products
- Applied Biological Materials CRISPR for SKP2
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for SKP2
- GenScript: Design CRISPR guide RNA sequences for SKP2
miRNA Products
- Search ViGene Biosciences for SKP2
Inhibitory RNA Products
- Origene RNAi, sirna, and shrna products in human, mouse, rat for SKP2
- Browse OriGene Inhibitory RNA Products For SKP2
- genomics-online: shRNA clones - Search results for available Skp2 gene related products
-
ViGene Biosciences ready-to-package AAV shRNAs for SKP2 gene
Clone Products
- Sino Biological Human cDNA Clone for SKP2
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- VectorBuilder custom plasmid, inducible vectors for SKP2
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for SKP2
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Addgene plasmids for SKP2
- genomics-online: cdna clones - Search results for available Skp2 gene related products
- orf clones - Search results for available Skp2 gene related products
- Applied Biological Materials Clones for SKP2
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
| ExUns: | 1a | · | 1b | · | 1c | · | 1d | ^ | 2 | ^ | 3a | · | 3b | ^ | 4a | · | 4b | ^ | 5 | ^ | 6a | · | 6b | ^ | 7 | ^ | 8 | ^ | 9 | ^ | 10 | ^ | 11a | · | 11b | ^ | 12a | · | 12b |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | - | ||||||||||||||||||||||||||||||||||||
| SP2: | - | ||||||||||||||||||||||||||||||||||||||
| SP3: | - | - | |||||||||||||||||||||||||||||||||||||
| SP4: | - | ||||||||||||||||||||||||||||||||||||||
| SP5: | - | - | - | - | - | - | - | - | - | ||||||||||||||||||||||||||||||
| SP6: | - | - | |||||||||||||||||||||||||||||||||||||
| SP7: | - | ||||||||||||||||||||||||||||||||||||||
| SP8: |
Expression for SKP2 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
-
Blood (Hematopoietic System)
- Proerythroblasts Hematopoietic Bone Marrow
- Hematopoietic Bone Marrow
- Brain (Nervous System)
- Intestine (Gastrointestinal Tract)
- Limb (Muscoskeletal System)
-
Placenta (Extraembryonic Tissues)
This gene is overexpressed in Platelet (68.6).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for SKP2 Gene
- Elite partner
NURSA nuclear receptor signaling pathways regulating expression of SKP2 Gene:
SKP2SOURCE GeneReport for Unigene cluster for SKP2 Gene:
Hs.23348Evidence on tissue expression from TISSUES for SKP2 Gene
- Liver(4.5)
- Nervous system(4.5)
- Lymph node(2)
Primer Products
-
OriGene qPCR primer pairs for SKP2
-
OriGene qPCR primer pairs and template standards for SKP2
- genomics-online: primer clones - Search results for available Skp2 gene related products
No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for SKP2 Gene
Orthologs for SKP2 Gene
This gene was present in the common ancestor of animals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | SKP2 33 34 |
|
||
| dog (Canis familiaris) |
Mammalia | SKP2 33 34 |
|
||
| cow (Bos Taurus) |
Mammalia | SKP2 33 34 |
|
||
| -- 34 |
|
OneToMany | |||
| -- 34 |
|
OneToMany | |||
| -- 34 |
|
OneToMany | |||
| rat (Rattus norvegicus) |
Mammalia | Skp2 33 |
|
||
| mouse (Mus musculus) |
Mammalia | Skp2 33 16 34 |
|
||
| platypus (Ornithorhynchus anatinus) |
Mammalia | -- 34 |
|
OneToMany | |
| -- 34 |
|
OneToMany | |||
| oppossum (Monodelphis domestica) |
Mammalia | SKP2 34 |
|
OneToOne | |
| chicken (Gallus gallus) |
Aves | SKP2 33 34 |
|
||
| lizard (Anolis carolinensis) |
Reptilia | SKP2 34 |
|
OneToOne | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | skp2 33 |
|
||
| African clawed frog (Xenopus laevis) |
Amphibia | Xl.12754 33 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | skp2 33 34 |
|
||
| wufa10b08 33 |
|
||||
| fruit fly (Drosophila melanogaster) |
Insecta | Skp2 33 34 |
|
||
| African malaria mosquito (Anopheles gambiae) |
Insecta | AgaP_AGAP005297 33 |
|
||
| worm (Caenorhabditis elegans) |
Secernentea | skpt-1 33 34 |
|
||
| sea squirt (Ciona savignyi) |
Ascidiacea | -- 34 |
|
OneToOne |
- Species where no ortholog for SKP2 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
Paralogs for SKP2 Gene
Pseudogenes.org Pseudogenes for SKP2 Gene
No data available for Paralogs for SKP2 Gene
Variants for SKP2 Gene
| SNP ID | Clin | Chr 05 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs1000139652 | -- | 36,152,468(+) | T/C/G | intron_variant | |
| rs1000168343 | -- | 36,177,818(+) | T/C | intron_variant | |
| rs1000193136 | -- | 36,157,133(+) | G/A | intron_variant | |
| rs1000251232 | -- | 36,177,078(+) | G/T | intron_variant | |
| rs1000425183 | -- | 36,163,512(+) | G/A | intron_variant |
Residual Variation Intolerance Score:
16.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
0.27;
5.95% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for SKP2 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- SKP2
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SKP2 Gene
Disorders for SKP2 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| lung cancer |
|
|
| cervical squamous cell carcinoma |
|
|
| pancreatic intraductal papillary-mucinous adenoma |
|
|
| breast cancer |
|
|
| prostate cancer |
|
Search SKP2 in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for SKP2
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
No data available for UniProtKB/Swiss-Prot and Genatlas for SKP2 Gene
Publications for SKP2 Gene
- The F-box protein Skp2 participates in c-Myc proteosomal degradation and acts as a cofactor for c-Myc-regulated transcription. (PMID: 12769844) von der Lehr N … Larsson LG (Molecular cell 2003) 3 4 22 58
- Acetylation-dependent regulation of Skp2 function. (PMID: 22770219) Inuzuka H … Wei W (Cell 2012) 3 4 58
- Ubiquitin-recognition protein Ufd1 couples the endoplasmic reticulum (ER) stress response to cell cycle control. (PMID: 21571647) Chen M … Ronai ZA (Proceedings of the National Academy of Sciences of the United States of America 2011) 3 4 58
- Centrosome-related genes, genetic variation, and risk of breast cancer. (PMID: 20508983) Olson JE … Couch FJ (Breast cancer research and treatment 2011) 3 44 58
- Phosphorylation of Ser72 is dispensable for Skp2 assembly into an active SCF ubiquitin ligase and its subcellular localization. (PMID: 20160477) Bashir T … Pagano M (Cell cycle (Georgetown, Tex.) 2010) 3 22 58
Products for SKP2 Gene
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- OriGene qPCR primer pairs and template standards for SKP2
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- Gene Synthesis: Any Gene in Any Vector
- Vector-based siRNA and miRNA, Ready for Transfection
- Gene Mutant Library, Variants up to 10^11
- Plasmid Preparation
- GenScript Custom Peptide Services for SKP2
- Cell Signaling Technology (CST) Antibodies for SKP2 (SKP2)
- Search for Antibodies & Assays
- Sino Biological Human cDNA Clone for SKP2
- Browse Sino Biological Cell Lysates
- Browse Sino Biological Recombinant Proteins
- Browse Sino Biological Antibodies
- Browse Sino Biological Assays
- Browse Sino Biological ELISA Kits
- Browse Sino Biological ELISA Pair Sets
- Browse Sino Biological CRO Services
- Browse Sino Biological Control Vectors
- Sino Biological Transfection Reagent
- Sino Biological Anti-His Tag Antibody
- Novus Biologicals Antibodies for SKP2
- Novus Biologicals lysates and proteins for SKP2
- Novus Biologicals
- Novus Biologicals Tissue Microarrays
- Browse Antibodies
- Browse Peptides and Proteins
- Browse Lysates
- Browse ELISA Kits
- Abcam antibodies for SKP2
- Abcam proteins for SKP2
- Find your target
- Browse Primary Antibodies
- Browse Conjugated Primary Antibodies
- Browse Secondary Antibodies
- Browse ELISA Kits
- Browse Matched Antibody Pairs
- Browse Proteins and Peptides
- Search Knockout (KO) Validated Antibodies
- Browse Monoclonal Antibodies
- Browse Recombinant Antibodies
- Cloud-Clone Corp. Antibodies for SKP2
- Cloud-Clone Corp. Proteins for SKP2
- Cloud-Clone Corp. Assay Kits for SKP2
- Browse Knockouts at Cloud-Clone Corp.
- Browse Knockins at Cloud-Clone Corp.
- Cloud-Clone Corp. disease models service
- Browse cDNA clones at Cloud-Clone Corp.
- Browse primers at Cloud-Clone Corp.
- Cloud-Clone Corp. primary cells service
- Invitrogen Antibodies for SKP2
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- ApexBio compounds for SKP2
- Cyagen custom Knockout/knockin (KOKI) mouse models for SKP2
- VectorBuilder custom plasmid, inducible vectors for SKP2
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for SKP2
- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Addgene plasmids for SKP2
- antibodies-online: Search results for available Skp2 related products ranked by validation data
- antibodies-online: Search results for available Skp2 related products ranked by validation data
- antibodies-online: Search results for available Skp2 related products ranked by validation data
- Search GeneTex for Antibodies for SKP2
- Search GeneTex for Proteins for SKP2
- ViGene Biosciences adenoviral particle packaged cDNA for SKP2 gene
- ViGene Biosciences lentiviral particle packaged cDNA for SKP2 gene
- ViGene Biosciences ready-to-package AAV shRNAs for SKP2 gene
- Search ViGene Biosciences for SKP2
- Santa Cruz Biotechnology (SCBT) Antibodies for SKP2
- Search Santa Cruz Biotechnology (SCBT) for SKP2 siRNA/shRNA
- Santa Cruz Biotechnology (SCBT) CRISPR for SKP2
- Horizon Cell Lines for SKP2
- genomics-online: cdna clones - Search results for available Skp2 gene related products
- orf clones - Search results for available Skp2 gene related products
- genomics-online: gRNA clones - Search results for available Skp2 gene related products
- genomics-online: primer clones - Search results for available Skp2 gene related products
- genomics-online: shRNA clones - Search results for available Skp2 gene related products
Sources for SKP2 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) ASD
- (29) ECgene
- (30) GeneAnnot
- (31) CGAP SAGE
- (32) SOURCE
- (33) HomoloGene
- (34) PanEnsembl
- (35) euGenes
- (36) SGD
- (37) FlyBase
- (38) WormBase
- (39) Pseudogene
- (40) DGV
- (41) dbSNP
- (42) GenAtlas
- (43) HGMD
- (44) GAD
- (45) BGMUT
- (46) HuGE
- (47) Atlas
- (48) Cell Signaling Technology
- (49) GenBank
- (50) H-invDB
- (51) HORDE
- (52) HUGE
- (53) IMGT
- (54) Leiden
- (55) miRBase
- (56) DME
- (57) OriGene
- (58) PubMed
- (59) R&D Systems
- (60) TGDB
- (61) Tocris
- (62) Abcam
- (63) Novus Biologicals
- (64) ProSpec
- (65) Sino Biological
- (66) GenScript
- (67) Qiagen
- (68) Cloud-Clone Corp.
- (69) OCA
- (70) Proteopedia
- (71) MOPED
- (72) neXtProt
- (73) Reactome
- (74) GeneGo (Thomson Reuters)
- (75) fRNAdb
- (76) DISEASES
- (77) SIMAP
- (78) GenomeRNAi
- (79) LifeMap
- (80) miRTarBase
- (81) MalaCards
- (82) Invitrogen
- (83) BitterDB
- (84) Vector BioLabs
- (85) ESI-BIO
- (86) RefSeq
- (87) BioSystems
- (88) MaxQB
- (89) IUPHAR
- (90) BioGPS
- (91) Illumina
- (92) COMPARTMENTS
- (93) HOMER
- (94) PaxDb
- (95) ApexBio
- (96) Addgene
- (97) antibodies-online
- (98) CYP
- (99) NONCODE
- (100) SwitchGear Genomics
- (101) TreeFam
- (102) PathCards
- (103) GeneReviews
- (104) GeneTex
- (105) Taconic Biosciences
- (106) GTEx
- (107) ProteomicsDB
- (108) SCBT
- (109) DGIdb
- (110) ClinicalTrials
- (111) FDA Approved Drugs
- (112) RVIS
- (113) SIGNOR
- (114) diseasecard
- (115) NIH Rare Diseases
- (116) Orphanet
- (117) UMLS
- (118) GTR
- (119) Disease Ontology
- (120) Genetics Home Reference
- (121) MeSH
- (122) MedlinePlus
- (123) CDC
- (124) NINDS
- (125) NCBI Bookshelf
- (126) ClinVar
- (127) Gene Damage Index
- (128) ViGene Biosciences
- (129) HPO
- (130) UDN
- (131) VISTA
- (132) FANTOM5
- (133) ENCODE
- (134) ProSci
- (135) Horizon
- (136) NURSA
- (137) IID
- (138) Cyagen
- (139) VectorBuilder
- (140) SNPedia
- (141) BRCA Exchange
- (142) St John's Lab
- (143) CIViC
- (144) ProteoGenix
- (145) dbSUPER
- (146) TISSUES
- (147) Gene ORGANizer
- (148) abm
- (149) CrownBio
- (150) Human Protein Atlas
- (151) GWAS Catalog
- (152) Monarch Initiative
- (153) DataMed
- (154) HumanCyc
- (155) genomics-online
- (156) UCNEbase
- (157) EPDnew