Aliases for SIRT5 Gene
- Sirtuin 5 2 3 5
- NAD-Dependent Protein Deacylase Sirtuin-5, Mitochondrial 3 4
- SIR2L5 3 4
- Sirtuin (Silent Mating Type Information Regulation 2 Homolog) 5 (S. Cerevisiae) 2
- Sirtuin (Silent Mating Type Information Regulation 2, S.Cerevisiae, Homolog) 5 2
- NAD-Dependent Lysine Demalonylase And Desuccinylase Sirtuin-5, Mitochondrial 3
- Silent Mating Type Information Regulation 2, S.Cerevisiae, Homolog 5 3
External Ids for SIRT5 Gene
Previous GeneCards Identifiers for SIRT5 Gene
This gene encodes a member of the sirtuin family of proteins, homologs to the yeast Sir2 protein. Members of the sirtuin family are characterized by a sirtuin core domain and grouped into four classes. The functions of human sirtuins have not yet been determined; however, yeast sirtuin proteins are known to regulate epigenetic gene silencing and suppress recombination of rDNA. Studies suggest that the human sirtuins may function as intracellular regulatory proteins with mono-ADP-ribosyltransferase activity. The protein encoded by this gene is included in class III of the sirtuin family. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Jul 2010]
GeneCards Summary for SIRT5 Gene
SIRT5 (Sirtuin 5) is a Protein Coding gene. Diseases associated with SIRT5 include Monckeberg Arteriosclerosis and Body Mass Index Quantitative Trait Locus 11. Among its related pathways are NAD metabolism and DNA damage_NHEJ mechanisms of DSBs repair. Gene Ontology (GO) annotations related to this gene include NAD+ ADP-ribosyltransferase activity and protein-malonyllysine demalonylase activity. An important paralog of this gene is SIRT4.
UniProtKB/Swiss-Prot Summary for SIRT5 Gene
NAD-dependent lysine demalonylase, desuccinylase and deglutarylase that specifically removes malonyl, succinyl and glutaryl groups on target proteins (PubMed:21908771, PubMed:22076378, PubMed:24703693, PubMed:29180469). Activates CPS1 and contributes to the regulation of blood ammonia levels during prolonged fasting: acts by mediating desuccinylation and deglutarylation of CPS1, thereby increasing CPS1 activity in response to elevated NAD levels during fasting (PubMed:22076378, PubMed:24703693). Activates SOD1 by mediating its desuccinylation, leading to reduced reactive oxygen species (PubMed:24140062). Activates SHMT2 by mediating its desuccinylation (PubMed:29180469). Modulates ketogenesis through the desuccinylation and activation of HMGCS2 (By similarity). Has weak NAD-dependent protein deacetylase activity; however this activity may not be physiologically relevant in vivo. Can deacetylate cytochrome c (CYCS) and a number of other proteins in vitro such as UOX.
Silent information regulator (Sir2)-like family deacetylases (also known as sirtuins) are a group of enzymes closely related to histone deacetylases. These enzymes can be found in the cytoplasm, mitochondria or nucleus of the cell and are ubiquitously expressed.