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This gene represents a homolog of the Drosophila single-minded (sim) gene, which encodes a transcription factor that is a master regulator of neurogenesis. The encoded protein is ubiquitinated by RING-IBR-RING-type E3 ubiquitin ligases, including the parkin RBR E3 ubiquitin protein ligase. This gene maps within the so-called Down syndrome chromosomal region, and is thus thought... See more...
Aliases for SIM2 Gene
Aliases for SIM2 Gene
External Ids for SIM2 Gene
- HGNC: 10883
- Entrez Gene: 6493
- Ensembl: ENSG00000159263
- OMIM: 600892
- UniProtKB: Q14190
Previous HGNC Symbols for SIM2 Gene
- SIM
Previous GeneCards Identifiers for SIM2 Gene
- GC21P034649
- GC21P036991
- GC21P036992
- GC21P036993
- GC21P038071
- GC21P023547
Summaries for SIM2 Gene
-
This gene represents a homolog of the Drosophila single-minded (sim) gene, which encodes a transcription factor that is a master regulator of neurogenesis. The encoded protein is ubiquitinated by RING-IBR-RING-type E3 ubiquitin ligases, including the parkin RBR E3 ubiquitin protein ligase. This gene maps within the so-called Down syndrome chromosomal region, and is thus thought to contribute to some specific Down syndrome phenotypes. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Sep 2014]
GeneCards Summary for SIM2 Gene
SIM2 (SIM BHLH Transcription Factor 2) is a Protein Coding gene. Diseases associated with SIM2 include Down Syndrome and Syphilitic Encephalitis. Gene Ontology (GO) annotations related to this gene include DNA-binding transcription factor activity and obsolete signal transducer activity. An important paralog of this gene is SIM1.
UniProtKB/Swiss-Prot Summary for SIM2 Gene
-
Transcription factor that may be a master gene of CNS development in cooperation with Arnt. It may have pleiotropic effects in the tissues expressed during development.
Additional gene information for SIM2 Gene
- HGNC(10883)
- Entrez Gene(6493)
- Ensembl(ENSG00000159263)
- OMIM(600892)
- UniProtKB(Q14190)
- Open Targets Platform(ENSG00000159263)
- Search for SIM2 at DataMed
- Search for SIM2 at HumanCyc
No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for SIM2 Gene
Genomics for SIM2 Gene
GeneHancer (GH) Regulatory Elements Pubs
Promoters and enhancers for SIM2 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around SIM2 on the GeneHancer Hub at the UCSC Golden Path
Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for SIM2
- Top Transcription factor binding sites by QIAGEN in the SIM2 gene promoter:
-
- E47
- HNF-4alpha1
- IRF-1
- NF-kappaB
- NF-kappaB1
- Nkx2-5
- Tal-1beta
Genomic Locations for SIM2 Gene
Genomic Locations for SIM2 Gene
- chr21:36,699,115-36,750,219
- (GRCh38/hg38)
- Size:
- 51,105 bases
- Orientation:
- Plus strand
- chr21:38,071,433-38,122,510
- (GRCh37/hg19)
- Size:
- 51,078 bases
- Orientation:
- Plus strand
Genomic View for SIM2 Gene
Genes around SIM2 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 21q22.13 by HGNC
- 21q22.13 by Entrez Gene
- 21q22.13 by Ensembl
SIM2 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for SIM2 Gene
Proteins for SIM2 Gene
-
Protein details for SIM2 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q14190-SIM2_HUMAN
- Recommended name:
- Single-minded homolog 2
- Protein Accession:
- Q14190
- O60766
- Q15470
- Q15471
- Q15472
- Q15473
- Q16532
- Q2TBD8
Protein attributes for SIM2 Gene
- Size:
- 667 amino acids
- Molecular mass:
- 73219 Da
- Quaternary structure:
-
- Efficient DNA binding requires dimerization with another bHLH protein. Heterodimer of SIM2 and ARNT.
Protein Expression for SIM2 Gene
Post-translational modifications for SIM2 Gene
Other Protein References for SIM2 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- Novus Biologicals Antibodies for SIM2
-
Abcam antibodies for SIM2
- Invitrogen Antibodies for SIM2 (AFLGC-SIM2)
-
Boster Bio Antibodies for SIM2
-
Santa Cruz Biotechnology (SCBT) Antibodies for SIM2
Protein Products
-
OriGene Purified Proteins for SIM2
- Search Origene for MassSpec and Protein Over-expression Lysates for SIM2
- Origene Custom Protein Services for SIM2
- antibodies-online: Show 2 available SIM2 Proteins ranked by validation data
- Compare Top SIM2 Proteins
-
Quality Products:
No data available for DME Specific Peptides for SIM2 Gene
Domains & Families for SIM2 Gene
Gene Families for SIM2 Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Predicted intracellular proteins
- Transcription factors
Protein Domains for SIM2 Gene
- InterPro:
- Blocks:
-
- PAS domain
- Nuclear translocator signature
- Basic helix-loop-helix dimerization domain bHLH
- PAC motif
- PAS fold-3
- PAS fold
- Single-minded, C-terminal
- ProtoNet:
Suggested Antigen Peptide Sequences for SIM2 Gene
- GenScript: Design optimal peptide antigens:
-
- Class E basic helix-loop-helix protein 15 (SIM2_HUMAN)
No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for SIM2 Gene
Function for SIM2 Gene
Molecular function for SIM2 Gene
- UniProtKB/Swiss-Prot Function:
- Transcription factor that may be a master gene of CNS development in cooperation with Arnt. It may have pleiotropic effects in the tissues expressed during development.
- GENATLAS Biochemistry:
- Drosophila master regulator of fruit fly neurogenesis,single-minded 2 homolog,expressed in brain,kidney,skeletal muscle,prostate,located in the Down syndrome critical region with four alternatively spliced isoforms,involved in the development of midline cells in the central nervous system
Phenotypes From GWAS Catalog for SIM2 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000981 | DNA-binding transcription factor activity, RNA polymerase II-specific | ISA | -- |
| GO:0003677 | DNA binding | IEA | -- |
| GO:0003700 | DNA-binding transcription factor activity | IEA,TAS | 8661114 |
| GO:0005515 | protein binding | IEA | -- |
| GO:0046982 | protein heterodimerization activity | IEA | -- |
Phenotypes for SIM2 Gene
- MGI mutant phenotypes for SIM2:
- inferred from 2 alleles
- GenomeRNAi human phenotypes for SIM2:
-
- Increased vaccinia virus (VACV) infection
- no effect
- Increased shRNA abundance (Z-score > 2)
- shRNA abundance <= 25%
- Decreased shRNA abundance (Z-score < -2)
- Upregulation of Wnt pathway
- Decreased viability in esophageal squamous lineage
- Decreased interferon-beta reporter expression
- Decreased epidermal growth factor (EGF) endocytosis
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for SIM2 - Select products 50% OFF >
- * SIM2 CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for SIM2
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for SIM2
-
Santa Cruz Biotechnology (SCBT) CRISPR for SIM2
miRNA for SIM2 Gene
- miRTarBase miRNAs that target SIM2
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for SIM2
- Browse OriGene Inhibitory RNA Products For SIM2
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for SIM2
Clone Products
- Applied Biological Materials (abm): Clones for SIM2 - Select products 50% OFF >
- * SIM2 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
- Sino Biological Human cDNA Clone for SIM2
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for SIM2
Cell Line Products
-
Horizon Cell Lines for SIM2
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for SIM2 Gene
Localization for SIM2 Gene
Subcellular locations from UniProtKB/Swiss-Prot for SIM2 Gene
- Nucleus.
| Compartment | Confidence |
|---|---|
| nucleus | 5 |
| plasma membrane | 2 |
| extracellular | 2 |
| cytoskeleton | 2 |
| mitochondrion | 2 |
| peroxisome | 1 |
| endoplasmic reticulum | 1 |
| endosome | 1 |
| cytosol | 1 |
| lysosome | 1 |
| golgi apparatus | 1 |
- Nuclear bodies (3)
- Nucleoplasm (3)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000790 | nuclear chromatin | ISA | -- |
| GO:0005634 | nucleus | IBA | 21873635 |
| GO:0005654 | nucleoplasm | IDA | -- |
| GO:0016604 | nuclear body | IDA | -- |
Pathways & Interactions for SIM2 Gene
Interacting Proteins for SIM2 Gene
GPS-Prot Interaction Network for SIM2
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000122 | negative regulation of transcription by RNA polymerase II | IEA | -- |
| GO:0006355 | regulation of transcription, DNA-templated | IEA | -- |
| GO:0006357 | regulation of transcription by RNA polymerase II | IBA | 21873635 |
| GO:0007275 | multicellular organism development | IEA | -- |
| GO:0007399 | nervous system development | TAS,IEA | -- |
No data available for Pathways by source for SIM2 Gene
Transcripts for SIM2 Gene
mRNA/cDNA for SIM2 Gene
- 2 REFSEQ mRNAs :
- 12 NCBI additional mRNA sequence :
- 5 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000290399 4461 nts (view in UCSC)
- ENST00000431229 1465 nts (view in UCSC)
- ENST00000460783 2235 nts (view in UCSC)
- ENST00000481185 3377 nts (view in UCSC)
- ENST00000483178 824 nts (view in UCSC)
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for SIM2 - Select products 50% OFF >
- * SIM2 CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for SIM2
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for SIM2
-
Santa Cruz Biotechnology (SCBT) CRISPR for SIM2
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for SIM2
- Browse OriGene Inhibitory RNA Products For SIM2
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for SIM2
Clone Products
- Applied Biological Materials (abm): Clones for SIM2 - Select products 50% OFF >
- * SIM2 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
- Sino Biological Human cDNA Clone for SIM2
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for SIM2
| ExUns: | 1a | · | 1b | ^ | 2a | · | 2b | · | 2c | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6 | ^ | 7 | ^ | 8 | ^ | 9 | ^ | 10 | ^ | 11a | · | 11b | ^ | 12 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | - | ||||||||||||||||||||||||||||
| SP2: | - | ||||||||||||||||||||||||||||||
| SP3: | - | ||||||||||||||||||||||||||||||
| SP4: |
Relevant External Links for SIM2 Gene
- GeneLoc Exon Structure for
- SIM2
Expression for SIM2 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
- Brain (Nervous System)
-
Limb (Muscoskeletal System)
- Limb Bud Mesenchyme Cells Limb Bud
- Limb Muscle Progenitor Cells Forelimb Myotome
- Lung (Respiratory System)
- Paraxial Mesoderm (Gastrulation Derivatives)
-
Mesoderm (Gastrulation Derivatives)
- Limb Bud Mesenchyme Cells Limb Bud
-
Skeletal Muscle (Muscoskeletal System)
- Limb Muscle Progenitor Cells Forelimb Myotome
- Gut Tube (Gastrointestinal Tract)
- Neural Tube (Nervous System)
- Kidney (Urinary System)
- Neural Crest (Gastrulation Derivatives)
- Lateral Plate Mesoderm (Gastrulation Derivatives)
mRNA differential expression in normal tissues according to GTEx for SIM2 Gene
This gene is overexpressed in Esophagus - Mucosa (x14.0) and Kidney - Cortex (x9.6).
This gene is overexpressed in Platelet (68.5).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for SIM2 Gene
Transcriptomic regulation report from SPP (The Signaling Pathways Project) for SIM2
SOURCE GeneReport for Unigene cluster for SIM2 Gene:
Hs.146186Evidence on tissue expression from TISSUES for SIM2 Gene
- Nervous system(4.6)
- Muscle(4.4)
- Skin(2.8)
- Kidney(2.3)
Primer Products
-
OriGene qPCR primer pairs for SIM2
Gene Expression Assay Products
No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for SIM2 Gene
Orthologs for SIM2 Gene
This gene was present in the common ancestor of animals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| Chimpanzee (Pan troglodytes) |
Mammalia | SIM2 30 31 |
|
OneToOne | |
| Dog (Canis familiaris) |
Mammalia | SIM2 30 31 |
|
OneToOne | |
| Cow (Bos Taurus) |
Mammalia | SIM2 30 31 |
|
OneToOne | |
| Mouse (Mus musculus) |
Mammalia | Sim2 30 17 31 |
|
OneToOne | |
| Rat (Rattus norvegicus) |
Mammalia | Sim2 30 |
|
||
| Platypus (Ornithorhynchus anatinus) |
Mammalia | SIM2 31 |
|
OneToOne | |
| Oppossum (Monodelphis domestica) |
Mammalia | SIM2 31 |
|
OneToOne | |
| Chicken (Gallus gallus) |
Aves | SIM2 30 31 |
|
OneToOne | |
| Lizard (Anolis carolinensis) |
Reptilia | SIM2 31 |
|
OneToOne | |
| Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | sim2 30 |
|
||
| African clawed frog (Xenopus laevis) |
Amphibia | sim2-A 30 |
|
||
| Zebrafish (Danio rerio) |
Actinopterygii | sim2 30 |
|
||
| SIM2 31 |
|
OneToOne | |||
| Fruit Fly (Drosophila melanogaster) |
Insecta | sim 31 32 |
|
OneToMany | |
| Worm (Caenorhabditis elegans) |
Secernentea | hlh-34 31 |
|
OneToMany | |
| Sea Squirt (Ciona savignyi) |
Ascidiacea | -- 31 |
|
OneToMany |
- Species where no ortholog for SIM2 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Eremothecium gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- Alpha proteobacteria (Wolbachia pipientis)
- Amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- Baker's yeast (Saccharomyces cerevisiae)
- Barley (Hordeum vulgare)
- Beta proteobacteria (Neisseria meningitidis)
- Bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- Common water flea (Daphnia pulex)
- Corn (Zea mays)
- E. coli (Escherichia coli)
- Filamentous fungi (Aspergillus nidulans)
- Firmicute Bacteria (Streptococcus pneumoniae)
- Fission Yeast (Schizosaccharomyces pombe)
- Green Algae (Chlamydomonas reinhardtii)
- Honey Bee (Apis mellifera)
- K. Lactis Yeast (Kluyveromyces lactis)
- Loblloly Pine (Pinus taeda)
- Malaria Parasite (Plasmodium falciparum)
- Medicago Trunc (Medicago Truncatula)
- Moss (Physcomitrella patens)
- Orangutan (Pongo pygmaeus)
- Pig (Sus scrofa)
- Rainbow Trout (Oncorhynchus mykiss)
- Rice (Oryza sativa)
- Rice Blast Fungus (Magnaporthe grisea)
- Schistosome Parasite (Schistosoma mansoni)
- Sea Anemone (Nematostella vectensis)
- Sea Vase (Ciona intestinalis)
- Sea Urchin (Strongylocentrotus purpuratus)
- Sorghum (Sorghum bicolor)
- Soybean (Glycine max)
- Stem Rust Fungus (Puccinia graminis)
- Sugarcane (Saccharum officinarum)
- Thale Cress (Arabidopsis thaliana)
- Tomato (Lycopersicon esculentum)
- Toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- Wheat (Triticum aestivum)
Evolution for SIM2 Gene
- ENSEMBL:
- Gene Tree for SIM2 (if available)
- TreeFam:
- Gene Tree for SIM2 (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for SIM2: view image
Paralogs for SIM2 Gene
Variants for SIM2 Gene
Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for SIM2 Gene
| SNP ID | Clinical significance and condition | Chr 21 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| 723859 | Benign: not provided | 36,726,223(+) | G/A | SYNONYMOUS_VARIANT | |
| 758382 | Likely Benign: not provided | 36,747,876(+) | C/T | SYNONYMOUS_VARIANT | |
| 770007 | Likely Benign: not provided | 36,747,792(+) | G/C | SYNONYMOUS_VARIANT | |
| 777618 | Benign: not provided | 36,744,946(+) | G/A | SYNONYMOUS_VARIANT | |
| 779193 | Benign: not provided | 36,719,859(+) | T/C | SYNONYMOUS_VARIANT |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| nsv1073128 | CNV | deletion | 25765185 |
| nsv1133526 | CNV | deletion | 24896259 |
| nsv519597 | CNV | loss | 19592680 |
| nsv828876 | CNV | loss | 20364138 |
| nsv953361 | CNV | deletion | 24416366 |
Residual Variation Intolerance Score:
16% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
8.65;
86.36% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for SIM2 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- SIM2
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SIM2 Gene
Disorders for SIM2 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| down syndrome |
|
|
| syphilitic encephalitis |
|
|
| hypothalamic neoplasm |
|
|
| cone-rod dystrophy 10 |
|
|
| inflammatory bowel disease 27 |
|
|
Search SIM2 in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for SIM2
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
- Open Targets Platform
No data available for UniProtKB/Swiss-Prot and Genatlas for SIM2 Gene
Publications for SIM2 Gene
- A novel nuclear localization signal in the human single-minded proteins SIM1 and SIM2. (PMID: 14697214) Yamaki A … Shimizu Y (Biochemical and biophysical research communications 2004) 3 4 23
- Cloning of two human homologs of the Drosophila single-minded gene SIM1 on chromosome 6q and SIM2 on 21q within the Down syndrome chromosomal region. (PMID: 9199934) Chrast R … Antonarakis SE (Genome research 1997) 3 4 23
- The mammalian single-minded (SIM) gene: mouse cDNA structure and diencephalic expression indicate a candidate gene for Down syndrome. (PMID: 8661114) Yamaki A … Shimizu N (Genomics 1996) 3 4 23
- Down syndrome-critical region contains a gene homologous to Drosophila sim expressed during rat and human central nervous system development. (PMID: 7568099) Dahmane N … Delabar JM (Proceedings of the National Academy of Sciences of the United States of America 1995) 3 4 23
- Single minded 2-s (SIM2-s) gene is expressed in human GBM cells and involved in GBM invasion. (PMID: 20448453) He Q … Zhang J (Cancer biology & therapy 2010) 3 23
ExternalLinks
Products for SIM2 Gene
- Custom Antibody Services
- Browse OriGene ELISA Kits
- Custom Assay Services
- OriGene Purified Proteins for SIM2
- Search Origene for MassSpec and Protein Over-expression Lysates for SIM2
- Origene Custom Protein Services for SIM2
- Origene shrna, sirna, and RNAi products in human, mouse, rat for SIM2
- Browse OriGene Inhibitory RNA Products For SIM2
- OriGene qPCR primer pairs for SIM2
- OriGene CRISPR knockouts for SIM2
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Browse OriGene miRNA Products For SIM2
- Sino Biological Human cDNA Clone for SIM2
- Browse Sino Biological Recombinant Proteins
- Browse Sino Biological Cell Lysates
- Browse Sino Biological Antibodies
- Browse Sino Biological Assays
- Browse cDNA Clones
- Browse ELISA Kits
- Browse CRO Services
- High-throughput Antibody Production Service
- Protein Production Service
- Epitope Tag Antibodies & Reporter Protein Antibodies
- Lentiviral ORF Clones
- Novus Biologicals Antibodies for SIM2
- Novus Biologicals proteins and lysates for SIM2
- Browse Antibodies
- Browse Peptides and Proteins
- Browse Lysates
- Browse ELISA Kits
- Abcam antibodies for SIM2
- Find your target
- Browse Primary Antibodies
- Browse Conjugated Primary Antibodies
- Browse Secondary Antibodies
- Browse ELISA Kits
- Browse Matched Antibody Pairs
- Browse Proteins and Peptides
- Search Knockout (KO) Validated Antibodies
- Browse Monoclonal Antibodies
- Browse Recombinant Antibodies
- Invitrogen Antibodies for SIM2 (AFLGC-SIM2)
- VectorBuilder Custom and pre-made DNA vectors for SIM2 (ie. gene expression, shRNA knockdown, CRISPR)
- VectorBuilder Viral vectors for SIM2 (ie. lentivirus, AAV, adenovirus)
- VectorBuilder CRISPR vectors for SIM2 (ie. knockout, knockin, CRISPRa, CRISPRi)
- VectorBuilder Virus packaging for SIM2 CRISPR vectors (ie. lentivirus, AAV, adenovirus)
- VectorBuilder Stable cell line generation for SIM2
- antibodies-online: Show 73 available SIM2 Antibodies ranked by validation data
- Compare Top SIM2 Antibodies
- antibodies-online: Search results for available SIM2 related products ranked by validation data
- antibodies-online: Show 2 available SIM2 Proteins ranked by validation data
- Compare Top SIM2 Proteins
- Quality Products:
- Santa Cruz Biotechnology (SCBT) Antibodies for SIM2
- Search Santa Cruz Biotechnology (SCBT) for SIM2 siRNA/shRNA
- Santa Cruz Biotechnology (SCBT) CRISPR for SIM2
- Horizon Cell Lines for SIM2
- Browse GeneCopoeia Cell Lines
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for SIM2
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for SIM2
- Search GeneCopoeia for miRNA 3'UTR Target clone products for SIM2
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for SIM2
- Boster Bio Antibodies for SIM2
- Browse Boster Bio ELISA Kits
Sources for SIM2 Gene
- (1) GeneCards
- (2) HGNC
- (3) NCBI Entrez Gene
- (4) UniProtKB/Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) Cell Signaling Technology
- (12) GO
- (13) UniProtKB/TrEMBL
- (14) InterPro
- (15) ProtoNet
- (16) Blocks
- (17) MGI
- (18) IUBMB
- (19) KEGG
- (20) MINT
- (21) STRING
- (22) IntAct
- (23) Novoseek
- (24) PharmGKB
- (25) DrugBank
- (26) HMDB
- (27) ASD
- (28) SAGE
- (29) SOURCE
- (30) HomoloGene
- (31) PanEnsembl
- (32) euGenes
- (33) SGD
- (34) FlyBase
- (35) WormBase
- (36) Pseudogene
- (37) DGV
- (38) dbSNP
- (39) GenAtlas
- (40) HGMD
- (41) GAD
- (42) BGMUT
- (43) HuGE
- (44) Atlas
- (45) GenBank
- (46) HORDE
- (47) HUGE
- (48) IMGT
- (49) Leiden
- (50) miRBase
- (51) DME
- (52) OriGene
- (53) PubMed
- (54) R&D Systems
- (55) TGDB
- (56) Tocris
- (57) Abcam
- (58) Novus Biologicals
- (59) ProSpec
- (60) Sino Biological
- (61) GenScript
- (62) Qiagen
- (63) OCA
- (64) Proteopedia
- (65) MOPED
- (66) neXtProt
- (67) Reactome
- (68) GeneGo (Thomson Reuters)
- (69) DISEASES
- (70) SIMAP
- (71) GenomeRNAi
- (72) LifeMap
- (73) miRTarBase
- (74) MalaCards
- (75) Invitrogen
- (76) BitterDB
- (77) ESI-BIO
- (78) RefSeq
- (79) BioSystems
- (80) MaxQB
- (81) IUPHAR
- (82) BioGPS
- (83) Illumina
- (84) COMPARTMENTS
- (85) HOMER
- (86) PaxDb
- (87) ApexBio
- (88) Addgene
- (89) antibodies-online
- (90) CYP
- (91) NONCODE
- (92) TreeFam
- (93) PathCards
- (94) GeneReviews
- (95) GeneTex
- (96) Taconic Biosciences
- (97) GTEx
- (98) ProteomicsDB
- (99) SCBT
- (100) DGIdb
- (101) ClinicalTrials
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