Aliases for SIK2 Gene

Aliases for SIK2 Gene

  • Salt Inducible Kinase 2 2 3 5
  • Serine/Threonine-Protein Kinase SNF1-Like Kinase 2 3 4
  • Serine/Threonine-Protein Kinase SIK2 3 4
  • Qin-Induced Kinase 3 4
  • SNF1-Like Kinase 2 2 3
  • EC 4 54
  • SNF1LK2 3 4
  • SIK-2 3 4
  • QIK 3 4
  • Salt-Inducible Serine/Threonine Kinase 2 3
  • Salt-Inducible Protein Kinase 2 3
  • Salt-Inducible Kinase 2 4
  • LOH11CR1I 3
  • EC 2.7.11 54
  • KIAA0781 4

External Ids for SIK2 Gene

Previous HGNC Symbols for SIK2 Gene

  • SNF1LK2

Previous GeneCards Identifiers for SIK2 Gene

  • GC11U900483
  • GC11P111011
  • GC11P110978
  • GC11P111473
  • GC11P107397

Summaries for SIK2 Gene

GeneCards Summary for SIK2 Gene

SIK2 (Salt Inducible Kinase 2) is a Protein Coding gene. Among its related pathways are LKB1 signaling events and Glucagon signaling pathway. Gene Ontology (GO) annotations related to this gene include transferase activity, transferring phosphorus-containing groups and protein tyrosine kinase activity. An important paralog of this gene is SIK1B.

UniProtKB/Swiss-Prot Summary for SIK2 Gene

  • Phosphorylates 'Ser-794' of IRS1 in insulin-stimulated adipocytes, potentially modulating the efficiency of insulin signal transduction. Inhibits CREB activity by phosphorylating and repressing TORCs, the CREB-specific coactivators.

Gene Wiki entry for SIK2 Gene

Additional gene information for SIK2 Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for SIK2 Gene

Genomics for SIK2 Gene

GeneHancer (GH) Regulatory Elements for SIK2 Gene

Promoters and enhancers for SIK2 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH11J111601 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER 761.6 +1.0 1010 4 ZNF24 ZBTB40 SP1 CTCF MLX RBPJ SMARCE1 POLR2A ATF1 HCFC1 SIK2 lnc-BTG4-4 piR-31264 NKAPD1 ENSG00000235286
GH11J111764 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER 20.9 +163.6 163625 3.3 ZBTB40 ZBTB6 POLR2A L3MBTL2 ZNF121 RELA NKRF ZFX MLLT1 ZSCAN21 PPP2R1B lnc-SIK2-3 ALG9 SIK2 RPS6P16 LAYN MIR34B MIR34C BTG4 C11orf88
GH11J111693 Enhancer 1.4 FANTOM5 Ensembl ENCODE dbSUPER 20.1 +94.5 94509 7.8 ZNF24 SMARCE1 TEAD4 MAFK CBFA2T2 SP7 PRDM1 SMARCA4 GMEB1 IKZF1 HSALNG0087128 SIK2 PPP2R1B NKAPD1 BTG4 C11orf88 MIR34B MIR34C LAYN RN7SKP273
GH11J111622 Enhancer 1.2 Ensembl ENCODE dbSUPER 23.2 +22.0 22003 2.9 MLX RBPJ NFYC HLF RAD21 SP1 MLLT1 ZNF687 ZNF644 KAT8 SIK2 ALG9 PPP2R1B lnc-BTG4-4 ENSG00000235286
GH11J111629 Enhancer 1.2 Ensembl ENCODE dbSUPER 22.9 +31.0 31010 8.4 FOXA1 NR2F6 CREB1 MIXL1 HLF RAD21 ELF3 SP1 CEBPG HNF1A SIK2 PPP2R1B lnc-BTG4-4 ENSG00000235286
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around SIK2 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the SIK2 gene promoter:
  • C/EBPbeta
  • CREB
  • deltaCREB
  • GCNF-1
  • GCNF-2
  • Nkx2-5
  • RFX1
  • XBP-1

Genomic Locations for SIK2 Gene

Genomic Locations for SIK2 Gene
129,998 bases
Plus strand
128,463 bases
Plus strand

Genomic View for SIK2 Gene

Genes around SIK2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SIK2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SIK2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SIK2 Gene

Proteins for SIK2 Gene

  • Protein details for SIK2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Serine/threonine-protein kinase SIK2
    Protein Accession:
    Secondary Accessions:
    • A8K5B8
    • B0YJ94
    • O94878
    • Q17RV0
    • Q6AZE2
    • Q76N03
    • Q8NCV7
    • Q96CZ8

    Protein attributes for SIK2 Gene

    926 amino acids
    Molecular mass:
    103915 Da
    Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
    Quaternary structure:
    • Interacts with and phosphorylates TORC2/CRTC2.
    • Sequence=BAA34501.3; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for SIK2 Gene

Selected DME Specific Peptides for SIK2 Gene


Post-translational modifications for SIK2 Gene

  • Phosphorylated at Thr-175 by STK11/LKB1 in complex with STE20-related adapter-alpha (STRADA) pseudo kinase and CAB39.
  • Acetylation at Lys-53 inhibits kinase activity. Deacetylated by HDAC6.
  • Ubiquitination at Lys692
  • Modification sites at PhosphoSitePlus

Other Protein References for SIK2 Gene

ENSEMBL proteins:
REFSEQ proteins:

Domains & Families for SIK2 Gene

Gene Families for SIK2 Gene

Human Protein Atlas (HPA):
  • Enzymes
  • Predicted membrane proteins

Suggested Antigen Peptide Sequences for SIK2 Gene

GenScript: Design optimal peptide antigens:
  • Serine/threonine-protein kinase SNF1-like kinase 2 (SIK2_HUMAN)

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. SNF1 subfamily.
  • Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. SNF1 subfamily.
genes like me logo Genes that share domains with SIK2: view

Function for SIK2 Gene

Molecular function for SIK2 Gene

UniProtKB/Swiss-Prot Function:
Phosphorylates 'Ser-794' of IRS1 in insulin-stimulated adipocytes, potentially modulating the efficiency of insulin signal transduction. Inhibits CREB activity by phosphorylating and repressing TORCs, the CREB-specific coactivators.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein]; Xref=Rhea:RHEA:17989, Rhea:RHEA-COMP:9863, Rhea:RHEA-COMP:11604, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999, ChEBI:CHEBI:30616, ChEBI:CHEBI:83421, ChEBI:CHEBI:456216; EC=; Evidence=. ;.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-threonyl-[protein]; Xref=Rhea:RHEA:46608, Rhea:RHEA-COMP:11060, Rhea:RHEA-COMP:11605, ChEBI:CHEBI:15378, ChEBI:CHEBI:30013, ChEBI:CHEBI:30616, ChEBI:CHEBI:61977, ChEBI:CHEBI:456216; EC=; Evidence=. ;.
UniProtKB/Swiss-Prot EnzymeRegulation:
Activated by phosphorylation on Thr-175.

Enzyme Numbers (IUBMB) for SIK2 Gene

Phenotypes From GWAS Catalog for SIK2 Gene

Gene Ontology (GO) - Molecular Function for SIK2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000287 magnesium ion binding IDA 14976552
GO:0004672 protein kinase activity IEA --
GO:0004674 protein serine/threonine kinase activity IBA,IDA 14976552
GO:0005515 protein binding IPI 20708153
GO:0005524 ATP binding IDA 14976552
genes like me logo Genes that share ontologies with SIK2: view
genes like me logo Genes that share phenotypes with SIK2: view

Animal Models for SIK2 Gene

MGI Knock Outs for SIK2:
  • Sik2 Sik2<tm1Htake>

Animal Model Products

  • Taconic Biosciences Mouse Models for SIK2

CRISPR Products

Clone Products

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for SIK2 Gene

Localization for SIK2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SIK2 Gene


Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SIK2 gene
Compartment Confidence
nucleus 4
cytosol 3
golgi apparatus 2
mitochondrion 1
plasma membrane 0

Subcellular locations from the

Human Protein Atlas (HPA)
  • Golgi apparatus (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for SIK2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IBA 21873635
GO:0005737 cytoplasm ISS,IBA --
GO:0031588 nucleotide-activated protein kinase complex IBA 21873635
genes like me logo Genes that share ontologies with SIK2: view

Pathways & Interactions for SIK2 Gene

genes like me logo Genes that share pathways with SIK2: view

Pathways by source for SIK2 Gene

1 BioSystems pathway for SIK2 Gene
1 KEGG pathway for SIK2 Gene
1 Cell Signaling Technology pathway for SIK2 Gene

SIGNOR curated interactions for SIK2 Gene

Is activated by:
Other effect:

Gene Ontology (GO) - Biological Process for SIK2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006468 protein phosphorylation IDA 14976552
GO:0016310 phosphorylation IEA --
GO:0032007 negative regulation of TOR signaling IBA 21873635
GO:0035556 intracellular signal transduction IDA 14976552
GO:0042149 cellular response to glucose starvation IBA 21873635
genes like me logo Genes that share ontologies with SIK2: view

Drugs & Compounds for SIK2 Gene

(17) Drugs for SIK2 Gene - From: DrugBank, ApexBio, HMDB, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
fostamatinib Approved, Investigational Pharma Target, inhibitor Kinase Inhibitors 0
Magnesium Approved, Experimental, Investigational Pharma 0
HG-9-91-01 Pharma Pan-SIK (salt-inducible kinases) inhibitor 0

(9) Additional Compounds for SIK2 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs

(1) ApexBio Compounds for SIK2 Gene

Compound Action Cas Number
HG-9-91-01 Pan-SIK (salt-inducible kinases) inhibitor 1456858-58-4
genes like me logo Genes that share compounds with SIK2: view

Drug Products

Transcripts for SIK2 Gene

mRNA/cDNA for SIK2 Gene

(1) REFSEQ mRNAs :
(16) Additional mRNA sequences :
(197) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for SIK2 Gene

No ASD Table

Relevant External Links for SIK2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for SIK2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for SIK2 Gene

mRNA differential expression in normal tissues according to GTEx for SIK2 Gene

This gene is overexpressed in Muscle - Skeletal (x4.6).

Protein differential expression in normal tissues from HIPED for SIK2 Gene

This gene is overexpressed in Lung (51.5) and Heart (9.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for SIK2 Gene

Protein tissue co-expression partners for SIK2 Gene

NURSA nuclear receptor signaling pathways regulating expression of SIK2 Gene:


SOURCE GeneReport for Unigene cluster for SIK2 Gene:


Evidence on tissue expression from TISSUES for SIK2 Gene

  • Liver(4.5)
  • Nervous system(2.7)
genes like me logo Genes that share expression patterns with SIK2: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for SIK2 Gene

Orthologs for SIK2 Gene

This gene was present in the common ancestor of animals.

Orthologs for SIK2 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia SIK2 33 32
  • 99.89 (n)
(Canis familiaris)
Mammalia SIK2 33 32
  • 89.18 (n)
(Mus musculus)
Mammalia Sik2 17 33 32
  • 88.7 (n)
(Bos Taurus)
Mammalia SIK2 33 32
  • 88.57 (n)
(Monodelphis domestica)
Mammalia SIK2 33
  • 87 (a)
(Ornithorhynchus anatinus)
Mammalia SIK2 33
  • 55 (a)
(Gallus gallus)
Aves SIK2 33 32
  • 74.31 (n)
(Anolis carolinensis)
Reptilia SIK2 33
  • 69 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia sik2 32
  • 70.52 (n)
(Danio rerio)
Actinopterygii sik2b 33 32
  • 65.15 (n)
sik2a 33
  • 64 (a)
fruit fly
(Drosophila melanogaster)
Insecta KP78b 33
  • 32 (a)
Sik3 33
  • 20 (a)
(Caenorhabditis elegans)
Secernentea kin-29 33
  • 28 (a)
Species where no ortholog for SIK2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SIK2 Gene

Gene Tree for SIK2 (if available)
Gene Tree for SIK2 (if available)
Evolutionary constrained regions (ECRs) for SIK2: view image

Paralogs for SIK2 Gene

(11) SIMAP similar genes for SIK2 Gene using alignment to 1 proteins:

  • SIK2_HUMAN Pseudogenes for SIK2 Gene

genes like me logo Genes that share paralogs with SIK2: view

Variants for SIK2 Gene

Sequence variations from dbSNP and Humsavar for SIK2 Gene

SNP ID Clin Chr 11 pos Variation AA Info Type
rs1000007272 -- 111,689,554(+) A/G intron_variant
rs1000050820 -- 111,641,713(+) C/T genic_upstream_transcript_variant, intron_variant
rs1000065784 -- 111,634,767(+) C/T genic_upstream_transcript_variant, intron_variant
rs1000070943 -- 111,713,438(+) A/G intron_variant
rs1000106835 -- 111,729,644(+) T/C 3_prime_UTR_variant, genic_downstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for SIK2 Gene

Variant ID Type Subtype PubMed ID
esv2745076 CNV deletion 23290073
esv3627742 CNV loss 21293372
nsv510273 OTHER sequence alteration 20534489
nsv832269 CNV loss 17160897
nsv975978 CNV duplication 23825009

Variation tolerance for SIK2 Gene

Residual Variation Intolerance Score: 10.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.24; 24.91% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for SIK2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SIK2 Gene

Disorders for SIK2 Gene

Additional Disease Information for SIK2

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for SIK2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SIK2 Gene

Publications for SIK2 Gene

  1. Identification and characterization of human FOXN5 and rat Foxn5 genes in silico. (PMID: 15067358) Katoh M … Katoh M (International journal of oncology 2004) 2 3 23 56
  2. Reversible acetylation regulates salt-inducible kinase (SIK2) and its function in autophagy. (PMID: 23322770) Yang FC … Lee SC (The Journal of biological chemistry 2013) 3 4 56
  3. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 43 56
  4. Amplification at 11q23 targets protein kinase SIK2 in diffuse large B-cell lymphoma. (PMID: 20367563) Nagel S … Macleod RA (Leukemia & lymphoma 2010) 3 23 56
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 56

Products for SIK2 Gene

Sources for SIK2 Gene