This gene encodes a member of the sirtuin family of proteins, homologs to the yeast Sir2 protein. Members of the sirtuin family are characterized by a sirtuin core domain and grouped into four classes. The functions of human sirtuins have not yet been determined; however, yeast sirtuin proteins are known to regulate epigenetic gene silencing and suppress recombination of rDNA. ... See more...

Aliases for SIRT5 Gene

Aliases for SIRT5 Gene

  • Sirtuin 5 2 3 5
  • NAD-Dependent Protein Deacylase Sirtuin-5, Mitochondrial 3 4
  • SIR2L5 3 4
  • Sirtuin (Silent Mating Type Information Regulation 2 Homolog) 5 (S. Cerevisiae) 2
  • Sirtuin (Silent Mating Type Information Regulation 2, S.Cerevisiae, Homolog) 5 2
  • NAD-Dependent Lysine Demalonylase And Desuccinylase Sirtuin-5, Mitochondrial 3
  • Silent Mating Type Information Regulation 2, S.Cerevisiae, Homolog 5 3
  • NAD-Dependent Deacetylase Sirtuin-5 3
  • Regulatory Protein SIR2 Homolog 5 4
  • SIR2-Like Protein 5 4
  • Sirtuin Type 5 3
  • Sir2-Like 5 3
  • EC 2.3.1.- 4
  • SIRT5 5

External Ids for SIRT5 Gene

Previous GeneCards Identifiers for SIRT5 Gene

  • GC06P013632
  • GC06P013682
  • GC06P013519

Summaries for SIRT5 Gene

Entrez Gene Summary for SIRT5 Gene

  • This gene encodes a member of the sirtuin family of proteins, homologs to the yeast Sir2 protein. Members of the sirtuin family are characterized by a sirtuin core domain and grouped into four classes. The functions of human sirtuins have not yet been determined; however, yeast sirtuin proteins are known to regulate epigenetic gene silencing and suppress recombination of rDNA. Studies suggest that the human sirtuins may function as intracellular regulatory proteins with mono-ADP-ribosyltransferase activity. The protein encoded by this gene is included in class III of the sirtuin family. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Jul 2010]

GeneCards Summary for SIRT5 Gene

SIRT5 (Sirtuin 5) is a Protein Coding gene. Diseases associated with SIRT5 include Monckeberg Arteriosclerosis and Body Mass Index Quantitative Trait Locus 11. Among its related pathways are NAD metabolism and DNA damage_NHEJ mechanisms of DSBs repair. Gene Ontology (GO) annotations related to this gene include NAD+ ADP-ribosyltransferase activity and protein-malonyllysine demalonylase activity. An important paralog of this gene is SIRT4.

UniProtKB/Swiss-Prot Summary for SIRT5 Gene

  • NAD-dependent lysine demalonylase, desuccinylase and deglutarylase that specifically removes malonyl, succinyl and glutaryl groups on target proteins (PubMed:21908771, PubMed:22076378, PubMed:24703693, PubMed:29180469). Activates CPS1 and contributes to the regulation of blood ammonia levels during prolonged fasting: acts by mediating desuccinylation and deglutarylation of CPS1, thereby increasing CPS1 activity in response to elevated NAD levels during fasting (PubMed:22076378, PubMed:24703693). Activates SOD1 by mediating its desuccinylation, leading to reduced reactive oxygen species (PubMed:24140062). Activates SHMT2 by mediating its desuccinylation (PubMed:29180469). Modulates ketogenesis through the desuccinylation and activation of HMGCS2 (By similarity). Has weak NAD-dependent protein deacetylase activity; however this activity may not be physiologically relevant in vivo. Can deacetylate cytochrome c (CYCS) and a number of other proteins in vitro such as UOX.

Tocris Summary for SIRT5 Gene

  • Silent information regulator (Sir2)-like family deacetylases (also known as sirtuins) are a group of enzymes closely related to histone deacetylases. These enzymes can be found in the cytoplasm, mitochondria or nucleus of the cell and are ubiquitously expressed.

Gene Wiki entry for SIRT5 Gene

No data available for CIViC Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for SIRT5 Gene

Genomics for SIRT5 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for SIRT5 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around SIRT5 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for SIRT5

Top Transcription factor binding sites by QIAGEN in the SIRT5 gene promoter:
  • AP-4
  • HOXA3
  • Pbx1a
  • POU2F1
  • POU2F1a

Genomic Locations for SIRT5 Gene

Latest Assembly
chr6:13,574,217-13,615,158
(GRCh38/hg38)
Size:
40,942 bases
Orientation:
Plus strand

Previous Assembly
chr6:13,574,506-13,615,390
(GRCh37/hg19 by Entrez Gene)
Size:
40,885 bases
Orientation:
Plus strand

chr6:13,574,816-13,614,790
(GRCh37/hg19 by Ensembl)
Size:
39,975 bases
Orientation:
Plus strand

Genomic View for SIRT5 Gene

Genes around SIRT5 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SIRT5 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SIRT5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SIRT5 Gene

Proteins for SIRT5 Gene

  • Protein details for SIRT5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NXA8-SIR5_HUMAN
    Recommended name:
    NAD-dependent protein deacylase sirtuin-5, mitochondrial
    Protein Accession:
    Q9NXA8
    Secondary Accessions:
    • B4DFM4
    • B4DYJ5
    • F5H5Z9
    • Q5T294
    • Q5T295
    • Q9Y6E6

    Protein attributes for SIRT5 Gene

    Size:
    310 amino acids
    Molecular mass:
    33881 Da
    Cofactor:
    Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
    Quaternary structure:
    • Interacts with CPS1 (By similarity). Interacts with PCCA (PubMed:23438705). Monomer (PubMed:17355872). Homodimer (PubMed:17355872). Forms homodimers upon suramin binding (PubMed:17355872).
    Miscellaneous:
    • The mechanism of demalonylation and desuccinylation involves the presence of a 1',2'-cyclic intermediate, suggesting that sirtuins use the ADP-ribose-peptidylamidate mechanism to remove acyl groups from substrate lysine residues.

    Three dimensional structures from OCA and Proteopedia for SIRT5 Gene

    Alternative splice isoforms for SIRT5 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SIRT5 Gene

Post-translational modifications for SIRT5 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Antibodies for research

  • Abcam antibodies for SIRT5
  • Santa Cruz Biotechnology (SCBT) Antibodies for SIRT5

No data available for DME Specific Peptides for SIRT5 Gene

Domains & Families for SIRT5 Gene

Gene Families for SIRT5 Gene

HGNC:
Human Protein Atlas (HPA):
  • FDA approved drug targets
  • Predicted intracellular proteins

Suggested Antigen Peptide Sequences for SIRT5 Gene

GenScript: Design optimal peptide antigens:
  • cDNA FLJ52482, highly similar to NAD-dependent deacetylase sirtuin-5 (EC3.5.1.-) (B4DFM4_HUMAN)
  • SIR2-like protein 5 (SIRT5_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q9NXA8

UniProtKB/Swiss-Prot:

SIR5_HUMAN :
  • In contrast to class I sirtuins, class III sirtuins have only weak deacetylase activity. Difference in substrate specificity is probably due to a larger hydrophobic pocket with 2 residues (Tyr-102 and Arg-105) that bind to malonylated and succinylated substrates and define the specificity (PubMed:22076378).
  • Belongs to the sirtuin family. Class III subfamily.
Domain:
  • In contrast to class I sirtuins, class III sirtuins have only weak deacetylase activity. Difference in substrate specificity is probably due to a larger hydrophobic pocket with 2 residues (Tyr-102 and Arg-105) that bind to malonylated and succinylated substrates and define the specificity (PubMed:22076378).
Family:
  • Belongs to the sirtuin family. Class III subfamily.
genes like me logo Genes that share domains with SIRT5: view

Function for SIRT5 Gene

Molecular function for SIRT5 Gene

UniProtKB/Swiss-Prot Function:
NAD-dependent lysine demalonylase, desuccinylase and deglutarylase that specifically removes malonyl, succinyl and glutaryl groups on target proteins (PubMed:21908771, PubMed:22076378, PubMed:24703693, PubMed:29180469). Activates CPS1 and contributes to the regulation of blood ammonia levels during prolonged fasting: acts by mediating desuccinylation and deglutarylation of CPS1, thereby increasing CPS1 activity in response to elevated NAD levels during fasting (PubMed:22076378, PubMed:24703693). Activates SOD1 by mediating its desuccinylation, leading to reduced reactive oxygen species (PubMed:24140062). Activates SHMT2 by mediating its desuccinylation (PubMed:29180469). Modulates ketogenesis through the desuccinylation and activation of HMGCS2 (By similarity). Has weak NAD-dependent protein deacetylase activity; however this activity may not be physiologically relevant in vivo. Can deacetylate cytochrome c (CYCS) and a number of other proteins in vitro such as UOX.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=H2O + N(6)-malonyl-L-lysyl-[protein] + NAD(+) = 2''-O-malonyl-ADP-D-ribose + L-lysyl-[protein] + nicotinamide; Xref=Rhea:RHEA:47672, Rhea:RHEA-COMP:9752, Rhea:RHEA-COMP:11878, ChEBI:CHEBI:15377, ChEBI:CHEBI:17154, ChEBI:CHEBI:29969, ChEBI:CHEBI:57540, ChEBI:CHEBI:87831, ChEBI:CHEBI:87833; Evidence={ECO:0000255|HAMAP-Rule:MF_03160, ECO:0000269|PubMed:22076378};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=H2O + N(6)-succinyl-L-lysyl-[protein] + NAD(+) = 2''-O-succinyl-ADP-D-ribose + L-lysyl-[protein] + nicotinamide; Xref=Rhea:RHEA:47668, Rhea:RHEA-COMP:9752, Rhea:RHEA-COMP:11877, ChEBI:CHEBI:15377, ChEBI:CHEBI:17154, ChEBI:CHEBI:29969, ChEBI:CHEBI:57540, ChEBI:CHEBI:87830, ChEBI:CHEBI:87832; Evidence={ECO:0000255|HAMAP-Rule:MF_03160, ECO:0000269|PubMed:22076378, ECO:0000269|PubMed:29180469};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=H2O + N(6)-glutaryl-L-lysyl-[protein] + NAD(+) = 2''-O-glutaryl-ADP-D-ribose + L-lysyl-[protein] + nicotinamide; Xref=Rhea:RHEA:47664, Rhea:RHEA-COMP:9752, Rhea:RHEA-COMP:11875, ChEBI:CHEBI:15377, ChEBI:CHEBI:17154, ChEBI:CHEBI:29969, ChEBI:CHEBI:57540, ChEBI:CHEBI:87828, ChEBI:CHEBI:87829; Evidence={ECO:0000255|HAMAP-Rule:MF_03160, ECO:0000269|PubMed:24703693};.
UniProtKB/Swiss-Prot BiophysicochemicalProperties:
Kinetic parameters: KM=6.1 uM for a synthetic histone H3K9 malonyllysine peptide {ECO:0000269|PubMed:22076378}; KM=5.8 uM for a synthetic histone H3K9 succinyllysine peptide {ECO:0000269|PubMed:22076378}; KM=8.7 uM for a synthetic GLUD1 peptide malonylated at 'Lys-503' {ECO:0000269|PubMed:22076378}; KM=14 uM for a synthetic GLUD1 peptide succinylated at 'Lys-503' {ECO:0000269|PubMed:22076378}; KM=150 uM for a synthetic ACSS1 peptide malonylated at 'Lys-628' {ECO:0000269|PubMed:22076378}; KM=450 uM for a synthetic ACSS1 peptide succinylated at 'Lys-628' {ECO:0000269|PubMed:22076378};
UniProtKB/Swiss-Prot EnzymeRegulation:
Inhibited by suramin. NAD-dependent lysine desuccinylase activity is inhibited by physiological nicotinamide concentrations, while deacetylase activity is not. In contrast, resveratrol activates deacetylase activity, while inhibiting desuccinylase activity.

Enzyme Numbers (IUBMB) for SIRT5 Gene

Phenotypes From GWAS Catalog for SIRT5 Gene

Gene Ontology (GO) - Molecular Function for SIRT5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003950 NOT NAD+ ADP-ribosyltransferase activity TAS 17456799
GO:0008270 zinc ion binding IEA,IDA 22076378
GO:0016740 transferase activity IEA --
GO:0034979 NAD-dependent protein deacetylase activity IEA,TAS --
GO:0036054 protein-malonyllysine demalonylase activity IEA,IDA 21908771
genes like me logo Genes that share ontologies with SIRT5: view
genes like me logo Genes that share phenotypes with SIRT5: view

Animal Models for SIRT5 Gene

MGI Knock Outs for SIRT5:

Animal Models for research

  • Taconic Biosciences Mouse Models for SIRT5

miRNA for SIRT5 Gene

miRTarBase miRNAs that target SIRT5

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for SIRT5

Clone products for research

  • Addgene plasmids for SIRT5

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for SIRT5 Gene

Localization for SIRT5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SIRT5 Gene

Mitochondrion matrix. Mitochondrion intermembrane space. Cytoplasm, cytosol. Nucleus. Note=Mainly mitochondrial. Also present extramitochondrially, with a fraction present in the cytosol and very small amounts also detected in the nucleus.
[Isoform 1]: Cytoplasm. Mitochondrion.
[Isoform 2]: Mitochondrion.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SIRT5 gene
Compartment Confidence
mitochondrion 5
nucleus 5
cytosol 5
plasma membrane 2
extracellular 2
cytoskeleton 2
peroxisome 2
endoplasmic reticulum 2
lysosome 2
endosome 1
golgi apparatus 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for SIRT5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA,TAS 23806337
GO:0005737 cytoplasm IEA --
GO:0005739 mitochondrion IEA,IDA 16079181
GO:0005758 mitochondrial intermembrane space IEA,IDA 18680753
GO:0005759 mitochondrial matrix TAS --
genes like me logo Genes that share ontologies with SIRT5: view

Pathways & Interactions for SIRT5 Gene

genes like me logo Genes that share pathways with SIRT5: view

Pathways by source for SIRT5 Gene

1 Sino Biological pathway for SIRT5 Gene
2 GeneGo (Thomson Reuters) pathways for SIRT5 Gene
  • DNA damage_NHEJ mechanisms of DSBs repair
  • NAD metabolism
2 Qiagen pathways for SIRT5 Gene
  • p53 Signaling
  • SUMO Pathway
2 Cell Signaling Technology pathways for SIRT5 Gene

SIGNOR curated interactions for SIRT5 Gene

Activates:
Inactivates:
Is inactivated by:

Gene Ontology (GO) - Biological Process for SIRT5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006471 NOT protein ADP-ribosylation ISS,TAS 17456799
GO:0006476 NOT protein deacetylation IEA,IDA 22076378
GO:0007005 mitochondrion organization TAS --
GO:0010566 regulation of ketone biosynthetic process ISS --
GO:0010667 negative regulation of cardiac muscle cell apoptotic process IMP --
genes like me logo Genes that share ontologies with SIRT5: view

Drugs & Compounds for SIRT5 Gene

(10) Drugs for SIRT5 Gene - From: DrugBank, ApexBio, DGIdb, HMDB, and Tocris

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Nicotinamide Approved, Investigational Pharma Target 474,474
Panobinostat Approved, Investigational Pharma Inhibition, inhibitor Histone deacetylase (HDAC)inhibitors 146
2'-O-Acetyl Adenosine-5-Diphosphoribose Experimental Pharma Target 0
Adenosine-5-Diphosphoribose Experimental Pharma Target 0
Cambinol Experimental Pharma Target, inhibitor 0

(2) Additional Compounds for SIRT5 Gene - From: Tocris

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
EX 527
49843-98-3
YK 3-237
1215281-19-8

(5) Tocris Compounds for SIRT5 Gene

Compound Action Cas Number
AGK 2 Selective SIRT2 inhibitor 304896-28-4
EX 527 Selective SIRT1 inhibitor 49843-98-3
Sirtinol Selective sirtuin family deacetylase inhibitor 410536-97-9
Splitomicin Sir2p inhibitor 5690-03-9
YK 3-237 SIRT1 activator 1215281-19-8

(1) ApexBio Compounds for SIRT5 Gene

Compound Action Cas Number
Splitomicin 5690-03-9
genes like me logo Genes that share compounds with SIRT5: view

Drug products for research

Transcripts for SIRT5 Gene

mRNA/cDNA for SIRT5 Gene

22 REFSEQ mRNAs :
15 NCBI additional mRNA sequence :
24 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for SIRT5

Clone products for research

  • Addgene plasmids for SIRT5

Alternative Splicing Database (ASD) splice patterns (SP) for SIRT5 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9 ^ 10 ^ 11a · 11b ^ 12 ^ 13 ^ 14a · 14b · 14c ^ 15a · 15b
SP1: - - - - - -
SP2: - - - - - - - -
SP3: - - -
SP4:
SP5: - -
SP6: - - - - - - -
SP7:
SP8:

Relevant External Links for SIRT5 Gene

GeneLoc Exon Structure for
SIRT5

Expression for SIRT5 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for SIRT5 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for SIRT5 Gene

This gene is overexpressed in Heart (9.5) and Brain (8.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for SIRT5 Gene



Protein tissue co-expression partners for SIRT5 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for SIRT5

SOURCE GeneReport for Unigene cluster for SIRT5 Gene:

Hs.567431

mRNA Expression by UniProt/SwissProt for SIRT5 Gene:

Q9NXA8-SIR5_HUMAN
Tissue specificity: Widely expressed.

Evidence on tissue expression from TISSUES for SIRT5 Gene

  • Nervous system(4.8)
  • Liver(4.6)
  • Eye(4.4)
  • Heart(3.1)
  • Muscle(3.1)
  • Kidney(2.8)
  • Blood(2.6)
  • Skin(2.5)
  • Pancreas(2.4)
  • Intestine(2.4)
  • Lung(2.2)
  • Thyroid gland(2.1)
  • Adrenal gland(2.1)
  • Spleen(2.1)
genes like me logo Genes that share expression patterns with SIRT5: view

No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for SIRT5 Gene

Orthologs for SIRT5 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for SIRT5 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia SIRT5 29 30
  • 98.92 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia SIRT5 29 30
  • 86.77 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia SIRT5 29 30
  • 86.45 (n)
OneToOne
Mouse
(Mus musculus)
Mammalia Sirt5 29 16 30
  • 84.09 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Sirt5 29
  • 83.98 (n)
Platypus
(Ornithorhynchus anatinus)
Mammalia SIRT5 30
  • 83 (a)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia SIRT5 30
  • 61 (a)
OneToOne
Chicken
(Gallus gallus)
Aves SIRT5 29 30
  • 73.66 (n)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia SIRT5 30
  • 76 (a)
OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia sirt5 29
  • 71.78 (n)
Str.16272 29
African clawed frog
(Xenopus laevis)
Amphibia Xl.15494 29
Zebrafish
(Danio rerio)
Actinopterygii sirt5 29 30
  • 68.59 (n)
OneToMany
SIRT5 (2 of 2) 30
  • 52 (a)
OneToMany
Rainbow Trout
(Oncorhynchus mykiss)
Actinopterygii Omy.10779 29
A. gosspyii yeast
(Eremothecium gossypii)
Saccharomycetes AGOS_ABL004W 29
  • 45.02 (n)
Baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes HST1 30
  • 13 (a)
ManyToMany
SIR2 30
  • 11 (a)
ManyToMany
Sea Squirt
(Ciona savignyi)
Ascidiacea -- 30
  • 57 (a)
OneToOne
Sea Vase
(Ciona intestinalis)
Ascidiacea Cin.8513 29
Species where no ortholog for SIRT5 was found in the sources mined by GeneCards:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for SIRT5 Gene

ENSEMBL:
Gene Tree for SIRT5 (if available)
TreeFam:
Gene Tree for SIRT5 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for SIRT5: view image
Alliance of Genome Resources:
Additional Orthologs for SIRT5

Paralogs for SIRT5 Gene

Paralogs for SIRT5 Gene

(1) SIMAP similar genes for SIRT5 Gene using alignment to 2 proteins:

  • SIR5_HUMAN
  • U3KQT8_HUMAN

Pseudogenes.org Pseudogenes for SIRT5 Gene

genes like me logo Genes that share paralogs with SIRT5: view

Variants for SIRT5 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for SIRT5 Gene

SNP ID Clinical significance and condition Chr 06 pos Variation AA Info Type
973211 Not Provided: not provided 13,604,478(+) A/T
NM_012241.5(SIRT5):c.857+3529A>T
MISSENSE_VARIANT,NON_CODING_TRANSCRIPT_VARIANT,INTRON
rs34162626 -- p.Glu305Gly
rs9464003 -- p.Phe285Leu

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for SIRT5 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for SIRT5 Gene

Variant ID Type Subtype PubMed ID
dgv3448e59 CNV duplication 20981092
esv3608129 CNV loss 21293372
nsv1119072 CNV deletion 24896259
nsv473115 CNV novel sequence insertion 20440878

Variation tolerance for SIRT5 Gene

Residual Variation Intolerance Score: 81.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.48; 64.31% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for SIRT5 Gene

Human Gene Mutation Database (HGMD)
SIRT5
SNPedia medical, phenotypic, and genealogical associations of SNPs for
SIRT5
Leiden Open Variation Database (LOVD)
SIRT5

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SIRT5 Gene

Disorders for SIRT5 Gene

MalaCards: The human disease database

(3) MalaCards diseases for SIRT5 Gene - From: COP

Disorder Aliases PubMed IDs
monckeberg arteriosclerosis
  • monckeberg medial calcific sclerosis
body mass index quantitative trait locus 11
  • bmiq11
disease of mental health
  • mental health
- elite association - COSMIC cancer census association via MalaCards
Search SIRT5 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for SIRT5

Human Genome Epidemiology Navigator
(HuGE)
Atlas
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
Open Targets Platform
genes like me logo Genes that share disorders with SIRT5: view

No data available for UniProtKB/Swiss-Prot and Genatlas for SIRT5 Gene

Publications for SIRT5 Gene

  1. Substrates and regulation mechanisms for the human mitochondrial sirtuins Sirt3 and Sirt5. (PMID: 18680753) Schlicker C … Steegborn C (Journal of molecular biology 2008) 3 4 22
  2. Characterization of five human cDNAs with homology to the yeast SIR2 gene: Sir2-like proteins (sirtuins) metabolize NAD and may have protein ADP-ribosyltransferase activity. (PMID: 10381378) Frye RA (Biochemical and biophysical research communications 1999) 2 3 4
  3. SHMT2 Desuccinylation by SIRT5 Drives Cancer Cell Proliferation. (PMID: 29180469) Yang X … Luo J (Cancer research 2018) 3 4
  4. Lysine glutarylation is a protein posttranslational modification regulated by SIRT5. (PMID: 24703693) Tan M … Zhao Y (Cell metabolism 2014) 3 4
  5. SIRT5-mediated lysine desuccinylation impacts diverse metabolic pathways. (PMID: 23806337) Park J … Zhao Y (Molecular cell 2013) 3 4

Products for SIRT5 Gene

Sources for SIRT5 Gene