The protein encoded by this gene is a member of the signal-regulatory-protein (SIRP) family, and also belongs to the immunoglobulin superfamily. SIRP family members are receptor-type transmembrane glycoproteins known to be involved in the negative regulation of receptor tyrosine kinase-coupled signaling processes. This protein can be phosphorylated by tyrosine kinases. The phos... See more...

Aliases for SIRPA Gene

Aliases for SIRPA Gene

  • Signal Regulatory Protein Alpha 2 3 5
  • SHPS1 2 3 4
  • SIRP 2 3 4
  • BIT 2 3 4
  • MFR 2 3 4
  • P84 2 3 4
  • Tyrosine-Protein Phosphatase Non-Receptor Type Substrate 1 3 4
  • CD172 Antigen-Like Family Member A 3 4
  • Inhibitory Receptor SHPS-1 3 4
  • Macrophage Fusion Receptor 3 4
  • PTPNS1 3 4
  • SHPS-1 2 4
  • MYD-1 2 3
  • Brain-Immunoglobulin-Like Molecule With Tyrosine-Based Activation Motifs 3
  • Brain Ig-Like Molecule With Tyrosine-Based Activation Motifs 4
  • Protein Tyrosine Phosphatase, Non-Receptor Type Substrate 1 2
  • Tyrosine Phosphatase SHP Substrate 1 3
  • Signal-Regulatory Protein Alpha-1 4
  • Signal-Regulatory Protein Alpha-2 4
  • Signal-Regulatory Protein Alpha-3 4
  • Signal-Regulatory Protein Alpha 2
  • SHP Substrate 1 4
  • CD172a Antigen 4
  • Myd-1 Antigen 3
  • MyD-1 Antigen 4
  • SIRP-ALPHA-1 2
  • Sirp-Alpha-1 4
  • Sirp-Alpha-2 4
  • Sirp-Alpha-3 4
  • SIRPalpha2 2
  • SIRPalpha 2
  • CD172A 3
  • CD172a 2
  • SIRPA 5
  • MYD1 4
  • Bit 4

External Ids for SIRPA Gene

Previous HGNC Symbols for SIRPA Gene

  • PTPNS1

Previous GeneCards Identifiers for SIRPA Gene

  • GC20P001822

Summaries for SIRPA Gene

Entrez Gene Summary for SIRPA Gene

  • The protein encoded by this gene is a member of the signal-regulatory-protein (SIRP) family, and also belongs to the immunoglobulin superfamily. SIRP family members are receptor-type transmembrane glycoproteins known to be involved in the negative regulation of receptor tyrosine kinase-coupled signaling processes. This protein can be phosphorylated by tyrosine kinases. The phospho-tyrosine residues of this PTP have been shown to recruit SH2 domain containing tyrosine phosphatases (PTP), and serve as substrates of PTPs. This protein was found to participate in signal transduction mediated by various growth factor receptors. CD47 has been demonstrated to be a ligand for this receptor protein. This gene and its product share very high similarity with several other members of the SIRP family. These related genes are located in close proximity to each other on chromosome 20p13. Multiple alternatively spliced transcript variants have been determined for this gene. [provided by RefSeq, Jul 2008]

GeneCards Summary for SIRPA Gene

SIRPA (Signal Regulatory Protein Alpha) is a Protein Coding gene. Diseases associated with SIRPA include Suppression Amblyopia and Bladder Neck Obstruction. Among its related pathways are Cell surface interactions at the vascular wall and Tyrosine Kinases / Adaptors. Gene Ontology (GO) annotations related to this gene include SH3 domain binding. An important paralog of this gene is SIRPB1.

UniProtKB/Swiss-Prot Summary for SIRPA Gene

  • Immunoglobulin-like cell surface receptor for CD47. Acts as docking protein and induces translocation of PTPN6, PTPN11 and other binding partners from the cytosol to the plasma membrane. Supports adhesion of cerebellar neurons, neurite outgrowth and glial cell attachment. May play a key role in intracellular signaling during synaptogenesis and in synaptic function (By similarity). Involved in the negative regulation of receptor tyrosine kinase-coupled cellular responses induced by cell adhesion, growth factors or insulin. Mediates negative regulation of phagocytosis, mast cell activation and dendritic cell activation. CD47 binding prevents maturation of immature dendritic cells and inhibits cytokine production by mature dendritic cells.

Gene Wiki entry for SIRPA Gene

Additional gene information for SIRPA Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for SIRPA Gene

Genomics for SIRPA Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for SIRPA Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around SIRPA on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for SIRPA

Top Transcription factor binding sites by QIAGEN in the SIRPA gene promoter:
  • STAT1
  • STAT1alpha
  • STAT1beta

Genomic Locations for SIRPA Gene

Genomic Locations for SIRPA Gene
chr20:1,894,167-1,940,592
(GRCh38/hg38)
Size:
46,426 bases
Orientation:
Plus strand
chr20:1,874,813-1,920,543
(GRCh37/hg19)
Size:
45,731 bases
Orientation:
Plus strand

Genomic View for SIRPA Gene

Genes around SIRPA on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SIRPA Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SIRPA Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SIRPA Gene

Proteins for SIRPA Gene

  • Protein details for SIRPA Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P78324-SHPS1_HUMAN
    Recommended name:
    Tyrosine-protein phosphatase non-receptor type substrate 1
    Protein Accession:
    P78324
    Secondary Accessions:
    • A2A2E1
    • A8K411
    • B2R6C3
    • O00683
    • O43799
    • Q8N517
    • Q8TAL8
    • Q9H0Z2
    • Q9UDX2
    • Q9UIJ6
    • Q9Y4U9

    Protein attributes for SIRPA Gene

    Size:
    504 amino acids
    Molecular mass:
    54967 Da
    Quaternary structure:
    • Binds PTPN11 when tyrosine-phosphorylated, except in macrophages, where it primarily binds PTPN6. Binds GRB2 in vitro. Binds FGR (By similarity). Binds JAK2 irrespective of its phosphorylation status and forms a stable complex. Binds SCAP1 and/or SCAP2. The resulting complex recruits FYB1. Binds PTK2B.

    Three dimensional structures from OCA and Proteopedia for SIRPA Gene

    Alternative splice isoforms for SIRPA Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SIRPA Gene

Post-translational modifications for SIRPA Gene

  • N-glycosylated.
  • Phosphorylated on tyrosine residues in response to stimulation with EGF, growth hormone, insulin and PDGF. Dephosphorylated by PTPN11.
  • Glycosylation at Asn110, Asn245, Asn270, Asn292, and Asn319
  • Modification sites at PhosphoSitePlus
  • Glycosylation from GlyConnect
    • SHPS1_HUMAN (650)

Antibody Products

No data available for DME Specific Peptides for SIRPA Gene

Domains & Families for SIRPA Gene

Gene Families for SIRPA Gene

Protein Domains for SIRPA Gene

InterPro:
Blocks:
  • Immunoglobulin V-set
  • Immunoglobulin C-type
ProtoNet:

Suggested Antigen Peptide Sequences for SIRPA Gene

GenScript: Design optimal peptide antigens:
  • Protein tyrosine phosphatase, non-receptor type substrate 1, isoform CRA_a (D3DVW9_HUMAN)
  • p84 (SHPS1_HUMAN)
genes like me logo Genes that share domains with SIRPA: view

No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for SIRPA Gene

Function for SIRPA Gene

Molecular function for SIRPA Gene

UniProtKB/Swiss-Prot Function:
Immunoglobulin-like cell surface receptor for CD47. Acts as docking protein and induces translocation of PTPN6, PTPN11 and other binding partners from the cytosol to the plasma membrane. Supports adhesion of cerebellar neurons, neurite outgrowth and glial cell attachment. May play a key role in intracellular signaling during synaptogenesis and in synaptic function (By similarity). Involved in the negative regulation of receptor tyrosine kinase-coupled cellular responses induced by cell adhesion, growth factors or insulin. Mediates negative regulation of phagocytosis, mast cell activation and dendritic cell activation. CD47 binding prevents maturation of immature dendritic cells and inhibits cytokine production by mature dendritic cells.

Phenotypes From GWAS Catalog for SIRPA Gene

Gene Ontology (GO) - Molecular Function for SIRPA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0017124 SH3 domain binding IEA --
GO:0019903 protein phosphatase binding ISS --
GO:0030695 GTPase regulator activity ISS --
GO:0086080 protein binding involved in heterotypic cell-cell adhesion ISS --
GO:0098632 cell-cell adhesion mediator activity IPI 11509594
genes like me logo Genes that share ontologies with SIRPA: view
genes like me logo Genes that share phenotypes with SIRPA: view

Animal Models for SIRPA Gene

MGI Knock Outs for SIRPA:
  • Sirpa Sirpa<tm1b(EUCOMM)Hmgu>
  • Sirpa Sirpa<tm1Nog>

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for SIRPA

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for SIRPA Gene

Localization for SIRPA Gene

Subcellular locations from UniProtKB/Swiss-Prot for SIRPA Gene

Membrane. Single-pass type I membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SIRPA gene
Compartment Confidence
plasma membrane 5
extracellular 5
cytoskeleton 2
mitochondrion 2
nucleus 2
endoplasmic reticulum 2
endosome 2
cytosol 2
lysosome 2
peroxisome 1
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for SIRPA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane IDA 24026300
GO:0009986 cell surface TAS 25795378
GO:0016020 membrane TAS 9062191
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with SIRPA: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for SIRPA Gene

Pathways & Interactions for SIRPA Gene

genes like me logo Genes that share pathways with SIRPA: view

Pathways by source for SIRPA Gene

2 GeneGo (Thomson Reuters) pathways for SIRPA Gene
  • Development_Thrombopoetin signaling via JAK-STAT pathway
  • Immune response IL-2 activation and signaling pathway
3 Cell Signaling Technology pathways for SIRPA Gene

SIGNOR curated interactions for SIRPA Gene

Is activated by:

Gene Ontology (GO) - Biological Process for SIRPA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001933 negative regulation of protein phosphorylation ISS --
GO:0007155 cell adhesion TAS 9070220
GO:0010468 regulation of gene expression IMP 11509594
GO:0016477 cell migration ISS --
GO:0022409 positive regulation of cell-cell adhesion IBA 21873635
genes like me logo Genes that share ontologies with SIRPA: view

Drugs & Compounds for SIRPA Gene

(6) Drugs for SIRPA Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(4) Additional Compounds for SIRPA Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with SIRPA: view

Transcripts for SIRPA Gene

mRNA/cDNA for SIRPA Gene

4 REFSEQ mRNAs :
15 NCBI additional mRNA sequence :
4 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for SIRPA

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for SIRPA Gene

No ASD Table

Relevant External Links for SIRPA Gene

GeneLoc Exon Structure for
SIRPA

Expression for SIRPA Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for SIRPA Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SIRPA Gene

This gene is overexpressed in Whole Blood (x5.7) and Brain - Cortex (x4.0).

Protein differential expression in normal tissues from HIPED for SIRPA Gene

This gene is overexpressed in Brain (22.5), Frontal cortex (19.7), and Cerebrospinal fluid (7.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for SIRPA Gene



Transcriptomic regulation report from SPP (The Signaling Pathways Project) for SIRPA

SOURCE GeneReport for Unigene cluster for SIRPA Gene:

Hs.581021

mRNA Expression by UniProt/SwissProt for SIRPA Gene:

P78324-SHPS1_HUMAN
Tissue specificity: Ubiquitous. Highly expressed in brain. Detected on myeloid cells, but not T-cells. Detected at lower levels in heart, placenta, lung, testis, ovary, colon, liver, small intestine, prostate, spleen, kidney, skeletal muscle and pancreas.

Evidence on tissue expression from TISSUES for SIRPA Gene

  • Nervous system(5)
  • Skin(4.7)
  • Blood(4.7)
  • Bone marrow(4.6)
  • Kidney(4.6)
  • Liver(4.5)
  • Spleen(3.2)
  • Lymph node(3.2)
  • Lung(3)
  • Intestine(3)
  • Heart(2.8)
  • Muscle(2.8)
  • Eye(2.2)
genes like me logo Genes that share expression patterns with SIRPA: view

No data available for Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for SIRPA Gene

Orthologs for SIRPA Gene

This gene was present in the common ancestor of chordates.

Orthologs for SIRPA Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia SIRPA 30 31
  • 98.75 (n)
OneToMany
-- 31
  • 80 (a)
OneToMany
Dog
(Canis familiaris)
Mammalia SIRPA 30
  • 85 (n)
-- 31
  • 77 (a)
ManyToMany
-- 31
  • 69 (a)
ManyToMany
-- 31
  • 68 (a)
ManyToMany
-- 31
  • 66 (a)
ManyToMany
-- 31
  • 66 (a)
ManyToMany
-- 31
  • 65 (a)
ManyToMany
Cow
(Bos Taurus)
Mammalia SIRPA 30 31
  • 83.63 (n)
ManyToMany
SIRPB1 31
  • 66 (a)
ManyToMany
-- 31
  • 39 (a)
ManyToMany
Rat
(Rattus norvegicus)
Mammalia Sirpa 30
  • 75.32 (n)
Mouse
(Mus musculus)
Mammalia Sirpa 30 17 31
  • 74.37 (n)
ManyToMany
Sirpb1b 31
  • 56 (a)
ManyToMany
Sirpb1c 31
  • 56 (a)
ManyToMany
Sirpb1a 31
  • 56 (a)
ManyToMany
Gm9733 31
  • 46 (a)
ManyToMany
Gm5150 31
  • 29 (a)
ManyToMany
Chicken
(Gallus gallus)
Aves LOC771734 30
  • 57.79 (n)
Lizard
(Anolis carolinensis)
Reptilia -- 31
  • 35 (a)
OneToMany
Species where no ortholog for SIRPA was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Oppossum (Monodelphis domestica)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)
  • Zebrafish (Danio rerio)

Evolution for SIRPA Gene

ENSEMBL:
Gene Tree for SIRPA (if available)
TreeFam:
Gene Tree for SIRPA (if available)
Aminode:
Evolutionary constrained regions (ECRs) for SIRPA: view image

Paralogs for SIRPA Gene

Paralogs for SIRPA Gene

(3) SIMAP similar genes for SIRPA Gene using alignment to 1 proteins:

  • SHPS1_HUMAN

Pseudogenes.org Pseudogenes for SIRPA Gene

genes like me logo Genes that share paralogs with SIRPA: view

Variants for SIRPA Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for SIRPA Gene

SNP ID Clinical significance and condition Chr 20 pos Variation AA Info Type
711169 Benign: not provided 1,921,595(+) G/A MISSENSE_VARIANT
711358 Likely Benign: not provided 1,922,583(+) G/C MISSENSE_VARIANT
714812 Benign: not provided 1,921,559(+) G/A MISSENSE_VARIANT
719584 Benign: not provided 1,937,433(+) G/A SYNONYMOUS_VARIANT
719936 Benign: not provided 1,922,629(+) C/T SYNONYMOUS_VARIANT

Additional dbSNP identifiers (rs#s) for SIRPA Gene

Structural Variations from Database of Genomic Variants (DGV) for SIRPA Gene

Variant ID Type Subtype PubMed ID
dgv7437n54 CNV loss 21841781
esv1005896 CNV gain 20482838
esv25632 CNV gain+loss 19812545
esv2722081 CNV deletion 23290073
esv2722082 CNV deletion 23290073
esv2722083 CNV deletion 23290073
esv2722085 CNV deletion 23290073
nsv3257 CNV insertion 18451855
nsv473862 CNV novel sequence insertion 20440878
nsv475546 CNV novel sequence insertion 20440878
nsv511629 CNV loss 21212237
nsv585258 CNV loss 21841781
nsv585259 CNV loss 21841781
nsv585260 CNV loss 21841781
nsv585261 CNV loss 21841781
nsv964370 CNV duplication 23825009
nsv979411 CNV duplication 23825009

Variation tolerance for SIRPA Gene

Residual Variation Intolerance Score: 75.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 21.36; 99.27% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for SIRPA Gene

Human Gene Mutation Database (HGMD)
SIRPA
SNPedia medical, phenotypic, and genealogical associations of SNPs for
SIRPA

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SIRPA Gene

Disorders for SIRPA Gene

MalaCards: The human disease database

(8) MalaCards diseases for SIRPA Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
suppression amblyopia
  • strabismic amblyopia
bladder neck obstruction
  • obstruction of bladder neck or vesicourethral orifice
hyperglycemia
theileriasis
  • infection by theileria
frontometaphyseal dysplasia
  • fmd
- elite association - COSMIC cancer census association via MalaCards
Search SIRPA in MalaCards View complete list of genes associated with diseases

Additional Disease Information for SIRPA

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
genes like me logo Genes that share disorders with SIRPA: view

No data available for UniProtKB/Swiss-Prot and Genatlas for SIRPA Gene

Publications for SIRPA Gene

  1. Mouse and human SHPS-1: molecular cloning of cDNAs and chromosomal localization of genes. (PMID: 9070220) Yamao T … Kasuga M (Biochemical and biophysical research communications 1997) 2 3 4 23
  2. Negative regulation of growth hormone receptor/JAK2 signaling by signal regulatory protein alpha. (PMID: 10842184) Stofega MR … Carter-Su C (The Journal of biological chemistry 2000) 3 4 23
  3. Gene structure of mouse BIT/SHPS-1. (PMID: 10585853) Sano S … Kubota M (The Biochemical journal 1999) 3 4 23
  4. SHPS-1 is a scaffold for assembling distinct adhesion-regulated multi-protein complexes in macrophages. (PMID: 10469599) Timms JF … Neel BG (Current biology : CB 1999) 3 4 23
  5. A family of proteins that inhibit signalling through tyrosine kinase receptors. (PMID: 9062191) Kharitonenkov A … Ullrich A (Nature 1997) 2 3 4

Products for SIRPA Gene

Sources for SIRPA Gene