Aliases for SKAP1 Gene
External Ids for SKAP1 Gene
Previous HGNC Symbols for SKAP1 Gene
Previous GeneCards Identifiers for SKAP1 Gene
This gene encodes a T cell adaptor protein, a class of intracellular molecules with modular domains capable of recruiting additional proteins but that exhibit no intrinsic enzymatic activity. The encoded protein contains a unique N-terminal region followed by a PH domain and C-terminal SH3 domain. Along with the adhesion and degranulation-promoting adaptor protein, the encoded protein plays a critical role in inside-out signaling by coupling T-cell antigen receptor stimulation to the activation of integrins. [provided by RefSeq, Jul 2008]
GeneCards Summary for SKAP1 Gene
SKAP1 (Src Kinase Associated Phosphoprotein 1) is a Protein Coding gene. Diseases associated with SKAP1 include Lactocele. Among its related pathways are T cell receptor signaling pathway and Ras signaling pathway. Gene Ontology (GO) annotations related to this gene include protein kinase binding and SH3 domain binding. An important paralog of this gene is SKAP2.
UniProtKB/Swiss-Prot Summary for SKAP1 Gene
Positively regulates T-cell receptor signaling by enhancing the MAP kinase pathway. Required for optimal conjugation between T-cells and antigen-presenting cells by promoting the clustering of integrin ITGAL on the surface of T-cells. May be involved in high affinity immunoglobulin epsilon receptor signaling in mast cells.