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This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbls class; in addition to an F-box, this protein contains 10 tandem leucine-rich repeats. This protein is an essential element of the cyclin A-CDK2 S-phase kinase. It specifically recognizes phosphorylated cyclin-dependent kinase inhibitor 1B (CDKN1B, also referred to as p27 or KIP1) predominantly in S phase and interacts with S-phase kinase-associated protein 1 (SKP1 or p19). In addition, this gene is established as a protooncogene causally involved in the pathogenesis of lymphomas. Alternative splicing of this gene generates three transcript variants encoding different isoforms. [provided by RefSeq, Jul 2011]
SKP2 (S-Phase Kinase Associated Protein 2) is a Protein Coding gene. Diseases associated with SKP2 include Lung Cancer and Myxofibrosarcoma. Among its related pathways are Small cell lung cancer and Cell cycle_Role of APC in cell cycle regulation. Gene Ontology (GO) annotations related to this gene include identical protein binding and ubiquitin-protein transferase activity. An important paralog of this gene is FBXL13.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005515 | protein binding | IEA,IPI | 11931757 |
GO:0016301 | kinase activity | IEA | -- |
GO:0042802 | identical protein binding | IPI | 22770219 |
GO:0061630 | ubiquitin protein ligase activity | IBA,IEA | -- |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005634 | nucleus | IBA | 21873635 |
GO:0005654 | nucleoplasm | IDA,TAS | -- |
GO:0005730 | nucleolus | IDA | -- |
GO:0005737 | cytoplasm | IEA | -- |
GO:0005829 | cytosol | IDA,TAS | -- |
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | Regulation of activated PAK-2p34 by proteasome mediated degradation |
.78
|
|
2 | Cell cycle Role of SCF complex in cell cycle regulation |
Cell cycle Regulation of G1/S transition (part 1)
.40
Cell cycle Role of SCF complex in cell cycle regulation
.40
|
Cell cycle ESR1 regulation of G1/S transition
.34
Immune response MIF-JAB1 signaling
.33
|
3 | Class I MHC mediated antigen processing and presentation | ||
4 | Cell cycle |
.58
|
.58
|
5 | Cell Cycle, Mitotic |
.83
|
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0000082 | G1/S transition of mitotic cell cycle | TAS,IEA | -- |
GO:0000086 | G2/M transition of mitotic cell cycle | IBA | 21873635 |
GO:0000209 | protein polyubiquitination | TAS | -- |
GO:0002376 | immune system process | IEA | -- |
GO:0006511 | ubiquitin-dependent protein catabolic process | IEA | -- |
ExUns: | 1a | · | 1b | · | 1c | · | 1d | ^ | 2 | ^ | 3a | · | 3b | ^ | 4a | · | 4b | ^ | 5 | ^ | 6a | · | 6b | ^ | 7 | ^ | 8 | ^ | 9 | ^ | 10 | ^ | 11a | · | 11b | ^ | 12a | · | 12b |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
SP1: | - | - | - | ||||||||||||||||||||||||||||||||||||
SP2: | - | ||||||||||||||||||||||||||||||||||||||
SP3: | - | - | |||||||||||||||||||||||||||||||||||||
SP4: | - | ||||||||||||||||||||||||||||||||||||||
SP5: | - | - | - | - | - | - | - | - | - | ||||||||||||||||||||||||||||||
SP6: | - | - | |||||||||||||||||||||||||||||||||||||
SP7: | - | ||||||||||||||||||||||||||||||||||||||
SP8: |
This gene was present in the common ancestor of animals.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Chimpanzee (Pan troglodytes) |
Mammalia | SKP2 30 31 |
|
OneToOne | |
Dog (Canis familiaris) |
Mammalia | SKP2 30 31 |
|
OneToOne | |
Cow (Bos Taurus) |
Mammalia | SKP2 30 31 |
|
OneToMany | |
-- 31 |
|
OneToMany | |||
-- 31 |
|
OneToMany | |||
-- 31 |
|
OneToMany | |||
Rat (Rattus norvegicus) |
Mammalia | Skp2 30 |
|
||
Mouse (Mus musculus) |
Mammalia | Skp2 30 17 31 |
|
OneToOne | |
Platypus (Ornithorhynchus anatinus) |
Mammalia | -- 31 |
|
OneToMany | |
-- 31 |
|
OneToMany | |||
Oppossum (Monodelphis domestica) |
Mammalia | SKP2 31 |
|
OneToOne | |
Chicken (Gallus gallus) |
Aves | SKP2 30 31 |
|
OneToOne | |
Lizard (Anolis carolinensis) |
Reptilia | SKP2 31 |
|
OneToOne | |
Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | skp2 30 |
|
||
African clawed frog (Xenopus laevis) |
Amphibia | Xl.12754 30 |
|
||
Zebrafish (Danio rerio) |
Actinopterygii | skp2 30 31 |
|
OneToOne | |
wufa10b08 30 |
|
||||
Fruit Fly (Drosophila melanogaster) |
Insecta | Skp2 30 31 |
|
OneToOne | |
African malaria mosquito (Anopheles gambiae) |
Insecta | AgaP_AGAP005297 30 |
|
||
Worm (Caenorhabditis elegans) |
Secernentea | skpt-1 30 31 |
|
OneToOne | |
Sea Squirt (Ciona savignyi) |
Ascidiacea | -- 31 |
|
OneToOne |
Disorder | Aliases | PubMed IDs |
---|---|---|
lung cancer |
|
|
myxofibrosarcoma |
|
|
hepatitis c virus |
|
|
pancreatic intraductal papillary-mucinous adenoma |
|
|
cervical squamous cell carcinoma |
|