This gene encodes a member of the sirtuin family of proteins, homologs to the yeast Sir2 protein. Members of the sirtuin family are characterized by a sirtuin core domain and grouped into four classes. The functions of human sirtuins have not yet been determined; however, yeast sirtuin proteins are known to regulate epigenetic gene silencing and suppress recombination of rDNA. ... See more...

Aliases for SIRT7 Gene

Aliases for SIRT7 Gene

  • Sirtuin 7 2 3 5
  • NAD-Dependent Protein Deacetylase Sirtuin-7 3 4
  • NAD-Dependent Protein Deacylase Sirtuin-7 3 4
  • Regulatory Protein SIR2 Homolog 7 3 4
  • SIR2-Like Protein 7 3 4
  • SIR2L7 3 4
  • Sirtuin (Silent Mating Type Information Regulation 2 Homolog) 7 (S. Cerevisiae) 2
  • Sirtuin (Silent Mating Type Information Regulation 2, S.Cerevisiae, Homolog) 7 2
  • Silent Mating Type Information Regulation 2, S.Cerevisiae, Homolog 7 3
  • NAD-Dependent Deacetylase Sirtuin-7 3
  • Sir2-Related Protein Type 7 3
  • Sirtuin Type 7 3
  • EC 2.3.1.286 4
  • EC 2.3.1.- 4
  • SIRT7 5

External Ids for SIRT7 Gene

Previous GeneCards Identifiers for SIRT7 Gene

  • GC17M079361
  • GC17M9I0172
  • GC17M080405
  • GC17M9I0548
  • GC17M9I7463
  • GC17M077464
  • GC17M077465
  • GC17M079869
  • GC17M075271

Summaries for SIRT7 Gene

Entrez Gene Summary for SIRT7 Gene

  • This gene encodes a member of the sirtuin family of proteins, homologs to the yeast Sir2 protein. Members of the sirtuin family are characterized by a sirtuin core domain and grouped into four classes. The functions of human sirtuins have not yet been determined; however, yeast sirtuin proteins are known to regulate epigenetic gene silencing and suppress recombination of rDNA. Studies suggest that the human sirtuins may function as intracellular regulatory proteins with mono-ADP-ribosyltransferase activity. The protein encoded by this gene is included in class IV of the sirtuin family. [provided by RefSeq, Jul 2008]

GeneCards Summary for SIRT7 Gene

SIRT7 (Sirtuin 7) is a Protein Coding gene. Diseases associated with SIRT7 include Monckeberg Arteriosclerosis and Body Mass Index Quantitative Trait Locus 11. Among its related pathways are NAD metabolism and DNA damage_NHEJ mechanisms of DSBs repair. Gene Ontology (GO) annotations related to this gene include chromatin binding and NAD-dependent histone deacetylase activity (H3-K18 specific). An important paralog of this gene is SIRT6.

UniProtKB/Swiss-Prot Summary for SIRT7 Gene

  • NAD-dependent protein-lysine deacylase that can act both as a deacetylase or deacylase (desuccinylase, depropionylase and deglutarylase), depending on the context (PubMed:22722849, PubMed:26907567, PubMed:30653310, PubMed:31542297). Specifically mediates deacetylation of histone H3 at 'Lys-18' (H3K18Ac) (PubMed:22722849, PubMed:30420520). In contrast to other histone deacetylases, displays strong preference for a specific histone mark, H3K18Ac, directly linked to control of gene expression (PubMed:22722849, PubMed:30653310). H3K18Ac is mainly present around the transcription start site of genes and has been linked to activation of nuclear hormone receptors; SIRT7 thereby acts as a transcription repressor (PubMed:22722849). Moreover, H3K18 hypoacetylation has been reported as a marker of malignancy in various cancers and seems to maintain the transformed phenotype of cancer cells (PubMed:22722849). Also able to mediate deacetylation of histone H3 at 'Lys-36' (H3K36Ac) in the context of nucleosomes (PubMed:30653310). Also mediates deacetylation of non-histone proteins, such as ATM, CDK9, DDX21, DDB1, FBL, FKBP5/FKBP51, GABPB1, RAN, RRP9/U3-55K and POLR1E/PAF53 (PubMed:24207024, PubMed:26867678, PubMed:28147277, PubMed:28886238, PubMed:28426094, PubMed:30540930, PubMed:31075303, PubMed:30944854, PubMed:28790157). Enriched in nucleolus where it stimulates transcription activity of the RNA polymerase I complex (PubMed:16618798, PubMed:19174463, PubMed:24207024). Acts by mediating the deacetylation of the RNA polymerase I subunit POLR1E/PAF53, thereby promoting the association of RNA polymerase I with the rDNA promoter region and coding region (PubMed:16618798, PubMed:19174463, PubMed:24207024). In response to metabolic stress, SIRT7 is released from nucleoli leading to hyperacetylation of POLR1E/PAF53 and decreased RNA polymerase I transcription (PubMed:24207024). Required to restore the transcription of ribosomal RNA (rRNA) at the exit from mitosis (PubMed:19174463). Promotes pre-ribosomal RNA (pre-rRNA) cleavage at the 5'-terminal processing site by mediating deacetylation of RRP9/U3-55K, a core subunit of the U3 snoRNP complex (PubMed:26867678). Mediates 'Lys-37' deacetylation of Ran, thereby regulating the nuclear export of NF-kappa-B subunit RELA/p65 (PubMed:31075303). Acts as a regulator of DNA damage repair by mediating deacetylation of ATM during the late stages of DNA damage response, promoting ATM dephosphorylation and deactivation (PubMed:30944854). Suppresses the activity of the DCX (DDB1-CUL4-X-box) E3 ubiquitin-protein ligase complexes by mediating deacetylation of DDB1, which prevents the interaction between DDB1 and CUL4 (CUL4A or CUL4B) (PubMed:28886238). Activates RNA polymerase II transcription by mediating deacetylation of CDK9, thereby promoting 'Ser-2' phosphorylation of the C-terminal domain (CTD) of RNA polymerase II (PubMed:28426094). Deacetylates FBL, promoting histone-glutamine methyltransferase activity of FBL (PubMed:30540930). Acts as a regulator of mitochondrial function by catalyzing deacetylation of GABPB1 (By similarity). Regulates Akt/AKT1 activity by mediating deacetylation of FKBP5/FKBP51 (PubMed:28147277). Required to prevent R-loop-associated DNA damage and transcription-associated genomic instability by mediating deacetylation and subsequent activation of DDX21, thereby overcoming R-loop-mediated stalling of RNA polymerases (PubMed:28790157). In addition to protein deacetylase activity, also acts as protein-lysine deacylase (PubMed:27436229, PubMed:27997115, PubMed:31542297). Acts as a protein depropionylase by mediating depropionylation of Osterix (SP7), thereby regulating bone formation by osteoblasts (By similarity). Acts as a histone deglutarylase by mediating deglutarylation of histone H4 on 'Lys-91' (H4K91glu); a mark that destabilizes nucleosomes by promoting dissociation of the H2A-H2B dimers from nucleosomes (PubMed:31542297). Acts as a histone desuccinylase: in response to DNA damage, recruited to DNA double-strand breaks (DSBs) and catalyzes desuccinylation of histone H3 on 'Lys-122' (H3K122succ), thereby promoting chromatin condensation and DSB repair (PubMed:27436229). Also promotes DSB repair by promoting H3K18Ac deacetylation, regulating non-homologous end joining (NHEJ) (By similarity). Along with its role in DNA repair, required for chromosome synapsis during prophase I of female meiosis by catalyzing H3K18Ac deacetylation (By similarity). Involved in transcriptional repression of LINE-1 retrotransposon via H3K18Ac deacetylation, and promotes their association with the nuclear lamina (PubMed:31226208). Required to stabilize ribosomal DNA (rDNA) heterochromatin and prevent cellular senescence induced by rDNA instability (PubMed:29728458). Acts as a negative regulator of SIRT1 by preventing autodeacetylation of SIRT1, restricting SIRT1 deacetylase activity (By similarity).

Tocris Summary for SIRT7 Gene

  • Silent information regulator (Sir2)-like family deacetylases (also known as sirtuins) are a group of enzymes closely related to histone deacetylases. These enzymes can be found in the cytoplasm, mitochondria or nucleus of the cell and are ubiquitously expressed.

Gene Wiki entry for SIRT7 Gene

No data available for CIViC Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for SIRT7 Gene

Genomics for SIRT7 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for SIRT7 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around SIRT7 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for SIRT7

Top Transcription factor binding sites by QIAGEN in the SIRT7 gene promoter:
  • AP-1
  • ATF-2
  • c-Jun
  • E2F
  • HOXA9
  • MyoD
  • TBP

Genomic Locations for SIRT7 Gene

Latest Assembly
chr17:81,911,939-81,921,323
(GRCh38/hg38)
Size:
9,385 bases
Orientation:
Minus strand

Previous Assembly
chr17:79,869,815-79,876,052
(GRCh37/hg19 by Entrez Gene)
Size:
6,238 bases
Orientation:
Minus strand

chr17:79,869,815-79,879,199
(GRCh37/hg19 by Ensembl)
Size:
9,385 bases
Orientation:
Minus strand

Genomic View for SIRT7 Gene

Genes around SIRT7 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SIRT7 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SIRT7 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SIRT7 Gene

Proteins for SIRT7 Gene

  • Protein details for SIRT7 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NRC8-SIR7_HUMAN
    Recommended name:
    NAD-dependent protein deacetylase sirtuin-7
    Protein Accession:
    Q9NRC8
    Secondary Accessions:
    • A8K2K0
    • B3KSU8
    • Q3MIK4
    • Q9NSZ6
    • Q9NUS6

    Protein attributes for SIRT7 Gene

    Size:
    400 amino acids
    Molecular mass:
    44898 Da
    Cofactor:
    Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
    Quaternary structure:
    • Interacts with UBTF and the RNA polymerase I complex (PubMed:16618798, PubMed:19174463). Interacts with components of the B-WICH complex, such as MYBBP1A, SMARCA5/SNF2H and BAZ1B/WSTF (PubMed:22586326). Interacts with ELK4, leading to stabilization at target promoters for H3K18Ac deacetylation (PubMed:22722849). Interacts with histone H2A and/or histone H2B (PubMed:22722849). Interacts with DNMT1 (By similarity). Interacts with SIRT1 (By similarity).
    SequenceCaution:
    • Sequence=CAB70848.2; Type=Miscellaneous discrepancy; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for SIRT7 Gene

    Alternative splice isoforms for SIRT7 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SIRT7 Gene

Post-translational modifications for SIRT7 Gene

  • Phosphorylated during mitosis.
  • Methylation at Arg-388 by PRMT6 inhibits the H3K18Ac histone deacetylase activity, promoting mitochondria biogenesis and maintaining mitochondria respiration.
  • Ubiquitinated via 'Lys-63'-linked ubiquitin chains (PubMed:28655758). Deubiquitinated by USP7, inhibiting the H3K18Ac histone deacetylase activity and regulating gluconeogenesis (PubMed:28655758).
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for SIRT7 Gene

Domains & Families for SIRT7 Gene

Gene Families for SIRT7 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for SIRT7 Gene

InterPro:
Blocks:
  • Silent information regulator protein Sir2

Suggested Antigen Peptide Sequences for SIRT7 Gene

GenScript: Design optimal peptide antigens:
  • SIR2-like protein 7 (SIRT7_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q9NRC8

UniProtKB/Swiss-Prot:

SIR7_HUMAN :
  • Belongs to the sirtuin family. Class IV subfamily.
Family:
  • Belongs to the sirtuin family. Class IV subfamily.
genes like me logo Genes that share domains with SIRT7: view

Function for SIRT7 Gene

Molecular function for SIRT7 Gene

UniProtKB/Swiss-Prot Function:
NAD-dependent protein-lysine deacylase that can act both as a deacetylase or deacylase (desuccinylase, depropionylase and deglutarylase), depending on the context (PubMed:22722849, PubMed:26907567, PubMed:30653310, PubMed:31542297). Specifically mediates deacetylation of histone H3 at 'Lys-18' (H3K18Ac) (PubMed:22722849, PubMed:30420520). In contrast to other histone deacetylases, displays strong preference for a specific histone mark, H3K18Ac, directly linked to control of gene expression (PubMed:22722849, PubMed:30653310). H3K18Ac is mainly present around the transcription start site of genes and has been linked to activation of nuclear hormone receptors; SIRT7 thereby acts as a transcription repressor (PubMed:22722849). Moreover, H3K18 hypoacetylation has been reported as a marker of malignancy in various cancers and seems to maintain the transformed phenotype of cancer cells (PubMed:22722849). Also able to mediate deacetylation of histone H3 at 'Lys-36' (H3K36Ac) in the context of nucleosomes (PubMed:30653310). Also mediates deacetylation of non-histone proteins, such as ATM, CDK9, DDX21, DDB1, FBL, FKBP5/FKBP51, GABPB1, RAN, RRP9/U3-55K and POLR1E/PAF53 (PubMed:24207024, PubMed:26867678, PubMed:28147277, PubMed:28886238, PubMed:28426094, PubMed:30540930, PubMed:31075303, PubMed:30944854, PubMed:28790157). Enriched in nucleolus where it stimulates transcription activity of the RNA polymerase I complex (PubMed:16618798, PubMed:19174463, PubMed:24207024). Acts by mediating the deacetylation of the RNA polymerase I subunit POLR1E/PAF53, thereby promoting the association of RNA polymerase I with the rDNA promoter region and coding region (PubMed:16618798, PubMed:19174463, PubMed:24207024). In response to metabolic stress, SIRT7 is released from nucleoli leading to hyperacetylation of POLR1E/PAF53 and decreased RNA polymerase I transcription (PubMed:24207024). Required to restore the transcription of ribosomal RNA (rRNA) at the exit from mitosis (PubMed:19174463). Promotes pre-ribosomal RNA (pre-rRNA) cleavage at the 5'-terminal processing site by mediating deacetylation of RRP9/U3-55K, a core subunit of the U3 snoRNP complex (PubMed:26867678). Mediates 'Lys-37' deacetylation of Ran, thereby regulating the nuclear export of NF-kappa-B subunit RELA/p65 (PubMed:31075303). Acts as a regulator of DNA damage repair by mediating deacetylation of ATM during the late stages of DNA damage response, promoting ATM dephosphorylation and deactivation (PubMed:30944854). Suppresses the activity of the DCX (DDB1-CUL4-X-box) E3 ubiquitin-protein ligase complexes by mediating deacetylation of DDB1, which prevents the interaction between DDB1 and CUL4 (CUL4A or CUL4B) (PubMed:28886238). Activates RNA polymerase II transcription by mediating deacetylation of CDK9, thereby promoting 'Ser-2' phosphorylation of the C-terminal domain (CTD) of RNA polymerase II (PubMed:28426094). Deacetylates FBL, promoting histone-glutamine methyltransferase activity of FBL (PubMed:30540930). Acts as a regulator of mitochondrial function by catalyzing deacetylation of GABPB1 (By similarity). Regulates Akt/AKT1 activity by mediating deacetylation of FKBP5/FKBP51 (PubMed:28147277). Required to prevent R-loop-associated DNA damage and transcription-associated genomic instability by mediating deacetylation and subsequent activation of DDX21, thereby overcoming R-loop-mediated stalling of RNA polymerases (PubMed:28790157). In addition to protein deacetylase activity, also acts as protein-lysine deacylase (PubMed:27436229, PubMed:27997115, PubMed:31542297). Acts as a protein depropionylase by mediating depropionylation of Osterix (SP7), thereby regulating bone formation by osteoblasts (By similarity). Acts as a histone deglutarylase by mediating deglutarylation of histone H4 on 'Lys-91' (H4K91glu); a mark that destabilizes nucleosomes by promoting dissociation of the H2A-H2B dimers from nucleosomes (PubMed:31542297). Acts as a histone desuccinylase: in response to DNA damage, recruited to DNA double-strand breaks (DSBs) and catalyzes desuccinylation of histone H3 on 'Lys-122' (H3K122succ), thereby promoting chromatin condensation and DSB repair (PubMed:27436229). Also promotes DSB repair by promoting H3K18Ac deacetylation, regulating non-homologous end joining (NHEJ) (By similarity). Along with its role in DNA repair, required for chromosome synapsis during prophase I of female meiosis by catalyzing H3K18Ac deacetylation (By similarity). Involved in transcriptional repression of LINE-1 retrotransposon via H3K18Ac deacetylation, and promotes their association with the nuclear lamina (PubMed:31226208). Required to stabilize ribosomal DNA (rDNA) heterochromatin and prevent cellular senescence induced by rDNA instability (PubMed:29728458). Acts as a negative regulator of SIRT1 by preventing autodeacetylation of SIRT1, restricting SIRT1 deacetylase activity (By similarity).
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=H2O + N(6)-acetyl-L-lysyl-[protein] + NAD(+) = 2''-O-acetyl-ADP-D-ribose + L-lysyl-[protein] + nicotinamide; Xref=Rhea:RHEA:43636, Rhea:RHEA-COMP:9752, Rhea:RHEA-COMP:10731, ChEBI:CHEBI:15377, ChEBI:CHEBI:17154, ChEBI:CHEBI:29969, ChEBI:CHEBI:57540, ChEBI:CHEBI:61930, ChEBI:CHEBI:83767; EC=2.3.1.286; Evidence={ECO:0000255|PROSITE-ProRule:PRU00236, ECO:0000269|PubMed:22722849, ECO:0000269|PubMed:24207024, ECO:0000269|PubMed:26867678, ECO:0000269|PubMed:26907567, ECO:0000269|PubMed:28147277, ECO:0000269|PubMed:28426094, ECO:0000269|PubMed:28790157, ECO:0000269|PubMed:28886238, ECO:0000269|PubMed:30420520, ECO:0000269|PubMed:30540930, ECO:0000269|PubMed:30653310, ECO:0000269|PubMed:30944854, ECO:0000269|PubMed:31075303};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=H2O + N(6)-glutaryl-L-lysyl-[protein] + NAD(+) = 2''-O-glutaryl-ADP-D-ribose + L-lysyl-[protein] + nicotinamide; Xref=Rhea:RHEA:47664, Rhea:RHEA-COMP:9752, Rhea:RHEA-COMP:11875, ChEBI:CHEBI:15377, ChEBI:CHEBI:17154, ChEBI:CHEBI:29969, ChEBI:CHEBI:57540, ChEBI:CHEBI:87828, ChEBI:CHEBI:87829; Evidence={ECO:0000269|PubMed:31542297};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=H2O + N(6)-succinyl-L-lysyl-[protein] + NAD(+) = 2''-O-succinyl-ADP-D-ribose + L-lysyl-[protein] + nicotinamide; Xref=Rhea:RHEA:47668, Rhea:RHEA-COMP:9752, Rhea:RHEA-COMP:11877, ChEBI:CHEBI:15377, ChEBI:CHEBI:17154, ChEBI:CHEBI:29969, ChEBI:CHEBI:57540, ChEBI:CHEBI:87830, ChEBI:CHEBI:87832; Evidence={ECO:0000269|PubMed:27436229};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=H2O + N(6)-propanoyl-L-lysyl-[protein] + NAD(+) = 3''-O-propanoyl-ADP-D-ribose + L-lysyl-[protein] + nicotinamide; Xref=Rhea:RHEA:23500, Rhea:RHEA-COMP:9752, Rhea:RHEA-COMP:13758, ChEBI:CHEBI:15377, ChEBI:CHEBI:17154, ChEBI:CHEBI:29969, ChEBI:CHEBI:57540, ChEBI:CHEBI:138019, ChEBI:CHEBI:145015; Evidence={ECO:0000250|UniProtKB:Q8BKJ9};.
UniProtKB/Swiss-Prot Induction:
Overexpressed in thyroid carcinoma cell lines and tissues, but not in adenomas.
UniProtKB/Swiss-Prot EnzymeRegulation:
NAD-dependent protein-lysine deacetylase and deacylase activities are activated by nucleic acids (PubMed:26907567, PubMed:27997115). Histone deacetylase activity is activated by DNA (PubMed:27997115). Protein-lysine deacylase activity is activated by RNA (PubMed:26907567). H3K18Ac histone deacetylase activity is inhibited by methylation at Arg-388 (PubMed:30420520). H3K18Ac histone deacetylase activity is inhibited by deubiquitination by USP7 (PubMed:28655758).

Enzyme Numbers (IUBMB) for SIRT7 Gene

Phenotypes From GWAS Catalog for SIRT7 Gene

Gene Ontology (GO) - Molecular Function for SIRT7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003682 chromatin binding IDA 22722849
GO:0003714 transcription corepressor activity IBA 21873635
GO:0004407 histone deacetylase activity IBA 21873635
GO:0005515 protein binding IPI 19174463
GO:0016740 transferase activity IEA --
genes like me logo Genes that share ontologies with SIRT7: view
genes like me logo Genes that share phenotypes with SIRT7: view

Animal Models for SIRT7 Gene

MGI Knock Outs for SIRT7:

miRNA for SIRT7 Gene

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for SIRT7

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for SIRT7 Gene

Localization for SIRT7 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SIRT7 Gene

Nucleus, nucleolus. Nucleus, nucleoplasm. Chromosome. Cytoplasm. Note=Mainly localizes in the nucleolus and nucleoplasm (PubMed:24207024, PubMed:28886238, PubMed:28790157, PubMed:31075303). Associated with rDNA promoter and transcribed region (PubMed:16079181, PubMed:19174463). Associated with nucleolar organizer regions during mitosis (PubMed:16079181, PubMed:19174463). In response to stress, released from nucleolus to nucleoplasm (PubMed:24207024). Associated with chromatin (PubMed:22722849). In response to DNA damage, recruited to DNA double-strand breaks (DSBs) sites (PubMed:27436229) (Probable). Located close to the nuclear membrane when in the cytoplasm (PubMed:11953824). {ECO:0000269 PubMed:11953824, ECO:0000269 PubMed:16079181, ECO:0000269 PubMed:19174463, ECO:0000269 PubMed:22722849, ECO:0000269 PubMed:24207024, ECO:0000269 PubMed:27436229, ECO:0000269 PubMed:28790157, ECO:0000269 PubMed:28886238, ECO:0000269 PubMed:31075303, ECO:0000305 PubMed:30944854}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SIRT7 gene
Compartment Confidence
nucleus 5
mitochondrion 4
cytosol 3
plasma membrane 2
extracellular 2
cytoskeleton 2
peroxisome 2
endoplasmic reticulum 2
lysosome 2
endosome 1
golgi apparatus 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nuclear speckles (3)
  • Nucleoplasm (3)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for SIRT7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000785 chromatin IEA,IDA 30944854
GO:0005634 nucleus IBA,IDA 31075303
GO:0005654 nucleoplasm IEA,IDA 24207024
GO:0005694 chromosome IEA --
GO:0005730 nucleolus IEA,IDA 16079181
genes like me logo Genes that share ontologies with SIRT7: view

Pathways & Interactions for SIRT7 Gene

PathCards logo

SuperPathways for SIRT7 Gene

genes like me logo Genes that share pathways with SIRT7: view

Pathways by source for SIRT7 Gene

2 GeneGo (Thomson Reuters) pathways for SIRT7 Gene
  • DNA damage_NHEJ mechanisms of DSBs repair
  • NAD metabolism
2 Qiagen pathways for SIRT7 Gene
  • p53 Signaling
  • SUMO Pathway
1 Cell Signaling Technology pathway for SIRT7 Gene

SIGNOR curated interactions for SIRT7 Gene

Activates:
Inactivates:

Gene Ontology (GO) - Biological Process for SIRT7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription by RNA polymerase II IDA 22722849
GO:0001649 osteoblast differentiation IEA,ISS --
GO:0006111 regulation of gluconeogenesis IMP 28655758
GO:0006281 DNA repair IEA --
GO:0006282 regulation of DNA repair IDA 27436229
genes like me logo Genes that share ontologies with SIRT7: view

Drugs & Compounds for SIRT7 Gene

(6) Drugs for SIRT7 Gene - From: ApexBio, DGIdb, HMDB, and Tocris

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Panobinostat Approved, Investigational Pharma Inhibition, inhibitor Histone deacetylase (HDAC)inhibitors 146
Nicotinamide Approved, Investigational Pharma 474,474
NAD Experimental Pharma 0
Splitomicin Pharma Sir2p inhibitor 0
AGK 2 Pharma Selective SIRT2 inhibitor 0

(3) Additional Compounds for SIRT7 Gene - From: HMDB and Tocris

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
O-acetyl-ADP-ribose
  • {[4-(acetyloxy)-3,5-dihydroxyoxolan-2-yl]methoxy}[({[5-(6-amino-9H-purin-9-yl)-3,4-dihydroxyoxolan-2-yl]methoxy}(hydroxy)phosphoryl)oxy]phosphinate
EX 527
49843-98-3
YK 3-237
1215281-19-8

(5) Tocris Compounds for SIRT7 Gene

Compound Action Cas Number
AGK 2 Selective SIRT2 inhibitor 304896-28-4
EX 527 Selective SIRT1 inhibitor 49843-98-3
Sirtinol Selective sirtuin family deacetylase inhibitor 410536-97-9
Splitomicin Sir2p inhibitor 5690-03-9
YK 3-237 SIRT1 activator 1215281-19-8

(1) ApexBio Compounds for SIRT7 Gene

Compound Action Cas Number
Splitomicin 5690-03-9
genes like me logo Genes that share compounds with SIRT7: view

Drug products for research

Transcripts for SIRT7 Gene

mRNA/cDNA for SIRT7 Gene

1 REFSEQ mRNAs :
12 NCBI additional mRNA sequence :
21 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for SIRT7

Alternative Splicing Database (ASD) splice patterns (SP) for SIRT7 Gene

No ASD Table

Relevant External Links for SIRT7 Gene

GeneLoc Exon Structure for
SIRT7

Expression for SIRT7 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for SIRT7 Gene

mRNA differential expression in normal tissues according to GTEx for SIRT7 Gene

This gene is overexpressed in Whole Blood (x5.3).

Protein differential expression in normal tissues from HIPED for SIRT7 Gene

This gene is overexpressed in Platelet (42.8), Serum (15.6), and Plasma (6.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for SIRT7 Gene



Transcriptomic regulation report from SPP (The Signaling Pathways Project) for SIRT7

SOURCE GeneReport for Unigene cluster for SIRT7 Gene:

Hs.514636

Evidence on tissue expression from TISSUES for SIRT7 Gene

  • Nervous system(4.7)
  • Intestine(4.5)
  • Liver(4.5)
  • Spleen(4.5)
  • Pancreas(2.8)
  • Skin(2.8)
  • Muscle(2.7)
  • Kidney(2.7)
  • Heart(2.6)
  • Blood(2.6)
  • Bone marrow(2.5)
  • Stomach(2.4)
  • Lymph node(2.3)
  • Lung(2.3)
  • Thyroid gland(2.1)
genes like me logo Genes that share expression patterns with SIRT7: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for SIRT7 Gene

Orthologs for SIRT7 Gene

This gene was present in the common ancestor of animals.

Orthologs for SIRT7 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia SIRT7 29 30
  • 99.33 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia SIRT7 29 30
  • 90.33 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia SIRT7 29 30
  • 89.5 (n)
OneToOne
Mouse
(Mus musculus)
Mammalia Sirt7 29 16 30
  • 86.77 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Sirt7 29
  • 86.43 (n)
Oppossum
(Monodelphis domestica)
Mammalia SIRT7 30
  • 85 (a)
OneToOne
Chicken
(Gallus gallus)
Aves PCYT2 29 30
  • 73.33 (n)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia SIRT7 30
  • 75 (a)
OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia sirt7 29
  • 62.45 (n)
Str.16209 29
African clawed frog
(Xenopus laevis)
Amphibia Xl.15780 29
Zebrafish
(Danio rerio)
Actinopterygii sirt7 30
  • 63 (a)
OneToOne
LOC796135 29
  • 62.84 (n)
Fruit Fly
(Drosophila melanogaster)
Insecta Sirt7 29 30
  • 55.68 (n)
OneToOne
CG11305 31
  • 52 (a)
Sea Vase
(Ciona intestinalis)
Ascidiacea Cin.8781 29
Species where no ortholog for SIRT7 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for SIRT7 Gene

ENSEMBL:
Gene Tree for SIRT7 (if available)
TreeFam:
Gene Tree for SIRT7 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for SIRT7: view image
Alliance of Genome Resources:
Additional Orthologs for SIRT7

Paralogs for SIRT7 Gene

Paralogs for SIRT7 Gene

(1) SIMAP similar genes for SIRT7 Gene using alignment to 3 proteins:

  • SIR7_HUMAN
  • I3L2A4_HUMAN
  • I3L480_HUMAN
genes like me logo Genes that share paralogs with SIRT7: view

Variants for SIRT7 Gene

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for SIRT7 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for SIRT7 Gene

Variant ID Type Subtype PubMed ID
esv21913 CNV gain+loss 19812545
esv29964 CNV loss 17803354
esv33468 CNV loss 17666407
nsv428351 CNV gain 18775914
nsv470620 CNV loss 18288195
nsv833569 CNV loss 17160897
nsv833571 CNV loss 17160897
nsv952392 CNV deletion 24416366

Variation tolerance for SIRT7 Gene

Residual Variation Intolerance Score: 25.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.87; 18.12% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for SIRT7 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
SIRT7
Leiden Open Variation Database (LOVD)
SIRT7

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for SIRT7 Gene

Disorders for SIRT7 Gene

MalaCards: The human disease database

(3) MalaCards diseases for SIRT7 Gene - From: COP

Disorder Aliases PubMed IDs
monckeberg arteriosclerosis
  • monckeberg medial calcific sclerosis
body mass index quantitative trait locus 11
  • bmiq11
disease of mental health
  • mental health
- elite association - COSMIC cancer census association via MalaCards
Search SIRT7 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for SIRT7

genes like me logo Genes that share disorders with SIRT7: view

No data available for UniProtKB/Swiss-Prot and Genatlas for SIRT7 Gene

Publications for SIRT7 Gene

  1. Phylogenetic classification of prokaryotic and eukaryotic Sir2-like proteins. (PMID: 10873683) Frye RA (Biochemical and biophysical research communications 2000) 2 3 4 22
  2. Mammalian Sir2 homolog SIRT7 is an activator of RNA polymerase I transcription. (PMID: 16618798) Ford E … Guarente L (Genes & development 2006) 2 3 4
  3. Evolutionarily conserved and nonconserved cellular localizations and functions of human SIRT proteins. (PMID: 16079181) Michishita E … Horikawa I (Molecular biology of the cell 2005) 3 4 22
  4. SIRT7-mediated ATM deacetylation is essential for its deactivation and DNA damage repair. (PMID: 30944854) Tang M … Zhu WG (Science advances 2019) 3 4
  5. Glutarylation of Histone H4 Lysine 91 Regulates Chromatin Dynamics. (PMID: 31542297) Bao X … Li XD (Molecular cell 2019) 3 4

Products for SIRT7 Gene

Sources for SIRT7 Gene