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The protein encoded by this gene is a transcriptional regulatory protein. It contains paired amphipathic helix (PAH) domains, which are important for protein-protein interactions and may mediate repression by the Mad-Max complex. [provided by RefSeq, Jul 2008] See more...
Aliases for SIN3A Gene
Aliases for SIN3A Gene
External Ids for SIN3A Gene
- HGNC: 19353
- NCBI Entrez Gene: 25942
- Ensembl: ENSG00000169375
- OMIM®: 607776
- UniProtKB/Swiss-Prot: Q96ST3
Previous GeneCards Identifiers for SIN3A Gene
- GC15M071541
- GC15M068754
- GC15M073239
- GC15M073379
- GC15M073450
- GC15M075661
- GC15M052420
Summaries for SIN3A Gene
-
The protein encoded by this gene is a transcriptional regulatory protein. It contains paired amphipathic helix (PAH) domains, which are important for protein-protein interactions and may mediate repression by the Mad-Max complex. [provided by RefSeq, Jul 2008]
GeneCards Summary for SIN3A Gene
SIN3A (SIN3 Transcription Regulator Family Member A) is a Protein Coding gene. Diseases associated with SIN3A include Witteveen-Kolk Syndrome and Chromosome 15Q24 Deletion Syndrome. Among its related pathways are Androgen receptor signaling pathway and Transcriptional misregulation in cancer. Gene Ontology (GO) annotations related to this gene include DNA-binding transcription factor activity and transcription factor binding. An important paralog of this gene is SIN3B.
UniProtKB/Swiss-Prot Summary for SIN3A Gene
-
Acts as a transcriptional repressor. Corepressor for REST. Interacts with MXI1 to repress MYC responsive genes and antagonize MYC oncogenic activities. Also interacts with MXD1-MAX heterodimers to repress transcription by tethering SIN3A to DNA. Acts cooperatively with OGT to repress transcription in parallel with histone deacetylation. Involved in the control of the circadian rhythms. Required for the transcriptional repression of circadian target genes, such as PER1, mediated by the large PER complex through histone deacetylation. Cooperates with FOXK1 to regulate cell cycle progression probably by repressing cell cycle inhibitor genes expression (By similarity). Required for cortical neuron differentiation and callosal axon elongation (By similarity).
Additional gene information for SIN3A Gene
No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for SIN3A Gene
Genomics for SIN3A Gene
GeneHancer (GH) Regulatory Elements Pubs
Promoters and enhancers for SIN3A Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around SIN3A on the GeneHancer Hub at the UCSC Golden Path
Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for SIN3A
- Top Transcription factor binding sites by QIAGEN in the SIN3A gene promoter:
-
- HFH-1
- Ik-2
- NRF-2
- Sox9
Genomic Locations for SIN3A Gene
Latest Assembly
- chr15:75,369,379-75,455,842
- (GRCh38/hg38)
- Size:
- 86,464 bases
- Orientation:
- Minus strand
Previous Assembly
- chr15:75,661,720-75,748,156
- (GRCh37/hg19 by Entrez Gene)
- Size:
- 86,437 bases
- Orientation:
- Minus strand
Genomic View for SIN3A Gene
Genes around SIN3A on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 15q24.2 by HGNC
- 15q24.2 by Entrez Gene
- 15q24.2 by Ensembl
SIN3A Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for SIN3A Gene
Proteins for SIN3A Gene
-
Protein details for SIN3A Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q96ST3-SIN3A_HUMAN
- Recommended name:
- Paired amphipathic helix protein Sin3a
- Protein Accession:
- Q96ST3
- B2RNS5
- Q8N8N4
- Q8NC83
- Q8WV18
- Q96L98
- Q9UFQ1
Protein attributes for SIN3A Gene
- Size:
- 1273 amino acids
- Molecular mass:
- 145175 Da
- Quaternary structure:
-
- Interacts with ARID4B, BRMS1L, HCFC1, HDAC1, HDAC2, MXI1, SAP30L, SAP130, SFPQ and TOPORS (PubMed:11259580, PubMed:11897684, PubMed:12670868, PubMed:12724404, PubMed:15451426, PubMed:16820529, PubMed:17803295). Interacts with OGT (via TPRs 1-6); the interaction mediates transcriptional repression in parallel with histone deacetylase (PubMed:12150998). Interacts with BAZ2A, MXD1, MXD3, MXD4, MBD2, DACH1, NCOR1, NR4A2, REST, RLIM, SAP30, SETDB1, SMYD2, and SUDS3 (PubMed:14525983). Interacts with PHF12 in a complex composed of HDAC1, PHF12 and SAP30 (By similarity). Interacts with TET1; the interaction recruits SIN3A to gene promoters (PubMed:21490601). The large PER complex involved in the histone deacetylation is composed of at least HDAC1, PER2, SFPQ and SIN3A (By similarity). Interacts with KLF11 (By similarity). Interacts with PPHLN1 (PubMed:17963697). Found in a complex with YY1, GON4L and HDAC1 (By similarity). Interacts (via PAH2) with FOXK1 (By similarity). Interacts with FOXK2 (By similarity). Found in a complex composed of at least SINHCAF, SIN3A, HDAC1, SAP30, RBBP4, OGT and TET1. Interacts with SINHCAF (By similarity). Interacts with SPHK2 (PubMed:19729656).
Protein Expression for SIN3A Gene
Post-translational modifications for SIN3A Gene
- SUMO1 sumoylated by TOPORS. Probably desumoylated by SENP2.
-
Ubiquitination at Lys343, Lys727, and Lys747
- NX_Q96ST3 (NX_Q96ST3-1)
- Modification sites at PhosphoSitePlus
Other Protein References for SIN3A Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibodies for research
- LifeSpan BioSciences SIN3A Antibody (LS-B3492) and SIN3A Antibody (LS-B10248)
- G Biosciences Immunotagā¢ SIN3A Antibody
- GeneTex Anti-SIN3A antibody
- Novus Biologicals Antibodies for SIN3A
-
Abcam antibodies for SIN3A
- Invitrogen Antibodies for SIN3A (AFLGC-SIN3A)
-
Santa Cruz Biotechnology (SCBT) Antibodies for SIN3A
- Sino Biological Antibodies for SIN3A
Protein products for research
- Search Origene for Purified Proteins, MassSpec and Protein Over-expression Lysates for SIN3A
- Origene Custom Protein Services for SIN3A
- Novus Biologicals proteins for SIN3A
-
Abcam proteins for SIN3A
Assay products for research
No data available for DME Specific Peptides for SIN3A Gene
Domains & Families for SIN3A Gene
Gene Families for SIN3A Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Cancer-related genes
- Plasma proteins
- Predicted intracellular proteins
Protein Domains for SIN3A Gene
Suggested Antigen Peptide Sequences for SIN3A Gene
- GenScript: Design optimal peptide antigens:
-
- Transcriptional corepressor Sin3a (SIN3A_HUMAN)
No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for SIN3A Gene
Function for SIN3A Gene
Molecular function for SIN3A Gene
- UniProtKB/Swiss-Prot Function:
- Acts as a transcriptional repressor. Corepressor for REST. Interacts with MXI1 to repress MYC responsive genes and antagonize MYC oncogenic activities. Also interacts with MXD1-MAX heterodimers to repress transcription by tethering SIN3A to DNA. Acts cooperatively with OGT to repress transcription in parallel with histone deacetylation. Involved in the control of the circadian rhythms. Required for the transcriptional repression of circadian target genes, such as PER1, mediated by the large PER complex through histone deacetylation. Cooperates with FOXK1 to regulate cell cycle progression probably by repressing cell cycle inhibitor genes expression (By similarity). Required for cortical neuron differentiation and callosal axon elongation (By similarity).
Phenotypes From GWAS Catalog for SIN3A Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0001102 | RNA polymerase II activating transcription factor binding | IPI | 22783022 |
| GO:0001103 | RNA polymerase II repressing transcription factor binding | IEA | -- |
| GO:0003677 | DNA binding | IEA | -- |
| GO:0003682 | chromatin binding | IEA | -- |
| GO:0003713 | transcription coactivator activity | IMP | 22783022 |
Phenotypes for SIN3A Gene
- MGI mutant phenotypes for SIN3A:
- inferred from 2 alleles
- GenomeRNAi human phenotypes for SIN3A:
-
- Increased vaccinia virus (VACV) infection
- Decreased NF-kappaB reporter expression
- shRNA abundance <= 50%
- no effect
- Decreased viability ratio
- Decreased viability after Maraba virus infection
- Increased IL-8 secretion
- Increased shRNA abundance (Z-score > 2)
- Decreased shRNA abundance (Z-score < -2)
- Decreased viability in ovarian lineage
- Increased epidermal growth factor (EGF) endocytosis, decreased transferrin (TF) endocytosis
- Decreased human papilloma virus 16 (HPV16) pseudovirus infection
- Increased caspase activity
- Increased Nanog expression
- Decreased TP53 mRNA expression
Animal Models for SIN3A Gene
- MGI Knock Outs for SIN3A:
-
- Sin3a Sin3a<tm1.1Rdp>
Animal Models for research
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
CRISPR products for research
- Applied Biological Materials (abm): CRISPR Clones for SIN3A - Starting at $85 >
- * SIN3A CRISPR as ready-to-use vector or virus: Non-viral | Lenti- | Adeno- | AAV- | siRNA - Browse All
- * Cas9 Nucleases, Nickases, Null Mutants, and GFP tag also available.
-
OriGene CRISPR knockouts for SIN3A
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for SIN3A
-
Santa Cruz Biotechnology (SCBT) CRISPR for SIN3A
miRNA for SIN3A Gene
- miRTarBase miRNAs that target SIN3A
-
- hsa-miR-155-5p (MIRT020539)
- hsa-miR-1-3p (MIRT023524)
- hsa-miR-455-3p (MIRT037870)
- hsa-miR-93-3p (MIRT038894)
- hsa-miR-92b-3p (MIRT040584)
- hsa-miR-92a-3p (MIRT049314)
- hsa-miR-218-5p (MIRT439630)
- hsa-miR-210-3p (MIRT439632)
- mmu-miR-377-3p (MIRT577742)
- mmu-miR-1927 (MIRT577743)
- mmu-miR-677-5p (MIRT585951)
- mmu-miR-501-3p (MIRT603368)
- mmu-miR-500-3p (MIRT603369)
- mmu-miR-1930-5p (MIRT603370)
- mmu-miR-466m-3p (MIRT605495)
- mmu-miR-466o-3p (MIRT605496)
- mmu-miR-466f-3p (MIRT605497)
- mmu-miR-466i-3p (MIRT605498)
- mmu-miR-329-3p (MIRT605499)
- mmu-miR-362-3p (MIRT605500)
- hsa-miR-5010-3p (MIRT653802)
- hsa-miR-2113 (MIRT653803)
- hsa-miR-6796-5p (MIRT653804)
- hsa-miR-6759-5p (MIRT653805)
- hsa-miR-4322 (MIRT653806)
- hsa-miR-4296 (MIRT653807)
- hsa-miR-4265 (MIRT653808)
- hsa-miR-4668-5p (MIRT653809)
- hsa-miR-4267 (MIRT653810)
- hsa-miR-4762-5p (MIRT653811)
- hsa-miR-5586-5p (MIRT653812)
- hsa-miR-208b-5p (MIRT653813)
- hsa-miR-208a-5p (MIRT653814)
- hsa-miR-548c-3p (MIRT653815)
- hsa-miR-1343-5p (MIRT737490)
- hsa-miR-149-3p (MIRT737787)
- hsa-miR-3150a-3p (MIRT740289)
- hsa-miR-3151-5p (MIRT740360)
- hsa-miR-3175 (MIRT740688)
- hsa-miR-4447 (MIRT744662)
- hsa-miR-4472 (MIRT744988)
- hsa-miR-4519 (MIRT745794)
- hsa-miR-4728-5p (MIRT747883)
- hsa-miR-491-5p (MIRT749231)
- hsa-miR-5190 (MIRT749922)
- hsa-miR-591 (MIRT751583)
- hsa-miR-6081 (MIRT751781)
- hsa-miR-6731-5p (MIRT754038)
- hsa-miR-6742-5p (MIRT754394)
- hsa-miR-6763-5p (MIRT755031)
- hsa-miR-6785-5p (MIRT755878)
- hsa-miR-6825-5p (MIRT757016)
- hsa-miR-6856-5p (MIRT757736)
- hsa-miR-6883-5p (MIRT758463)
- hsa-miR-8085 (MIRT760242)
- hsa-miR-939-5p (MIRT760781)
miRNA products for research
Inhibitory RNAs for research
- Origene shrna, sirna, and RNAi products in human, mouse, rat for SIN3A
- Browse OriGene Inhibitory RNA Products For SIN3A
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for SIN3A
Clone products for research
- Applied Biological Materials (abm): Clones for SIN3A - Starting at $45 >
- * SIN3A as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Retro- | Protein Vector - Browse All
- * Viral Packaging Services and High Titer Production Services also available.
-
- MG211790
- MG223187
- MG224052
- MG224462
- MR211790
- MR211790L3
- MR211790L4
- MR223187
- MR223187L3
- MR223187L4
- MR224052
- MR224052L3
- MR224052L4
- MR224462
- MR224462L3
- MR224462L4
- RC213240
- RC213240L1
- RC213240L2
- RC213240L3
- RC213240L4
- RC227540
- RC227540L3
- RC227540L4
- RC227622
- RC227622L1
- RC227622L2
- RC227622L3
- RC227622L4
- RG213240
- RG227540
- RG227622
- RR213450
- RR213450L3
- RR213450L4
- MR211790L3V
- MR211790L4V
- MR223187L3V
- MR223187L4V
- MR224052L3V
- MR224052L4V
- MR224462L3V
- MR224462L4V
- RC213240L1V
- RC213240L2V
- RC213240L3V
- RC213240L4V
- RC227540L3V
- RC227540L4V
- RC227622L1V
- RC227622L2V
- RC227622L3V
- RC227622L4V
- RR213450L3V
- RR213450L4V
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for SIN3A
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for SIN3A
Cell Lines for research
-
Horizon Cell Lines for SIN3A
No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targets and HOMER Transcription for SIN3A Gene
Localization for SIN3A Gene
Subcellular locations from UniProtKB/Swiss-Prot for SIN3A Gene
- Nucleus. Nucleus, nucleolus. Note=Recruited to the nucleolus by SAP30L.
| Compartment | Confidence |
|---|---|
| nucleus | 5 |
| cytosol | 3 |
| plasma membrane | 2 |
| extracellular | 2 |
| cytoskeleton | 2 |
| mitochondrion | 2 |
| peroxisome | 1 |
| endoplasmic reticulum | 1 |
| endosome | 1 |
| lysosome | 1 |
| golgi apparatus | 1 |
- Nucleoplasm (4)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000118 | histone deacetylase complex | IBA | 21873635 |
| GO:0000776 | kinetochore | IEA | -- |
| GO:0000785 | chromatin | IBA | 21873635 |
| GO:0005634 | nucleus | IEA,ISS | -- |
| GO:0005654 | nucleoplasm | IDA,TAS | -- |
Pathways & Interactions for SIN3A Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 | ||
| 2 | Macrophage Differentiation and Growth Inhibition by METS |
DNA Methylation and Transcriptional Repression
.30
|
Macrophage Differentiation and Growth Inhibition by METS
.30
|
| 3 | RNA Polymerase II Transcription Initiation And Promoter Clearance |
Protein Acetylation and Deacetylation
.51
|
Transcription Ligand-Dependent Transcription of Retinoid-Target genes
.32
|
| 4 | Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha) | ||
| 5 | Metabolism |
.40
|
|
Pathways by source for SIN3A Gene
11 BioSystems pathways for SIN3A Gene
10 Reactome pathways for SIN3A Gene
4 KEGG pathways for SIN3A Gene
4 GeneGo (Thomson Reuters) pathways for SIN3A Gene
- Immune response Function of MEF2 in T lymphocytes
- Signal transduction Activin A signaling regulation
- Transcription Ligand-Dependent Transcription of Retinoid-Target genes
- Transcription Sin3 and NuRD in transcription regulation
8 Qiagen pathways for SIN3A Gene
- DNA Methylation and Transcriptional Repression
- Estrogen Pathway
- Glucocorticoid Receptor Signaling
- Huntington's Disease Pathway
- Macrophage Differentiation and Growth Inhibition by METS
1 Cell Signaling Technology pathway for SIN3A Gene
1 GeneTex pathway for SIN3A Gene
Interacting Proteins for SIN3A Gene
Selected Interacting proteins:
Q96ST3-SIN3A_HUMAN
ENSP00000378402
for SIN3A Gene via
UniProtKB
MINT
STRING
IID
GPS-Prot Interaction Network for SIN3A
SIGNOR curated interactions for SIN3A Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000122 | negative regulation of transcription by RNA polymerase II | IMP | 22783022 |
| GO:0001701 | in utero embryonic development | IEA | -- |
| GO:0002218 | activation of innate immune response | IMP | 22783022 |
| GO:0002230 | positive regulation of defense response to virus by host | IMP | 22783022 |
| GO:0002244 | hematopoietic progenitor cell differentiation | IEA | -- |
Transcripts for SIN3A Gene
mRNA/cDNA for SIN3A Gene
- 3 REFSEQ mRNAs :
- 19 NCBI additional mRNA sequence :
- 15 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000360439 5050 nts (view in UCSC)
- ENST00000394947 6723 nts (view in UCSC)
- ENST00000394949 4930 nts (view in UCSC)
- ENST00000562776 590 nts (view in UCSC)
- ENST00000564778 617 nts (view in UCSC)
CRISPR products for research
- Applied Biological Materials (abm): CRISPR Clones for SIN3A - Starting at $85 >
- * SIN3A CRISPR as ready-to-use vector or virus: Non-viral | Lenti- | Adeno- | AAV- | siRNA - Browse All
- * Cas9 Nucleases, Nickases, Null Mutants, and GFP tag also available.
-
OriGene CRISPR knockouts for SIN3A
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for SIN3A
-
Santa Cruz Biotechnology (SCBT) CRISPR for SIN3A
miRNA products for research
Inhibitory RNAs for research
- Origene shrna, sirna, and RNAi products in human, mouse, rat for SIN3A
- Browse OriGene Inhibitory RNA Products For SIN3A
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for SIN3A
Clone products for research
- Applied Biological Materials (abm): Clones for SIN3A - Starting at $45 >
- * SIN3A as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Retro- | Protein Vector - Browse All
- * Viral Packaging Services and High Titer Production Services also available.
-
- MG211790
- MG223187
- MG224052
- MG224462
- MR211790
- MR211790L3
- MR211790L4
- MR223187
- MR223187L3
- MR223187L4
- MR224052
- MR224052L3
- MR224052L4
- MR224462
- MR224462L3
- MR224462L4
- RC213240
- RC213240L1
- RC213240L2
- RC213240L3
- RC213240L4
- RC227540
- RC227540L3
- RC227540L4
- RC227622
- RC227622L1
- RC227622L2
- RC227622L3
- RC227622L4
- RG213240
- RG227540
- RG227622
- RR213450
- RR213450L3
- RR213450L4
- MR211790L3V
- MR211790L4V
- MR223187L3V
- MR223187L4V
- MR224052L3V
- MR224052L4V
- MR224462L3V
- MR224462L4V
- RC213240L1V
- RC213240L2V
- RC213240L3V
- RC213240L4V
- RC227540L3V
- RC227540L4V
- RC227622L1V
- RC227622L2V
- RC227622L3V
- RC227622L4V
- RR213450L3V
- RR213450L4V
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for SIN3A
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for SIN3A
| ExUns: | 1 | ^ | 2 | ^ | 3 | ^ | 4a | · | 4b | ^ | 5 | ^ | 6 | ^ | 7 | ^ | 8 | ^ | 9a | · | 9b | · | 9c | ^ | 10a | · | 10b | · | 10c | · | 10d | · | 10e | ^ | 11 | ^ | 12 | ^ | 13 | ^ | 14 | ^ | 15 | ^ | 16 | ^ | 17 | ^ | 18 | ^ | 19 | ^ |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||
| SP2: | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||
| SP3: | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||
| SP4: | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||||
| SP5: | - | |||||||||||||||||||||||||||||||||||||||||||||||||||
| SP6: | - | - | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||
| SP7: | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||
| SP8: | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||
| SP9: | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||||
| SP10: | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||
| SP11: |
| ExUns: | 20 | ^ | 21 | ^ | 22 | ^ | 23 | ^ | 24 | ^ | 25a | · | 25b | ^ | 26a | · | 26b | ^ | 27 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | ||||||||||||||||||
| SP2: | - | ||||||||||||||||||
| SP3: | - | ||||||||||||||||||
| SP4: | |||||||||||||||||||
| SP5: | |||||||||||||||||||
| SP6: | |||||||||||||||||||
| SP7: | |||||||||||||||||||
| SP8: | |||||||||||||||||||
| SP9: | |||||||||||||||||||
| SP10: | |||||||||||||||||||
| SP11: |
Relevant External Links for SIN3A Gene
- GeneLoc Exon Structure for
- SIN3A
Expression for SIN3A Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
-
Ovary (Reproductive System)
- Ovarian Mesenchymal Stroma Cells Ovary Interstitium
- Oviduct
-
Gonad (Reproductive System)
- Testis Somatic Cells Primitive Gonad
-
Testis (Reproductive System)
- Testis Somatic Cells Primitive Gonad
- Brain (Nervous System)
- Intestine (Gastrointestinal Tract)
- Blood (Hematopoietic System)
This gene is overexpressed in Lymph node (15.3) and Peripheral blood mononuclear cells (13.4).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for SIN3A Gene
- Elite partner
Transcriptomic regulation report from SPP (The Signaling Pathways Project) for SIN3A
SOURCE GeneReport for Unigene cluster for SIN3A Gene:
Hs.513039mRNA Expression by UniProt/SwissProt for SIN3A Gene:
Q96ST3-SIN3A_HUMAN
Tissue specificity:
Expressed in the developing brain, with highest levels of expression detected in the ventricular zone of various cortical regions.
Evidence on tissue expression from TISSUES for SIN3A Gene
- Nervous system(4.8)
- Lung(4.5)
- Liver(4.5)
- Blood(2.5)
- Intestine(2.5)
- Skin(2.4)
- Kidney(2.4)
- Muscle(2.3)
- Thyroid gland(2.3)
- Heart(2.3)
- Bone marrow(2.2)
- Spleen(2.2)
- Lymph node(2.1)
- Eye(2)
Primer products for research
-
OriGene qPCR primer pairs for SIN3A
Gene Expression Assays for research
No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for SIN3A Gene
Orthologs for SIN3A Gene
This gene was present in the common ancestor of animals and fungi.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| Chimpanzee (Pan troglodytes) |
Mammalia | SIN3A 29 30 |
|
OneToOne | |
| Oppossum (Monodelphis domestica) |
Mammalia | SIN3A 30 |
|
OneToOne | |
| Cow (Bos Taurus) |
Mammalia | SIN3A 29 30 |
|
OneToOne | |
| Dog (Canis familiaris) |
Mammalia | SIN3A 29 30 |
|
OneToOne | |
| Mouse (Mus musculus) |
Mammalia | Sin3a 29 16 30 |
|
OneToOne | |
| Rat (Rattus norvegicus) |
Mammalia | Sin3a 29 |
|
||
| Platypus (Ornithorhynchus anatinus) |
Mammalia | SIN3A 30 |
|
OneToOne | |
| Chicken (Gallus gallus) |
Aves | SIN3A 29 30 |
|
OneToOne | |
| Lizard (Anolis carolinensis) |
Reptilia | SIN3A 30 |
|
OneToOne | |
| Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | sin3a 29 |
|
||
| Str.14936 29 |
|
||||
| African clawed frog (Xenopus laevis) |
Amphibia | Sin3 29 |
|
||
| Zebrafish (Danio rerio) |
Actinopterygii | sin3aa 30 |
|
OneToMany | |
| sin3ab 30 |
|
OneToMany | |||
| wufb95g11 29 |
|
||||
| Fruit Fly (Drosophila melanogaster) |
Insecta | Sin3A 29 30 |
|
OneToMany | |
| African malaria mosquito (Anopheles gambiae) |
Insecta | AgaP_AGAP007892 29 |
|
||
| Worm (Caenorhabditis elegans) |
Secernentea | sin-3 30 |
|
OneToMany | |
| Baker's yeast (Saccharomyces cerevisiae) |
Saccharomycetes | SIN3 30 32 |
|
OneToMany | |
| Sea Squirt (Ciona savignyi) |
Ascidiacea | CSA.3742 30 |
|
OneToMany | |
| Sea Vase (Ciona intestinalis) |
Ascidiacea | Cin.4585 29 |
|
- Species where no ortholog for SIN3A was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Eremothecium gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- Alicante grape (Vitis vinifera)
- Alpha proteobacteria (Wolbachia pipientis)
- Amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- Barley (Hordeum vulgare)
- Beta proteobacteria (Neisseria meningitidis)
- Bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- Common water flea (Daphnia pulex)
- Corn (Zea mays)
- E. coli (Escherichia coli)
- Filamentous fungi (Aspergillus nidulans)
- Firmicute Bacteria (Streptococcus pneumoniae)
- Fission Yeast (Schizosaccharomyces pombe)
- Green Algae (Chlamydomonas reinhardtii)
- Honey Bee (Apis mellifera)
- K. Lactis Yeast (Kluyveromyces lactis)
- Loblloly Pine (Pinus taeda)
- Malaria Parasite (Plasmodium falciparum)
- Medicago Trunc (Medicago Truncatula)
- Moss (Physcomitrella patens)
- Orangutan (Pongo pygmaeus)
- Pig (Sus scrofa)
- Rainbow Trout (Oncorhynchus mykiss)
- Rice (Oryza sativa)
- Rice Blast Fungus (Magnaporthe grisea)
- Schistosome Parasite (Schistosoma mansoni)
- Sea Anemone (Nematostella vectensis)
- Sea Urchin (Strongylocentrotus purpuratus)
- Sorghum (Sorghum bicolor)
- Soybean (Glycine max)
- Stem Rust Fungus (Puccinia graminis)
- Sugarcane (Saccharum officinarum)
- Thale Cress (Arabidopsis thaliana)
- Tomato (Lycopersicon esculentum)
- Toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- Wheat (Triticum aestivum)
Evolution for SIN3A Gene
- ENSEMBL:
- Gene Tree for SIN3A (if available)
- TreeFam:
- Gene Tree for SIN3A (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for SIN3A: view image
- Alliance of Genome Resources:
- Additional Orthologs for SIN3A
Paralogs for SIN3A Gene
(1) SIMAP similar genes for SIN3A Gene using alignment to 9 proteins:
- SIN3A_HUMAN
- H3BMA2_HUMAN
- H3BNA0_HUMAN
- H3BNZ3_HUMAN
- H3BP90_HUMAN
- H3BQ76_HUMAN
- H3BQ88_HUMAN
- H3BQL7_HUMAN
- H3BT34_HUMAN
Pseudogenes.org Pseudogenes for SIN3A Gene
Variants for SIN3A Gene
Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for SIN3A Gene
| SNP ID | Clinical significance and condition | Chr 15 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| 1031165 | Pathogenic: Witteveen-kolk syndrome | 75,409,923(-) |
CT/C NM_001145358.2(SIN3A):c.1229del (p.Lys410fs) |
FRAMESHIFT | |
| 1031166 | Likely Pathogenic: Witteveen-kolk syndrome | 75,396,346(-) |
G/A NM_001145358.2(SIN3A):c.2005C>T (p.Leu669Phe) |
MISSENSE | |
| 1031167 | Pathogenic: Witteveen-kolk syndrome | 75,394,697(-) |
C/CAA NM_001145358.2(SIN3A):c.2258_2259dup (p.Glu754fs) |
FRAMESHIFT | |
| 1031168 | Uncertain Significance: Witteveen-kolk syndrome | 75,411,724(-) |
T/G NM_001145358.2(SIN3A):c.776A>C (p.His259Pro) |
MISSENSE | |
| 1036145 | Uncertain Significance: not provided | 75,392,310(-) |
C/T NM_001145358.2(SIN3A):c.2783G>A (p.Arg928Gln) |
MISSENSE |
All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| dgv1243n106 | CNV | deletion | 24896259 |
| dgv2621n100 | CNV | gain | 25217958 |
| esv2749894 | CNV | deletion | 23290073 |
| esv2749895 | CNV | deletion | 23290073 |
| esv3636926 | CNV | gain | 21293372 |
| nsv1116463 | OTHER | inversion | 24896259 |
| nsv1615 | CNV | insertion | 18451855 |
| nsv474716 | CNV | novel sequence insertion | 20440878 |
| nsv525265 | CNV | gain | 19592680 |
| nsv827389 | CNV | gain | 20364138 |
| nsv976952 | CNV | duplication | 23825009 |
| nsv977737 | CNV | duplication | 23825009 |
Residual Variation Intolerance Score:
1.44% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
2.02;
37.25% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for SIN3A Gene
SNP Genotyping and Copy Number Assays for research
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SIN3A Gene
Disorders for SIN3A Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| witteveen-kolk syndrome |
|
|
| chromosome 15q24 deletion syndrome |
|
|
| rett syndrome |
|
|
| gene duplication disease |
|
|
| gait apraxia |
|
|
Search SIN3A in MalaCards
View complete list of genes associated with diseases
UniProtKB/Swiss-Prot
SIN3A_HUMAN- Witteveen-Kolk syndrome (WITKOS) [MIM:613406]: An autosomal dominant syndrome characterized by global developmental delay, mild to severe intellectual disability, and facial dysmorphism. Additional features include short stature, microcephaly, joint hypermotility, and small hands and feet with digital abnormalities. Brain imaging shows dilated ventricles, thin corpus callosum and, in some cases, dysgyria or polymicrogyria. {ECO:0000269 PubMed:27399968, ECO:0000269 PubMed:30267900}. Note=The disease is caused by variants affecting the gene represented in this entry.
Additional Disease Information for SIN3A
- Atlas
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
- Open Targets Platform
- Open Targets Platform
No data available for Genatlas for SIN3A Gene
Publications for SIN3A Gene
- Haploinsufficiency of MeCP2-interacting transcriptional co-repressor SIN3A causes mild intellectual disability by affecting the development of cortical integrity. (PMID: 27399968) Witteveen JS ā¦ Kolk SM (Nature genetics 2016) 3 4 72
- PSF is a novel corepressor that mediates its effect through Sin3A and the DNA binding domain of nuclear hormone receptors. (PMID: 11259580) Mathur M ā¦ Samuels HH (Molecular and cellular biology 2001) 3 4 22
- Novel SIN3A mutation identified in a Japanese patient with Witteveen-Kolk syndrome. (PMID: 30267900) Narumi-Kishimoto Y ā¦ Hata K (European journal of medical genetics 2019) 3 4
- GWAS for discovery and replication of genetic loci associated with sudden cardiac arrest in patients with coronary artery disease. (PMID: 21658281) Aouizerat BE ā¦ Tseng ZH (BMC cardiovascular disorders 2011) 3 40
- A genome-wide association study in 19 633 Japanese subjects identified LHX3-QSOX2 and IGF1 as adult height loci. (PMID: 20189936) Okada Y ā¦ Kamatani N (Human molecular genetics 2010) 3 40
ExternalLinks
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- VectorBuilder Custom and pre-made DNA vectors for SIN3A (ie. gene expression, shRNA knockdown, CRISPR)
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- antibodies-online: Show 80 available SIN3A Antibodies ranked by validation data
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Sources for SIN3A Gene
- (1) GeneCards
- (2) HGNC
- (3) NCBI Entrez Gene
- (4) UniProtKB/Swiss-Prot
- (5) Ensembl
- (6) OMIM® (Updated: 05-Apr-2021)
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) Cell Signaling Technology
- (12) GO
- (13) UniProtKB/TrEMBL
- (14) InterPro
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22)