This gene encodes a member of the sirtuin family of NAD-dependent enzymes that are implicated in cellular stress resistance, genomic stability, aging and energy homeostasis. The encoded protein is localized to the nucleus, exhibits ADP-ribosyl transferase and histone deacetylase activities, and plays a role in DNA repair, maintenance of telomeric chromatin, inflammation, lipid ... See more...

Aliases for SIRT6 Gene

Aliases for SIRT6 Gene

  • Sirtuin 6 2 3 5
  • NAD-Dependent Protein Deacetylase Sirtuin-6 3 4
  • Regulatory Protein SIR2 Homolog 6 3 4
  • SIR2-Like Protein 6 3 4
  • SIR2L6 3 4
  • Sirtuin (Silent Mating Type Information Regulation 2, S. Cerevisiae, Homolog) 6 2
  • Sirtuin (Silent Mating Type Information Regulation 2 Homolog) 6 (S. Cerevisiae) 2
  • Sir2-Related Protein Type 6 3
  • Sirtuin Type 6 3
  • EC 2.3.1.286 4
  • SIRT6 5

External Ids for SIRT6 Gene

Previous GeneCards Identifiers for SIRT6 Gene

  • GC19M004266
  • GC19M004114
  • GC19M004125
  • GC19M003937

Summaries for SIRT6 Gene

Entrez Gene Summary for SIRT6 Gene

  • This gene encodes a member of the sirtuin family of NAD-dependent enzymes that are implicated in cellular stress resistance, genomic stability, aging and energy homeostasis. The encoded protein is localized to the nucleus, exhibits ADP-ribosyl transferase and histone deacetylase activities, and plays a role in DNA repair, maintenance of telomeric chromatin, inflammation, lipid and glucose metabolism. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Mar 2016]

GeneCards Summary for SIRT6 Gene

SIRT6 (Sirtuin 6) is a Protein Coding gene. Diseases associated with SIRT6 include Mood Disorder and Monckeberg Arteriosclerosis. Among its related pathways are Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins. and NAD metabolism. Gene Ontology (GO) annotations related to this gene include chromatin binding and NAD-dependent histone deacetylase activity (H3-K9 specific). An important paralog of this gene is SIRT7.

UniProtKB/Swiss-Prot Summary for SIRT6 Gene

  • NAD-dependent protein deacetylase. Has deacetylase activity towards histone H3K9Ac and H3K56Ac. Modulates acetylation of histone H3 in telomeric chromatin during the S-phase of the cell cycle. Deacetylates histone H3K9Ac at NF-kappa-B target promoters and may down-regulate the expression of a subset of NF-kappa-B target genes. Acts as a corepressor of the transcription factor HIF1A to control the expression of multiple glycolytic genes to regulate glucose homeostasis. Required for genomic stability. Regulates the production of TNF protein. Has a role in the regulation of life span (By similarity). Deacetylation of nucleosomes interferes with RELA binding to target DNA. May be required for the association of WRN with telomeres during S-phase and for normal telomere maintenance. Required for genomic stability. Required for normal IGF1 serum levels and normal glucose homeostasis. Modulates cellular senescence and apoptosis. On DNA damage, promotes DNA end resection via deacetylation of RBBP8. Has very weak deacetylase activity and can bind NAD(+) in the absence of acetylated substrate.

Tocris Summary for SIRT6 Gene

  • Silent information regulator (Sir2)-like family deacetylases (also known as sirtuins) are a group of enzymes closely related to histone deacetylases. These enzymes can be found in the cytoplasm, mitochondria or nucleus of the cell and are ubiquitously expressed.

Gene Wiki entry for SIRT6 Gene

Additional gene information for SIRT6 Gene

No data available for CIViC Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for SIRT6 Gene

Genomics for SIRT6 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for SIRT6 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around SIRT6 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for SIRT6

Top Transcription factor binding sites by QIAGEN in the SIRT6 gene promoter:
  • ARP-1
  • FOXI1
  • FOXJ2
  • FOXJ2 (long isoform)
  • HEN1
  • MIF-1
  • Nkx2-5
  • Olf-1
  • RFX1

Genomic Locations for SIRT6 Gene

Genomic Locations for SIRT6 Gene
chr19:4,174,109-4,182,566
(GRCh38/hg38)
Size:
8,458 bases
Orientation:
Minus strand
chr19:4,174,106-4,182,601
(GRCh37/hg19)
Size:
8,496 bases
Orientation:
Minus strand

Genomic View for SIRT6 Gene

Genes around SIRT6 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SIRT6 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SIRT6 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SIRT6 Gene

Proteins for SIRT6 Gene

  • Protein details for SIRT6 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8N6T7-SIR6_HUMAN
    Recommended name:
    NAD-dependent protein deacetylase sirtuin-6
    Protein Accession:
    Q8N6T7
    Secondary Accessions:
    • B2RCD0
    • O75291
    • Q6IAF5
    • Q6PK99
    • Q8NCD2
    • Q9BSI5
    • Q9BWP3
    • Q9NRC7
    • Q9UQD1

    Protein attributes for SIRT6 Gene

    Size:
    355 amino acids
    Molecular mass:
    39119 Da
    Cofactor:
    Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
    Quaternary structure:
    • Interacts with RELA. Interacts with RBBP8; the interaction deacetylates RBBP8.
    SequenceCaution:
    • Sequence=AAC34468.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=AAD15478.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=AAH04218.1; Type=Erroneous translation; Note=Wrong choice of CCDS.; Evidence={ECO:0000305};
    Miscellaneous:
    • The reported ADP-ribosyltransferase activity of sirtuins is likely some inefficient side reaction of the deacetylase activity and may not be physiologically relevant.

    Three dimensional structures from OCA and Proteopedia for SIRT6 Gene

    Alternative splice isoforms for SIRT6 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SIRT6 Gene

Post-translational modifications for SIRT6 Gene

  • Ubiquitination at Lys245 and Lys267
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for SIRT6 Gene

Domains & Families for SIRT6 Gene

Gene Families for SIRT6 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for SIRT6 Gene

InterPro:
Blocks:
  • Silent information regulator protein Sir2
ProtoNet:

Suggested Antigen Peptide Sequences for SIRT6 Gene

GenScript: Design optimal peptide antigens:
  • cDNA FLJ52470, highly similar to Mono-ADP-ribosyltransferase sirtuin-6 (EC 2.4.2.31) (B4DDV3_HUMAN)
  • SIR2-like protein 6 (SIRT6_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q8N6T7

UniProtKB/Swiss-Prot:

SIR6_HUMAN :
  • Belongs to the sirtuin family. Class IV subfamily.
Family:
  • Belongs to the sirtuin family. Class IV subfamily.
genes like me logo Genes that share domains with SIRT6: view

Function for SIRT6 Gene

Molecular function for SIRT6 Gene

UniProtKB/Swiss-Prot Function:
NAD-dependent protein deacetylase. Has deacetylase activity towards histone H3K9Ac and H3K56Ac. Modulates acetylation of histone H3 in telomeric chromatin during the S-phase of the cell cycle. Deacetylates histone H3K9Ac at NF-kappa-B target promoters and may down-regulate the expression of a subset of NF-kappa-B target genes. Acts as a corepressor of the transcription factor HIF1A to control the expression of multiple glycolytic genes to regulate glucose homeostasis. Required for genomic stability. Regulates the production of TNF protein. Has a role in the regulation of life span (By similarity). Deacetylation of nucleosomes interferes with RELA binding to target DNA. May be required for the association of WRN with telomeres during S-phase and for normal telomere maintenance. Required for genomic stability. Required for normal IGF1 serum levels and normal glucose homeostasis. Modulates cellular senescence and apoptosis. On DNA damage, promotes DNA end resection via deacetylation of RBBP8. Has very weak deacetylase activity and can bind NAD(+) in the absence of acetylated substrate.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=H2O + N(6)-acetyl-L-lysyl-[protein] + NAD(+) = 2''-O-acetyl-ADP-D-ribose + L-lysyl-[protein] + nicotinamide; Xref=Rhea:RHEA:43636, Rhea:RHEA-COMP:9752, Rhea:RHEA-COMP:10731, ChEBI:CHEBI:15377, ChEBI:CHEBI:17154, ChEBI:CHEBI:29969, ChEBI:CHEBI:57540, ChEBI:CHEBI:61930, ChEBI:CHEBI:83767; EC=2.3.1.286; Evidence={ECO:0000255|PROSITE-ProRule:PRU00236, ECO:0000269|PubMed:18337721};.

Enzyme Numbers (IUBMB) for SIRT6 Gene

Phenotypes From GWAS Catalog for SIRT6 Gene

Gene Ontology (GO) - Molecular Function for SIRT6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003682 chromatin binding IEA --
GO:0003714 transcription corepressor activity IEA,IBA 21873635
GO:0003950 NAD+ ADP-ribosyltransferase activity TAS 17456799
GO:0003956 NAD(P)+-protein-arginine ADP-ribosyltransferase activity IEA,ISS --
GO:0004407 histone deacetylase activity IBA 21873635
genes like me logo Genes that share ontologies with SIRT6: view
genes like me logo Genes that share phenotypes with SIRT6: view

Animal Models for SIRT6 Gene

MGI Knock Outs for SIRT6:

Animal Model Products

CRISPR Products

miRNA for SIRT6 Gene

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for SIRT6

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for SIRT6 Gene

Localization for SIRT6 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SIRT6 Gene

Nucleus, nucleoplasm. Note=Predominantly nuclear. Associated with telomeric heterochromatin regions.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SIRT6 gene
Compartment Confidence
nucleus 5
mitochondrion 3
cytosol 3
plasma membrane 2
extracellular 2
cytoskeleton 2
peroxisome 2
endoplasmic reticulum 2
lysosome 2
endosome 1
golgi apparatus 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for SIRT6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IBA,ISS --
GO:0005654 nucleoplasm IDA,TAS --
GO:0005724 nuclear telomeric heterochromatin IBA --
GO:0005730 NOT nucleolus IDA 16079181
GO:0005737 cytoplasm IEA --
genes like me logo Genes that share ontologies with SIRT6: view

Pathways & Interactions for SIRT6 Gene

genes like me logo Genes that share pathways with SIRT6: view

Pathways by source for SIRT6 Gene

2 GeneGo (Thomson Reuters) pathways for SIRT6 Gene
  • DNA damage_NHEJ mechanisms of DSBs repair
  • NAD metabolism
2 Qiagen pathways for SIRT6 Gene
  • p53 Signaling
  • SUMO Pathway
1 Cell Signaling Technology pathway for SIRT6 Gene

SIGNOR curated interactions for SIRT6 Gene

Activates:

Gene Ontology (GO) - Biological Process for SIRT6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription by RNA polymerase II IBA 21873635
GO:0003247 post-embryonic cardiac muscle cell growth involved in heart morphogenesis IEA --
GO:0006284 base-excision repair IEA --
GO:0006471 protein ADP-ribosylation IEA,TAS 17456799
GO:0006476 protein deacetylation IMP 27457971
genes like me logo Genes that share ontologies with SIRT6: view

Drugs & Compounds for SIRT6 Gene

(9) Drugs for SIRT6 Gene - From: ApexBio, DGIdb, HMDB, and Tocris

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Panobinostat Approved, Investigational Pharma Inhibition, inhibitor Histone deacetylase (HDAC)inhibitors 145
Nicotinamide Approved, Investigational Pharma 427,427
NADH Approved Nutra 0
NAD Experimental Pharma Agonist, Full agonist, Activator 0
NADP Experimental Pharma 0

(3) Additional Compounds for SIRT6 Gene - From: HMDB and Tocris

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
O-acetyl-ADP-ribose
EX 527
49843-98-3
YK 3-237
1215281-19-8

(5) Tocris Compounds for SIRT6 Gene

Compound Action Cas Number
AGK 2 Selective SIRT2 inhibitor 304896-28-4
EX 527 Selective SIRT1 inhibitor 49843-98-3
Sirtinol Selective sirtuin family deacetylase inhibitor 410536-97-9
Splitomicin Sir2p inhibitor 5690-03-9
YK 3-237 SIRT1 activator 1215281-19-8

(1) ApexBio Compounds for SIRT6 Gene

Compound Action Cas Number
Splitomicin 5690-03-9
genes like me logo Genes that share compounds with SIRT6: view

Drug Products

Transcripts for SIRT6 Gene

mRNA/cDNA for SIRT6 Gene

9 REFSEQ mRNAs :
18 NCBI additional mRNA sequence :
15 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for SIRT6

Alternative Splicing Database (ASD) splice patterns (SP) for SIRT6 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b ^ 3a · 3b · 3c · 3d ^ 4a · 4b ^ 5 ^ 6a · 6b ^ 7a · 7b ^ 8a · 8b · 8c · 8d ^ 9a · 9b · 9c · 9d · 9e
SP1: - - - - - - -
SP2: - - - - - - - -
SP3: - - - - - -
SP4: - - - - - - - -
SP5: - - - - - -
SP6: - - - -
SP7: - - - - - - - - - -
SP8: - - - - -
SP9: - - - - - - - -
SP10: - - - - -
SP11: - - - - - - -
SP12: - - - - - - - -
SP13: -
SP14: - -
SP15: - - - - - -
SP16: - - - - - -
SP17: - -

Relevant External Links for SIRT6 Gene

GeneLoc Exon Structure for
SIRT6

Expression for SIRT6 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for SIRT6 Gene

Protein differential expression in normal tissues from HIPED for SIRT6 Gene

This gene is overexpressed in Breast (47.1) and NK cells (10.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for SIRT6 Gene



Transcriptomic regulation report from SPP (The Signaling Pathways Project) for SIRT6

SOURCE GeneReport for Unigene cluster for SIRT6 Gene:

Hs.423756

Evidence on tissue expression from TISSUES for SIRT6 Gene

  • Liver(4.6)
  • Blood(4.6)
  • Heart(4.6)
  • Lung(4.5)
  • Spleen(4.5)
  • Eye(4.4)
  • Nervous system(3.6)
  • Muscle(2.9)
  • Skin(2.8)
  • Kidney(2.8)
  • Intestine(2.8)
  • Pancreas(2.7)
  • Bone marrow(2.5)
  • Stomach(2.3)
  • Lymph node(2.2)
  • Thyroid gland(2.1)
  • Adrenal gland(2.1)
genes like me logo Genes that share expression patterns with SIRT6: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for SIRT6 Gene

Orthologs for SIRT6 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for SIRT6 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia SIRT6 30 31
  • 99.34 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia SIRT6 30 31
  • 86.85 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia SIRT6 30 31
  • 86.1 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Sirt6 30
  • 83.03 (n)
Mouse
(Mus musculus)
Mammalia Sirt6 30 17 31
  • 82.93 (n)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia SIRT6 31
  • 78 (a)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia SIRT6 31
  • 74 (a)
OneToOne
Chicken
(Gallus gallus)
Aves SIRT6 30 31
  • 73.54 (n)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia SIRT6 31
  • 66 (a)
OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia sirt6 30
  • 70.62 (n)
MGC76070 30
African clawed frog
(Xenopus laevis)
Amphibia Xl.19602 30
Zebrafish
(Danio rerio)
Actinopterygii sirt6 30 31
  • 68.67 (n)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP001458 30
  • 58.15 (n)
Fruit Fly
(Drosophila melanogaster)
Insecta Sirt6 30 31
  • 54.35 (n)
OneToOne
CG6284 32
  • 51 (a)
Worm
(Caenorhabditis elegans)
Secernentea sir-2.4 31 32
  • 33 (a)
OneToOne
Thale Cress
(Arabidopsis thaliana)
eudicotyledons SRT1 30
  • 51.85 (n)
Rice
(Oryza sativa)
Liliopsida Os04g0271000 30
  • 52.96 (n)
Os.2316 30
Corn
(Zea mays)
Liliopsida Zm.4848 30
Sea Squirt
(Ciona savignyi)
Ascidiacea -- 31
  • 59 (a)
OneToOne
Species where no ortholog for SIRT6 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)

Evolution for SIRT6 Gene

ENSEMBL:
Gene Tree for SIRT6 (if available)
TreeFam:
Gene Tree for SIRT6 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for SIRT6: view image

Paralogs for SIRT6 Gene

Paralogs for SIRT6 Gene

(1) SIMAP similar genes for SIRT6 Gene using alignment to 7 proteins:

  • SIR6_HUMAN
  • B4DDV3_HUMAN
  • M0QXA0_HUMAN
  • M0QZ09_HUMAN
  • M0R0B2_HUMAN
  • M0R1F6_HUMAN
  • M0R1N9_HUMAN
genes like me logo Genes that share paralogs with SIRT6: view

Variants for SIRT6 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for SIRT6 Gene

SNP ID Clinical significance and condition Chr 19 pos Variation AA Info Type
724568 Likely Benign: not provided 4,179,217(-) G/A SYNONYMOUS_VARIANT,INTRON_VARIANT
743024 Likely Benign: not provided 4,175,931(-) G/A SYNONYMOUS_VARIANT
745137 Likely Benign: not provided 4,174,803(-) G/A SYNONYMOUS_VARIANT,THREE_PRIME_UTR_VARIANT
777379 Benign: not provided 4,174,862(-) C/T MISSENSE_VARIANT,THREE_PRIME_UTR_VARIANT
790378 Likely Benign: not provided 4,174,748(-) C/A MISSENSE_VARIANT,THREE_PRIME_UTR_VARIANT

Additional dbSNP identifiers (rs#s) for SIRT6 Gene

Structural Variations from Database of Genomic Variants (DGV) for SIRT6 Gene

Variant ID Type Subtype PubMed ID
nsv833716 CNV loss 17160897

Variation tolerance for SIRT6 Gene

Residual Variation Intolerance Score: 42.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.38; 42.16% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for SIRT6 Gene

Human Gene Mutation Database (HGMD)
SIRT6
SNPedia medical, phenotypic, and genealogical associations of SNPs for
SIRT6

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SIRT6 Gene

Disorders for SIRT6 Gene

MalaCards: The human disease database

(5) MalaCards diseases for SIRT6 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
mood disorder
  • episodic mood disorder
monckeberg arteriosclerosis
  • monckeberg medial calcific sclerosis
hutchinson-gilford progeria syndrome
  • hgps
body mass index quantitative trait locus 11
  • bmiq11
diabetes mellitus, noninsulin-dependent
  • niddm
- elite association - COSMIC cancer census association via MalaCards
Search SIRT6 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for SIRT6

genes like me logo Genes that share disorders with SIRT6: view

No data available for UniProtKB/Swiss-Prot and Genatlas for SIRT6 Gene

Publications for SIRT6 Gene

  1. Phylogenetic classification of prokaryotic and eukaryotic Sir2-like proteins. (PMID: 10873683) Frye RA (Biochemical and biophysical research communications 2000) 2 3 4 23
  2. Evolutionarily conserved and nonconserved cellular localizations and functions of human SIRT proteins. (PMID: 16079181) Michishita E … Horikawa I (Molecular biology of the cell 2005) 3 4 23
  3. Structure and biochemical functions of SIRT6. (PMID: 21362626) Pan PW … Denu JM (The Journal of biological chemistry 2011) 3 4
  4. Cell cycle-dependent deacetylation of telomeric histone H3 lysine K56 by human SIRT6. (PMID: 19625767) Michishita E … Chua KF (Cell cycle (Georgetown, Tex.) 2009) 3 4
  5. SIRT6 links histone H3 lysine 9 deacetylation to NF-kappaB-dependent gene expression and organismal life span. (PMID: 19135889) Kawahara TL … Chua KF (Cell 2009) 3 4

Products for SIRT6 Gene

Sources for SIRT6 Gene