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Aliases for SKAP2 Gene

Aliases for SKAP2 Gene

  • Src Kinase Associated Phosphoprotein 2 2 3 5
  • Src-Associated Adapter Protein With PH And SH3 Domains 3 4
  • Src Family-Associated Phosphoprotein 2 3 4
  • Retinoic Acid-Induced Protein 70 3 4
  • Pyk2/RAFTK-Associated Protein 3 4
  • SKAP55 Homolog 3 4
  • SKAP-55HOM 3 4
  • SKAP-HOM 3 4
  • SKAP55R 3 4
  • SCAP2 3 4
  • PRAP 3 4
  • RA70 3 4
  • SAPS 3 4
  • Src Kinase-Associated Phosphoprotein Of 55-Related Protein 3
  • Src Kinase-Associated Phosphoprotein 55-Related Protein 4
  • Fyn-Associated Phosphoprotein SKAP55 Homologue 3
  • Src Kinase-Associated Phosphoprotein 2 3
  • Src Family Associated Phosphoprotein 2 2

External Ids for SKAP2 Gene

Previous HGNC Symbols for SKAP2 Gene

  • SCAP2

Previous GeneCards Identifiers for SKAP2 Gene

  • GC07M026674

Summaries for SKAP2 Gene

Entrez Gene Summary for SKAP2 Gene

  • The protein encoded by this gene shares homology with Src kinase-associated phosphoprotein 1, and is a substrate of Src family kinases. It is an adaptor protein that is thought to play an essential role in the Src signaling pathway, and in regulating proper activation of the immune system. This protein contains an amino terminal coiled-coil domain for self-dimerization, a plecskstrin homology (PH) domain required for interactions with lipids at the membrane, and a Src homology (SH3) domain at the carboxy terminus. Some reports indicate that this protein inhibits actin polymerization through interactions with actin assembly factors, and might negatively regulate the invasiveness of tumors by modulating actin assembly. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jan 2015]

GeneCards Summary for SKAP2 Gene

SKAP2 (Src Kinase Associated Phosphoprotein 2) is a Protein Coding gene. Diseases associated with SKAP2 include Oral Candidiasis and Candidiasis. Among its related pathways are Cell junction organization. Gene Ontology (GO) annotations related to this gene include SH3/SH2 adaptor activity. An important paralog of this gene is SKAP1.

UniProtKB/Swiss-Prot for SKAP2 Gene

  • May be involved in B-cell and macrophage adhesion processes. In B-cells, may act by coupling the B-cell receptor (BCR) to integrin activation. May play a role in src signaling pathway.

Gene Wiki entry for SKAP2 Gene

Additional gene information for SKAP2 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SKAP2 Gene

Genomics for SKAP2 Gene

GeneHancer (GH) Regulatory Elements for SKAP2 Gene

Promoters and enhancers for SKAP2 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH07J026862 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 658.4 +131.1 131125 3.1 HDGF PKNOX1 SMAD1 ARNT ARID4B SIN3A DMAP1 ZNF2 ZBTB7B YY1 SKAP2 HOTAIRM1 HMGB3P20 TPM3P4 RPL23P7 PSMC1P2 HNRNPA2B1 HOXA-AS3 HOXA4 HOXA6
GH07J027088 Promoter 0.7 EPDnew 650.2 -92.9 -92884 0.1 MAX EZH2 SKAP2 HOTAIRM1 NHP2P2
GH07J027095 Promoter/Enhancer 3.4 VISTA UCNEbase EPDnew FANTOM5 Ensembl ENCODE dbSUPER 13.1 -143.0 -142956 86.3 MLX FEZF1 DMAP1 YY1 ZNF213 ZNF143 SP3 NFYC SSRP1 ZNF610 HOXA2 HOXA9 HOXA10 HOXA1 HOXA3 HOXA6 HOXA4 HOXA5 HOXA7 HNRNPA2B1
GH07J026685 Enhancer 1.1 Ensembl ENCODE 20 +308.9 308917 2.2 PKNOX1 MZF1 FEZF1 ZNF2 RAD21 RARA ZEB1 ZNF335 GLIS2 ZNF366 SKAP2 GC07P026673 GC07M026718 GC07P026242
GH07J027030 Enhancer 0.9 Ensembl ENCODE 23.5 -36.3 -36279 2 PKNOX1 RB1 SIN3A CEBPG ZNF384 FEZF1 ZIC2 POLR2A ETV6 L3MBTL2 HOTAIRM1 SKAP2 HOXA1 HOXA2 HOXA-AS2 HOXA3 TPM3P4 NHP2P2
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around SKAP2 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the SKAP2 gene promoter:
  • ER-alpha
  • POU2F1a
  • POU2F1
  • LCR-F1
  • MEF-2A
  • aMEF-2
  • CBF-A
  • CBF(2)
  • CBF-B
  • CP1A

Genomic Locations for SKAP2 Gene

Genomic Locations for SKAP2 Gene
328,178 bases
Minus strand
328,178 bases
Minus strand

Genomic View for SKAP2 Gene

Genes around SKAP2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SKAP2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SKAP2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SKAP2 Gene

Proteins for SKAP2 Gene

  • Protein details for SKAP2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Src kinase-associated phosphoprotein 2
    Protein Accession:
    Secondary Accessions:
    • A4D173
    • Q53GP6
    • Q75MK6
    • Q75MZ4
    • Q9UBZ3
    • Q9UED8

    Protein attributes for SKAP2 Gene

    359 amino acids
    Molecular mass:
    41217 Da
    Quaternary structure:
    • Homodimer (By similarity). Interacts with PTPNS1. Part of a complex consisting of SKAP2, FYB1 and PTPNS1. Part of a complex consisting of SKAP2, FYB1 and LILRB3. May interact with actin (By similarity). Interacts with FYB1, which is required for SKAP2 protein stability. Interacts with LAT, GRB2, PTK2B and PRAM1. May interact with FYN, HCK and LYN. Interacts with FASLG.

    Three dimensional structures from OCA and Proteopedia for SKAP2 Gene

neXtProt entry for SKAP2 Gene

Post-translational modifications for SKAP2 Gene

  • Phosphorylated in resting platelets. Phosphorylated by FYN on Tyr-261 upon T-cell activation (Probable). Dephosphorylated on Tyr-75 by PTPN22.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for SKAP2 Gene

No data available for DME Specific Peptides for SKAP2 Gene

Domains & Families for SKAP2 Gene

Gene Families for SKAP2 Gene

Protein Domains for SKAP2 Gene

Graphical View of Domain Structure for InterPro Entry



  • The SH3 domain interacts with FYB1 and PTK2B.
  • Belongs to the SKAP family.
  • The SH3 domain interacts with FYB1 and PTK2B.
  • Belongs to the SKAP family.
genes like me logo Genes that share domains with SKAP2: view

Function for SKAP2 Gene

Molecular function for SKAP2 Gene

UniProtKB/Swiss-Prot Function:
May be involved in B-cell and macrophage adhesion processes. In B-cells, may act by coupling the B-cell receptor (BCR) to integrin activation. May play a role in src signaling pathway.
UniProtKB/Swiss-Prot Induction:
By retinoic acid.

Phenotypes From GWAS Catalog for SKAP2 Gene

Gene Ontology (GO) - Molecular Function for SKAP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005070 SH3/SH2 adaptor activity TAS 9671755
GO:0005515 protein binding IPI 21719704
genes like me logo Genes that share ontologies with SKAP2: view
genes like me logo Genes that share phenotypes with SKAP2: view

Animal Models for SKAP2 Gene

MGI Knock Outs for SKAP2:

Animal Model Products

  • Taconic Biosciences Mouse Models for SKAP2

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for SKAP2 Gene

Localization for SKAP2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SKAP2 Gene


Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SKAP2 gene
Compartment Confidence
plasma membrane 5
cytosol 5
nucleus 3
extracellular 2
lysosome 2
endosome 2
cytoskeleton 1
mitochondrion 1
golgi apparatus 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (3)
  • Nucleoplasm (3)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for SKAP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005654 nucleoplasm IDA --
GO:0005737 cytoplasm IBA --
GO:0005829 cytosol TAS,IDA --
GO:0005886 plasma membrane IDA 11390434
genes like me logo Genes that share ontologies with SKAP2: view

Pathways & Interactions for SKAP2 Gene

genes like me logo Genes that share pathways with SKAP2: view

Pathways by source for SKAP2 Gene

Gene Ontology (GO) - Biological Process for SKAP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002757 immune response-activating signal transduction IBA --
GO:0007165 signal transduction TAS 9837776
GO:0008285 negative regulation of cell proliferation IEA --
GO:0009967 positive regulation of signal transduction IEA --
GO:0042113 B cell activation IEA --
genes like me logo Genes that share ontologies with SKAP2: view

No data available for SIGNOR curated interactions for SKAP2 Gene

Drugs & Compounds for SKAP2 Gene

(11) Drugs for SKAP2 Gene - From: ApexBio and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Kaempferol Experimental Pharma Apoptosis inducer;antioxidant;flavonoid 0
1-NM-PP1 Pharma Pp60c-src inhibitor 0
KX2-391 Pharma Src inhibitor,highly selective, Kinase Inhibitors, SRC/BCR-ABL tyrosine kinase inhibitors 0
NVP-BHG712 Pharma EphB4 inhibitor,potent and selective 0
WH-4-023 Pharma Lck/Src inhibitor,potent and selective 0

(3) Additional Compounds for SKAP2 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs

(5) ApexBio Compounds for SKAP2 Gene

Compound Action Cas Number
1-NM-PP1 Pp60c-src inhibitor 221244-14-0
Kaempferol Apoptosis inducer;antioxidant;flavonoid 520-18-3
KX2-391 Src inhibitor,highly selective 897016-82-9
NVP-BHG712 EphB4 inhibitor,potent and selective 940310-85-0
WH-4-023 Lck/Src inhibitor,potent and selective 837422-57-8
genes like me logo Genes that share compounds with SKAP2: view

Drug Products

Transcripts for SKAP2 Gene

mRNA/cDNA for SKAP2 Gene

Unigene Clusters for SKAP2 Gene

Src kinase associated phosphoprotein 2:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for SKAP2 Gene

No ASD Table

Relevant External Links for SKAP2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for SKAP2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for SKAP2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SKAP2 Gene

This gene is overexpressed in Whole Blood (x9.0).

Protein differential expression in normal tissues from HIPED for SKAP2 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (36.3), Platelet (11.2), and Cervix (6.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for SKAP2 Gene

Protein tissue co-expression partners for SKAP2 Gene

NURSA nuclear receptor signaling pathways regulating expression of SKAP2 Gene:


SOURCE GeneReport for Unigene cluster for SKAP2 Gene:


mRNA Expression by UniProt/SwissProt for SKAP2 Gene:

Tissue specificity: Ubiquitously expressed. Present in platelets (at protein level).

Evidence on tissue expression from TISSUES for SKAP2 Gene

  • Lung(4.9)
  • Nervous system(4.8)
  • Blood(4.5)
  • Intestine(4.5)
  • Liver(4.3)
  • Pancreas(4.1)
  • Spleen(4)
  • Stomach(3.9)
  • Kidney(2.3)
genes like me logo Genes that share expression patterns with SKAP2: view

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for SKAP2 Gene

Orthologs for SKAP2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for SKAP2 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia SKAP2 34 33
  • 99.54 (n)
(Canis familiaris)
Mammalia SKAP2 34 33
  • 93.59 (n)
(Bos Taurus)
Mammalia SKAP2 34 33
  • 91.62 (n)
(Rattus norvegicus)
Mammalia Skap2 33
  • 88.92 (n)
(Mus musculus)
Mammalia Skap2 16 34 33
  • 88.55 (n)
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 86 (a)
-- 34
  • 67 (a)
(Monodelphis domestica)
Mammalia SKAP2 34
  • 76 (a)
(Gallus gallus)
Aves SKAP2 34 33
  • 79.2 (n)
(Anolis carolinensis)
Reptilia SKAP2 34
  • 70 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia skap2 33
  • 68.31 (n)
African clawed frog
(Xenopus laevis)
Amphibia Xl.9007 33
(Danio rerio)
Actinopterygii skap2 34 33
  • 64.76 (n)
zgc65975 33
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.3678 33
Species where no ortholog for SKAP2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for SKAP2 Gene

Gene Tree for SKAP2 (if available)
Gene Tree for SKAP2 (if available)
Evolutionary constrained regions (ECRs) for SKAP2: view image

Paralogs for SKAP2 Gene

Paralogs for SKAP2 Gene

(2) SIMAP similar genes for SKAP2 Gene using alignment to 2 proteins:

  • C9JQ17_HUMAN
genes like me logo Genes that share paralogs with SKAP2: view

Variants for SKAP2 Gene

Sequence variations from dbSNP and Humsavar for SKAP2 Gene

SNP ID Clin Chr 07 pos Variation AA Info Type
rs1000002105 -- 26,671,820(-) T/C intron_variant
rs1000002713 -- 26,761,003(-) T/C intron_variant
rs1000054715 -- 26,752,017(-) C/A intron_variant
rs1000060462 -- 26,848,186(-) C/G intron_variant
rs1000068783 -- 26,707,048(-) A/G intron_variant

Structural Variations from Database of Genomic Variants (DGV) for SKAP2 Gene

Variant ID Type Subtype PubMed ID
dgv426e215 CNV deletion 23714750
esv2734163 CNV deletion 23290073
esv2734164 CNV deletion 23290073
esv2734165 CNV deletion 23290073
nsv1018125 CNV loss 25217958
nsv1020378 CNV gain 25217958
nsv507380 OTHER sequence alteration 20534489
nsv5672 CNV deletion 18451855
nsv7393 OTHER inversion 18451855
nsv830929 CNV gain 17160897

Variation tolerance for SKAP2 Gene

Residual Variation Intolerance Score: 64.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.11; 75.52% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for SKAP2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SKAP2 Gene

Disorders for SKAP2 Gene

MalaCards: The human disease database

(7) MalaCards diseases for SKAP2 Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
oral candidiasis
  • candidiasis of mouth
  • disseminated candidiasis
candida glabrata
sjogren-larsson syndrome
  • sls
tibial neuropathy
  • posterior tibial neuropathy
- elite association - COSMIC cancer census association via MalaCards
Search SKAP2 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for SKAP2

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with SKAP2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for SKAP2 Gene

Publications for SKAP2 Gene

  1. SKAP-HOM, a novel adaptor protein homologous to the FYN-associated protein SKAP55. (PMID: 9755858) Marie-Cardine A … Schraven B (FEBS letters 1998) 2 3 4 22 58
  2. RA70 is a src kinase-associated protein expressed ubiquitously. (PMID: 9837776) Kouroku Y … Momoi T (Biochemical and biophysical research communications 1998) 2 3 4 22 58
  3. Identification and characterization of a novel Pyk2/related adhesion focal tyrosine kinase-associated protein that inhibits alpha-synuclein phosphorylation. (PMID: 12893833) Takahashi T … Matsumoto M (The Journal of biological chemistry 2003) 3 4 22 58
  4. FYB (FYN binding protein) serves as a binding partner for lymphoid protein and FYN kinase substrate SKAP55 and a SKAP55-related protein in T cells. (PMID: 9671755) Liu J … Rudd CE (Proceedings of the National Academy of Sciences of the United States of America 1998) 3 4 22 58
  5. Substrate specificity of lymphoid-specific tyrosine phosphatase (Lyp) and identification of Src kinase-associated protein of 55 kDa homolog (SKAP-HOM) as a Lyp substrate. (PMID: 21719704) Yu X … Zhang ZY (The Journal of biological chemistry 2011) 3 4 58

Products for SKAP2 Gene

Sources for SKAP2 Gene

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