Aliases for SIRT3 Gene
- Sirtuin 3 2 3 5
- NAD-Dependent Protein Deacetylase Sirtuin-3, Mitochondrial 3 4
- Regulatory Protein SIR2 Homolog 3 3 4
- SIR2-Like Protein 3 3 4
- SIR2L3 3 4
- Sirtuin (Silent Mating Type Information Regulation 2 Homolog) 3 (S. Cerevisiae) 2
- Sirtuin (Silent Mating Type Information Regulation 2, S.Cerevisiae, Homolog) 3 2
External Ids for SIRT3 Gene
Previous GeneCards Identifiers for SIRT3 Gene
SIRT3 encodes a member of the sirtuin family of class III histone deacetylases, homologs to the yeast Sir2 protein. The encoded protein is found exclusively in mitochondria, where it can eliminate reactive oxygen species, inhibit apoptosis, and prevent the formation of cancer cells. SIRT3 has far-reaching effects on nuclear gene expression, cancer, cardiovascular disease, neuroprotection, aging, and metabolic control. [provided by RefSeq, May 2019]
GeneCards Summary for SIRT3 Gene
SIRT3 (Sirtuin 3) is a Protein Coding gene. Diseases associated with SIRT3 include Aging and Mitochondrial Complex I Deficiency, Nuclear Type 1. Among its related pathways are NAD metabolism and Central carbon metabolism in cancer. Gene Ontology (GO) annotations related to this gene include enzyme binding and NAD+ ADP-ribosyltransferase activity. An important paralog of this gene is SIRT2.
UniProtKB/Swiss-Prot Summary for SIRT3 Gene
NAD-dependent protein deacetylase (PubMed:12186850, PubMed:12374852, PubMed:16788062, PubMed:18680753, PubMed:18794531, PubMed:23283301, PubMed:24121500, PubMed:24252090, PubMed:19535340). Activates or deactivates mitochondrial target proteins by deacetylating key lysine residues (PubMed:12186850, PubMed:12374852, PubMed:16788062, PubMed:18680753, PubMed:18794531, PubMed:23283301, PubMed:24121500, PubMed:24252090). Known targets include ACSS1, IDH, GDH, SOD2, PDHA1, LCAD, SDHA and the ATP synthase subunit ATP5PO (PubMed:16788062, PubMed:18680753, PubMed:24121500, PubMed:24252090, PubMed:19535340). Contributes to the regulation of the cellular energy metabolism (PubMed:24252090). Important for regulating tissue-specific ATP levels (PubMed:18794531). In response to metabolic stress, deacetylates transcription factor FOXO3 and recruits FOXO3 and mitochondrial RNA polymerase POLRMT to mtDNA to promote mtDNA transcription (PubMed:23283301). Acts as a regulator of ceramide metabolism by mediating deacetylation of ceramide synthases CERS1, CERS2 and CERS6, thereby increasing their activity and promoting mitochondrial ceramide accumulation (By similarity).
Silent information regulator (Sir2)-like family deacetylases (also known as sirtuins) are a group of enzymes closely related to histone deacetylases. These enzymes can be found in the cytoplasm, mitochondria or nucleus of the cell and are ubiquitously expressed.