Aliases for SKIDA1 Gene

Aliases for SKIDA1 Gene

  • SKI/DACH Domain Containing 1 2 3 5
  • SKI/DACH Domain-Containing Protein 1 3 4
  • Protein DLN-1 3 4
  • C10orf140 3 4
  • Chromosome 10 Open Reading Frame 140 2
  • DLN-1 3
  • DLN1 4

External Ids for SKIDA1 Gene

Previous HGNC Symbols for SKIDA1 Gene

  • C10orf140

Previous GeneCards Identifiers for SKIDA1 Gene

  • GC10M021802

Summaries for SKIDA1 Gene

GeneCards Summary for SKIDA1 Gene

SKIDA1 (SKI/DACH Domain Containing 1) is a Protein Coding gene. An important paralog of this gene is EPOP.

Additional gene information for SKIDA1 Gene

No data available for Entrez Gene Summary , CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for SKIDA1 Gene

Genomics for SKIDA1 Gene

GeneHancer (GH) Regulatory Elements for SKIDA1 Gene

Promoters and enhancers for SKIDA1 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around SKIDA1 on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for SKIDA1

Genomic Locations for SKIDA1 Gene

Genomic Locations for SKIDA1 Gene
chr10:21,510,754-21,527,188
(GRCh38/hg38)
Size:
16,435 bases
Orientation:
Minus strand
chr10:21,802,407-21,814,611
(GRCh37/hg19)
Size:
12,205 bases
Orientation:
Minus strand

Genomic View for SKIDA1 Gene

Genes around SKIDA1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SKIDA1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SKIDA1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SKIDA1 Gene

Proteins for SKIDA1 Gene

  • Protein details for SKIDA1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q1XH10-SKDA1_HUMAN
    Recommended name:
    SKI/DACH domain-containing protein 1
    Protein Accession:
    Q1XH10
    Secondary Accessions:
    • B1ANA5
    • E9PAX1
    • F5H7M0
    • Q6ZMX4
    • Q8N3C3

    Protein attributes for SKIDA1 Gene

    Size:
    908 amino acids
    Molecular mass:
    98148 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for SKIDA1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SKIDA1 Gene

Post-translational modifications for SKIDA1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for SKIDA1 Gene

No data available for DME Specific Peptides for SKIDA1 Gene

Domains & Families for SKIDA1 Gene

Gene Families for SKIDA1 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for SKIDA1 Gene

Suggested Antigen Peptide Sequences for SKIDA1 Gene

GenScript: Design optimal peptide antigens:
  • Protein DLN-1 (DLN1_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q1XH10

UniProtKB/Swiss-Prot:

SKDA1_HUMAN :
  • Belongs to the DACH/dachshund family.
Family:
  • Belongs to the DACH/dachshund family.
genes like me logo Genes that share domains with SKIDA1: view

Function for SKIDA1 Gene

Phenotypes From GWAS Catalog for SKIDA1 Gene

genes like me logo Genes that share phenotypes with SKIDA1: view

Animal Models for SKIDA1 Gene

MGI Knock Outs for SKIDA1:
  • Skida1 Skida1<tm1.1(KOMP)Wtsi>
  • Skida1 Skida1<tm1(KOMP)Wtsi>

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for SKIDA1

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for SKIDA1 Gene

Localization for SKIDA1 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SKIDA1 gene
Compartment Confidence
nucleus 3
cytosol 3
cytoskeleton 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (2)
  • Nuclear bodies (2)
  • Nucleoplasm (2)
See all subcellular structures

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for SKIDA1 Gene

Pathways & Interactions for SKIDA1 Gene

PathCards logo

SuperPathways for SKIDA1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for SKIDA1 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for SKIDA1 Gene

Drugs & Compounds for SKIDA1 Gene

No Compound Related Data Available

Transcripts for SKIDA1 Gene

mRNA/cDNA for SKIDA1 Gene

1 REFSEQ mRNAs :
8 NCBI additional mRNA sequence :
4 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for SKIDA1

Alternative Splicing Database (ASD) splice patterns (SP) for SKIDA1 Gene

No ASD Table

Relevant External Links for SKIDA1 Gene

GeneLoc Exon Structure for
SKIDA1

Expression for SKIDA1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for SKIDA1 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for SKIDA1

SOURCE GeneReport for Unigene cluster for SKIDA1 Gene:

Hs.350848
genes like me logo Genes that share expression patterns with SKIDA1: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for SKIDA1 Gene

Orthologs for SKIDA1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for SKIDA1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SKIDA1 31 30
  • 99.42 (n)
OneToOne
dog
(Canis familiaris)
Mammalia SKIDA1 31 30
  • 96.08 (n)
OneToOne
rat
(Rattus norvegicus)
Mammalia Skida1 30
  • 94.06 (n)
mouse
(Mus musculus)
Mammalia Skida1 17 31 30
  • 92.06 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia SKIDA1 31
  • 78 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia SKIDA1 31
  • 77 (a)
OneToOne
cow
(Bos Taurus)
Mammalia SKIDA1 31
  • 76 (a)
OneToOne
chicken
(Gallus gallus)
Aves C2H10ORF140 30
  • 77.38 (n)
SKIDA1 31
  • 74 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia -- 31
  • 49 (a)
ManyToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.9327 30
zebrafish
(Danio rerio)
Actinopterygii SKIDA1 31
  • 42 (a)
OneToOne
Species where no ortholog for SKIDA1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for SKIDA1 Gene

ENSEMBL:
Gene Tree for SKIDA1 (if available)
TreeFam:
Gene Tree for SKIDA1 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for SKIDA1: view image

Paralogs for SKIDA1 Gene

Paralogs for SKIDA1 Gene

genes like me logo Genes that share paralogs with SKIDA1: view

Variants for SKIDA1 Gene

Polymorphic Variants from UniProtKB/Swiss-Prot for SKIDA1 Gene

SKDA1_HUMAN-Q1XH10
The poly-Ala region of SKIDA1 is highly polymorphic and the number of Ala can vary.

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for SKIDA1 Gene

SNP ID Clinical significance and condition Chr 10 pos Variation AA Info Type
806453 Uncertain Significance: not provided 21,516,055(-) G/A MISSENSE_VARIANT
806454 Uncertain Significance: not provided 21,516,738(-) G/A MISSENSE_VARIANT

Additional dbSNP identifiers (rs#s) for SKIDA1 Gene

Structural Variations from Database of Genomic Variants (DGV) for SKIDA1 Gene

Variant ID Type Subtype PubMed ID
dgv133n67 CNV gain 20364138
dgv134n67 CNV gain 20364138
dgv135n67 CNV gain 20364138
nsv1052477 CNV gain 25217958
nsv1068291 CNV deletion 25765185
nsv1143624 CNV deletion 24896259
nsv517469 CNV loss 19592680
nsv527055 CNV loss 19592680
nsv550200 CNV loss 21841781
nsv550201 CNV loss 21841781
nsv825289 CNV loss 20364138

Variation tolerance for SKIDA1 Gene

Residual Variation Intolerance Score: 52% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.36; 63.39% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for SKIDA1 Gene

Human Gene Mutation Database (HGMD)
SKIDA1
SNPedia medical, phenotypic, and genealogical associations of SNPs for
SKIDA1

Disorders for SKIDA1 Gene

Additional Disease Information for SKIDA1

No disorders were found for SKIDA1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SKIDA1 Gene

Publications for SKIDA1 Gene

  1. Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation. (PMID: 28112733) Hendriks IA … Nielsen ML (Nature structural & molecular biology 2017) 4 54
  2. A High-Density Map for Navigating the Human Polycomb Complexome. (PMID: 27705803) Hauri S … Beisel C (Cell reports 2016) 3 54
  3. GWAS meta-analysis and replication identifies three new susceptibility loci for ovarian cancer. (PMID: 23535730) Pharoah PD … Sellers TA (Nature genetics 2013) 3 54
  4. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey SD … DREAM investigators (Diabetes care 2010) 3 54
  5. Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip. (PMID: 19913121) Talmud PJ … BRIGHT Consortium (American journal of human genetics 2009) 3 54

Products for SKIDA1 Gene

Sources for SKIDA1 Gene