Aliases for SKIV2L Gene
External Ids for SKIV2L Gene
Previous HGNC Symbols for SKIV2L Gene
Previous GeneCards Identifiers for SKIV2L Gene
DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of this family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. This gene encodes a DEAD box protein, which is a human homologue of yeast SKI2 and may be involved in antiviral activity by blocking translation of poly(A) deficient mRNAs. This gene is located in the class III region of the major histocompatibility complex. [provided by RefSeq, Jul 2008]
GeneCards Summary for SKIV2L Gene
SKIV2L (Ski2 Like RNA Helicase) is a Protein Coding gene. Diseases associated with SKIV2L include Trichohepatoenteric Syndrome 2 and Trichohepatoenteric Syndrome 1. Among its related pathways are Chaperonin-mediated protein folding and Gene Expression. Gene Ontology (GO) annotations related to this gene include nucleic acid binding and helicase activity. An important paralog of this gene is MTREX.
UniProtKB/Swiss-Prot Summary for SKIV2L Gene
Helicase; has ATPase activity. Component of the SKI complex which is thought to be involved in exosome-mediated RNA decay and associates with transcriptionally active genes in a manner dependent on PAF1 complex (PAF1C).