Aliases for SIN3A Gene
Aliases for SIN3A Gene
External Ids for SIN3A Gene
- HGNC: 19353
- Entrez Gene: 25942
- Ensembl: ENSG00000169375
- OMIM: 607776
- UniProtKB: Q96ST3
Previous GeneCards Identifiers for SIN3A Gene
- GC15M071541
- GC15M068754
- GC15M073239
- GC15M073379
- GC15M073450
- GC15M075661
- GC15M052420
Summaries for SIN3A Gene
-
The protein encoded by this gene is a transcriptional regulatory protein. It contains paired amphipathic helix (PAH) domains, which are important for protein-protein interactions and may mediate repression by the Mad-Max complex. [provided by RefSeq, Jul 2008]
GeneCards Summary for SIN3A Gene
SIN3A (SIN3 Transcription Regulator Family Member A) is a Protein Coding gene. Diseases associated with SIN3A include Witteveen-Kolk Syndrome and Rett Syndrome. Among its related pathways are C-MYB transcription factor network and SMAD Signaling Network. Gene Ontology (GO) annotations related to this gene include DNA binding transcription factor activity and transcription factor binding. An important paralog of this gene is SIN3B.
UniProtKB/Swiss-Prot for SIN3A Gene
-
Acts as a transcriptional repressor. Corepressor for REST. Interacts with MXI1 to repress MYC responsive genes and antagonize MYC oncogenic activities. Also interacts with MXD1-MAX heterodimers to repress transcription by tethering SIN3A to DNA. Acts cooperatively with OGT to repress transcription in parallel with histone deacetylation. Involved in he control of the circadian rhythms. Required for the transcriptional repression of circadian target genes, such as PER1, mediated by the large PER complex through histone deacetylation. Cooperates with FOXK1 to regulate cell cycle progression probably by repressing cell cycle inhibitor genes expression (By similarity).
Additional gene information for SIN3A Gene
- Monarch Initiative
- Search for SIN3A at DataMed
- Search for SIN3A at HumanCyc
No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SIN3A Gene
Genomics for SIN3A Gene
GeneHancer (GH) Regulatory Elements for SIN3A Gene
Promoters and enhancers for SIN3A Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)
GeneHancers around SIN3A on UCSC Golden Path with GeneCards custom track
- Top Transcription factor binding sites by QIAGEN in the SIN3A gene promoter:
-
- Ik-2
- Sox9
- HFH-1
- NRF-2
Regulatory Element Products
Genomic Locations for SIN3A Gene
Genomic Locations for SIN3A Gene
- chr15:75,369,379-75,455,842
- (GRCh38/hg38)
- Size:
- 86,464 bases
- Orientation:
- Minus strand
- chr15:75,661,720-75,748,183
- (GRCh37/hg19)
- Size:
- 86,464 bases
- Orientation:
- Minus strand
Genomic View for SIN3A Gene
Genes around SIN3A on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 15q24.2 by Entrez Gene
- 15q24.2 by HGNC
- 15q24.2 by Ensembl
SIN3A Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for SIN3A Gene
Proteins for SIN3A Gene
-
Protein details for SIN3A Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q96ST3-SIN3A_HUMAN
- Recommended name:
- Paired amphipathic helix protein Sin3a
- Protein Accession:
- Q96ST3
- B2RNS5
- Q8N8N4
- Q8NC83
- Q8WV18
- Q96L98
- Q9UFQ1
Protein attributes for SIN3A Gene
- Size:
- 1273 amino acids
- Molecular mass:
- 145175 Da
- Quaternary structure:
-
- Interacts with ARID4B, BRMS1L, HCFC1, HDAC1, HDAC2, MXI1, SAP30L, SAP130, SFPQ and TOPORS. Interacts with OGT (via TPRs 1-6); the interaction mediates transcriptional repression in parallel with histone deacetylase (By similarity). Interacts with BAZ2A, MXD3, MXD4, MBD2, DACH1, NCOR1, NR4A2, REST, RLIM, SAP30, SETDB1, SMYD2, and SUDS3. Interacts with PHF12 in a complex composed of HDAC1, PHF12 and SAP30. Interacts with TET1; the interaction recruits SIN3A to gene promoters. The large PER complex involved in the histone deacetylation is composed of at least HDAC1, PER2, SFPQ and SIN3A. Interacts with KLF11 (By similarity). Interacts with PPHLN1 (PubMed:17963697). Found in a complex with YY1, GON4L and HDAC1 (By similarity). Interacts (via PAH2) with FOXK1 (By similarity). Found in a complex composed of at least SINHCAF, SIN3A, HDAC1, SAP30, RBBP4, OGT and TET1. Interacts with SINHCAF (By similarity).
Protein Expression for SIN3A Gene
Post-translational modifications for SIN3A Gene
- SUMO1 sumoylated by TOPORS. Probably desumoylated by SENP2.
- Ubiquitination at isoforms=747, isoforms=727, and isoforms=343
- Modification sites at PhosphoSitePlus
Other Protein References for SIN3A Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- R&D Systems Antibodies for SIN3A (SIN3A)
- Novus Biologicals Antibodies for SIN3A
-
Abcam antibodies for SIN3A
- Invitrogen Antibodies for SIN3A (AFLGC-SIN3A)
- GeneTex SIN3A Antibody for SIN3A
-
Santa Cruz Biotechnology (SCBT) Antibodies for SIN3A
- Sino Biological Antibodies for SIN3A
Protein Products
- Search Origene for Purified Proteins, MassSpec and Protein Over-expression Lysates for SIN3A
- Origene Custom Protein Services for SIN3A
- Novus Biologicals proteins for SIN3A
- Search GeneTex for Proteins for SIN3A
-
Abcam proteins for SIN3A
Assay Products
No data available for DME Specific Peptides for SIN3A Gene
Domains & Families for SIN3A Gene
Gene Families for SIN3A Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Cancer-related genes
- Plasma proteins
- Predicted intracellular proteins
Protein Domains for SIN3A Gene
- InterPro:
- Blocks:
- ProtoNet:
Suggested Antigen Peptide Sequences for SIN3A Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
No data available for UniProtKB/Swiss-Prot for SIN3A Gene
Function for SIN3A Gene
Molecular function for SIN3A Gene
- UniProtKB/Swiss-Prot Function:
- Acts as a transcriptional repressor. Corepressor for REST. Interacts with MXI1 to repress MYC responsive genes and antagonize MYC oncogenic activities. Also interacts with MXD1-MAX heterodimers to repress transcription by tethering SIN3A to DNA. Acts cooperatively with OGT to repress transcription in parallel with histone deacetylation. Involved in he control of the circadian rhythms. Required for the transcriptional repression of circadian target genes, such as PER1, mediated by the large PER complex through histone deacetylation. Cooperates with FOXK1 to regulate cell cycle progression probably by repressing cell cycle inhibitor genes expression (By similarity).
Phenotypes From GWAS Catalog for SIN3A Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000976 | transcription regulatory region sequence-specific DNA binding | ISS | -- |
| GO:0001102 | RNA polymerase II activating transcription factor binding | IPI | 22783022 |
| GO:0001103 | RNA polymerase II repressing transcription factor binding | IEA | -- |
| GO:0003677 | DNA binding | IEA | -- |
| GO:0003682 | chromatin binding | IEA | -- |
Phenotypes for SIN3A Gene
- MGI mutant phenotypes for SIN3A:
- inferred from 2 alleles
- GenomeRNAi human phenotypes for SIN3A:
-
- Decreased viability ratio
- Increased shRNA abundance (Z-score > 2)
- Decreased shRNA abundance (Z-score < -2)
- Increased TP53 mRNA expression
- Decreased TP53 mRNA expression
- Decreased viability in esophageal squamous lineage
- Increased Nanog expression
- Decreased viability
- no effect
- Increased caspase activity
- Increased vaccinia virus (VACV) infection
- Decreased human papilloma virus 16 (HPV16) pseudovirus infection
- Decreased viability after Maraba virus infection
- Decreased NF-kappaB reporter expression
- shRNA abundance <= 50%
- Decreased IL-8 secretion
- Increased transferrin (TF) endocytosis
Animal Models for SIN3A Gene
- MGI Knock Outs for SIN3A:
-
- Sin3a Sin3a<tm1.1Rdp>
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
- Cyagen custom Knockout/knockin (KOKI) mouse models for SIN3A
-
CRISPR Products
-
OriGene CRISPR knockouts for SIN3A
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for SIN3A
- genomics-online: gRNA clones - Search results for 108 available SIN3A gene related products
- Overview of 108 available SIN3A gene related products
-
Recommended
- Applied Biological Materials CRISPR for SIN3A
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for SIN3A
- GenScript: Design CRISPR guide RNA sequences for SIN3A
miRNA for SIN3A Gene
- miRTarBase miRNAs that target SIN3A
-
- hsa-mir-155-5p (MIRT020539)
- hsa-mir-1-3p (MIRT023524)
- hsa-mir-455-3p (MIRT037870)
- hsa-mir-93-3p (MIRT038894)
- hsa-mir-92b-3p (MIRT040584)
- hsa-mir-92a-3p (MIRT049314)
- hsa-mir-218-5p (MIRT439630)
- hsa-mir-210-3p (MIRT439632)
- hsa-mir-5010-3p (MIRT653802)
- hsa-mir-2113 (MIRT653803)
- hsa-mir-6796-5p (MIRT653804)
- hsa-mir-6759-5p (MIRT653805)
- hsa-mir-4322 (MIRT653806)
- hsa-mir-4296 (MIRT653807)
- hsa-mir-4265 (MIRT653808)
- hsa-mir-4668-5p (MIRT653809)
- hsa-mir-4267 (MIRT653810)
- hsa-mir-4762-5p (MIRT653811)
- hsa-mir-5586-5p (MIRT653812)
- hsa-mir-208b-5p (MIRT653813)
- hsa-mir-208a-5p (MIRT653814)
- hsa-mir-548c-3p (MIRT653815)
- hsa-mir-1343-5p (MIRT737490)
- hsa-mir-149-3p (MIRT737787)
- hsa-mir-3150a-3p (MIRT740289)
- hsa-mir-3151-5p (MIRT740360)
- hsa-mir-3175 (MIRT740688)
- hsa-mir-4447 (MIRT744662)
- hsa-mir-4472 (MIRT744988)
- hsa-mir-4519 (MIRT745794)
- hsa-mir-4728-5p (MIRT747883)
- hsa-mir-491-5p (MIRT749231)
- hsa-mir-5190 (MIRT749922)
- hsa-mir-591 (MIRT751583)
- hsa-mir-6081 (MIRT751781)
- hsa-mir-6731-5p (MIRT754038)
- hsa-mir-6742-5p (MIRT754394)
- hsa-mir-6763-5p (MIRT755031)
- hsa-mir-6785-5p (MIRT755878)
- hsa-mir-6825-5p (MIRT757016)
- hsa-mir-6856-5p (MIRT757736)
- hsa-mir-6883-5p (MIRT758463)
- hsa-mir-8085 (MIRT760242)
- hsa-mir-939-5p (MIRT760781)
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for SIN3A
- Browse OriGene Inhibitory RNA Products For SIN3A
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for SIN3A
- genomics-online: shRNA clones - Search results for 108 available SIN3A gene related products
- Overview of 108 available SIN3A gene related products
-
Recommended
Clone Products
-
OriGene ORF clones in human for SIN3A
- RC213240
- RC213240L1
- RC213240L2
- RC213240L3
- RC213240L4
- RC227540
- RC227540L1
- RC227540L2
- RC227540L3
- RC227540L4
- RC227622
- RC227622L1
- RC227622L2
- RC227622L3
- RC227622L4
- RG213240
- RG227540
- RG227622
- RC213240L1V
- RC213240L2V
- RC213240L3V
- RC213240L4V
- RC227540L1V
- RC227540L2V
- RC227540L3V
- RC227540L4V
- RC227622L1V
- RC227622L2V
- RC227622L3V
- RC227622L4V
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for SIN3A
- genomics-online: cdna clones - Search results for 108 available SIN3A gene related products
- Overview of 108 available SIN3A gene related products
-
Recommended
- orf clones - Search results for 108 available SIN3A gene related products
- Overview of 108 available SIN3A gene related products
-
Recommended
- Applied Biological Materials Clones for SIN3A
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targets and HOMER Transcription for SIN3A Gene
Localization for SIN3A Gene
Subcellular locations from UniProtKB/Swiss-Prot for SIN3A Gene
- Nucleus. Nucleus, nucleolus. Note=Recruited to the nucleolus by SAP30L.
| Compartment | Confidence |
|---|---|
| nucleus | 5 |
| cytosol | 2 |
| plasma membrane | 1 |
| cytoskeleton | 1 |
- Nucleoplasm (4)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000118 | histone deacetylase complex | IBA | -- |
| GO:0000776 | kinetochore | IEA | -- |
| GO:0000785 | chromatin | IEA,IBA | -- |
| GO:0005634 | nucleus | ISS,IEA | -- |
| GO:0005654 | nucleoplasm | IDA,TAS | -- |
Pathways & Interactions for SIN3A Gene
Pathways by source for SIN3A Gene
1 GeneTex pathway for SIN3A Gene
11 BioSystems pathways for SIN3A Gene
10 Reactome pathways for SIN3A Gene
3 KEGG pathways for SIN3A Gene
4 GeneGo (Thomson Reuters) pathways for SIN3A Gene
8 Qiagen pathways for SIN3A Gene
1 Cell Signaling Technology pathway for SIN3A Gene
Interacting Proteins for SIN3A Gene
Selected Interacting proteins:
Q96ST3-SIN3A_HUMAN
ENSP00000353622
for SIN3A Gene via
UniProtKB
MINT
STRING
IID
GPS-Prot Interaction Network for SIN3A
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000122 | negative regulation of transcription by RNA polymerase II | IMP | 22783022 |
| GO:0001701 | in utero embryonic development | IEA | -- |
| GO:0002218 | activation of innate immune response | IMP | 22783022 |
| GO:0002230 | positive regulation of defense response to virus by host | IMP | 22783022 |
| GO:0002244 | hematopoietic progenitor cell differentiation | IEA | -- |
No data available for SIGNOR curated interactions for SIN3A Gene
Transcripts for SIN3A Gene
mRNA/cDNA for SIN3A Gene
- (7) REFSEQ mRNAs :
- (15) Additional mRNA sequences :
- (219) Selected AceView cDNA sequences:
- (15) Ensembl transcripts including schematic representations, and UCSC links where relevant :
-
- ENST00000394947 6737 bps (uc002baj.4)
- ENST00000360439 5050 bps (uc010uml.3)
- ENST00000394949 4930 bps (uc002bai.4)
- ENST00000566640 944 bps (uc059ltc.1)
- ENST00000570124 593 bps (uc059ltd.1)
Unigene Clusters for SIN3A Gene
- SIN3 transcription regulator homolog A (yeast):
- Representative Sequences:
CRISPR Products
-
OriGene CRISPR knockouts for SIN3A
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for SIN3A
- genomics-online: gRNA clones - Search results for 108 available SIN3A gene related products
- Overview of 108 available SIN3A gene related products
-
Recommended
- Applied Biological Materials CRISPR for SIN3A
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for SIN3A
- GenScript: Design CRISPR guide RNA sequences for SIN3A
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for SIN3A
- Browse OriGene Inhibitory RNA Products For SIN3A
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for SIN3A
- genomics-online: shRNA clones - Search results for 108 available SIN3A gene related products
- Overview of 108 available SIN3A gene related products
-
Recommended
Clone Products
-
OriGene ORF clones in human for SIN3A
- RC213240
- RC213240L1
- RC213240L2
- RC213240L3
- RC213240L4
- RC227540
- RC227540L1
- RC227540L2
- RC227540L3
- RC227540L4
- RC227622
- RC227622L1
- RC227622L2
- RC227622L3
- RC227622L4
- RG213240
- RG227540
- RG227622
- RC213240L1V
- RC213240L2V
- RC213240L3V
- RC213240L4V
- RC227540L1V
- RC227540L2V
- RC227540L3V
- RC227540L4V
- RC227622L1V
- RC227622L2V
- RC227622L3V
- RC227622L4V
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for SIN3A
- genomics-online: cdna clones - Search results for 108 available SIN3A gene related products
- Overview of 108 available SIN3A gene related products
-
Recommended
- orf clones - Search results for 108 available SIN3A gene related products
- Overview of 108 available SIN3A gene related products
-
Recommended
- Applied Biological Materials Clones for SIN3A
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
| ExUns: | 1 | ^ | 2 | ^ | 3 | ^ | 4a | · | 4b | ^ | 5 | ^ | 6 | ^ | 7 | ^ | 8 | ^ | 9a | · | 9b | · | 9c | ^ | 10a | · | 10b | · | 10c | · | 10d | · | 10e | ^ | 11 | ^ | 12 | ^ | 13 | ^ | 14 | ^ | 15 | ^ | 16 | ^ | 17 | ^ | 18 | ^ | 19 | ^ |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||
| SP2: | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||
| SP3: | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||
| SP4: | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||||
| SP5: | - | |||||||||||||||||||||||||||||||||||||||||||||||||||
| SP6: | - | - | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||
| SP7: | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||
| SP8: | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||
| SP9: | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||||
| SP10: | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||
| SP11: |
| ExUns: | 20 | ^ | 21 | ^ | 22 | ^ | 23 | ^ | 24 | ^ | 25a | · | 25b | ^ | 26a | · | 26b | ^ | 27 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | ||||||||||||||||||
| SP2: | - | ||||||||||||||||||
| SP3: | - | ||||||||||||||||||
| SP4: | |||||||||||||||||||
| SP5: | |||||||||||||||||||
| SP6: | |||||||||||||||||||
| SP7: | |||||||||||||||||||
| SP8: | |||||||||||||||||||
| SP9: | |||||||||||||||||||
| SP10: | |||||||||||||||||||
| SP11: |
Expression for SIN3A Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
-
Ovary (Reproductive System)
- Ovarian Mesenchymal Stroma Cells Ovary Interstitium
- Oviduct
-
Gonad (Reproductive System)
- Testis Somatic Cells Primitive Gonad
-
Testis (Reproductive System)
- Testis Somatic Cells Primitive Gonad
- Brain (Nervous System)
- Intestine (Gastrointestinal Tract)
- Blood (Hematopoietic System)
This gene is overexpressed in Lymph node (15.3) and Peripheral blood mononuclear cells (13.4).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for SIN3A Gene
- Elite partner
NURSA nuclear receptor signaling pathways regulating expression of SIN3A Gene:
SIN3ASOURCE GeneReport for Unigene cluster for SIN3A Gene:
Hs.513039Evidence on tissue expression from TISSUES for SIN3A Gene
- Nervous system(4.7)
- Lung(4.3)
- Liver(4.2)
Primer Products
-
OriGene qPCR primer pairs for SIN3A
- genomics-online: primer clones - Search results for 108 available SIN3A gene related products
- Overview of 108 available SIN3A gene related products
-
Recommended
Gene Expression Assay Products
No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for SIN3A Gene
Orthologs for SIN3A Gene
This gene was present in the common ancestor of animals and fungi.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | SIN3A 34 33 |
|
OneToOne | |
| oppossum (Monodelphis domestica) |
Mammalia | SIN3A 34 |
|
OneToOne | |
| cow (Bos Taurus) |
Mammalia | SIN3A 34 33 |
|
OneToOne | |
| dog (Canis familiaris) |
Mammalia | SIN3A 34 33 |
|
OneToOne | |
| mouse (Mus musculus) |
Mammalia | Sin3a 16 34 33 |
|
||
| rat (Rattus norvegicus) |
Mammalia | Sin3a 33 |
|
||
| platypus (Ornithorhynchus anatinus) |
Mammalia | SIN3A 34 |
|
OneToOne | |
| chicken (Gallus gallus) |
Aves | SIN3A 34 33 |
|
OneToOne | |
| lizard (Anolis carolinensis) |
Reptilia | SIN3A 34 |
|
OneToOne | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | sin3a 33 |
|
||
| Str.14936 33 |
|
||||
| African clawed frog (Xenopus laevis) |
Amphibia | Sin3 33 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | sin3aa 34 |
|
OneToMany | |
| sin3ab 34 |
|
OneToMany | |||
| wufb95g11 33 |
|
||||
| fruit fly (Drosophila melanogaster) |
Insecta | Sin3A 34 33 |
|
OneToMany | |
| African malaria mosquito (Anopheles gambiae) |
Insecta | AgaP_AGAP007892 33 |
|
||
| worm (Caenorhabditis elegans) |
Secernentea | sin-3 34 |
|
OneToMany | |
| baker's yeast (Saccharomyces cerevisiae) |
Saccharomycetes | SIN3 36 34 |
|
||
| sea squirt (Ciona savignyi) |
Ascidiacea | CSA.3742 34 |
|
OneToMany | |
| Cin.4585 33 |
|
||||
| sea squirt (Ciona intestinalis) |
Ascidiacea | Cin.4585 33 |
|
- Species where no ortholog for SIN3A was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
Evolution for SIN3A Gene
- ENSEMBL:
- Gene Tree for SIN3A (if available)
- TreeFam:
- Gene Tree for SIN3A (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for SIN3A: view image
Paralogs for SIN3A Gene
(1) SIMAP similar genes for SIN3A Gene using alignment to 9 proteins:
- SIN3A_HUMAN
- H3BMA2_HUMAN
- H3BNA0_HUMAN
- H3BNZ3_HUMAN
- H3BP90_HUMAN
- H3BQ76_HUMAN
- H3BQ88_HUMAN
- H3BQL7_HUMAN
- H3BT34_HUMAN
Pseudogenes.org Pseudogenes for SIN3A Gene
Variants for SIN3A Gene
| SNP ID | Clin | Chr 15 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs879255618 | pathogenic, Witteveen-kolk syndrome | 75,411,697(-) | GGGGG/GGGGGG | coding_sequence_variant, frameshift | |
| rs879255619 | pathogenic, Witteveen-kolk syndrome | 75,410,282(-) | TCTTTCT/TCT | coding_sequence_variant, splice_acceptor_variant | |
| rs879255620 | pathogenic, Witteveen-kolk syndrome | 75,400,135(-) | AAA/AA | coding_sequence_variant, frameshift | |
| rs879255621 | pathogenic, Witteveen-kolk syndrome | 75,380,702(-) | G/A | coding_sequence_variant, stop_gained | |
| rs886037847 | pathogenic, Witteveen-kolk syndrome | 75,389,717(-) | TCTCTCTC/TCTCTC | coding_sequence_variant, frameshift |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| dgv1243n106 | CNV | deletion | 24896259 |
| dgv2621n100 | CNV | gain | 25217958 |
| esv2749894 | CNV | deletion | 23290073 |
| esv2749895 | CNV | deletion | 23290073 |
| esv3636926 | CNV | gain | 21293372 |
| nsv1116463 | OTHER | inversion | 24896259 |
| nsv1615 | CNV | insertion | 18451855 |
| nsv474716 | CNV | novel sequence insertion | 20440878 |
| nsv525265 | CNV | gain | 19592680 |
| nsv827389 | CNV | gain | 20364138 |
| nsv976952 | CNV | duplication | 23825009 |
| nsv977737 | CNV | duplication | 23825009 |
Residual Variation Intolerance Score:
1.44% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
2.02;
37.25% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for SIN3A Gene
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SIN3A Gene
Disorders for SIN3A Gene
(3) MalaCards diseases for SIN3A Gene - From: HGMD, OMIM, ClinVar, GTR, Orphanet, DISEASES, and GeneCards
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| witteveen-kolk syndrome |
|
|
| rett syndrome |
|
|
| chromosome 15q24 deletion syndrome |
|
|
Search SIN3A in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for SIN3A
- Genetic Association Database
- (GAD)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
No data available for UniProtKB/Swiss-Prot and Genatlas for SIN3A Gene
Publications for SIN3A Gene
- PSF is a novel corepressor that mediates its effect through Sin3A and the DNA binding domain of nuclear hormone receptors. (PMID: 11259580) Mathur M … Samuels HH (Molecular and cellular biology 2001) 3 4 22 58
- GWAS for discovery and replication of genetic loci associated with sudden cardiac arrest in patients with coronary artery disease. (PMID: 21658281) Aouizerat BE … Tseng ZH (BMC cardiovascular disorders 2011) 3 44 58
- A genome-wide association study in 19 633 Japanese subjects identified LHX3-QSOX2 and IGF1 as adult height loci. (PMID: 20189936) Okada Y … Kamatani N (Human molecular genetics 2010) 3 44 58
- Genetic identification of a network of factors that functionally interact with the nucleosome remodeling ATPase ISWI. (PMID: 18535655) Burgio G … Corona DF (PLoS genetics 2008) 3 22 58
- Adamantyl-substituted retinoid-related molecules bind small heterodimer partner and modulate the Sin3A repressor. (PMID: 17210713) Farhana L … Fontana JA (Cancer research 2007) 3 22 58
Products for SIN3A Gene
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- Invitrogen Antibodies for SIN3A (AFLGC-SIN3A)
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- antibodies-online: Search results for 57 available SIN3A Antibodies ranked by validation data
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- GeneTex SIN3A Antibody for SIN3A
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- Horizon Cell Lines for SIN3A
- genomics-online: cdna clones - Search results for 108 available SIN3A gene related products
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Sources for SIN3A Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) ASD
- (29) ECgene
- (30) GeneAnnot
- (31) CGAP SAGE
- (32) SOURCE
- (33) HomoloGene
- (34) PanEnsembl
- (35) euGenes
- (36) SGD
- (37) FlyBase
- (38) WormBase
- (39) Pseudogene
- (40) DGV
- (41) dbSNP
- (42) GenAtlas
- (43) HGMD
- (44) GAD
- (45) BGMUT
- (46) HuGE
- (47) Atlas
- (48) Cell Signaling Technology
- (49) GenBank
- (50) H-invDB
- (51) HORDE
- (52) HUGE
- (53) IMGT
- (54) Leiden
- (55) miRBase
- (56) DME
- (57) OriGene
- (58) PubMed
- (59) R&D Systems
- (60) TGDB
- (61) Tocris
- (62) Abcam
- (63) Novus Biologicals
- (64) ProSpec
- (65) Sino Biological
- (66) GenScript
- (67) Qiagen
- (68) Cloud-Clone Corp.
- (69) OCA
- (70) Proteopedia
- (71) MOPED
- (72) neXtProt
- (73) Reactome
- (74) GeneGo (Thomson Reuters)
- (75) fRNAdb
- (76) DISEASES
- (77) SIMAP
- (78) GenomeRNAi
- (79) LifeMap
- (80) miRTarBase
- (81) MalaCards
- (82) Invitrogen
- (83) BitterDB
- (84) Vector BioLabs
- (85) ESI-BIO
- (86) RefSeq
- (87) BioSystems
- (88) MaxQB
- (89) IUPHAR
- (90) BioGPS
- (91) Illumina
- (92) COMPARTMENTS
- (93) HOMER
- (94) PaxDb
- (95) ApexBio
- (96) Addgene
- (97) antibodies-online
- (98) CYP
- (99) NONCODE
- (100) SwitchGear Genomics
- (101) TreeFam
- (102) PathCards
- (103) GeneReviews
- (104) GeneTex
- (105) Taconic Biosciences
- (106) GTEx
- (107) ProteomicsDB
- (108) SCBT
- (109) DGIdb
- (110) ClinicalTrials
- (111) FDA Approved Drugs
- (112) RVIS
- (113) SIGNOR
- (114) diseasecard
- (115) NIH Rare Diseases
- (116) Orphanet
- (117) UMLS
- (118) GTR
- (119) Disease Ontology
- (120) Genetics Home Reference
- (121) MeSH
- (122) MedlinePlus
- (123) CDC
- (124) NINDS
- (125) NCBI Bookshelf
- (126) ClinVar
- (127) Gene Damage Index
- (128) ViGene Biosciences
- (129) HPO
- (130) UDN
- (131) VISTA
- (132) FANTOM5
- (133) ENCODE
- (134) ProSci
- (135) Horizon
- (136) NURSA
- (137) IID
- (138) Cyagen
- (139) VectorBuilder
- (140) SNPedia
- (141) BRCA Exchange
- (142) St John's Lab
- (143) CIViC
- (144) ProteoGenix
- (145) dbSUPER
- (146) TISSUES
- (147) Gene ORGANizer
- (148) abm
- (149) CrownBio
- (150) Human Protein Atlas
- (151) GWAS Catalog
- (152) Monarch Initiative
- (153) DataMed
- (154) HumanCyc
- (155) genomics-online
- (156) UCNEbase
- (157) EPDnew
- (158) Applied Biosystems
- (159) GlyConnect
- (160) Aminode
- (161) GeneCopoeia
- (162) GPS-Prot
- (163) RNACentral
- (164) LncRNADisease
- (165) LOVD
- (166) miR2Disease
- (167) DiseaseEnhancer
- (168) Boster Bio
- (169) Biorbyt