Aliases for SIRPB2 Gene

Aliases for SIRPB2 Gene

  • Signal Regulatory Protein Beta 2 2 3 5
  • Protein Tyrosine Phosphatase, Non-Receptor Type Substrate 1-Like 3 2 3
  • Protein Tyrosine Phosphatase Non-Receptor Type Substrate Protein 3 4
  • Signal-Regulatory Protein Beta-2 3 4
  • SIRP-Beta-2 3 4
  • DJ776F14.2 2 3
  • PTPNS1L3 3 4
  • PTPN1L 3 4
  • Protein Tyrosine Phosphatase Non-Receptor Type Substrate 1-Like 3 4
  • Protein Tyrosine Phosphatase, Non-Receptor Type 1-Like 2
  • Signal-Regulatory Protein Beta 2 2
  • SIRPB2 5

External Ids for SIRPB2 Gene

Previous HGNC Symbols for SIRPB2 Gene

  • PTPN1L
  • PTPNS1L3

Previous GeneCards Identifiers for SIRPB2 Gene

  • GC20M001597
  • GC20M001604
  • GC20M001557
  • GC20M001400
  • GC20M001451

Summaries for SIRPB2 Gene

GeneCards Summary for SIRPB2 Gene

SIRPB2 (Signal Regulatory Protein Beta 2) is a Protein Coding gene. An important paralog of this gene is SIRPA.

Additional gene information for SIRPB2 Gene

No data available for Entrez Gene Summary , CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for SIRPB2 Gene

Genomics for SIRPB2 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for SIRPB2 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH20J001486 Promoter/Enhancer 1.6 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 648.4 +1.2 1153 4.4 CEBPB NR2F2 ZNF184 SPI1 EBF1 POLR2A JUND ZMYM3 MYC MAX SIRPB2 NSFL1C SDCBP2 SIRPB1 SIRPD ENSG00000242324 FKBP1A SIRPA lnc-NSFL1C-1
GH20J001493 Enhancer 0.4 FANTOM5 dbSUPER 626.2 -2.0 -1962 0.2 SIRPB2 SDCBP2 SIRPA SIRPB1 piR-51070 SIRPD
GH20J001464 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER 21.7 +23.8 23770 6.7 ZNF221 SP1 HNRNPL GATAD2A CTCF ZNF629 TFE3 RFX1 IKZF1 NFKBIZ NSFL1C lnc-SNPH-7 SIRPB2 SDCBP2 SNPH FKBP1A lnc-NSFL1C-1 lnc-NSFL1C-2
GH20J001476 Promoter/Enhancer 1.2 EPDnew Ensembl ENCODE dbSUPER 21.4 +13.3 13313 3 IKZF1 CEBPB JUND JUN FOS FOSL2 ZFP3 NSFL1C SIRPB2 lnc-NSFL1C-1
GH20J001815 Enhancer 1.2 FANTOM5 ENCODE dbSUPER 16.9 -329.2 -329191 11.5 PRDM10 PRDM1 CEBPB SP1 YBX1 JUN MAFF MAFK ZBTB17 TRIM28 SDCBP2 SIRPB2 SIRPB1 SIRPA SDCBP2-AS1 ZNF343 CKAP2LP1 NSFL1C LOC105372501 lnc-SIRPA-1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around SIRPB2 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for SIRPB2

Genomic Locations for SIRPB2 Gene

Genomic Locations for SIRPB2 Gene
21,022 bases
Minus strand
20,848 bases
Minus strand

Genomic View for SIRPB2 Gene

Genes around SIRPB2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SIRPB2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SIRPB2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SIRPB2 Gene

Proteins for SIRPB2 Gene

  • Protein details for SIRPB2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Signal-regulatory protein beta-2
    Protein Accession:
    Secondary Accessions:
    • B4DLM9
    • E9PCW6
    • Q6TCH9

    Protein attributes for SIRPB2 Gene

    342 amino acids
    Molecular mass:
    36968 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for SIRPB2 Gene


neXtProt entry for SIRPB2 Gene

Post-translational modifications for SIRPB2 Gene

  • Glycosylation at Asn179, Asn116, and Asn231
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for SIRPB2 Gene

Domains & Families for SIRPB2 Gene

Gene Families for SIRPB2 Gene

Protein Domains for SIRPB2 Gene

Suggested Antigen Peptide Sequences for SIRPB2 Gene

GenScript: Design optimal peptide antigens:
  • Protein tyrosine phosphatase non-receptor type substrate protein (SIRB2_HUMAN)
genes like me logo Genes that share domains with SIRPB2: view

No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for SIRPB2 Gene

Function for SIRPB2 Gene

Phenotypes From GWAS Catalog for SIRPB2 Gene

genes like me logo Genes that share phenotypes with SIRPB2: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for SIRPB2

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for SIRPB2 Gene

Localization for SIRPB2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SIRPB2 Gene

Membrane. Single-pass type I membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SIRPB2 gene
Compartment Confidence
plasma membrane 4

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nuclear bodies (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for SIRPB2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane IBA 21873635
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with SIRPB2: view

Pathways & Interactions for SIRPB2 Gene

PathCards logo

SuperPathways for SIRPB2 Gene

No Data Available

Interacting Proteins for SIRPB2 Gene

Gene Ontology (GO) - Biological Process for SIRPB2 Gene


No data available for Pathways by source and SIGNOR curated interactions for SIRPB2 Gene

Drugs & Compounds for SIRPB2 Gene

No Compound Related Data Available

Transcripts for SIRPB2 Gene

mRNA/cDNA for SIRPB2 Gene

10 NCBI additional mRNA sequence :
8 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for SIRPB2

Alternative Splicing Database (ASD) splice patterns (SP) for SIRPB2 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b · 3c ^ 4a · 4b ^ 5 ^ 6 ^ 7a · 7b ^ 8a · 8b
SP1: - -
SP2: -
SP3: - - -
SP4: -

Relevant External Links for SIRPB2 Gene

GeneLoc Exon Structure for

Expression for SIRPB2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for SIRPB2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

  • Blood (Hematopoietic System)

mRNA differential expression in normal tissues according to GTEx for SIRPB2 Gene

This gene is overexpressed in Whole Blood (x32.0).

Protein differential expression in normal tissues from HIPED for SIRPB2 Gene

This gene is overexpressed in Monocytes (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for SIRPB2 Gene

Protein tissue co-expression partners for SIRPB2 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for SIRPB2

SOURCE GeneReport for Unigene cluster for SIRPB2 Gene:


Evidence on tissue expression from TISSUES for SIRPB2 Gene

  • Blood(4)
genes like me logo Genes that share expression patterns with SIRPB2: view

Primer Products

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for SIRPB2 Gene

Orthologs for SIRPB2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for SIRPB2 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia SIRPB2 30 31
  • 99.22 (n)
(Bos Taurus)
Mammalia SIRPB2 30 31
  • 81 (n)
(Canis familiaris)
Mammalia SIRPB2 30 31
  • 80.51 (n)
(Monodelphis domestica)
Mammalia -- 31
  • 44 (a)
-- 31
  • 38 (a)
-- 31
  • 19 (a)
-- 31
  • 15 (a)
(Mus musculus)
Mammalia F830045P16Rik 31
  • 6 (a)
(Gallus gallus)
Aves -- 31
  • 20 (a)
-- 31
  • 16 (a)
-- 31
  • 15 (a)
(Anolis carolinensis)
Reptilia -- 31
  • 19 (a)
-- 31
  • 13 (a)
-- 31
  • 12 (a)
Species where no ortholog for SIRPB2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rat (Rattus norvegicus)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)
  • Zebrafish (Danio rerio)

Evolution for SIRPB2 Gene

Gene Tree for SIRPB2 (if available)
Gene Tree for SIRPB2 (if available)
Evolutionary constrained regions (ECRs) for SIRPB2: view image

Paralogs for SIRPB2 Gene

Paralogs for SIRPB2 Gene

(2) SIMAP similar genes for SIRPB2 Gene using alignment to 4 proteins:

  • F2Z2Y9_HUMAN
  • F5H204_HUMAN
genes like me logo Genes that share paralogs with SIRPB2: view

Variants for SIRPB2 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for SIRPB2 Gene

SNP ID Clinical significance and condition Chr 20 pos Variation AA Info Type
rs6033876 - p.Gly153Glu
rs6042507 - p.Glu215Ala
rs8119290 - p.Leu304Phe

Additional dbSNP identifiers (rs#s) for SIRPB2 Gene

Structural Variations from Database of Genomic Variants (DGV) for SIRPB2 Gene

Variant ID Type Subtype PubMed ID
nsv3252 CNV insertion 18451855
nsv522008 CNV gain 19592680
nsv585206 CNV gain 21841781
nsv833893 CNV loss 17160897
nsv952971 CNV duplication 24416366

Variation tolerance for SIRPB2 Gene

Residual Variation Intolerance Score: 87.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.70; 57.37% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for SIRPB2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SIRPB2 Gene

Disorders for SIRPB2 Gene

Additional Disease Information for SIRPB2

No disorders were found for SIRPB2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SIRPB2 Gene

Publications for SIRPB2 Gene

  1. The SIRP family of receptors and immune regulation. (PMID: 16691243) Barclay AN … Brown MH (Nature reviews. Immunology 2006) 2 3
  2. A nomenclature for signal regulatory protein family members. (PMID: 16339511) van den Berg TK … Barclay AN (Journal of immunology (Baltimore, Md. : 1950) 2005) 2 3
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4
  4. SIRPB1 promotes prostate cancer cell proliferation via Akt activation. (PMID: 31905248) Song Q … Wang Z (The Prostate 2020) 3
  5. Genome-wide and gene-centric analyses of circulating myeloperoxidase levels in the charge and care consortia. (PMID: 23620142) Reiner AP … Allayee H (Human molecular genetics 2013) 3

Products for SIRPB2 Gene

  • Signalway ELISA kits for SIRPB2

Sources for SIRPB2 Gene