Aliases for SKA1 Gene
External Ids for SKA1 Gene
Previous HGNC Symbols for SKA1 Gene
Previous GeneCards Identifiers for SKA1 Gene
GeneCards Summary for SKA1 Gene
SKA1 (Spindle And Kinetochore Associated Complex Subunit 1) is a Protein Coding gene. Diseases associated with SKA1 include Hypophosphatemic Rickets, X-Linked Dominant and Acute Poststreptococcal Glomerulonephritis. Among its related pathways are Signaling by Rho GTPases and Mitotic Metaphase and Anaphase. Gene Ontology (GO) annotations related to this gene include microtubule binding.
UniProtKB/Swiss-Prot for SKA1 Gene
Component of the SKA1 complex, a microtubule-binding subcomplex of the outer kinetochore that is essential for proper chromosome segregation (PubMed:17093495, PubMed:19289083, PubMed:23085020). Required for timely anaphase onset during mitosis, when chromosomes undergo bipolar attachment on spindle microtubules leading to silencing of the spindle checkpoint (PubMed:17093495). The SKA1 complex is a direct component of the kinetochore-microtubule interface and directly associates with microtubules as oligomeric assemblies (PubMed:19289083). The complex facilitates the processive movement of microspheres along a microtubule in a depolymerization-coupled manner (PubMed:19289083). Affinity for microtubules is synergistically enhanced in the presence of the ndc-80 complex and may allow the ndc-80 complex to track depolymerizing microtubules (PubMed:23085020). In the complex, it mediates the interaction with microtubules (PubMed:19289083, PubMed:23085020).