Aliases for SIVA1 Gene
External Ids for SIVA1 Gene
Previous GeneCards Identifiers for SIVA1 Gene
This gene encodes an E3 ubiquitin ligase that regulates cell cycle progression, cell proliferation and apoptosis. The N-terminus of this protein binds to the cytoplasmic tail of the CD27 antigen, a member of the tumor necrosis factor receptor (TNFR) superfamily. In response to UV radiation-induced DNA damage, this protein has been shown to mediate the ubiquitination of proliferating cell nuclear antigen (PCNA), an important step in translesion DNA synthesis. [provided by RefSeq, Sep 2018]
GeneCards Summary for SIVA1 Gene
SIVA1 (SIVA1 Apoptosis Inducing Factor) is a Protein Coding gene. Among its related pathways are Apoptosis Modulation and Signaling and NF-kappaB Signaling. Gene Ontology (GO) annotations related to this gene include virus receptor activity and CD27 receptor binding.
UniProtKB/Swiss-Prot Summary for SIVA1 Gene
Induces CD27-mediated apoptosis. Inhibits BCL2L1 isoform Bcl-x(L) anti-apoptotic activity. Inhibits activation of NF-kappa-B and promotes T-cell receptor-mediated apoptosis.