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SKA2 (Spindle And Kinetochore Associated Complex Subunit 2) is a Protein Coding gene. Diseases associated with SKA2 include Post-Traumatic Stress Disorder and Mulibrey Nanism. Among its related pathways are Signaling by GPCR and Mitotic Prometaphase. Gene Ontology (GO) annotations related to this gene include microtubule binding.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005515 | protein binding | IPI | 17093495 |
GO:0008017 | microtubule binding | IEA,IDA | 19289083 |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0000775 | chromosome, centromeric region | IEA | -- |
GO:0000776 | kinetochore | IEA | -- |
GO:0000777 | condensed chromosome kinetochore | IEA | -- |
GO:0000940 | condensed chromosome outer kinetochore | IEA,IDA | 17093495 |
GO:0005694 | chromosome | IEA | -- |
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | Cell Cycle, Mitotic |
.83
|
.60
|
2 | Mitotic Metaphase and Anaphase |
.94
|
|
3 | Mitotic Prometaphase | ||
4 | Signaling by Rho GTPases | ||
5 | Signaling by GPCR |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0000278 | mitotic cell cycle | IMP | 19289083 |
GO:0007049 | cell cycle | IEA | -- |
GO:0007059 | chromosome segregation | IEA,IMP | 19289083 |
GO:0031110 | regulation of microtubule polymerization or depolymerization | IDA | 19289083 |
GO:0051301 | cell division | IEA,IMP | 17093495 |
ExUns: | 1a | · | 1b | · | 1c | · | 1d | ^ | 2 | ^ | 3 | ^ | 4a | · | 4b | ^ | 5a | · | 5b | · | 5c | · | 5d | · | 5e | · | 5f | · | 5g |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
SP1: | - | - | |||||||||||||||||||||||||||
SP2: | - | - | - | ||||||||||||||||||||||||||
SP3: | - | - | |||||||||||||||||||||||||||
SP4: | - | - | |||||||||||||||||||||||||||
SP5: | - | - | - | - | |||||||||||||||||||||||||
SP6: | - | - | - | - | |||||||||||||||||||||||||
SP7: | - | - | - | ||||||||||||||||||||||||||
SP8: | - | - | - | - | - | ||||||||||||||||||||||||
SP9: | - | - | - | - |
This gene was present in the common ancestor of chordates.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Chimpanzee (Pan troglodytes) |
Mammalia | SKA2 30 31 |
|
OneToOne | |
Dog (Canis familiaris) |
Mammalia | SKA2 30 31 |
|
OneToOne | |
Cow (Bos Taurus) |
Mammalia | SKA2 30 31 |
|
OneToOne | |
Mouse (Mus musculus) |
Mammalia | Ska2 30 17 31 |
|
OneToOne | |
Rat (Rattus norvegicus) |
Mammalia | Ska2 30 |
|
||
Oppossum (Monodelphis domestica) |
Mammalia | SKA2 31 |
|
OneToOne | |
Platypus (Ornithorhynchus anatinus) |
Mammalia | SKA2 31 |
|
OneToOne | |
Chicken (Gallus gallus) |
Aves | SKA2 30 31 |
|
OneToOne | |
Lizard (Anolis carolinensis) |
Reptilia | SKA2 31 |
|
OneToOne | |
Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | ska2 30 |
|
||
Zebrafish (Danio rerio) |
Actinopterygii | im:7140390 30 |
|
||
SKA2 31 |
|
OneToOne |
Variant ID | Type | Subtype | PubMed ID |
---|---|---|---|
dgv3270n100 | CNV | gain | 25217958 |
dgv3271n100 | CNV | gain | 25217958 |
esv2758699 | CNV | gain | 17122850 |
esv2761969 | CNV | loss | 21179565 |
esv28194 | CNV | loss | 19812545 |
esv3573764 | CNV | gain | 25503493 |
esv990139 | CNV | deletion | 20482838 |
nsv1065063 | CNV | gain | 25217958 |
nsv575802 | CNV | loss | 21841781 |
nsv833499 | CNV | loss | 17160897 |
Disorder | Aliases | PubMed IDs |
---|---|---|
post-traumatic stress disorder |
|
|
mulibrey nanism |
|
|