This gene encodes a component of SCF complexes, which are composed of this protein, cullin 1, a ring-box protein, and one member of the F-box family of proteins. This protein binds directly to the F-box motif found in F-box proteins. SCF complexes are involved in the regulated ubiquitination of specific protein substrates, which targets them for degradation by the proteosome. S... See more...

Aliases for SKP1 Gene

Aliases for SKP1 Gene

  • S-Phase Kinase Associated Protein 1 2 3 5
  • Transcription Elongation Factor B Polypeptide 1-Like 3 4
  • Cyclin-A/CDK2-Associated Protein P19 3 4
  • S-Phase Kinase-Associated Protein 1 3 4
  • Organ Of Corti Protein II 3 4
  • Organ Of Corti Protein 2 3 4
  • P19skp1 3 4
  • OCP-II 3 4
  • TCEB1L 3 4
  • SKP1A 3 4
  • EMC19 3 4
  • OCP-2 3 4
  • OCP2 3 4
  • SIII 3 4
  • P19A 3 4
  • RNA Polymerase II Elongation Factor-Like Protein OCP2 3
  • RNA Polymerase II Elongation Factor-Like Protein 4
  • S-Phase Kinase-Associated Protein 1A (P19A) 2
  • Cyclin A/CDK2-Associated P19 3

External Ids for SKP1 Gene

Previous HGNC Symbols for SKP1 Gene

  • SKP1A

Previous GeneCards Identifiers for SKP1 Gene

  • GC05M133521
  • GC05M128677
  • GC05M133484

Summaries for SKP1 Gene

Entrez Gene Summary for SKP1 Gene

  • This gene encodes a component of SCF complexes, which are composed of this protein, cullin 1, a ring-box protein, and one member of the F-box family of proteins. This protein binds directly to the F-box motif found in F-box proteins. SCF complexes are involved in the regulated ubiquitination of specific protein substrates, which targets them for degradation by the proteosome. Specific F-box proteins recognize different target protein(s), and many specific SCF substrates have been identified including regulators of cell cycle progression and development. Studies have also characterized the protein as an RNA polymerase II elongation factor. Alternative splicing of this gene results in two transcript variants. A related pseudogene has been identified on chromosome 7. [provided by RefSeq, Jul 2008]

GeneCards Summary for SKP1 Gene

SKP1 (S-Phase Kinase Associated Protein 1) is a Protein Coding gene. Diseases associated with SKP1 include Keratoconus 1 and Keratoconus. Among its related pathways are Downstream signaling events of B Cell Receptor (BCR) and Signaling by Wnt. Gene Ontology (GO) annotations related to this gene include ubiquitin-protein transferase activity.

UniProtKB/Swiss-Prot Summary for SKP1 Gene

  • Essential component of the SCF (SKP1-CUL1-F-box protein) ubiquitin ligase complex, which mediates the ubiquitination of proteins involved in cell cycle progression, signal transduction and transcription. In the SCF complex, serves as an adapter that links the F-box protein to CUL1. The functional specificity of the SCF complex depends on the F-box protein as substrate recognition component. SCF(BTRC) and SCF(FBXW11) direct ubiquitination of CTNNB1 and participate in Wnt signaling. SCF(FBXW11) directs ubiquitination of phosphorylated NFKBIA. SCF(BTRC) directs ubiquitination of NFKBIB, NFKBIE, ATF4, SMAD3, SMAD4, CDC25A, FBXO5, CEP68 and probably NFKB2 (PubMed:25704143). SCF(SKP2) directs ubiquitination of phosphorylated CDKN1B/p27kip and is involved in regulation of G1/S transition. SCF(SKP2) directs ubiquitination of ORC1, CDT1, RBL2, ELF4, CDKN1A, RAG2, FOXO1A, and probably MYC and TAL1. SCF(FBXW7) directs ubiquitination of cyclin E, NOTCH1 released notch intracellular domain (NICD), and probably PSEN1. SCF(FBXW2) directs ubiquitination of GCM1. SCF(FBXO32) directs ubiquitination of MYOD1. SCF(FBXO7) directs ubiquitination of BIRC2 and DLGAP5. SCF(FBXO33) directs ubiquitination of YBX1. SCF(FBXO11) directs ubiquitination of BCL6 and DTL but does not seem to direct ubiquitination of TP53. SCF(BTRC) mediates the ubiquitination of NFKBIA at 'Lys-21' and 'Lys-22'; the degradation frees the associated NFKB1-RELA dimer to translocate into the nucleus and to activate transcription. SCF(CCNF) directs ubiquitination of CCP110. SCF(FBXL3) and SCF(FBXL21) direct ubiquitination of CRY1 and CRY2. SCF(FBXO9) directs ubiquitination of TTI1 and TELO2. SCF(FBXO10) directs ubiquitination of BCL2.

Gene Wiki entry for SKP1 Gene

Additional gene information for SKP1 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for SKP1 Gene

Genomics for SKP1 Gene

GeneHancer (GH) Regulatory Elements for SKP1 Gene

Promoters and enhancers for SKP1 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around SKP1 on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for SKP1

Top Transcription factor binding sites by QIAGEN in the SKP1 gene promoter:
  • GATA-2
  • HNF-4alpha1
  • Ik-1
  • Nkx3-1
  • Nkx3-1 v1
  • Pax-4a
  • POU2F1
  • POU2F1a
  • S8

Genomic Locations for SKP1 Gene

Genomic Locations for SKP1 Gene
chr5:134,148,935-134,177,038
(GRCh38/hg38)
Size:
28,104 bases
Orientation:
Minus strand
chr5:133,484,633-133,512,729
(GRCh37/hg19)
Size:
28,097 bases
Orientation:
Minus strand

Genomic View for SKP1 Gene

Genes around SKP1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SKP1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SKP1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SKP1 Gene

Proteins for SKP1 Gene

  • Protein details for SKP1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P63208-SKP1_HUMAN
    Recommended name:
    S-phase kinase-associated protein 1
    Protein Accession:
    P63208
    Secondary Accessions:
    • D3DQ97
    • D3DQ98
    • P34991
    • Q8TAY2

    Protein attributes for SKP1 Gene

    Size:
    163 amino acids
    Molecular mass:
    18658 Da
    Quaternary structure:
    • Interacts with KDM2B, forming heterodimers (PubMed:27568929). The KDM2B-SKP1 heterodimeric complex interacts with the PCGF1-BCORL heterodimeric complex to form a homotetrameric polycomb repression complex 1 (PRC1.1) (PubMed:27568929). Component of multiple SCF (SKP1-CUL1-F-box) E3 ubiquitin-protein ligase complexes formed of CUL1, SKP1, RBX1 and a variable F-box domain-containing protein as substrate-specific subunit. Component of the SCF(FBXW11) complex containing FBXW11. Component of the SCF(SKP2) complex containing SKP2, in which it interacts directly with SKP1, SKP2 and RBX1. Component of the SCF(FBXW2) complex containing FBXw2. Component of the SCF(FBXO32) complex containing FBXO32. Component of the probable SCF(FBXO7) complex containing FBXO7. Component of the SCF(FBXO10) complex containing FBXO10. Component of the SCF(FBXO11) complex containing FBXO11. Component of the SCF(FBXO25) complex containing FBXO25. Component of the SCF(FBXO33) complex containing FBXO33. Component of the probable SCF(FBXO4) complex containing FBXO4. Component of the SCF(FBXO44) complex, composed of SKP1, CUL1 and FBXO44. Component of the SCF(BTRC) complex, composed of SKP1, CUL1 and BTRC. This complex binds phosphorylated NFKBIA. Part of a SCF complex consisting of CUL1, RBX1, SKP1 and FBXO2. Component of a SCF(SKP2)-like complex containing CUL1, SKP1, TRIM21 and SKP2. Component of the SCF(FBXO17) complex, composed of SKP1, CUL1 and FBXO17. Component of the SCF(FBXO27) complex, composed of SKP1, CUL1 and FBXO27. Component of the SCF(CCNF) complex consisting of CUL1, RBX1, SKP1 and CCNF. Component of the SCF(FBXL3) complex composed of CUL1, SKP1, RBX1 and FBXL3. Component of the SCF(FBXL21) complex composed of CUL1, SKP1, RBX1 and FBXL21. Component of the SCF(FBXO9) composed of CUL1, SKP1, RBX1 and FBXO9. Component of the SCF(FBXW7) composed of CUL1, SKP1, RBX1 and FBXW7 (PubMed:28727686). Interacts with CEP68 (PubMed:25503564). Interacts with NOTCH2 (PubMed:29149593). Interacts with FBXW15 (By similarity). The SKP1-KDM2A and SKP1-KDM2B complexes interact with UBB (PubMed:30033217).
    • (Microbial infection) Interacts with vaccinia virus protein C9L.

    Three dimensional structures from OCA and Proteopedia for SKP1 Gene

    Alternative splice isoforms for SKP1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SKP1 Gene

Post-translational modifications for SKP1 Gene

  • Undergoes autophagy-mediated degradation in the liver in a time-dependent manner.
  • Ubiquitination at Lys121, Lys130, Lys137, Lys142, and Lys155
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for SKP1 Gene

Domains & Families for SKP1 Gene

Gene Families for SKP1 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for SKP1 Gene

Suggested Antigen Peptide Sequences for SKP1 Gene

GenScript: Design optimal peptide antigens:
  • p19skp1 (SKP1_HUMAN)

Graphical View of Domain Structure for InterPro Entry

P63208

UniProtKB/Swiss-Prot:

SKP1_HUMAN :
  • Belongs to the SKP1 family.
Family:
  • Belongs to the SKP1 family.
genes like me logo Genes that share domains with SKP1: view

Function for SKP1 Gene

Molecular function for SKP1 Gene

UniProtKB/Swiss-Prot Function:
Essential component of the SCF (SKP1-CUL1-F-box protein) ubiquitin ligase complex, which mediates the ubiquitination of proteins involved in cell cycle progression, signal transduction and transcription. In the SCF complex, serves as an adapter that links the F-box protein to CUL1. The functional specificity of the SCF complex depends on the F-box protein as substrate recognition component. SCF(BTRC) and SCF(FBXW11) direct ubiquitination of CTNNB1 and participate in Wnt signaling. SCF(FBXW11) directs ubiquitination of phosphorylated NFKBIA. SCF(BTRC) directs ubiquitination of NFKBIB, NFKBIE, ATF4, SMAD3, SMAD4, CDC25A, FBXO5, CEP68 and probably NFKB2 (PubMed:25704143). SCF(SKP2) directs ubiquitination of phosphorylated CDKN1B/p27kip and is involved in regulation of G1/S transition. SCF(SKP2) directs ubiquitination of ORC1, CDT1, RBL2, ELF4, CDKN1A, RAG2, FOXO1A, and probably MYC and TAL1. SCF(FBXW7) directs ubiquitination of cyclin E, NOTCH1 released notch intracellular domain (NICD), and probably PSEN1. SCF(FBXW2) directs ubiquitination of GCM1. SCF(FBXO32) directs ubiquitination of MYOD1. SCF(FBXO7) directs ubiquitination of BIRC2 and DLGAP5. SCF(FBXO33) directs ubiquitination of YBX1. SCF(FBXO11) directs ubiquitination of BCL6 and DTL but does not seem to direct ubiquitination of TP53. SCF(BTRC) mediates the ubiquitination of NFKBIA at 'Lys-21' and 'Lys-22'; the degradation frees the associated NFKB1-RELA dimer to translocate into the nucleus and to activate transcription. SCF(CCNF) directs ubiquitination of CCP110. SCF(FBXL3) and SCF(FBXL21) direct ubiquitination of CRY1 and CRY2. SCF(FBXO9) directs ubiquitination of TTI1 and TELO2. SCF(FBXO10) directs ubiquitination of BCL2.

Phenotypes From GWAS Catalog for SKP1 Gene

Gene Ontology (GO) - Molecular Function for SKP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004842 ubiquitin-protein transferase activity IDA 20347421
GO:0005515 protein binding IPI 11238952
GO:0008013 beta-catenin binding IDA 12820959
GO:0019904 protein domain specific binding IPI 15996101
GO:0061630 contributes_to ubiquitin protein ligase activity IDA 12820959
genes like me logo Genes that share ontologies with SKP1: view
genes like me logo Genes that share phenotypes with SKP1: view

Animal Model Products

CRISPR Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for SKP1 Gene

Localization for SKP1 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SKP1 gene
Compartment Confidence
nucleus 5
cytosol 5
cytoskeleton 3
plasma membrane 2
extracellular 2
mitochondrion 2
endoplasmic reticulum 2
endosome 2
lysosome 2
golgi apparatus 2
peroxisome 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nucleoplasm (3)
  • Cytosol (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for SKP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005623 cell IEA --
GO:0005634 nucleus IDA 18929646
GO:0005654 nucleoplasm TAS --
GO:0005737 cytoplasm IDA 18929646
GO:0005813 centrosome IEA --
genes like me logo Genes that share ontologies with SKP1: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for SKP1 Gene

Pathways & Interactions for SKP1 Gene

PathCards logo

SuperPathways for SKP1 Gene

SuperPathway Contained pathways
1 CDK-mediated phosphorylation and removal of Cdc6
.78
2 Activated TLR4 signalling
3 Signaling by NOTCH1
4 HIV Life Cycle
.45
5 Cell cycle Role of SCF complex in cell cycle regulation
.40
.40
.34
.33
genes like me logo Genes that share pathways with SKP1: view

Pathways by source for SKP1 Gene

5 GeneGo (Thomson Reuters) pathways for SKP1 Gene
  • Cell cycle ESR1 regulation of G1/S transition
  • Cell cycle Regulation of G1/S transition (part 1)
  • Cell cycle Role of SCF complex in cell cycle regulation
  • Immune response MIF-JAB1 signaling
  • Proteolysis_Putative ubiquitin pathway
1 GeneTex pathway for SKP1 Gene

UniProtKB/Swiss-Prot P63208-SKP1_HUMAN

  • Pathway: Protein modification; protein ubiquitination.

SIGNOR curated interactions for SKP1 Gene

Activates:
Is activated by:

Gene Ontology (GO) - Biological Process for SKP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000086 G2/M transition of mitotic cell cycle TAS --
GO:0000209 protein polyubiquitination TAS --
GO:0002223 stimulatory C-type lectin receptor signaling pathway TAS --
GO:0006511 ubiquitin-dependent protein catabolic process IEA --
GO:0006879 cellular iron ion homeostasis TAS --
genes like me logo Genes that share ontologies with SKP1: view

Drugs & Compounds for SKP1 Gene

(6) Drugs for SKP1 Gene - From: DrugBank and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
(2S)-2-(1H-indol-3-yl)hexanoic acid Experimental Pharma Target 0
(2S)-2-(1H-indol-3-yl)pentanoic acid Experimental Pharma Target 0
(2S)-8-[(tert-butoxycarbonyl)amino]-2-(1H-indol-3-yl)octanoic acid Experimental Pharma Target 0
1-naphthaleneacetic acid Experimental Pharma Target 0
Indoleacetic acid Experimental Pharma Target 0
genes like me logo Genes that share compounds with SKP1: view

Transcripts for SKP1 Gene

mRNA/cDNA for SKP1 Gene

2 REFSEQ mRNAs :
13 NCBI additional mRNA sequence :
13 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for SKP1 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6a · 6b ^ 7
SP1: - - - -
SP2: - - -
SP3: - -
SP4: -
SP5: - -

Relevant External Links for SKP1 Gene

GeneLoc Exon Structure for
SKP1

Expression for SKP1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for SKP1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for SKP1 Gene

This gene is overexpressed in Brain (19.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for SKP1 Gene



Protein tissue co-expression partners for SKP1 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for SKP1

SOURCE GeneReport for Unigene cluster for SKP1 Gene:

Hs.171626

Evidence on tissue expression from TISSUES for SKP1 Gene

  • Blood(4.8)
  • Liver(4.8)
  • Lung(4.8)
  • Nervous system(4.8)
  • Skin(4.6)
  • Muscle(3.8)
  • Pancreas(3.8)
  • Kidney(3.5)
  • Heart(2.6)
  • Intestine(2.5)
  • Eye(2.4)
  • Adrenal gland(2.3)
  • Thyroid gland(2.3)
  • Gall bladder(2.1)
  • Spleen(2.1)
  • Lymph node(2)
genes like me logo Genes that share expression patterns with SKP1: view

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for SKP1 Gene

Orthologs for SKP1 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for SKP1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SKP1 30
  • 100 (n)
-- 31
  • 94 (a)
OneToMany
cow
(Bos Taurus)
Mammalia -- 31
  • 98 (a)
ManyToMany
SKP1 30
  • 92.84 (n)
dog
(Canis familiaris)
Mammalia SKP1 31 30
  • 97.14 (n)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 31
  • 95 (a)
OneToMany
mouse
(Mus musculus)
Mammalia Skp1a 17 31 30
  • 94.48 (n)
rat
(Rattus norvegicus)
Mammalia Skp1 30
  • 94.48 (n)
oppossum
(Monodelphis domestica)
Mammalia -- 31
  • 83 (a)
ManyToMany
chicken
(Gallus gallus)
Aves SKP1 31 30
  • 88.55 (n)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 31
  • 100 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia skp1 30
  • 84.25 (n)
African clawed frog
(Xenopus laevis)
Amphibia skp1a-prov 30
zebrafish
(Danio rerio)
Actinopterygii skp1 31 30
  • 84.05 (n)
OneToMany
zgc73186 30
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.11291 30
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP008719 30
  • 70.16 (n)
fruit fly
(Drosophila melanogaster)
Insecta skpA 31 30
  • 69.96 (n)
ManyToMany
skpB 31
  • 69 (a)
ManyToMany
skpF 31
  • 54 (a)
ManyToMany
skpC 31
  • 54 (a)