Aliases for SIK3 Gene
External Ids for SIK3 Gene
Previous GeneCards Identifiers for SIK3 Gene
GeneCards Summary for SIK3 Gene
SIK3 (SIK Family Kinase 3) is a Protein Coding gene. Diseases associated with SIK3 include Spondyloepimetaphyseal Dysplasia, Krakow Type and Mesomelia. Among its related pathways are LKB1 signaling events. Gene Ontology (GO) annotations related to this gene include transferase activity, transferring phosphorus-containing groups and protein tyrosine kinase activity. An important paralog of this gene is SIK2.
UniProtKB/Swiss-Prot Summary for SIK3 Gene
Positive regulator of mTOR signaling that functions by triggering the degradation of DEPTOR, an mTOR inhibitor. Involved in the dynamic regulation of mTOR signaling in chondrocyte differentiation during skeletogenesis (PubMed:30232230). Negatively regulates cAMP signaling pathway possibly by acting on CRTC2/TORC2 and CRTC3/TORC3 (Probable). Prevents HDAC4 translocation to the nucleus (By similarity).