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Aliases for SIRT7 Gene

Aliases for SIRT7 Gene

  • Sirtuin 7 2 3 5
  • Regulatory Protein SIR2 Homolog 7 3 4
  • SIR2-Like Protein 7 3 4
  • SIR2L7 3 4
  • Sirtuin (Silent Mating Type Information Regulation 2 Homolog) 7 (S. Cerevisiae) 2
  • Sirtuin (Silent Mating Type Information Regulation 2, S.Cerevisiae, Homolog) 7 2
  • Silent Mating Type Information Regulation 2, S.Cerevisiae, Homolog 7 3
  • NAD-Dependent Protein Deacetylase Sirtuin-7 3
  • NAD-Dependent Deacetylase Sirtuin-7 3
  • Sir2-Related Protein Type 7 3
  • Sirtuin Type 7 3
  • EC 3.5.1.- 4

External Ids for SIRT7 Gene

Previous GeneCards Identifiers for SIRT7 Gene

  • GC17M079361
  • GC17M9I0172
  • GC17M080405
  • GC17M9I0548
  • GC17M9I7463
  • GC17M077464
  • GC17M077465
  • GC17M079869
  • GC17M075271

Summaries for SIRT7 Gene

Entrez Gene Summary for SIRT7 Gene

  • This gene encodes a member of the sirtuin family of proteins, homologs to the yeast Sir2 protein. Members of the sirtuin family are characterized by a sirtuin core domain and grouped into four classes. The functions of human sirtuins have not yet been determined; however, yeast sirtuin proteins are known to regulate epigenetic gene silencing and suppress recombination of rDNA. Studies suggest that the human sirtuins may function as intracellular regulatory proteins with mono-ADP-ribosyltransferase activity. The protein encoded by this gene is included in class IV of the sirtuin family. [provided by RefSeq, Jul 2008]

GeneCards Summary for SIRT7 Gene

SIRT7 (Sirtuin 7) is a Protein Coding gene. Among its related pathways are NAD metabolism and Signaling events mediated by HDAC Class I. Gene Ontology (GO) annotations related to this gene include chromatin binding and NAD-dependent histone deacetylase activity (H3-K18 specific). An important paralog of this gene is SIRT6.

UniProtKB/Swiss-Prot for SIRT7 Gene

  • NAD-dependent protein deacetylase that specifically mediates deacetylation of histone H3 at Lys-18 (H3K18Ac). In contrast to other histone deacetylases, displays selectivity for a single histone mark, H3K18Ac, directly linked to control of gene expression. H3K18Ac is mainly present around the transcription start site of genes and has been linked to activation of nuclear hormone receptors. SIRT7 thereby acts as a transcription repressor. Moreover, H3K18 hypoacetylation has been reported as a marker of malignancy in various cancers and seems to maintain the transformed phenotype of cancer cells. These data suggest that SIRT7 may play a key role in oncogenic transformation by suppresses expression of tumor suppressor genes by locus-specific deacetylation of H3K18Ac at promoter regions. Also required to restore the transcription of ribosomal RNA (rRNA) at the exit from mitosis: promotes the association of RNA polymerase I with the rDNA promoter region and coding region. Stimulates transcription activity of the RNA polymerase I complex. May also deacetylate p53/TP53 and promotes cell survival, however such data need additional confirmation.

Tocris Summary for SIRT7 Gene

  • Silent information regulator (Sir2)-like family deacetylases (also known as sirtuins) are a group of enzymes closely related to histone deacetylases. These enzymes can be found in the cytoplasm, mitochondria or nucleus of the cell and are ubiquitously expressed.

Gene Wiki entry for SIRT7 Gene

Additional gene information for SIRT7 Gene

No data available for CIViC summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SIRT7 Gene

Genomics for SIRT7 Gene

GeneHancer (GH) Regulatory Elements for SIRT7 Gene

Promoters and enhancers for SIRT7 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH17J081916 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 650.7 -1.3 -1256 13.1 MLX FEZF1 DMAP1 YY1 SLC30A9 ZNF213 E2F8 ZNF143 SP3 NFYC ENSG00000264769 SIRT7 MAFG TBCD CEP131 HGS FAAP100 OGFOD3 ENSG00000262663 HEXDC
GH17J082211 Promoter/Enhancer 2.5 EPDnew Ensembl ENCODE dbSUPER 10 -294.7 -294680 8.5 MLX ZFP64 DMAP1 YY1 SLC30A9 ZNF213 ZNF143 ZNF548 SP3 NFYC CCDC57 ENSG00000264548 SLC16A3 TBCD NARF-IT1 FAAP100 HGS ENSG00000260563 CEP131 OGFOD3
GH17J082492 Promoter/Enhancer 2.4 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 10 -574.2 -574170 6 CLOCK ZFP64 FEZF1 IRF4 YY1 SLC30A9 ZNF213 E2F8 ZNF416 ZNF143 FOXK2 GC17M082510 PIR58219 TRX-CAT1-8 TBCD ENSG00000260563 ARL2BPP9 GPS1 NARF-IT1 HGS
GH17J081294 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 10 +625.9 625892 2.7 HDGF CLOCK SMAD1 FOXA2 ARNT ZFP64 ARID4B SIN3A YY1 POLR2B SLC38A10 HGS FAAP100 ENSG00000265678 TEPSIN ENSG00000260563 CSNK1D CEP131 DUS1L NDUFAF8
GH17J082518 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 10 -599.6 -599633 4.7 HDGF PKNOX1 CLOCK MLX ARNT ARID4B NEUROD1 SIN3A DMAP1 ZNF2 FOXK2 HGS ALYREF LOC105371942 DUS1L ENSG00000262652 ENSG00000260563 HEXDC FAAP100 ARL2BPP9
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around SIRT7 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the SIRT7 gene promoter:
  • ATF-2
  • c-Jun
  • AP-1
  • MyoD
  • E2F
  • TBP
  • HOXA9

Genomic Locations for SIRT7 Gene

Genomic Locations for SIRT7 Gene
chr17:81,911,939-81,921,323
(GRCh38/hg38)
Size:
9,385 bases
Orientation:
Minus strand
chr17:79,869,815-79,879,199
(GRCh37/hg19)
Size:
9,385 bases
Orientation:
Minus strand

Genomic View for SIRT7 Gene

Genes around SIRT7 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SIRT7 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SIRT7 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SIRT7 Gene

Proteins for SIRT7 Gene

  • Protein details for SIRT7 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NRC8-SIR7_HUMAN
    Recommended name:
    NAD-dependent protein deacetylase sirtuin-7
    Protein Accession:
    Q9NRC8
    Secondary Accessions:
    • A8K2K0
    • B3KSU8
    • Q3MIK4
    • Q9NSZ6
    • Q9NUS6

    Protein attributes for SIRT7 Gene

    Size:
    400 amino acids
    Molecular mass:
    44898 Da
    Cofactor:
    Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
    Quaternary structure:
    • Interacts with UBTF and the RNA polymerase I complex. Interacts with components of the B-WICH complex, such as MYBBP1A, SMARCA5/SNF2H and BAZ1B/WSTF. Interacts with ELK4, leading to stabilization at target promoters for H3K18Ac deacetylation. Interacts with histone H2A and/or histone H2B.
    Miscellaneous:
    • Overexpressed in human thyroid carcinoma cell lines and tissues, but not in adenomas.
    SequenceCaution:
    • Sequence=CAB70848.2; Type=Miscellaneous discrepancy; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for SIRT7 Gene

    Alternative splice isoforms for SIRT7 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SIRT7 Gene

Post-translational modifications for SIRT7 Gene

Other Protein References for SIRT7 Gene

No data available for DME Specific Peptides for SIRT7 Gene

Domains & Families for SIRT7 Gene

Gene Families for SIRT7 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Suggested Antigen Peptide Sequences for SIRT7 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9NRC8

UniProtKB/Swiss-Prot:

SIR7_HUMAN :
  • Belongs to the sirtuin family. Class IV subfamily.
Family:
  • Belongs to the sirtuin family. Class IV subfamily.
genes like me logo Genes that share domains with SIRT7: view

Function for SIRT7 Gene

Molecular function for SIRT7 Gene

UniProtKB/Swiss-Prot Function:
NAD-dependent protein deacetylase that specifically mediates deacetylation of histone H3 at Lys-18 (H3K18Ac). In contrast to other histone deacetylases, displays selectivity for a single histone mark, H3K18Ac, directly linked to control of gene expression. H3K18Ac is mainly present around the transcription start site of genes and has been linked to activation of nuclear hormone receptors. SIRT7 thereby acts as a transcription repressor. Moreover, H3K18 hypoacetylation has been reported as a marker of malignancy in various cancers and seems to maintain the transformed phenotype of cancer cells. These data suggest that SIRT7 may play a key role in oncogenic transformation by suppresses expression of tumor suppressor genes by locus-specific deacetylation of H3K18Ac at promoter regions. Also required to restore the transcription of ribosomal RNA (rRNA) at the exit from mitosis: promotes the association of RNA polymerase I with the rDNA promoter region and coding region. Stimulates transcription activity of the RNA polymerase I complex. May also deacetylate p53/TP53 and promotes cell survival, however such data need additional confirmation.
UniProtKB/Swiss-Prot CatalyticActivity:
NAD(+) + an acetylprotein = nicotinamide + O-acetyl-ADP-ribose + a protein.

Enzyme Numbers (IUBMB) for SIRT7 Gene

Phenotypes From GWAS Catalog for SIRT7 Gene

Gene Ontology (GO) - Molecular Function for SIRT7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003682 chromatin binding IDA 22722849
GO:0005515 protein binding IPI 19174463
GO:0016787 hydrolase activity IEA --
GO:0046872 metal ion binding IEA --
GO:0070403 NAD+ binding IEA --
genes like me logo Genes that share ontologies with SIRT7: view
genes like me logo Genes that share phenotypes with SIRT7: view

Animal Models for SIRT7 Gene

MGI Knock Outs for SIRT7:

Animal Model Products

CRISPR Products

miRNA for SIRT7 Gene

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for SIRT7

Clone Products

  • Addgene plasmids for SIRT7

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for SIRT7 Gene

Localization for SIRT7 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SIRT7 Gene

Cytoplasm. Nucleus, nucleolus. Note=Located close to the nuclear membrane when in the cytoplasm. Associated with chromatin. Associated with rDNA promoter and transcribed region. Associated with nucleolar organizer regions during mitosis.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SIRT7 gene
Compartment Confidence
nucleus 5
mitochondrion 3
extracellular 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nucleoli fibrillar center (3)
  • Vesicles (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for SIRT7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005730 nucleolus IDA,IEA 16079181
GO:0005731 nucleolus organizer region IDA 19174463
GO:0005737 cytoplasm IEA --
genes like me logo Genes that share ontologies with SIRT7: view

Pathways & Interactions for SIRT7 Gene

genes like me logo Genes that share pathways with SIRT7: view

Pathways by source for SIRT7 Gene

1 Sino Biological pathway for SIRT7 Gene
2 GeneGo (Thomson Reuters) pathways for SIRT7 Gene
2 Qiagen pathways for SIRT7 Gene
1 Cell Signaling Technology pathway for SIRT7 Gene

SIGNOR curated interactions for SIRT7 Gene

Inactivates:

Gene Ontology (GO) - Biological Process for SIRT7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription by RNA polymerase II IDA 22722849
GO:0006325 chromatin organization IEA --
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0007072 positive regulation of transcription involved in exit from mitosis IMP 19174463
genes like me logo Genes that share ontologies with SIRT7: view

Drugs & Compounds for SIRT7 Gene

(6) Drugs for SIRT7 Gene - From: ApexBio, DGIdb, HMDB, and Tocris

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Panobinostat Approved, Investigational Pharma Inhibition, inhibitor Histone deacetylase (HDAC)inhibitors 136
Nicotinamide Approved, Investigational Nutra 942,946
Splitomicin Pharma Sir2p inhibitor 0
NAD Pharma Full agonist, Agonist, Activator 0
AGK 2 Pharma Selective SIRT2 inhibitor 0

(3) Additional Compounds for SIRT7 Gene - From: HMDB and Tocris

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
O-acetyl-ADP-ribose
EX 527
49843-98-3
YK 3-237
1215281-19-8

(5) Tocris Compounds for SIRT7 Gene

Compound Action Cas Number
AGK 2 Selective SIRT2 inhibitor 304896-28-4
EX 527 Selective SIRT1 inhibitor 49843-98-3
Sirtinol Selective sirtuin family deacetylase inhibitor 410536-97-9
Splitomicin Sir2p inhibitor 5690-03-9
YK 3-237 SIRT1 activator 1215281-19-8

(1) ApexBio Compounds for SIRT7 Gene

Compound Action Cas Number
Splitomicin 5690-03-9
genes like me logo Genes that share compounds with SIRT7: view

Drug Products

Transcripts for SIRT7 Gene

Unigene Clusters for SIRT7 Gene

Sirtuin 7:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for SIRT7

Clone Products

  • Addgene plasmids for SIRT7

Alternative Splicing Database (ASD) splice patterns (SP) for SIRT7 Gene

No ASD Table

Relevant External Links for SIRT7 Gene

GeneLoc Exon Structure for
SIRT7
ECgene alternative splicing isoforms for
SIRT7

Expression for SIRT7 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for SIRT7 Gene

mRNA differential expression in normal tissues according to GTEx for SIRT7 Gene

This gene is overexpressed in Whole Blood (x5.3).

Protein differential expression in normal tissues from HIPED for SIRT7 Gene

This gene is overexpressed in Platelet (42.8), Serum (15.6), and Plasma (6.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for SIRT7 Gene



NURSA nuclear receptor signaling pathways regulating expression of SIRT7 Gene:

SIRT7

SOURCE GeneReport for Unigene cluster for SIRT7 Gene:

Hs.514636

Evidence on tissue expression from TISSUES for SIRT7 Gene

  • Nervous system(4.5)
  • Liver(4.4)
  • Intestine(4.2)
  • Spleen(4.2)
genes like me logo Genes that share expression patterns with SIRT7: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for SIRT7 Gene

Orthologs for SIRT7 Gene

This gene was present in the common ancestor of animals.

Orthologs for SIRT7 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SIRT7 34 33
  • 99.33 (n)
OneToOne
cow
(Bos Taurus)
Mammalia SIRT7 34 33
  • 90.33 (n)
OneToOne
dog
(Canis familiaris)
Mammalia SIRT7 34 33
  • 89.5 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Sirt7 16 34 33
  • 86.77 (n)
rat
(Rattus norvegicus)
Mammalia Sirt7 33
  • 86.43 (n)
oppossum
(Monodelphis domestica)
Mammalia SIRT7 34
  • 85 (a)
OneToOne
chicken
(Gallus gallus)
Aves PCYT2 34 33
  • 73.33 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia SIRT7 34
  • 75 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia sirt7 33
  • 62.45 (n)
Str.16209 33
African clawed frog
(Xenopus laevis)
Amphibia Xl.15780 33
zebrafish
(Danio rerio)
Actinopterygii sirt7 34
  • 63 (a)
OneToOne
LOC796135 33
  • 62.84 (n)
fruit fly
(Drosophila melanogaster)
Insecta Sirt7 34 33
  • 55.68 (n)
OneToOne
CG11305 35
  • 52 (a)
sea squirt
(Ciona savignyi)
Ascidiacea Cin.8781 33
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.8781 33
Species where no ortholog for SIRT7 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for SIRT7 Gene

ENSEMBL:
Gene Tree for SIRT7 (if available)
TreeFam:
Gene Tree for SIRT7 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for SIRT7: view image

Paralogs for SIRT7 Gene

Paralogs for SIRT7 Gene

(1) SIMAP similar genes for SIRT7 Gene using alignment to 3 proteins:

  • SIR7_HUMAN
  • I3L2A4_HUMAN
  • I3L480_HUMAN
genes like me logo Genes that share paralogs with SIRT7: view

Variants for SIRT7 Gene

Sequence variations from dbSNP and Humsavar for SIRT7 Gene

SNP ID Clin Chr 17 pos Variation AA Info Type
rs1000041849 -- 81,919,917(-) A/G upstream_transcript_variant
rs1000738479 -- 81,911,673(-) C/T downstream_transcript_variant
rs1001332798 -- 81,916,018(-) A/G intron_variant
rs1001389602 -- 81,915,908(-) C/T intron_variant
rs1002716626 -- 81,916,761(-) A/C 5_prime_UTR_variant, intron_variant

Structural Variations from Database of Genomic Variants (DGV) for SIRT7 Gene

Variant ID Type Subtype PubMed ID
nsv952392 CNV deletion 24416366
nsv833571 CNV loss 17160897
nsv833569 CNV loss 17160897
nsv470620 CNV loss 18288195
nsv428351 CNV gain 18775914
esv33468 CNV loss 17666407
esv29964 CNV loss 17803354
esv21913 CNV gain+loss 19812545

Variation tolerance for SIRT7 Gene

Residual Variation Intolerance Score: 25.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.87; 18.12% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for SIRT7 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
SIRT7

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SIRT7 Gene

Disorders for SIRT7 Gene

Additional Disease Information for SIRT7

No disorders were found for SIRT7 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SIRT7 Gene

Publications for SIRT7 Gene

  1. Phylogenetic classification of prokaryotic and eukaryotic Sir2-like proteins. (PMID: 10873683) Frye RA (Biochemical and biophysical research communications 2000) 2 3 4 22 58
  2. Mammalian Sir2 homolog SIRT7 is an activator of RNA polymerase I transcription. (PMID: 16618798) Ford E … Guarente L (Genes & development 2006) 2 3 4 58
  3. Evolutionarily conserved and nonconserved cellular localizations and functions of human SIRT proteins. (PMID: 16079181) Michishita E … Horikawa I (Molecular biology of the cell 2005) 3 4 22 58
  4. Functional proteomics establishes the interaction of SIRT7 with chromatin remodeling complexes and expands its role in regulation of RNA polymerase I transcription. (PMID: 22586326) Tsai YC … Cristea IM (Molecular & cellular proteomics : MCP 2012) 3 4 58
  5. SIRT7 links H3K18 deacetylation to maintenance of oncogenic transformation. (PMID: 22722849) Barber MF … Chua KF (Nature 2012) 3 4 58

Products for SIRT7 Gene

Sources for SIRT7 Gene

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