Aliases for SIMC1 Gene

Aliases for SIMC1 Gene

  • SUMO Interacting Motifs Containing 1 2 3 5
  • Platform Element For Inhibition Of Autolytic Degradation 2 3
  • SUMO-Interacting Motif-Containing Protein 1 3 4
  • Oocyte Maturation Associated 1 2 3
  • C5orf25 3 4
  • SUMO-Interacting Motifs Containing 1 2
  • Chromosome 5 Open Reading Frame 25 2
  • PLEIAD 3
  • OOMA1 3

External Ids for SIMC1 Gene

Previous HGNC Symbols for SIMC1 Gene

  • C5orf25

Previous GeneCards Identifiers for SIMC1 Gene

  • GC05P175666
  • GC05P175675

Summaries for SIMC1 Gene

GeneCards Summary for SIMC1 Gene

SIMC1 (SUMO Interacting Motifs Containing 1) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include SUMO polymer binding. An important paralog of this gene is SKIDA1.

Additional gene information for SIMC1 Gene

No data available for Entrez Gene Summary , CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for SIMC1 Gene

Genomics for SIMC1 Gene

GeneHancer (GH) Regulatory Elements for SIMC1 Gene

Promoters and enhancers for SIMC1 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around SIMC1 on UCSC Golden Path with GeneCards custom track

Genomic Locations for SIMC1 Gene

Genomic Locations for SIMC1 Gene
chr5:176,238,367-176,345,991
(GRCh38/hg38)
Size:
107,625 bases
Orientation:
Plus strand
chr5:175,665,365-175,772,994
(GRCh37/hg19)
Size:
107,630 bases
Orientation:
Plus strand

Genomic View for SIMC1 Gene

Genes around SIMC1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SIMC1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SIMC1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SIMC1 Gene

Proteins for SIMC1 Gene

  • Protein details for SIMC1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8NDZ2-SIMC1_HUMAN
    Recommended name:
    SUMO-interacting motif-containing protein 1
    Protein Accession:
    Q8NDZ2
    Secondary Accessions:
    • J3KQQ8
    • Q6NXN8
    • Q6ZTU4
    • Q8IZ15

    Protein attributes for SIMC1 Gene

    Size:
    872 amino acids
    Molecular mass:
    96838 Da
    Quaternary structure:
    • Interacts (via SIM domains) with SUMO1 and SUMO2.

    Alternative splice isoforms for SIMC1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SIMC1 Gene

Post-translational modifications for SIMC1 Gene

  • Ubiquitination at Lys543
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for SIMC1 Gene

Domains & Families for SIMC1 Gene

Gene Families for SIMC1 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for SIMC1 Gene

ProtoNet:

Suggested Antigen Peptide Sequences for SIMC1 Gene

GenScript: Design optimal peptide antigens:
  • cDNA FLJ56998 (B4DRM7_HUMAN)
genes like me logo Genes that share domains with SIMC1: view

No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for SIMC1 Gene

Function for SIMC1 Gene

Phenotypes From GWAS Catalog for SIMC1 Gene

Gene Ontology (GO) - Molecular Function for SIMC1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0032184 SUMO polymer binding IDA 23086935
genes like me logo Genes that share ontologies with SIMC1: view
genes like me logo Genes that share phenotypes with SIMC1: view

Animal Model Products

CRISPR Products

miRNA for SIMC1 Gene

miRTarBase miRNAs that target SIMC1

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for SIMC1 Gene

Localization for SIMC1 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SIMC1 gene
Compartment Confidence
nucleus 3
cytosol 2

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nucleoli fibrillar center (3)
  • Nucleus (3)
See all subcellular structures

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for SIMC1 Gene

Pathways & Interactions for SIMC1 Gene

PathCards logo

SuperPathways for SIMC1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for SIMC1 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for SIMC1 Gene

Drugs & Compounds for SIMC1 Gene

No Compound Related Data Available

Transcripts for SIMC1 Gene

CRISPR Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for SIMC1 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7a · 7b ^ 8 ^ 9 ^ 10 ^ 11 ^ 12
SP1: - - -
SP2: -
SP3: -
SP4:

Relevant External Links for SIMC1 Gene

GeneLoc Exon Structure for
SIMC1
ECgene alternative splicing isoforms for
SIMC1

Expression for SIMC1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for SIMC1 Gene

mRNA differential expression in normal tissues according to GTEx for SIMC1 Gene

This gene is overexpressed in Ovary (x4.9).

Protein differential expression in normal tissues from HIPED for SIMC1 Gene

This gene is overexpressed in Fetal testis (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for SIMC1 Gene



Protein tissue co-expression partners for SIMC1 Gene

NURSA nuclear receptor signaling pathways regulating expression of SIMC1 Gene:

SIMC1

SOURCE GeneReport for Unigene cluster for SIMC1 Gene:

Hs.719847
genes like me logo Genes that share expression patterns with SIMC1: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for SIMC1 Gene

Orthologs for SIMC1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for SIMC1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SIMC1 33 32
  • 99.76 (n)
OneToOne
dog
(Canis familiaris)
Mammalia SIMC1 33 32
  • 92.01 (n)
OneToOne
cow
(Bos Taurus)
Mammalia SIMC1 33 32
  • 88.23 (n)
OneToOne
rat
(Rattus norvegicus)
Mammalia Simc1 32
  • 87.77 (n)
mouse
(Mus musculus)
Mammalia Simc1 17 33 32
  • 87.6 (n)
oppossum
(Monodelphis domestica)
Mammalia -- 33
  • 49 (a)
OneToMany
-- 33
  • 35 (a)
OneToMany
chicken
(Gallus gallus)
Aves SIMC1 33
  • 48 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia SIMC1 33
  • 38 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii SIMC1 33
  • 19 (a)
OneToOne
Species where no ortholog for SIMC1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for SIMC1 Gene

ENSEMBL:
Gene Tree for SIMC1 (if available)
TreeFam:
Gene Tree for SIMC1 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for SIMC1: view image

Paralogs for SIMC1 Gene

Paralogs for SIMC1 Gene

Pseudogenes.org Pseudogenes for SIMC1 Gene

genes like me logo Genes that share paralogs with SIMC1: view

Variants for SIMC1 Gene

Sequence variations from dbSNP and Humsavar for SIMC1 Gene

SNP ID Clin Chr 05 pos Variation AA Info Type
rs1000013784 -- 176,294,860(+) G/A genic_upstream_transcript_variant, intron_variant
rs1000018476 -- 176,341,136(+) G/A intron_variant
rs1000037761 -- 176,257,641(+) C/T genic_upstream_transcript_variant, intron_variant
rs1000066142 -- 176,294,627(+) T/A genic_upstream_transcript_variant, intron_variant
rs1000111705 -- 176,304,343(+) A/C genic_upstream_transcript_variant, intron_variant

Structural Variations from Database of Genomic Variants (DGV) for SIMC1 Gene

Variant ID Type Subtype PubMed ID
dgv5832n100 CNV gain 25217958
dgv5833n100 CNV gain 25217958
dgv5835n100 CNV gain+loss 25217958
dgv5836n100 CNV loss 25217958
dgv5838n100 CNV gain 25217958
dgv5841n100 CNV gain 25217958
dgv5843n100 CNV gain 25217958
dgv731n27 CNV gain 19166990
esv1074689 CNV deletion 17803354
esv2677756 CNV deletion 23128226
esv2759395 CNV gain 17122850
esv2760985 CNV gain+loss 21179565
esv33353 CNV gain+loss 17666407
esv34563 CNV gain 17911159
esv3607669 CNV loss 21293372
nsv1015753 CNV gain+loss 25217958
nsv1023853 CNV gain 25217958
nsv1074352 CNV deletion 25765185
nsv1109747 CNV deletion 24896259
nsv1125415 OTHER inversion 24896259
nsv428131 CNV gain 18775914
nsv462548 CNV gain 19166990
nsv462549 CNV gain 19166990
nsv516952 CNV gain+loss 19592680
nsv600340 CNV gain 21841781
nsv600341 CNV gain 21841781
nsv830557 CNV loss 17160897
nsv950721 CNV duplication 24416366
nsv964977 CNV duplication 23825009
nsv964978 CNV duplication 23825009
nsv980761 CNV duplication 23825009

Variation tolerance for SIMC1 Gene

Residual Variation Intolerance Score: 75.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.59; 65.21% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for SIMC1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
SIMC1

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SIMC1 Gene

Disorders for SIMC1 Gene

Additional Disease Information for SIMC1

No disorders were found for SIMC1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SIMC1 Gene

Publications for SIMC1 Gene

  1. Poly-small ubiquitin-like modifier (PolySUMO)-binding proteins identified through a string search. (PMID: 23086935) Sun H … Hunter T (The Journal of biological chemistry 2012) 2 3 4 56
  2. PLEIAD/SIMC1/C5orf25, a novel autolysis regulator for a skeletal-muscle-specific calpain, CAPN3, scaffolds a CAPN3 substrate, CTBP1. (PMID: 23707407) Ono Y … Sorimachi H (Journal of molecular biology 2013) 2 3 56
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 56
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 56
  5. Robust phosphoproteomic profiling of tyrosine phosphorylation sites from human T cells using immobilized metal affinity chromatography and tandem mass spectrometry. (PMID: 15144186) Brill LM … Peters EC (Analytical chemistry 2004) 3 4 56

Products for SIMC1 Gene

Sources for SIMC1 Gene