SIKE interacts with IKK-epsilon (IKBKE; MIM 605048) and TBK1 (MIM 604834) and acts as a suppressor of TLR3 (MIM 603029) and virus-triggered interferon activation pathways (Huang et al., 2005 [PubMed 16281057]).[supplied by OMIM, Mar 2008] See more...

Aliases for SIKE1 Gene

Aliases for SIKE1 Gene

  • Suppressor Of IKBKE 1 2 3 4 5
  • SIKE 2 3 4
  • Suppressor Of IKK Epsilon 2 3
  • Suppressor Of IKK-Epsilon 4
  • FLJ21168 2
  • SIKE1 5

External Ids for SIKE1 Gene

Previous GeneCards Identifiers for SIKE1 Gene

  • GC01M115115
  • GC01M115312
  • GC01M113170

Summaries for SIKE1 Gene

Entrez Gene Summary for SIKE1 Gene

  • SIKE interacts with IKK-epsilon (IKBKE; MIM 605048) and TBK1 (MIM 604834) and acts as a suppressor of TLR3 (MIM 603029) and virus-triggered interferon activation pathways (Huang et al., 2005 [PubMed 16281057]).[supplied by OMIM, Mar 2008]

GeneCards Summary for SIKE1 Gene

SIKE1 (Suppressor Of IKBKE 1) is a Protein Coding gene. Diseases associated with SIKE1 include Cerebral Cavernous Malformations 3 and Neuropathy, Hereditary Sensory And Autonomic, Type V. Among its related pathways are RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways and Innate Immune System. An important paralog of this gene is FGFR1OP2.

UniProtKB/Swiss-Prot Summary for SIKE1 Gene

  • Physiological suppressor of IKK-epsilon and TBK1 that plays an inhibitory role in virus- and TLR3-triggered IRF3. Inhibits TLR3-mediated activation of interferon-stimulated response elements (ISRE) and the IFN-beta promoter. May act by disrupting the interactions of IKBKE or TBK1 with TICAM1/TRIF, IRF3 and DDX58/RIG-I. Does not inhibit NF-kappa-B activation pathways.

No data available for CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for SIKE1 Gene

Genomics for SIKE1 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for SIKE1 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around SIKE1 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for SIKE1

Genomic Locations for SIKE1 Gene

Latest Assembly
chr1:114,769,479-114,780,685
(GRCh38/hg38)
Size:
11,207 bases
Orientation:
Minus strand

Previous Assembly
chr1:115,312,100-115,323,306
(GRCh37/hg19 by Entrez Gene)
Size:
11,207 bases
Orientation:
Minus strand

chr1:115,312,100-115,323,306
(GRCh37/hg19 by Ensembl)
Size:
11,207 bases
Orientation:
Minus strand

Genomic View for SIKE1 Gene

Genes around SIKE1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SIKE1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SIKE1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SIKE1 Gene

Proteins for SIKE1 Gene

  • Protein details for SIKE1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9BRV8-SIKE1_HUMAN
    Recommended name:
    Suppressor of IKBKE 1
    Protein Accession:
    Q9BRV8
    Secondary Accessions:
    • Q5TEZ7
    • Q5TEZ9
    • Q68DZ4
    • Q9H778

    Protein attributes for SIKE1 Gene

    Size:
    207 amino acids
    Molecular mass:
    23721 Da
    Quaternary structure:
    • Interacts with IKBKE and TBK1 via its coiled coil region. Interaction with TBK1 is disrupted upon viral infection or TLR3 stimulation (PubMed:16281057). Interacts with CDC42BPB (PubMed:25743393).

    Three dimensional structures from OCA and Proteopedia for SIKE1 Gene

    Alternative splice isoforms for SIKE1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SIKE1 Gene

Post-translational modifications for SIKE1 Gene

  • Ubiquitination at Lys154
  • Modification sites at PhosphoSitePlus

Other Protein References for SIKE1 Gene

No data available for DME Specific Peptides for SIKE1 Gene

Domains & Families for SIKE1 Gene

Gene Families for SIKE1 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for SIKE1 Gene

InterPro:

Suggested Antigen Peptide Sequences for SIKE1 Gene

GenScript: Design optimal peptide antigens:
  • Suppressor of IKK-epsilon (SIKE1_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q9BRV8

UniProtKB/Swiss-Prot:

SIKE1_HUMAN :
  • Belongs to the SIKE family.
Family:
  • Belongs to the SIKE family.
genes like me logo Genes that share domains with SIKE1: view

Function for SIKE1 Gene

Molecular function for SIKE1 Gene

UniProtKB/Swiss-Prot Function:
Physiological suppressor of IKK-epsilon and TBK1 that plays an inhibitory role in virus- and TLR3-triggered IRF3. Inhibits TLR3-mediated activation of interferon-stimulated response elements (ISRE) and the IFN-beta promoter. May act by disrupting the interactions of IKBKE or TBK1 with TICAM1/TRIF, IRF3 and DDX58/RIG-I. Does not inhibit NF-kappa-B activation pathways.

Phenotypes From GWAS Catalog for SIKE1 Gene

Gene Ontology (GO) - Molecular Function for SIKE1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 18782753
GO:0019901 protein kinase binding IPI 25743393
GO:0031267 small GTPase binding IPI 25743393
genes like me logo Genes that share ontologies with SIKE1: view
genes like me logo Genes that share phenotypes with SIKE1: view

miRNA for SIKE1 Gene

miRTarBase miRNAs that target SIKE1

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for SIKE1

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for SIKE1 Gene

Localization for SIKE1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SIKE1 Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SIKE1 gene
Compartment Confidence
cytosol 5
nucleus 3
plasma membrane 2
cytoskeleton 1
mitochondrion 1
peroxisome 1
endoplasmic reticulum 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Focal adhesion sites (2)
  • Vesicles (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for SIKE1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with SIKE1: view

Pathways & Interactions for SIKE1 Gene

genes like me logo Genes that share pathways with SIKE1: view

Gene Ontology (GO) - Biological Process for SIKE1 Gene

None

No data available for SIGNOR curated interactions for SIKE1 Gene

Drugs & Compounds for SIKE1 Gene

No Compound Related Data Available

Transcripts for SIKE1 Gene

mRNA/cDNA for SIKE1 Gene

2 REFSEQ mRNAs :
10 NCBI additional mRNA sequence :
10 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for SIKE1

Alternative Splicing Database (ASD) splice patterns (SP) for SIKE1 Gene

ExUns: 1a · 1b · 1c · 1d · 1e · 1f · 1g ^ 2 ^ 3a · 3b · 3c ^ 4a · 4b ^ 5a · 5b · 5c
SP1: - - - -
SP2: - - -
SP3: - - - - -
SP4: - -
SP5: - -
SP6: -
SP7: - - -

Relevant External Links for SIKE1 Gene

GeneLoc Exon Structure for
SIKE1

Expression for SIKE1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for SIKE1 Gene

Protein differential expression in normal tissues from HIPED for SIKE1 Gene

This gene is overexpressed in Plasma (17.0), Peripheral blood mononuclear cells (14.8), Pancreatic juice (10.4), and Bone (8.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for SIKE1 Gene



Protein tissue co-expression partners for SIKE1 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for SIKE1

SOURCE GeneReport for Unigene cluster for SIKE1 Gene:

Hs.709277

mRNA Expression by UniProt/SwissProt for SIKE1 Gene:

Q9BRV8-SIKE1_HUMAN
Tissue specificity: Widely expressed. Expressed in brain, heart, skeletal muscle, colon, thymus, spleen, kidney, liver, small intestine, placenta, lung and leukocytes. Present in all cell lines tested (at protein level).

Evidence on tissue expression from TISSUES for SIKE1 Gene

  • Muscle(4.4)
  • Nervous system(2.7)
genes like me logo Genes that share expression patterns with SIKE1: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for SIKE1 Gene

Orthologs for SIKE1 Gene

This gene was present in the common ancestor of animals.

Orthologs for SIKE1 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia SIKE1 29 30
  • 99.36 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia SIKE1 29 30
  • 94.47 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia SIKE1 29 30
  • 94.36 (n)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia SIKE1 30
  • 92 (a)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia SIKE1 30
  • 88 (a)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Sike1 29
  • 86.96 (n)
Mouse
(Mus musculus)
Mammalia Sike1 29 16 30
  • 86.8 (n)
OneToOne
Chicken
(Gallus gallus)
Aves SIKE1 29 30
  • 70.57 (n)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia SIKE1 30
  • 67 (a)
OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia sike1 29
  • 68.01 (n)
Str.10737 29
African clawed frog
(Xenopus laevis)
Amphibia Xl.12065 29
Zebrafish
(Danio rerio)
Actinopterygii LOC568173 29
  • 62.94 (n)
SIKE1 30
  • 57 (a)
OneToOne
Fruit Fly
(Drosophila melanogaster)
Insecta CG10158 30
  • 18 (a)
OneToMany
Sea Squirt
(Ciona savignyi)
Ascidiacea CSA.8091 30
  • 29 (a)
OneToMany
Species where no ortholog for SIKE1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for SIKE1 Gene

ENSEMBL:
Gene Tree for SIKE1 (if available)
TreeFam:
Gene Tree for SIKE1 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for SIKE1: view image
Alliance of Genome Resources:
Additional Orthologs for SIKE1

Paralogs for SIKE1 Gene

Paralogs for SIKE1 Gene

(1) SIMAP similar genes for SIKE1 Gene using alignment to 1 proteins:

  • SIKE1_HUMAN
genes like me logo Genes that share paralogs with SIKE1: view

Variants for SIKE1 Gene

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for SIKE1 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for SIKE1 Gene

Variant ID Type Subtype PubMed ID
esv2716496 CNV deletion 23290073
esv2716507 CNV deletion 23290073
esv2716518 CNV deletion 23290073
esv28734 CNV loss 19812545
esv3587275 CNV loss 21293372
nsv824265 CNV gain 20364138

Variation tolerance for SIKE1 Gene

Residual Variation Intolerance Score: 28.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.37; 8.26% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for SIKE1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
SIKE1
Leiden Open Variation Database (LOVD)
SIKE1

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for SIKE1 Gene

Disorders for SIKE1 Gene

MalaCards: The human disease database

(2) MalaCards diseases for SIKE1 Gene - From: COP

- elite association - COSMIC cancer census association via MalaCards
Search SIKE1 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for SIKE1

genes like me logo Genes that share disorders with SIKE1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for SIKE1 Gene

Publications for SIKE1 Gene

  1. SIKE is an IKK epsilon/TBK1-associated suppressor of TLR3- and virus-triggered IRF-3 activation pathways. (PMID: 16281057) Huang J … Shu HB (The EMBO journal 2005) 2 3 4 22
  2. CCM-3/STRIPAK promotes seamless tube extension through endocytic recycling. (PMID: 25743393) Lant B … Derry WB (Nature communications 2015) 3 4
  3. A reference map of the human binary protein interactome. (PMID: 32296183) Luck K … Calderwood MA (Nature 2020) 3
  4. Prognostic values of inhibitory κB kinases mRNA expression in human gastric cancer. (PMID: 30487159) Gayed DT … Chen JC (Bioscience reports 2019) 3
  5. Mammalian APE1 controls miRNA processing and its interactome is linked to cancer RNA metabolism. (PMID: 28986522) Antoniali G … Tell G (Nature communications 2017) 3

Products for SIKE1 Gene

Sources for SIKE1 Gene