Aliases for SIKE1 Gene
External Ids for SIKE1 Gene
Previous GeneCards Identifiers for SIKE1 Gene
SIKE interacts with IKK-epsilon (IKBKE; MIM 605048) and TBK1 (MIM 604834) and acts as a suppressor of TLR3 (MIM 603029) and virus-triggered interferon activation pathways (Huang et al., 2005 [PubMed 16281057]).[supplied by OMIM, Mar 2008]
GeneCards Summary for SIKE1 Gene
SIKE1 (Suppressor Of IKBKE 1) is a Protein Coding gene. Diseases associated with SIKE1 include Cerebral Cavernous Malformations 3 and Neuropathy, Hereditary Sensory And Autonomic, Type V. Among its related pathways are RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways and Innate Immune System. An important paralog of this gene is FGFR1OP2.
UniProtKB/Swiss-Prot Summary for SIKE1 Gene
Physiological suppressor of IKK-epsilon and TBK1 that plays an inhibitory role in virus- and TLR3-triggered IRF3. Inhibits TLR3-mediated activation of interferon-stimulated response elements (ISRE) and the IFN-beta promoter. May act by disrupting the interactions of IKBKE or TBK1 with TICAM1/TRIF, IRF3 and DDX58/RIG-I. Does not inhibit NF-kappa-B activation pathways.